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Scott Oakes

TitleProfessor
InstitutionUniversity of Chicago
DepartmentPathology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Scott Oakes’s laboratory studies how mammalian cells commit “suicide” in response to various forms of damage and what goes wrong with this process in cancer and other diseases. In particular, they focus on a type of stress that occurs when the cell’s protein folding factory—an organelle called the endoplasmic reticulum—is overwhelmed and protein quality control fails. He is actively engaged in developing drugs to control cell fate under these conditions, which have potential to benefit patients with diseases from cancer to neurodegeneration.

    Collapse Biography 
    Collapse education and training
    Dana-Farber Cancer Institute, Harvard Medical School, Boston, MAPostdoctoral Scholar2005 Biochemistry & Cell Biology
    Brigham and Women's Hospital, Harvard Medical School, Boston, MAResidency2000 Pathology
    University of Connecticut School of Medicine, Farmington, CTM.D.1998 Medicine
    Howard Hughes Medical Institute, National Institutes of Health, Bethesda, M.D.Research Scholar1996 Immunology
    Elmira College, Elmira, NYB.A.1993 Biochemistry
    Collapse awards and honors
    2023Investigator Award, Neuroendocrine Tumor Research Foundation (NETRF)
    2019Outstanding Investigator Award, American Society for Investigative Pathology (ASIP)
    2018Stein Innovation Award, Research to Prevent Blindness , Inc.
    2017Outstanding Mentor Award, University of California San Francisco
    2015 - 2017Neuroendocrine Tumor Award, American Association for Cancer Research (AACR)
    2013 - 2015Scholar-Innovator Award, Harrington Discovery Institute
    2013Elected Member, American Society for Clinical Investigation (ASCI)
    2012 - 2015Research Scholar Award, American Cancer Society
    2007 - 2011Early Career Physician Scientist Award, Howard Hughes Medical Institute
    2006 - 2007Junior Investigator Award, American Cancer Society
    2003 - 2008Mentored Clinical Scientist Development Award (K08), NIAMS, NIH
    1995 - 1996Research Scholar, Howard Hughes Medical Institute
    1993Valedictorian, Elmira College

    Collapse Research 
    Collapse research activities and funding
    RM1GM153533     (PINCUS, DAVID)Aug 1, 2024 - Jul 31, 2029
    NIH
    Multimodal Investigation of Cellular Adaptation Across Timescales
    Role: Co-Principal Investigator
    R01CA292876     (MOELLERING, RAYMOND E)Jun 1, 2024 - May 31, 2029
    NIH
    Direct targeting of HIF1a-driven transcription in TNBC with engineered STRs
    Role: Co-Principal Investigator
    R01EY027810     (GOULD, DOUGLAS ;OAKES, SCOTT A.;PAPA, FEROZ R)Feb 1, 2018 - Jan 31, 2024
    NIH
    Role of the Unfolded Protein Response in Photoreceptor Degeneration
    Role: Principal Investigator (MPI)
    R01CA219815     (OAKES, SCOTT A.)Jan 1, 2018 - Dec 31, 2023
    NIH
    Targeting the Unfolded Protein Response in PanNETs
    Role: Principal Investigator
    T32CA177555     (OAKES, SCOTT A.)Sep 12, 2013 - Aug 31, 2018
    NIH
    Molecular Pathology of Cancer
    Role: Principal Investigator
    R01DK095306     (PAPA, FEROZ R)Aug 1, 2013 - Jul 31, 2018
    NIH
    Attenuating ER and oxidative stress signaling to reduce cell degeneration in vivo
    Role: Principal Investigator (MPI)
    R01CA136577     (OAKES, SCOTT A.)May 1, 2009 - Feb 28, 2015
    NIH
    Signaling Cell Death from the Endoplasmic Reticulum
    Role: Principal Investigator
    K08AI054650     (OAKES, SCOTT A)May 1, 2003 - Apr 30, 2008
    NIH
    BAX/BAK control ER-mitochondria apoptotic crosstalk
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kesaraju S, Li Y, Xing J, Tracy M, Wannemo K, Holder A, Zhao P, Khan MA, Kainov J, Rana N, Sidahmed M, Hyoju S, Smith L, Matthews J, Tay S, Khalili-Araghi F, Rana M, Oakes SA, Shen L, Weber CR. Inflammation-Induced Claudin-2 Upregulation Limits Pancreatitis Progression by Enhancing Tight Junction-Controlled Pancreatic Ductal Transport. bioRxiv. 2024 Nov 13. PMID: 39605652; PMCID: PMC11601259.
      Citations:    
    2. Qiao Z, Nguyen LC, Yang D, Dann C, Thomas DM, Henn M, Valdespino A, Swenson CS, Oakes SA, Rosner MR, Moellering RE. Direct inhibition of tumor hypoxia response with synthetic transcriptional repressors. Nat Chem Biol. 2024 Aug 30. PMID: 39215099.
      Citations:    Fields:    
    3. Muralidharan C, Huang F, Enriquez JR, Wang JE, Nelson JB, Nargis T, May SC, Chakraborty A, Figatner KT, Navitskaya S, Anderson CM, Calvo V, Surguladze D, Mulvihill MJ, Yi X, Sarkar S, Oakes SA, Webb-Robertson BM, Sims EK, Staschke KA, Eizirik DL, Nakayasu ES, Stokes ME, Tersey SA, Mirmira RG. Inhibition of the eukaryotic initiation factor-2a kinase PERK decreases risk of autoimmune diabetes in mice. J Clin Invest. 2024 Jun 18; 134(16). PMID: 38889047; PMCID: PMC11324307.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Muralidharan C, Huang F, Enriquez JR, Wang JE, Nelson JB, Nargis T, May SC, Chakraborty A, Figatner KT, Navitskaya S, Anderson CM, Calvo V, Surguladze D, Mulvihill MJ, Yi X, Sarkar S, Oakes SA, Webb-Robertson BM, Sims EK, Staschke KA, Eizirik DL, Nakayasu ES, Stokes ME, Tersey SA, Mirmira RG. Inhibition of the Eukaryotic Initiation Factor-2-a Kinase PERK Decreases Risk of Autoimmune Diabetes in Mice. bioRxiv. 2024 Jun 03. PMID: 38895427; PMCID: PMC11185543.
      Citations:    
    5. Pincus D, Oakes SA. Unfolding emergency calls stress granules to the ER. Nat Cell Biol. 2024 Jun; 26(6):845-846. PMID: 38822214.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Liu Y, Carbonetto P, Willwerscheid J, Oakes SA, Macleod KF, Stephens M. Dissecting tumor transcriptional heterogeneity from single-cell RNA-seq data by generalized binary covariance decomposition. bioRxiv. 2024 May 26. PMID: 37645713; PMCID: PMC10462040.
      Citations:    
    7. Malnassy G, Ziolkowski L, Macleod KF, Oakes SA. The Integrated Stress Response in Pancreatic Development, Tissue Homeostasis, and Cancer. Gastroenterology. 2024 Dec; 167(7):1292-1306. PMID: 38768690; PMCID: PMC11570703.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Mirmira RG, Kulkarni RN, Xu P, Drossos T, Varady K, Knutson KL, Reutrakul S, Martyn-Nemeth P, Sargis RM, Wallia A, Tuchman AM, Weissberg-Benchell J, Danielson KK, Oakes SA, Thomas CC, Layden BT, May SC, Burbea Hoffmann M, Gatta E, Solway J, Philipson LH. Stress and human health in diabetes: A report from the 19th Chicago Biomedical Consortium symposium. J Clin Transl Sci. 2023; 7(1):e263. PMID: 38229904; PMCID: PMC10790105.
      Citations:    
    9. Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, Ouaamari AE, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Pandol SJ, Sander M, Olesen SS. Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433-448. Diabetes. 2023 Aug 01; 72(8):1173. PMID: 37116182; PMCID: PMC10382644.
      Citations:    Fields:    
    10. Massoudi D, Kuo YM, Iwawaki T, Oakes SA, Papa FR, Gould DB, Gorman S. Deletion of the Unfolded Protein Response Transducer IRE1a Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration. Invest Ophthalmol Vis Sci. 2023 04 03; 64(4):30. PMID: 37097227; PMCID: PMC10148664.
      Citations: 2     Fields:    Translation:AnimalsCells
    11. Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Pandol SJ, Sander M, Olesen SS. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes. 2023 04 01; 72(4):433-448. PMID: 36940317; PMCID: PMC10033248.
      Citations: 4     Fields:    Translation:Humans
    12. Son RG, Kandasamy B, Bowden T, Azzam RK, Oakes SA, Philipson LH, Greeley SAW. Acute Recurrent Pancreatitis in a Child With INS-Related Monogenic Diabetes and a Heterozygous Pathogenic CFTR Mutation. J Endocr Soc. 2023 Jan 06; 7(3):bvac182. PMID: 36655002; PMCID: PMC9836200.
      Citations:    
    13. Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Sander M, Pandol SJ, Olesen SS. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Pancreas. 2022 10 01; 51(9):1061-1073. PMID: 37078927; PMCID: PMC10328394.
      Citations: 4     Fields:    Translation:Humans
    14. Nguyen LC, Renner DM, Silva D, Yang D, Parenti NA, Medina KM, Nicolaescu V, Gula H, Drayman N, Valdespino A, Mohamed A, Dann C, Wannemo K, Robinson-Mailman L, Gonzalez A, Cao M, Qiao Z, Moellering RE, Tay S, Randall G, Beers MF, Rosner MR, Oakes SA, Weiss SR, Stock L. SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells. mBio. 2022 10 26; 13(5):e0241522. PMID: 36125275; PMCID: PMC9600248.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    15. Ibarra J, Elbanna YA, Kurylowicz K, Ciboddo M, Greenbaum HS, Arellano NS, Rodriguez D, Evers M, Bock-Hughes A, Liu C, Smith Q, Lutze J, Nicholson B, Silva D, Maxwell L, Dowgielewicz J, Rumi E, Pietra D, Casetti IC, Catricala S, Gurbuxani S, Schneider RK, Oakes SA, Elf SE, Baumeister J, Kalmer M, Olschok K, Koschmieder S. Type I but Not Type II Calreticulin Mutations Activate the IRE1a/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms. Blood Cancer Discov. 2022 07 06; 3(4):298-315. PMID: 35405004; PMCID: PMC9338758.
      Citations: 13     Fields:    Translation:HumansCells
    16. Nguyen LC, Renner DM, Silva D, Yang D, Parenti N, Medina KM, Nicolaescu V, Gula H, Drayman N, Valdespino A, Mohamed A, Dann C, Wannemo K, Robinson-Mailman L, Gonzalez A, Cao M, Qiao Z, Moellering RE, Tay S, Randall G, Beers MF, Rosner MR, Oakes SA, Weiss SR, Stock L. SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1a/XBP1 ER stress pathway in human lung-derived cells. bioRxiv. 2022 Jun 13. PMID: 35821981; PMCID: PMC9275661.
      Citations:    
    17. Stormo AED, Shavarebi F, FitzGibbon M, Earley EM, Ahrendt H, Lum LS, Verschueren E, Swaney DL, Skibinski G, Ravisankar A, van Haren J, Davis EJ, Johnson JR, Von Dollen J, Balen C, Porath J, Crosio C, Mirescu C, Iaccarino C, Dauer WT, Nichols RJ, Wittmann T, Cox TC, Finkbeiner S, Krogan NJ, Oakes SA, Hiniker A. The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity. J Cell Biol. 2022 04 04; 221(4). PMID: 35266954; PMCID: PMC8919618.
      Citations: 8     Fields:    Translation:HumansCells
    18. Nguyen LC, Yang D, Nicolaescu V, Best TJ, Gula H, Saxena D, Gabbard JD, Chen SN, Ohtsuki T, Friesen JB, Drayman N, Mohamed A, Dann C, Silva D, Robinson-Mailman L, Valdespino A, Jones KA, Azizi SA, Demarco JK, Severson WE, Anderson CD, Millis JM, Dickinson BC, Tay S, Oakes SA, Pauli GF, Palmer KE, National COVID Cohort Collaborative Consortium, Meltzer DO, Randall G, Rosner MR, Stock L, Suárez E. Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses. Sci Adv. 2022 Feb 25; 8(8):eabi6110. PMID: 35050692.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    19. Nguyen LC, Yang D, Nicolaescu V, Best TJ, Ohtsuki T, Chen SN, Friesen JB, Drayman N, Mohamed A, Dann C, Silva D, Gula H, Jones KA, Millis JM, Dickinson BC, Tay S, Oakes SA, Pauli GF, Meltzer DO, Randall G, Rosner MR. Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response. bioRxiv. 2021 Mar 10. PMID: 33758843; PMCID: PMC7987002.
      Citations: 1     
    20. Oakes SA. Endoplasmic Reticulum Stress Signaling in Cancer Cells. Am J Pathol. 2020 05; 190(5):934-946. PMID: 32112719; PMCID: PMC7237829.
      Citations: 134     Fields:    Translation:HumansAnimalsCells
    21. Moore PC, Qi JY, Thamsen M, Ghosh R, Peng J, Gliedt MJ, Meza-Acevedo R, Warren RE, Hiniker A, Kim GE, Maly DJ, Backes BJ, Papa FR, Oakes SA. Parallel Signaling through IRE1a and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival. Cancer Res. 2019 12 15; 79(24):6190-6203. PMID: 31672843; PMCID: PMC6911642.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    22. Moore PC, Cortez JT, Chamberlain CE, Alba D, Berger AC, Quandt Z, Chan A, Cheng MH, Bautista JL, Peng J, German MS, Anderson MS, Oakes SA. Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma. J Clin Invest. 2019 08 01; 129(11):4676-4681. PMID: 31369399; PMCID: PMC6819098.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    23. Brondfield S, Boscardin C, Strewler G, Hyland K, Oakes SA, Nishimura H, Crawford J, Hauer KE. A Medical Student Inquiry Behavior Assessment Tool: Development and Validity Evidence. Acad Med. 2019 04; 94(4):586-594. PMID: 30431452.
      Citations: 2     Fields:    Translation:Humans
    24. Hiniker A, Oakes SA, Rao RC. Bilateral Choroidal Metastases from Pancreatic Adenocarcinoma. Ophthalmology. 2017 12; 124(12):1825. PMID: 29157429; PMCID: PMC5821071.
      Citations: 1     Fields:    Translation:Humans
    25. Moore PC, Oakes SA. CPEB4 links the clock and the UPR to protect the liver. Nat Cell Biol. 2017 01 31; 19(2):79-81. PMID: 28139654; PMCID: PMC5555618.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    26. Oakes SA. Endoplasmic reticulum proteostasis: a key checkpoint in cancer. Am J Physiol Cell Physiol. 2017 Feb 01; 312(2):C93-C102. PMID: 27856431; PMCID: PMC5336598.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    27. Wang ES, Reyes NA, Melton C, Huskey NE, Momcilovic O, Goga A, Blelloch R, Oakes SA. Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation. Curr Biol. 2015 Dec 07; 25(23):3110-8. PMID: 26585277; PMCID: PMC4703423.
      Citations: 10     Fields:    Translation:AnimalsCells
    28. Hetz C, Chevet E, Oakes SA. Erratum: Proteostasis control by the unfolded protein response. Nat Cell Biol. 2015 Aug; 17(8):1088. PMID: 26239530; PMCID: PMC5573253.
      Citations: 2     Fields:    
    29. Hetz C, Oakes SA, Chevet E. Proteostasis control by the unfolded protein response. Nat Cell Biol. 2015 Jul; 17(7):829-38. PMID: 26123108; PMCID: PMC5546321.
      Citations: 343     Fields:    Translation:HumansAnimalsCells
    30. Huskey NE, Guo T, Evason KJ, Momcilovic O, Pardo D, Creasman KJ, Judson RL, Blelloch R, Oakes SA, Hebrok M, Goga A. CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation. Stem Cell Reports. 2015 Mar 10; 4(3):374-89. PMID: 25733019; PMCID: PMC4375943.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    31. Guo WT, Wang XW, Yan YL, Li YP, Yin X, Zhang Q, Melton C, Shenoy A, Reyes NA, Oakes SA, Blelloch R, Wang Y. Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells. Cell Death Differ. 2015 Jul; 22(7):1158-69. PMID: 25501598; PMCID: PMC4572863.
      Citations: 24     Fields:    Translation:AnimalsCells
    32. Oakes SA, Papa FR. The role of endoplasmic reticulum stress in human pathology. Annu Rev Pathol. 2015; 10:173-94. PMID: 25387057; PMCID: PMC5568783.
      Citations: 598     Fields:    Translation:HumansAnimalsCells
    33. Crane CA, Austgen K, Haberthur K, Hofmann C, Moyes KW, Avanesyan L, Fong L, Campbell MJ, Cooper S, Oakes SA, Parsa AT, Lanier LL. Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12823-8. PMID: 25136121; PMCID: PMC4156766.
      Citations: 90     Fields:    Translation:HumansCells
    34. Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR, Schürer SC. Allosteric inhibition of the IRE1a RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014 Jul 31; 158(3):534-48. PMID: 25018104; PMCID: PMC4244221.
      Citations: 254     Fields:    Translation:HumansAnimalsCells
    35. van Dis V, Kuijpers M, Haasdijk ED, Teuling E, Oakes SA, Hoogenraad CC, Jaarsma D. Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons. Acta Neuropathol Commun. 2014 Apr 07; 2:38. PMID: 24708899; PMCID: PMC4023628.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    36. Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Oakes SA, Papa FR, Maly DJ, Schürer SC. Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012 Dec; 8(12):982-9. PMID: 23086298; PMCID: PMC3508346.
      Citations: 102     Fields:    Translation:HumansCells
    37. Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA. IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012 Nov 09; 338(6108):818-22. PMID: 23042294; PMCID: PMC3742121.
      Citations: 329     Fields:    Translation:HumansAnimalsCells
    38. Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR. IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 2012 Aug 08; 16(2):250-64. PMID: 22883233; PMCID: PMC4014071.
      Citations: 420     Fields:    Translation:HumansAnimalsCells
    39. Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12722-7. PMID: 22802621; PMCID: PMC3411950.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    40. Austgen K, Johnson ET, Park TJ, Curran T, Oakes SA. The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress. Nat Cell Biol. 2011 Dec 18; 14(1):87-92. PMID: 22179045; PMCID: PMC3245775.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    41. Austgen K, Oakes SA, Ganem D. Multiple defects, including premature apoptosis, prevent Kaposi's sarcoma-associated herpesvirus replication in murine cells. J Virol. 2012 Feb; 86(3):1877-82. PMID: 22130538; PMCID: PMC3264352.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    42. Shore GC, Papa FR, Oakes SA. Signaling cell death from the endoplasmic reticulum stress response. Curr Opin Cell Biol. 2011 Apr; 23(2):143-9. PMID: 21146390; PMCID: PMC3078187.
      Citations: 184     Fields:    Translation:HumansAnimalsCells
    43. Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal. 2010 Nov 09; 3(147):ra81. PMID: 21062993; PMCID: PMC3001107.
      Citations: 166     Fields:    Translation:HumansAnimalsCells
    44. Reyes NA, Fisher JK, Austgen K, VandenBerg S, Huang EJ, Oakes SA. Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis. J Clin Invest. 2010 Oct; 120(10):3673-9. PMID: 20890041; PMCID: PMC2947232.
      Citations: 59     Fields:    Translation:AnimalsCells
    45. Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR. IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell. 2009 Aug 07; 138(3):562-75. PMID: 19665977; PMCID: PMC2762408.
      Citations: 450     Fields:    Translation:AnimalsCells
    46. Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa FR, Oakes SA. Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol. 2008 Jun; 28(12):3943-51. PMID: 18426910; PMCID: PMC2423129.
      Citations: 96     Fields:    Translation:AnimalsCells
    47. Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa FR. A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress. Biochem Biophys Res Commun. 2008 Jan 25; 365(4):777-83. PMID: 18035051.
      Citations: 29     Fields:    Translation:AnimalsCells
    48. Oakes SA. Mitochondria control calcium entry at the immunological synapse. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15171-2. PMID: 17881558; PMCID: PMC2000514.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    49. Oakes SA, Lin SS, Bassik MC. The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins. Curr Mol Med. 2006 Feb; 6(1):99-109. PMID: 16472117.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    50. Oakes SA, Scorrano L, Opferman JT, Bassik MC, Nishino M, Pozzan T, Korsmeyer SJ. Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2005 Jan 04; 102(1):105-10. PMID: 15613488; PMCID: PMC544078.
      Citations: 177     Fields:    Translation:AnimalsCells
    51. Oakes SA, Korsmeyer SJ. Untangling the web: mitochondrial fission and apoptosis. Dev Cell. 2004 Oct; 7(4):460-2. PMID: 15469833.
      Citations: 6     Fields:    Translation:HumansCells
    52. Bassik MC, Scorrano L, Oakes SA, Pozzan T, Korsmeyer SJ. Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J. 2004 Mar 10; 23(5):1207-16. PMID: 15010700; PMCID: PMC380968.
      Citations: 110     Fields:    Translation:HumansAnimalsCells
    53. Oakes SA, Opferman JT, Pozzan T, Korsmeyer SJ, Scorrano L. Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members. Biochem Pharmacol. 2003 Oct 15; 66(8):1335-40. PMID: 14555206.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    54. Scorrano L, Oakes SA, Opferman JT, Cheng EH, Sorcinelli MD, Pozzan T, Korsmeyer SJ. BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science. 2003 Apr 04; 300(5616):135-9. PMID: 12624178.
      Citations: 491     Fields:    Translation:AnimalsCells
    55. Scorrano L, Ashiya M, Buttle K, Weiler S, Oakes SA, Mannella CA, Korsmeyer SJ. A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev Cell. 2002 Jan; 2(1):55-67. PMID: 11782314.
      Citations: 390     Fields:    Translation:AnimalsCells
    56. Candotti F, Oakes SA, Johnston JA, Giliani S, Schumacher RF, Mella P, Fiorini M, Ugazio AG, Badolato R, Notarangelo LD, Bozzi F, Macchi P, Strina D, Vezzoni P, Blaese RM, O'Shea JJ, Villa A. Structural and functional basis for JAK3-deficient severe combined immunodeficiency. Blood. 1997 Nov 15; 90(10):3996-4003. PMID: 9354668.
      Citations: 48     Fields:    Translation:HumansCells
    57. Taylor N, Candotti F, Smith S, Oakes SA, Jahn T, Isakov J, Puck JM, O'Shea JJ, Weinberg K, Johnston JA. Interleukin-4 signaling in B lymphocytes from patients with X-linked severe combined immunodeficiency. J Biol Chem. 1997 Mar 14; 272(11):7314-9. PMID: 9054429.
      Citations: 7     Fields:    Translation:HumansCells
    58. Oakes SA, Candotti F, Johnston JA, Chen YQ, Ryan JJ, Taylor N, Liu X, Hennighausen L, Notarangelo LD, Paul WE, Blaese RM, O'Shea JJ. Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways. Immunity. 1996 Dec; 5(6):605-15. PMID: 8986719.
      Citations: 34     Fields:    Translation:HumansCells
    59. Candotti F, Oakes SA, Johnston JA, Notarangelo LD, O'Shea JJ, Blaese RM. In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction. J Exp Med. 1996 Jun 01; 183(6):2687-92. PMID: 8676091; PMCID: PMC2192605.
      Citations: 15     Fields:    Translation:HumansCells
    60. Johnston JA, Wang LM, Hanson EP, Sun XJ, White MF, Oakes SA, Pierce JH, O'Shea JJ. Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases. J Biol Chem. 1995 Dec 01; 270(48):28527-30. PMID: 7499365.
      Citations: 29     Fields:    Translation:HumansCells
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