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Storb, Ursula
One or more keywords matched the following items that are connected to Storb, Ursula
Item TypeName
Concept Alleles
Concept Amino Acid Sequence
Concept Base Sequence
Concept Genes, Immunoglobulin
Concept DNA, Recombinant
Concept Gene Expression Regulation
Concept Genes, Switch
Concept Gene Conversion
Concept Genes
Concept Genes, MHC Class II
Concept Multigene Family
Concept Molecular Sequence Data
Concept Repetitive Sequences, Nucleic Acid
Concept Nucleic Acid Conformation
Concept Gene Rearrangement, B-Lymphocyte
Concept Gene Rearrangement
Concept Gene Rearrangement, T-Lymphocyte
Concept Gene Rearrangement, B-Lymphocyte, Heavy Chain
Concept Gene Rearrangement, B-Lymphocyte, Light Chain
Concept Gene Expression
Concept Genes, Reporter
Concept Gene Deletion
Concept Gene Expression Regulation, Developmental
Concept Interferon-Stimulated Gene Factor 3
Concept Interferon-Stimulated Gene Factor 3, gamma Subunit
Concept Transgenes
Concept Artificial Gene Fusion
Concept Genes, bcl-2
Concept Gene Expression Profiling
Concept Genes, myc
Concept Genes, RAG-1
Concept Gene Expression Regulation, Enzymologic
Concept Gene Silencing
Concept Gene Targeting
Concept Gene Knock-In Techniques
Concept Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Academic Article The molecular basis of somatic hypermutation of immunoglobulin genes.
Academic Article Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate.
Academic Article The mechanism of somatic hypermutation studied with transgenic and transfected target genes.
Academic Article Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.
Academic Article N region diversity of a transgenic substrate in fetal and adult lymphoid cells.
Academic Article Somatic hypermutation of a lambda 2 transgene under the control of the lambda enhancer or the heavy chain intron enhancer.
Academic Article Identification and characterization of the murine Rag1 promoter.
Academic Article Progress in understanding the mechanism and consequences of somatic hypermutation.
Academic Article Gamma 2b provides only some of the signals normally given via mu in B cell development.
Academic Article Somatic hypermutation of an artificial test substrate within an Ig kappa transgene.
Academic Article B lymphocytes of xeroderma pigmentosum or Cockayne syndrome patients with inherited defects in nucleotide excision repair are fully capable of somatic hypermutation of immunoglobulin genes.
Academic Article The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes.
Academic Article Immunoglobulin transgenes as targets for somatic hypermutation.
Academic Article The composition of coding joints formed in V(D)J recombination is strongly affected by the nucleotide sequence of the coding ends and their relationship to the recombination signal sequences.
Academic Article Rearrangement and expression of immunoglobulin genes in transgenic mice.
Academic Article Somatic hypermutation of immunoglobulin genes is linked to transcription.
Academic Article Mef2 proteins, required for muscle differentiation, bind an essential site in the Ig lambda enhancer.
Academic Article Cis-acting sequences that affect somatic hypermutation of Ig genes.
Academic Article An efficient method for high-fidelity BAC/PAC retrofitting with a selectable marker for mammalian cell transfection.
Academic Article Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.
Academic Article Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.
Academic Article Hypomethylation is necessary but not sufficient for V(D)J recombination within a transgenic substrate.
Academic Article The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells.
Academic Article The role of DNA repair in somatic hypermutation of immunoglobulin genes.
Academic Article A cis-acting element that directs the activity of the murine methylation modifier locus Ssm1.
Academic Article Insertion of phosphoglycerine kinase (PGK)-neo 5' of Jlambda1 dramatically enhances VJlambda1 rearrangement.
Academic Article Signal joint formation is inhibited in murine scid preB cells and fibroblasts in substrates with homopolymeric coding ends.
Academic Article Effects of sequence and structure on the hypermutability of immunoglobulin genes.
Academic Article Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.
Academic Article A novel cytidine deaminase affects antibody diversity.
Academic Article A point mutation in the constant region of Ig lambda1 prevents normal B cell development due to defective BCR signaling.
Academic Article Two conserved essential motifs of the murine immunoglobulin lambda enhancers bind B-cell-specific factors.
Academic Article A novel cytidine deaminase AIDs in the delivery of error-prone polymerases to immunoglobulin genes.
Academic Article Mutation pattern of immunoglobulin transgenes is compatible with a model of somatic hypermutation in which targeting of the mutator is linked to the direction of DNA replication.
Academic Article Ig gene somatic hypermutation in mice defective for DNA polymerase delta proofreading.
Academic Article Identification and localization of an enhancer for the human lambda L chain Ig gene complex.
Academic Article Immunology. Autoreactive B cells migrate into T cell territory.
Academic Article Delay of early B-lymphocyte development by gamma 2b immunoglobulin transgene: effect on differentiation-specific molecules.
Academic Article The published data.
Academic Article The contested role of uracil DNA glycosylase in immunoglobulin gene diversification.
Academic Article Factors affecting the rearrangement efficiency of an Ig test gene.
Academic Article Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney.
Academic Article A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B.
Academic Article Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies.
Academic Article A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci.
Academic Article Brca1 in immunoglobulin gene conversion and somatic hypermutation.
Academic Article Analysis of somatic mutations in kappa transgenes.
Academic Article Expression of immunoglobulin and globin genes in B and T lymphocytes and other cells.
Academic Article The switch region associated with immunoglobulin C mu genes is DNase I hypersensitive in T lymphocytes.
Academic Article Cloning of a gamma 2b gene encoding anti-Pseudomonas aeruginosa H chains and its introduction into the germ line of mice.
Academic Article Elevated PC responsive B cells and anti-PC antibody production in transgenic mice harboring anti-PC immunoglobulin genes.
Academic Article Quantitation of immunoglobulin genes by nucleic acid hybridization with RNA from myeloma and spleen microsomes.
Academic Article Misalignment of V and J gene segments resulting in a nonfunctional immunoglobulin gene.
Academic Article Comparison of different rearranged immunoglobulin kappa genes of a myeloma by electronmicroscopy and restriction mapping of cloned DNA: implications for "allelic exclusion".
Academic Article Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice.
Academic Article Structural alterations in J regions of mouse immunoglobulin lambda genes are associated with differential gene expression.
Academic Article Rearrangement of immunoglobulin genes.
Academic Article Ig lambda-producing B cells do not show feedback inhibition of gene rearrangement.
Academic Article Analysis of immunoglobulin genes: DNA/RNA hybridization with immunoglobulin kappa-chain mRNA and isolation and translation of hybridized RNA.
Academic Article Immunoglobulin genes in DNA restriction fragments.
Academic Article Immunoglobulin gene 'remnant' DNA--implications for antibody gene recombination.
Academic Article Somatic mutation of immunoglobulin light-chain variable-region genes.
Academic Article Nucleosome stability dramatically impacts the targeting of somatic hypermutation.
Academic Article Association of two different repetitive DNA elements near immunoglobulin light chain genes.
Academic Article Gamma 2b transgenic mice as a model for the role of immunoglobulins in B cell development.
Academic Article Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.
Academic Article lambda 5, but not mu, is required for B cell maturation in a unique gamma 2b transgenic mouse line.
Academic Article Expression, allelic exclusion and somatic mutation of mouse immunoglobulin kappa genes.
Academic Article Transgenic mice with immunoglobulin genes.
Academic Article The order and orientation of mouse lambda-genes explain lambda-rearrangement patterns.
Academic Article Fusion of a scid pre-B cells with a wild type (myeloma) B cell results in correct rearrangement of a V(D)J recombination substrate.
Academic Article Myeloma with multiple rearranged immunoglobulin kappa genes: only one kappa gene codes for kappa chains.
Academic Article Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice.
Academic Article Sequences of immunoglobulin lambda 1 genes in a lambda 1 defective mouse strain.
Academic Article Evolution of mouse immunoglobulin lambda genes.
Academic Article Expression of lambda and kappa genes can occur in all B cells and is initiated around the same pre-B-cell developmental stage.
Academic Article Immunoglobulin gamma 2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell development.
Academic Article Attracting AID to targets of somatic hypermutation.
Academic Article Rearranged and germline immunoglobulin kappa genes: different states of DNase I sensitivity of constant kappa genes in immunocompetent and nonimmune cells.
Academic Article Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III.
Academic Article Methylation patterns of immunoglobulin genes in lymphoid cells: correlation of expression and differentiation with undermethylation.
Academic Article Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.
Academic Article The bulk chromatin structure of a murine transgene does not vary with its transcriptional or DNA methylation status.
Academic Article Crossing the SJL lambda locus into kappa-knockout mice reveals a dysfunction of the lambda 1-containing immunoglobulin receptor in B cell differentiation.
Academic Article Molecular aspects of somatic hypermutation of immunoglobulin genes.
Academic Article The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression.
Academic Article DNA polymerases in immunity: profiting from errors.
Academic Article Immunoglobulin genes: generating diversity with AID and UNG.
Academic Article DNA methylation precedes chromatin modifications under the influence of the strain-specific modifier Ssm1.
Academic Article Precursors of both conventional and Ly-1 B cells can escape feedback inhibition of Ig gene rearrangement.
Academic Article The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions.
Academic Article Targeting of AID to immunoglobulin genes.
Academic Article Inhibition of immunoglobulin gene rearrangement by the expression of a lambda 2 transgene.
Academic Article The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated.
Academic Article Physical linkage of mouse lambda genes by pulsed-field gel electrophoresis suggests that the rearrangement process favors proximate target sequences.
Academic Article Expression of immunoglobulin genes in transgenic mice and transfected cells.
Academic Article High-frequency deletional rearrangement of immunoglobulin kappa gene segments introduced into a pre-B-cell line.
Academic Article Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains.
Academic Article B cells expressing Ig transgenes respond to a T-dependent antigen only in the presence of Ia-compatible T cells.
Academic Article Pre-B cells in kappa-transgenic mice.
Academic Article Immunoglobulin gene rearrangements in hybridoma cells.
Academic Article High expression of cloned immunoglobulin kappa gene in transgenic mice is restricted to B lymphocytes.
Academic Article Mapping of immunoglobulin variable region genes: relationship to the 'deletion' model of immunoglobulin gene rearrangement.
Academic Article Evidence for multiple immunoglobulin genes.
Academic Article Changes in RNA polymerase II progression influence somatic hypermutation of Ig-related genes by AID.
Academic Article Why does somatic hypermutation by AID require transcription of its target genes?
Academic Article Identification of Ssm1b, a novel modifier of DNA methylation, and its expression during mouse embryogenesis.
Academic Article Ssm1b expression and function in germ cells of adult mice and in early embryos.
Grant CONTROL OF IMMUNOGLOBULIN SYNTHESIS
Grant CONTROL OF IMMUNOGLOBULIN SYNTHESIS
Grant EXPRESSION OF IMMUNOGLOBULIN GENES IN TRANSGENIC MICE
Grant CONTROL OF IMMUNOGLOBULIN SYNTHESIS
Grant EXPRESSION OF IMMUNOGLOBULIN GENES
Grant MUTATION OF IG GENES
Grant T LYMPHOCYTE SPECIFIC GENES
Grant Mechanism of Immunoglobulin Hypermutation
Grant AID in somatic mutation of immunoglobulin genes
Grant Mechanism of Immunoglobulin Hypermutation
Grant Immunoglobulin Somatic Mutation
Grant Identification of the DNA methylation/chromatin modifier Ssm1
Grant EXPRESSION OF IMMUNOGLOBULIN GENES
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  • Genes