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Gajewski, Thomas F.
One or more keywords matched the following items that are connected to Gajewski, Thomas F.
Item TypeName
Concept Antigens, Neoplasm
Concept Antigen-Presenting Cells
Concept Antigens
Concept Antigens, Differentiation
Concept Antigens, Surface
Concept Antigens, Differentiation, T-Lymphocyte
Concept Histocompatibility Antigens Class II
Concept Histocompatibility Antigens
Concept H-2 Antigens
Concept Receptors, Antigen, B-Cell
Concept HLA-A2 Antigen
Concept HLA-A Antigens
Concept CD28 Antigens
Concept Histocompatibility Antigens Class I
Concept CD8 Antigens
Concept Antigens, CD
Concept Receptors, Antigen, T-Cell, gamma-delta
Concept Lymphocyte Function-Associated Antigen-1
Concept T-Cell Antigen Receptor Specificity
Concept Receptors, Antigen, T-Cell, alpha-beta
Concept Antigen Presentation
Concept B7-1 Antigen
Concept CD40 Antigens
Concept B7-H1 Antigen
Concept CD47 Antigen
Concept CTLA-4 Antigen
Concept Thy-1 Antigens
Concept CD2 Antigens
Concept Leukocyte Common Antigens
Concept gp100 Melanoma Antigen
Concept B7-2 Antigen
Concept MART-1 Antigen
Concept Receptors, Antigen, T-Cell
Concept CD4 Antigens
Concept CD5 Antigens
Academic Article Differential regulation of murine T lymphocyte subsets.
Academic Article Differential function of intestinal intraepithelial lymphocyte subsets.
Academic Article B7-1 but not B7-2 efficiently costimulates CD8+ T lymphocytes in the P815 tumor system in vitro.
Academic Article Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.
Academic Article Liver of MRL/lpr mice contain interleukin-4-producing lymphocytes and accessory cells that support the proliferation of Th2 helper T lymphocyte clones.
Academic Article Induction of a cytolytic T-cell response in mice with a recombinant adenovirus coding for tumor antigen P815A.
Academic Article Antigen-specific regression of established tumors induced by active immunization with irradiated IL-12- but not B7-1-transfected tumor cells.
Academic Article Antigen recognition and allogeneic tumor rejection in CD8+ TCR transgenic/RAG(-/-) mice.
Academic Article The expression of mouse gene P1A in testis does not prevent safe induction of cytolytic T cells against a P1A-encoded tumor antigen.
Academic Article Blocked Ras activation in anergic CD4+ T cells.
Academic Article Rational development of tumour antigen-specific immunization in melanoma.
Academic Article Interleukin-12-secreting human papillomavirus type 16-transformed cells provide a potent cancer vaccine that generates E7-directed immunity.
Academic Article B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28.
Academic Article Biochemical analysis of activated T lymphocytes. Protein phosphorylation and Ras, ERK, and JNK activation.
Academic Article B7.1 is a quantitatively stronger costimulus than B7.2 in the activation of naive CD8+ TCR-transgenic T cells.
Academic Article Antigen-specific blockade of T cells in vivo using dimeric MHC peptide.
Academic Article CD28 is not required for c-Jun N-terminal kinase activation in T cells.
Academic Article Improved efficacy of dendritic cell vaccines and successful immunization with tumor antigen peptide-pulsed peripheral blood mononuclear cells by coadministration of recombinant murine interleukin-12.
Academic Article Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).
Academic Article Transplantation and the CD28/CTLA4/B7 pathway.
Academic Article Immunization of HLA-A2+ melanoma patients with MAGE-3 or MelanA peptide-pulsed autologous peripheral blood mononuclear cells plus recombinant human interleukin 12.
Academic Article Cutting edge: spontaneous rejection of poorly immunogenic P1.HTR tumors by Stat6-deficient mice.
Academic Article Differential activation of murine TH1 and TH2 clones.
Academic Article Immunization with Melan-A peptide-pulsed peripheral blood mononuclear cells plus recombinant human interleukin-12 induces clinical activity and T-cell responses in advanced melanoma.
Academic Article B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism.
Academic Article Death of peripheral CD8+ T cells in the absence of MHC class I is Fas-dependent and not blocked by Bcl-xL.
Academic Article Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase.
Academic Article Epitope spreading upon P815 tumor rejection triggered by vaccination with the single class I MHC-restricted peptide P1A.
Academic Article Differential Ras signaling via the antigen receptor and IL-2 receptor in primary T lymphocytes.
Academic Article Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.
Academic Article Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration.
Academic Article Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy.
Academic Article Gene array and protein expression profiles suggest post-transcriptional regulation during CD8+ T cell differentiation.
Academic Article CD4+ murine T cell clones that express high levels of immunoglobulin binding belong to the interleukin 4-producing T helper cell type 2 subset.
Academic Article Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.
Academic Article Disparate functions of immature and mature human myeloid dendritic cells: implications for dendritic cell-based vaccines.
Academic Article Absence of programmed death receptor 1 alters thymic development and enhances generation of CD4/CD8 double-negative TCR-transgenic T cells.
Academic Article Update on vaccines for solid tumors.
Academic Article Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro.
Academic Article Phase 2 study of the g209-2M melanoma peptide vaccine and low-dose interleukin-2 in advanced melanoma: Cancer and Leukemia Group B 509901.
Academic Article Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones.
Academic Article Cutting edge: cytotoxic granule polarization and cytolysis can occur without central supramolecular activation cluster formation in CD8+ effector T cells.
Academic Article Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection.
Academic Article Immune suppression in the tumor microenvironment.
Academic Article Tumor progression despite massive influx of activated CD8(+) T cells in a patient with malignant melanoma ascites.
Academic Article Molecular regulation of T-cell anergy.
Academic Article Failure at the effector phase: immune barriers at the level of the melanoma tumor microenvironment.
Academic Article The HLA-A2-restricted PSMA peptide LLHETDSAV is poorly immunogenic in patients with metastatic prostate cancer.
Academic Article Negative regulation of T-cell function by PD-1.
Academic Article Peripheral survival of naïve CD8+ T cells.
Academic Article Protein kinase Ctheta focusing at the cSMAC is a consequence rather than cause of TCR signaling and is dependent on the MEK/ERK pathway.
Academic Article Identifying and overcoming immune resistance mechanisms in the melanoma tumor microenvironment.
Academic Article Induction of cytotoxic granules in human memory CD8+ T cell subsets requires cell cycle progression.
Academic Article Cross-priming of T cells to intracranial tumor antigens elicits an immune response that fails in the effector phase but can be augmented with local immunotherapy.
Academic Article Phenotypic and functional analysis of murine CD3+,CD4-,CD8- TCR-gamma delta-expressing peripheral T cells.
Academic Article Costimulatory and coinhibitory receptors in anti-tumor immunity.
Academic Article Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4+ T cells.
Academic Article Nakahara memorial lecture. Regulation of T lymphocyte responses: interactions among receptors.
Academic Article ICAM-1 contributes to but is not essential for tumor antigen cross-priming and CD8+ T cell-mediated tumor rejection in vivo.
Academic Article Evidence implicating I region-restricted antigen presentation in alloantigen and nominal antigen recognition by a dual-reactive helper T lymphocyte clone.
Academic Article Murine hepatic accessory cells support the proliferation of Th1 but not Th2 helper T lymphocyte clones.
Academic Article Regulation of T-cell activation: differences among T-cell subsets.
Academic Article Costimulation with B7-1, IL-6, and IL-12 is sufficient for primary generation of murine antitumor cytolytic T lymphocytes in vitro.
Academic Article Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.
Academic Article Clinical development of mAbs to block the PD1 pathway as an immunotherapy for cancer.
Academic Article Differential activation of Th1 and Th2 CD4+ cells by murine brain microvessel endothelial cells and smooth muscle/pericytes.
Academic Article Differential requirement for protein tyrosine kinase Fyn in the functional activation of antigen-specific T lymphocyte clones through the TCR or Thy-1.
Academic Article Anergic T-lymphocyte clones have altered inositol phosphate, calcium, and tyrosine kinase signaling pathways.
Academic Article Targeting the primary tumor to generate CTL for the effective eradication of spontaneous metastases.
Academic Article From defined human tumor antigens to effective immunization?
Academic Article The expanding universe of regulatory T cell subsets in cancer.
Academic Article An adenoviral vector encoding dominant negative Cbl lowers the threshold for T cell activation in post-thymic T cells.
Academic Article "Anergy" of TH0 helper T lymphocytes induces downregulation of TH1 characteristics and a transition to a TH2-like phenotype.
Academic Article Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-?1 phosphorylation.
Academic Article Cellular and molecular requirements for rejection of B16 melanoma in the setting of regulatory T cell depletion and homeostatic proliferation.
Academic Article Control of T lymphocyte signal transduction through clonal anergy.
Academic Article A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3.
Academic Article Expression and function of CTLA-4 in Th1 and Th2 cells.
Academic Article Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells.
Academic Article PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells.
Academic Article Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cells.
Academic Article Overcoming immune resistance in the tumor microenvironment by blockade of indoleamine 2,3-dioxygenase and programmed death ligand 1.
Academic Article Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level.
Academic Article Immune-mediated red cell aplasia after anti-CTLA-4 immunotherapy for metastatic melanoma.
Academic Article PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model.
Academic Article Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.
Academic Article CD40 ligation reverses T cell tolerance in acute myeloid leukemia.
Academic Article Targeting the tumor microenvironment with interferon-ß bridges innate and adaptive immune responses.
Academic Article Therapeutic activity of high-dose intratumoral IFN-ß requires direct effect on the tumor vasculature.
Academic Article Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction.
Academic Article STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Academic Article Innate immune recognition of cancer.
Academic Article Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells.
Academic Article A randomized pilot phase I study of modified carcinoembryonic antigen (CEA) peptide (CAP1-6D)/montanide/GM-CSF-vaccine in patients with pancreatic adenocarcinoma.
Academic Article Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Academic Article Endogenous and pharmacologic targeting of the STING pathway in cancer immunotherapy.
Academic Article Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy.
Academic Article Tumor and Host Factors Controlling Antitumor Immunity and Efficacy of Cancer Immunotherapy.
Academic Article Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA.
Academic Article MYC - a thorn in the side of cancer immunity.
Academic Article Molecular Drivers of the Non-T-cell-Inflamed Tumor Microenvironment in Urothelial Bladder Cancer.
Academic Article The composition of the microbiota modulates allograft rejection.
Academic Article The host STING pathway at the interface of cancer and immunity.
Academic Article NK Cells Restrain Spontaneous Antitumor CD8+ T Cell Priming through PD-1/PD-L1 Interactions with Dendritic Cells.
Academic Article Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanoma.
Academic Article The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment.
Academic Article Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy.
Academic Article Improving Efficacy and Safety of Agonistic Anti-CD40 Antibody Through Extracellular Matrix Affinity.
Academic Article Intratumoral CD8+ T-cell Apoptosis Is a Major Component of T-cell Dysfunction and Impedes Antitumor Immunity.
Academic Article High-Throughput Stability Screening of Neoantigen/HLA Complexes Improves Immunogenicity Predictions.
Academic Article Secondary resistance to immunotherapy associated with ß-catenin pathway activation or PTEN loss in metastatic melanoma.
Academic Article ACCELERATE and European Medicines Agency Paediatric Strategy Forum for medicinal product development of checkpoint inhibitors for use in combination therapy in paediatric patients.
Academic Article Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-?-signaling mutant cancer cells.
Academic Article Perspectives in melanoma: meeting report from the "Melanoma Bridge" (December 5th-7th, 2019, Naples, Italy).
Academic Article Checkpoint Blockade-Induced Dermatitis and Colitis Are Dominated by Tissue-Resident Memory T Cells and Th1/Tc1 Cytokines.
Concept Histocompatibility Antigen H-2D
Academic Article Phase 1 dose-escalation study of SEA-CD40: a non-fucosylated CD40 agonist, in advanced solid tumors and lymphomas.
Academic Article Perspectives in Melanoma: meeting report from the Melanoma Bridge (December 1st-3rd, 2022-Naples, Italy).
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