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Gokhan Mutlu

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine-Pulmonary/Critical Care
AddressChicago IL 60637
Email
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    Collapse Overview 
    Collapse overview
    Professor of Medicine
    Chief, Section of Pulmonary and Critical Care Medicine

    1986-1992 MD, Istanbul University
    1992-1994 Residency in Internal Medicine, Istanbul University
    1994-1997 Residency in Internal Medicine, University of Illinois at Chicago/Michael Reese Hospital
    1997-2000 Fellowship in Pulmonary and Critical Care Medicine, University of Illinois at Chicago
    2000-2001 Fellowship in Sleep Medicine, University of Illinois at Chicago


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Adbala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Mutlu GM, Budinger GRS. Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis. Cell Metab. 2018 Oct 04. PMID: 30318339.
      View in: PubMed
    2. Hamanaka RB, Mutlu GM. Alveolar Epithelial Cells Burn Fat to Survive Acute Lung Injury. Am J Respir Cell Mol Biol. 2018 Oct 02. PMID: 30278142.
      View in: PubMed
    3. Duan FF, Barron G, Meliton A, Mutlu GM, Dulin NO, Schuger L. P311 Promotes Lung Fibrosis via Stimulation of TGF-ß1, 2 and 3 Translation. Am J Respir Cell Mol Biol. 2018 Sep 19. PMID: 30230348.
      View in: PubMed
    4. Wu D, Woods PS, Duong HT, Mutlu GM. Role of Cellular Metabolism in Pulmonary Diseases. Am J Respir Cell Mol Biol. 2018 07; 59(1):127-129. PMID: 29634283.
      View in: PubMed
    5. Adegunsoye A, Oldham JM, Bellam SK, Chung JH, Chung PA, Biblowitz KM, Montner S, Lee C, Hsu S, Husain AN, Vij R, Mutlu G, Noth I, Churpek MM, Strek ME. African-American race and mortality in interstitial lung disease: a multicentre propensity-matched analysis. Eur Respir J. 2018 Jun; 51(6). PMID: 29724923.
      View in: PubMed
    6. Mutlu EA, Comba IY, Cho T, Engen PA, Yazici C, Soberanes S, Hamanaka RB, Nigdelioglu R, Meliton AY, Ghio AJ, Budinger GRS, Mutlu GM. Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome. Environ Pollut. 2018 Sep; 240:817-830. PMID: 29783199.
      View in: PubMed
    7. Mutlu GM, Budinger GRS. Letter by Mutlu and Budinger Regarding Article, "Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification". Circulation. 2018 Mar 13; 137(11):1203-1204. PMID: 29530899.
      View in: PubMed
    8. Wang T, Pehrsson EC, Purushotham D, Li D, Zhuo X, Zhang B, Lawson HA, Province MA, Krapp C, Lan Y, Coarfa C, Katz TA, Tang WY, Wang Z, Biswal S, Rajagopalan S, Colacino JA, Tsai ZT, Sartor MA, Neier K, Dolinoy DC, Pinto J, Hamanaka RB, Mutlu GM, Patisaul HB, Aylor DL, Crawford GE, Wiltshire T, Chadwick LH, Duncan CG, Garton AE, McAllister KA. The NIEHS TaRGET II Consortium and environmental epigenomics. Nat Biotechnol. 2018 Mar 06; 36(3):225-227. PMID: 29509741.
      View in: PubMed
    9. Wu D, Hamanaka RB, Fang Y, Mutlu GM. Letter by Wu et al Regarding Article, "Mechanical Activation of Hypoxia-Inducible Factor 1a Drives Endothelial Dysfunction at Atheroprone Sites". Arterioscler Thromb Vasc Biol. 2017 Dec; 37(12):e197-e198. PMID: 29162600.
      View in: PubMed
    10. Hamanaka RB, Nigdelioglu R, Meliton AY, Tian Y, Witt LJ, O'Leary E, Sun KA, Woods PS, Wu D, Ansbro B, Ard S, Rohde JM, Dulin NO, Guzy RD, Mutlu GM. Inhibition of PHGDH Attenuates Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2017 Oct 11. PMID: 29019702.
      View in: PubMed
    11. Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Mutlu GM, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H. Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. J Exp Med. 2017 Jul 10. PMID: 28694385.
      View in: PubMed
    12. Wu D, Huang RT, Hamanaka RB, Krause M, Oh MJ, Kuo CH, Nigdelioglu R, Meliton AY, Witt L, Dai G, Civelek M, Prabhakar NR, Fang Y, Mutlu GM. HIF-1a is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium. Elife. 2017 May 30; 6. PMID: 28556776.
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    13. Huang RT, Wu D, Meliton A, Oh MJ, Krause M, Lloyd JA, Nigdelioglu R, Hamanaka RB, Jain MK, Birukova A, Kress JP, Birukov KG, Mutlu GM, Fang Y. Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling. Am J Respir Crit Care Med. 2017 Mar 01; 195(5):639-651. PMID: 27855271.
      View in: PubMed
    14. Gileles-Hillel A, Almendros I, Khalyfa A, Nigdelioglu R, Qiao Z, Hamanaka RB, Mutlu GM, Akbarpour M, Gozal D. Prolonged Exposures to Intermittent Hypoxia Promote Visceral White Adipose Tissue Inflammation in a Murine Model of Severe Sleep Apnea: Effect of Normoxic Recovery. Sleep. 2017 Mar 01; 40(3). PMID: 28329220.
      View in: PubMed
    15. Hamanaka RB, Mutlu GM. PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epidermal Keratinocytes. J Invest Dermatol. 2017 Jun; 137(6):1267-1276. PMID: 28108301.
      View in: PubMed
    16. La J, Reed E, Chan L, Smolyaninova LV, Akomova OA, Mutlu GM, Orlov SN, Dulin NO. Downregulation of TGF-ß Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase. PLoS One. 2016; 11(12):e0168363. PMID: 28006004.
      View in: PubMed
    17. Nigdelioglu R, Hamanaka RB, Meliton AY, O'Leary E, Witt LJ, Cho T, Sun K, Bonham C, Wu D, Woods PS, Husain AN, Wolfgeher D, Dulin NO, Chandel NS, Mutlu GM. Transforming Growth Factor (TGF)-ß Promotes de Novo Serine Synthesis for Collagen Production. J Biol Chem. 2016 Dec 30; 291(53):27239-27251. PMID: 27836973.
      View in: PubMed
    18. Bindu S, Pillai VB, Kanwal A, Samant S, Mutlu GM, Verdin E, Dulin N, Gupta MP. SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage. Am J Physiol Lung Cell Mol Physiol. 2017 Jan 01; 312(1):L68-L78. PMID: 27815257.
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    19. Nicholson TT, Raparia K, Mutlu GM, Sporn PH, Bharat A. Wandering Pleural Mesothelial Fatty Cyst. Am J Respir Crit Care Med. 2016 Nov 01; 194(9):1164-1165. PMID: 27556583.
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    20. Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Vadász I, Morty RE, Schmoldt C, Bespalowa J, Wolff T, Pleschka S, Mayer K, Gattenloehner S, Fink L, Lohmeyer J, Seeger W, Sznajder JI, Mutlu GM, Budinger GR, Herold S. Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection. J Clin Invest. 2016 Apr 01; 126(4):1566-80. PMID: 26999599; PMCID: PMC4811131.
    21. La J, Reed EB, Koltsova S, Akimova O, Hamanaka RB, Mutlu GM, Orlov SN, Dulin NO. Regulation of myofibroblast differentiation by cardiac glycosides. Am J Physiol Lung Cell Mol Physiol. 2016 May 01; 310(9):L815-23. PMID: 26851261.
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    22. Nicholson TT, Mutlu GM. Pneumothorax following bronchoalveolar lavage for the diagnosis of non-tuberculous mycobacterial infection. An «atypical» complication of bronchoscopy? Arch Bronconeumol. 2016 May; 52(5):278-9. PMID: 26574159.
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    23. Ghio AJ, Soukup JM, Dailey LA, Tong H, Kesic MJ, Budinger GR, Mutlu GM. Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect. Chem Res Toxicol. 2015 Nov 16; 28(11):2104-11. PMID: 26462088; PMCID: PMC4838017 [Available on 11/16/16].
    24. Soveg F, Abdala-Valencia H, Campbell J, Morales-Nebreda L, Mutlu GM, Cook-Mills JM. Regulation of allergic lung inflammation by endothelial cell transglutaminase 2. Am J Physiol Lung Cell Mol Physiol. 2015 Sep 15; 309(6):L573-83. PMID: 26209276; PMCID: PMC4572420.
    25. Morales-Nebreda LI, Rogel MR, Eisenberg JL, Hamill KJ, Soberanes S, Nigdelioglu R, Chi M, Cho T, Radigan KA, Ridge KM, Misharin AV, Woychek A, Hopkinson S, Perlman H, Mutlu GM, Pardo A, Selman M, Jones JC, Budinger GR. Lung-specific loss of a3 laminin worsens bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2015 Apr; 52(4):503-12. PMID: 25188360.
      View in: PubMed
    26. Boe AE, Eren M, Morales-Nebreda L, Murphy SB, Budinger GR, Mutlu GM, Miyata T, Vaughan DE. Nitric oxide prevents alveolar senescence and emphysema in a mouse model. PLoS One. 2015; 10(3):e0116504. PMID: 25756287; PMCID: PMC4355068.
    27. Meliton AY, Meng F, Tian Y, Sarich N, Mutlu GM, Birukova AA, Birukov KG. Oxidized phospholipids protect against lung injury and endothelial barrier dysfunction caused by heat-inactivated Staphylococcus aureus. Am J Physiol Lung Cell Mol Physiol. 2015 Mar 15; 308(6):L550-62. PMID: 25575515.
      View in: PubMed
    28. Cheresh P, Morales-Nebreda L, Kim SJ, Yeldandi A, Williams DB, Cheng Y, Mutlu GM, Budinger GR, Ridge K, Schumacker PT, Bohr VA, Kamp DW. Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice. Am J Respir Cell Mol Biol. 2015 Jan; 52(1):25-36. PMID: 24918270.
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    29. Meng F, Meliton A, Moldobaeva N, Mutlu G, Kawasaki Y, Akiyama T, Birukova AA. Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction. Am J Physiol Lung Cell Mol Physiol. 2015 Mar 01; 308(5):L452-63. PMID: 25539852.
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    30. Chiarella SE, Budinger GR, Mutlu GM. ß2-Agonist therapy may contribute to the air pollution and IL-6-associated risk of developing severe asthma with dual-positive TH2/TH17 cells. J Allergy Clin Immunol. 2015 Jan; 135(1):290-1. PMID: 25445822.
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    31. Misharin AV, Cuda CM, Saber R, Turner JD, Gierut AK, Haines GK, Berdnikovs S, Filer A, Clark AR, Buckley CD, Mutlu GM, Budinger GR, Perlman H. Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice. Cell Rep. 2014 Oct 23; 9(2):591-604. PMID: 25373902.
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    32. Radigan KA, Morales-Nebreda L, Soberanes S, Nicholson T, Nigdelioglu R, Cho T, Chi M, Hamanaka RB, Misharin AV, Perlman H, Budinger GR, Mutlu GM. Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages. PLoS One. 2014; 9(9):e108138. PMID: 25232724.
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    33. Morales-Nebreda L, Chi M, Lecuona E, Chandel NS, Dada LA, Ridge K, Soberanes S, Nigdelioglu R, Sznajder JI, Mutlu GM, Budinger GR, Radigan KA. Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury. J Virol Methods. 2014 Dec; 209:116-20. PMID: 25239366.
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    34. Lam AP, Herazo-Maya JD, Sennello JA, Flozak AS, Russell S, Mutlu GM, Budinger GR, DasGupta R, Varga J, Kaminski N, Gottardi CJ. Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2014 Jul 15; 190(2):185-95. PMID: 24921217.
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    35. Budinger GR, Mutlu GM. Reply: ß2-agonists and acute respiratory distress syndrome. Am J Respir Crit Care Med. 2014 Jun 01; 189(11):1448. PMID: 24881949.
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    36. Chiarella SE, Soberanes S, Urich D, Morales-Nebreda L, Nigdelioglu R, Green D, Young JB, Gonzalez A, Rosario C, Misharin AV, Ghio AJ, Wunderink RG, Donnelly HK, Radigan KA, Perlman H, Chandel NS, Budinger GR, Mutlu GM. ß2-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis. J Clin Invest. 2014 Jul; 124(7):2935-46. PMID: 24865431.
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    37. Morales-Nebreda L, Mutlu GM, Scott Budinger GR, Radigan KA. Loss of TLR4 does not prevent influenza A-induced mortality. Am J Respir Crit Care Med. 2014 May 15; 189(10):1280-1. PMID: 24832747.
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    38. Radigan KA, Mutlu GM. Markers of prognosis specific to influenza infection: are we there yet? Am J Respir Crit Care Med. 2014 May 15; 189(10):1159-60. PMID: 24832741.
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    39. Wheaton WW, Weinberg SE, Hamanaka RB, Soberanes S, Sullivan LB, Anso E, Glasauer A, Dufour E, Mutlu GM, Budigner GS, Chandel NS. Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. Elife. 2014 May 13; 3:e02242. PMID: 24843020.
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    40. Eren M, Boe AE, Murphy SB, Place AT, Nagpal V, Morales-Nebreda L, Urich D, Quaggin SE, Budinger GR, Mutlu GM, Miyata T, Vaughan DE. PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. Proc Natl Acad Sci U S A. 2014 May 13; 111(19):7090-5. PMID: 24778222.
      View in: PubMed
    41. Budinger GR, Mutlu GM. ß2-agonists and acute respiratory distress syndrome. Am J Respir Crit Care Med. 2014 Mar 15; 189(6):624-5. PMID: 24628310.
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    42. Wiese KM, Mutlu GM. Babesiosis. Am J Respir Crit Care Med. 2014 Mar 01; 189(5):602. PMID: 24579836.
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    43. Misharin AV, Morales-Nebreda L, Mutlu GM, Budinger GR, Perlman H. Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung. Am J Respir Cell Mol Biol. 2013 Oct; 49(4):503-10. PMID: 23672262.
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    44. Ghio AJ, Tong H, Soukup JM, Dailey LA, Cheng WY, Samet JM, Kesic MJ, Bromberg PA, Turi JL, Upadhyay D, Scott Budinger GR, Mutlu GM. Sequestration of mitochondrial iron by silica particle initiates a biological effect. Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15; 305(10):L712-24. PMID: 23997175.
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    45. Budinger GRS, Mutlu GM. Balancing the risks and benefits of oxygen therapy in critically III adults. Chest. 2013 Apr; 143(4):1151-1162. PMID: 23546490.
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    46. Do-Umehara HC, Chen C, Urich D, Zhou L, Qiu J, Jang S, Zander A, Baker MA, Eilers M, Sporn PH, Ridge KM, Sznajder JI, Budinger GR, Mutlu GM, Lin A, Liu J. Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-d. Nat Immunol. 2013 May; 14(5):461-9. PMID: 23525087.
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    47. Jain M, Rivera S, Monclus EA, Synenki L, Zirk A, Eisenbart J, Feghali-Bostwick C, Mutlu GM, Budinger GR, Chandel NS. Mitochondrial reactive oxygen species regulate transforming growth factor-ß signaling. J Biol Chem. 2013 Jan 11; 288(2):770-7. PMID: 23204521.
      View in: PubMed
    48. Bhattacharyya S, Kelley K, Melichian DS, Tamaki Z, Fang F, Su Y, Feng G, Pope RM, Budinger GR, Mutlu GM, Lafyatis R, Radstake T, Feghali-Bostwick C, Varga J. Toll-like receptor 4 signaling augments transforming growth factor-ß responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma. Am J Pathol. 2013 Jan; 182(1):192-205. PMID: 23141927.
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    49. Abdala-Valencia H, Berdnikovs S, McCary CA, Urick D, Mahadevia R, Marchese ME, Swartz K, Wright L, Mutlu GM, Cook-Mills JM. Inhibition of allergic inflammation by supplementation with 5-hydroxytryptophan. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 15; 303(8):L642-60. PMID: 22842218.
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    50. Radigan KA, Urich D, Misharin AV, Chiarella SE, Soberanes S, Gonzalez A, Perlman H, Wunderink RG, Budinger GR, Mutlu GM. The effect of rosuvastatin in a murine model of influenza A infection. PLoS One. 2012; 7(4):e35788. PMID: 22536437.
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    51. Soberanes S, Gonzalez A, Urich D, Chiarella SE, Radigan KA, Osornio-Vargas A, Joseph J, Kalyanaraman B, Ridge KM, Chandel NS, Mutlu GM, De Vizcaya-Ruiz A, Budinger GR. Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway. Sci Rep. 2012; 2:275. PMID: 22355787.
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    52. Dada L, Gonzalez AR, Urich D, Soberanes S, Manghi TS, Chiarella SE, Chandel NS, Budinger GR, Mutlu GM. Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 receptor. PLoS One. 2012; 7(1):e30448. PMID: 22272351.
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    53. Duch MC, Budinger GR, Liang YT, Soberanes S, Urich D, Chiarella SE, Campochiaro LA, Gonzalez A, Chandel NS, Hersam MC, Mutlu GM. Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung. Nano Lett. 2011 Dec 14; 11(12):5201-7. PMID: 22023654.
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    54. Mutlu GM, Budinger GR, Wu M, Lam AP, Zirk A, Rivera S, Urich D, Chiarella SE, Go LH, Ghosh AK, Selman M, Pardo A, Varga J, Kamp DW, Chandel NS, Sznajder JI, Jain M. Proteasomal inhibition after injury prevents fibrosis by modulating TGF-ß(1) signalling. Thorax. 2012 Feb; 67(2):139-46. PMID: 21921091.
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    55. Mutlu GM, Bryce PJ, Budinger GR. Linking air pollution exposure with thrombosis. Blood. 2011 Sep 01; 118(9):2636-7. PMID: 21885614.
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    56. Urich D, Eisenberg JL, Hamill KJ, Takawira D, Chiarella SE, Soberanes S, Gonzalez A, Koentgen F, Manghi T, Hopkinson SB, Misharin AV, Perlman H, Mutlu GM, Budinger GR, Jones JC. Lung-specific loss of the laminin a3 subunit confers resistance to mechanical injury. J Cell Sci. 2011 Sep 01; 124(Pt 17):2927-37. PMID: 21878500.
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    57. Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Mutlu GM, Chandel NS, Prakriya M, Sznajder JI. Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation. Mol Cell Biol. 2011 Sep; 31(17):3546-56. PMID: 21730292.
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    58. Budinger GR, Mutlu GM. Update in environmental and occupational medicine 2010. Am J Respir Crit Care Med. 2011 Jun 15; 183(12):1614-9. PMID: 21693716.
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    59. Mutlu EA, Engen PA, Soberanes S, Urich D, Forsyth CB, Nigdelioglu R, Chiarella SE, Radigan KA, Gonzalez A, Jakate S, Keshavarzian A, Budinger GR, Mutlu GM. Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice. Part Fibre Toxicol. 2011 Jun 09; 8:19. PMID: 21658250.
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    60. Budinger GR, McKell JL, Urich D, Foiles N, Weiss I, Chiarella SE, Gonzalez A, Soberanes S, Ghio AJ, Nigdelioglu R, Mutlu EA, Radigan KA, Green D, Kwaan HC, Mutlu GM. Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanisms. PLoS One. 2011 Apr 11; 6(4):e18525. PMID: 21494547.
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    61. Lam AP, Flozak AS, Russell S, Wei J, Jain M, Mutlu GM, Budinger GR, Feghali-Bostwick CA, Varga J, Gottardi CJ. Nuclear ß-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation. Am J Respir Cell Mol Biol. 2011 Nov; 45(5):915-22. PMID: 21454805.
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    62. Jain M, Budinger GR, Lo A, Urich D, Rivera SE, Ghosh AK, Gonzalez A, Chiarella SE, Marks K, Donnelly HK, Soberanes S, Varga J, Radigan KA, Chandel NS, Mutlu GM. Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-?. Am J Respir Crit Care Med. 2011 Jun 01; 183(11):1490-8. PMID: 21317313.
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    63. Budinger GR, Mutlu GM, Urich D, Soberanes S, Buccellato LJ, Hawkins K, Chiarella SE, Radigan KA, Eisenbart J, Agrawal H, Berkelhamer S, Hekimi S, Zhang J, Perlman H, Schumacker PT, Jain M, Chandel NS. Epithelial cell death is an important contributor to oxidant-mediated acute lung injury. Am J Respir Crit Care Med. 2011 Apr 15; 183(8):1043-54. PMID: 20959557.
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    64. Kuzniar TJ, Balagani R, Radigan KA, Factor P, Mutlu GM. Coma with absent brainstem reflexes resulting from zolpidem overdose. Am J Ther. 2010 Sep-Oct; 17(5):e172-4. PMID: 20862780.
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    65. Wolfe L, Lakadamyali H, Mutlu GM. Joubert syndrome associated with severe central sleep apnea. J Clin Sleep Med. 2010 Aug 15; 6(4):384-8. PMID: 20726289.
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    66. Van Hee VC, Kaufman JD, Budinger GR, Mutlu GM. Update in environmental and occupational medicine 2009. Am J Respir Crit Care Med. 2010 Jun 01; 181(11):1174-80. PMID: 20516491.
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    67. Mutlu GM, Budinger GR, Green AA, Urich D, Soberanes S, Chiarella SE, Alheid GF, McCrimmon DR, Szleifer I, Hersam MC. Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity. Nano Lett. 2010 May 12; 10(5):1664-70. PMID: 20377197.
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    68. Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu GM, Budinger GR, Chandel NS. Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8788-93. PMID: 20421486.
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    69. Weiss CH, Budinger GR, Mutlu GM, Jain M. Proteasomal regulation of pulmonary fibrosis. Proc Am Thorac Soc. 2010 Feb; 7(1):77-83. PMID: 20160152.
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    70. Mutlu GM, Budinger GR. Not much turbulence: addition of heliox to noninvasive ventilation fails to improve outcomes in patients with exacerbations of chronic obstructive pulmonary disease. Crit Care Med. 2010 Jan; 38(1):319-20. PMID: 20023482.
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    71. Mork T, Mutlu GM, Kuzniar TJ. Dysphonia and chest pain as presenting symptoms of pneumomediastinum. Tuberk Toraks. 2010; 58(2):184-7. PMID: 20865573.
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    72. Lin Z, Yin P, Reierstad S, O'Halloran M, Coon VJ, Pearson EK, Mutlu GM, Bulun SE. Adenosine A1 receptor, a target and regulator of estrogen receptoralpha action, mediates the proliferative effects of estradiol in breast cancer. Oncogene. 2010 Feb 25; 29(8):1114-22. PMID: 19935720.
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    73. Flozak AS, Lam AP, Russell S, Jain M, Peled ON, Sheppard KA, Beri R, Mutlu GM, Budinger GR, Gottardi CJ. Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells. J Biol Chem. 2010 Jan 29; 285(5):3157-67. PMID: 19933277.
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    74. Balachandran JS, Jaleel M, Jain M, Mahajan N, Kalhan R, Balagani R, Donnelly HK, Greenstein E, Mutlu GM. Head CT is of limited diagnostic value in critically ill patients who remain unresponsive after discontinuation of sedation. BMC Anesthesiol. 2009 May 07; 9:3. PMID: 19422697.
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    75. Chandel NS, Budinger GR, Mutlu GM, Varga J, Synenki L, Donnelly HK, Zirk A, Eisenbart J, Jovanovic B, Jain M. Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways. Crit Care Med. 2009 May; 37(5):1678-84. PMID: 19325470.
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    76. Emerling BM, Weinberg F, Snyder C, Burgess Z, Mutlu GM, Viollet B, Budinger GR, Chandel NS. Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio. Free Radic Biol Med. 2009 May 15; 46(10):1386-91. PMID: 19268526.
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    77. Urich D, Soberanes S, Burgess Z, Chiarella SE, Ghio AJ, Ridge KM, Kamp DW, Chandel NS, Mutlu GM, Budinger GR. Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation. FASEB J. 2009 Jul; 23(7):2055-64. PMID: 19237507.
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    78. Soberanes S, Urich D, Baker CM, Burgess Z, Chiarella SE, Bell EL, Ghio AJ, De Vizcaya-Ruiz A, Liu J, Ridge KM, Kamp DW, Chandel NS, Schumacker PT, Mutlu GM, Budinger GR. Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution. J Biol Chem. 2009 Jan 23; 284(4):2176-86. PMID: 19033436.
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    79. Budinger GR, Urich D, DeBiase PJ, Chiarella SE, Burgess ZO, Baker CM, Soberanes S, Mutlu GM, Jones JC. Stretch-induced activation of AMP kinase in the lung requires dystroglycan. Am J Respir Cell Mol Biol. 2008 Dec; 39(6):666-72. PMID: 18556591.
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    80. Mutlu GM, Green D, Bellmeyer A, Baker CM, Burgess Z, Rajamannan N, Christman JW, Foiles N, Kamp DW, Ghio AJ, Chandel NS, Dean DA, Sznajder JI, Budinger GR. Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway. J Clin Invest. 2007 Oct; 117(10):2952-61. PMID: 17885684.
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    81. Mutlu GM, Factor P. Alveolar epithelial beta2-adrenergic receptors. Am J Respir Cell Mol Biol. 2008 Feb; 38(2):127-34. PMID: 17709598.
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    82. Wang HL, Akinci IO, Baker CM, Urich D, Bellmeyer A, Jain M, Chandel NS, Mutlu GM, Budinger GR. The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell death. J Immunol. 2007 Aug 01; 179(3):1834-41. PMID: 17641050.
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    83. Mutlu GM, Machado-Aranda D, Norton JE, Bellmeyer A, Urich D, Zhou R, Dean DA. Electroporation-mediated gene transfer of the Na+,K+ -ATPase rescues endotoxin-induced lung injury. Am J Respir Crit Care Med. 2007 Sep 15; 176(6):582-90. PMID: 17556717.
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    84. Factor P, Mutlu GM, Chen L, Mohameed J, Akhmedov AT, Meng FJ, Jilling T, Lewis ER, Johnson MD, Xu A, Kass D, Martino JM, Bellmeyer A, Albazi JS, Emala C, Lee HT, Dobbs LG, Matalon S. Adenosine regulation of alveolar fluid clearance. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):4083-8. PMID: 17360481.
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    85. Bellmeyer A, Martino JM, Chandel NS, Scott Budinger GR, Dean DA, Mutlu GM. Leptin resistance protects mice from hyperoxia-induced acute lung injury. Am J Respir Crit Care Med. 2007 Mar 15; 175(6):587-94. PMID: 17185651.
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    86. Kuzniar TJ, Blum MG, Kasibowska-Kuzniar K, Mutlu GM. Predictors of acute lung injury and severe hypoxemia in patients undergoing operative talc pleurodesis. Ann Thorac Surg. 2006 Dec; 82(6):1976-81. PMID: 17126094.
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    87. Mutlu GM, Wunderink RG. Severe pseudomonal infections. Curr Opin Crit Care. 2006 Oct; 12(5):458-63. PMID: 16943726.
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    88. Soberanes S, Panduri V, Mutlu GM, Ghio A, Bundinger GR, Kamp DW. p53 mediates particulate matter-induced alveolar epithelial cell mitochondria-regulated apoptosis. Am J Respir Crit Care Med. 2006 Dec 01; 174(11):1229-38. PMID: 16946128.
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    89. Mutlu GM, Mutlu EA, Bellmeyer A, Rubinstein I. Pulmonary adverse events of anti-tumor necrosis factor-alpha antibody therapy. Am J Med. 2006 Aug; 119(8):639-46. PMID: 16887405.
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    90. Mutlu GM, Rubinstein I. Clinical manifestations of sarcoidosis among inner-city African-American dwellers. J Natl Med Assoc. 2006 Jul; 98(7):1140-3. PMID: 16895285.
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    91. Mutlu GM, Factor P. Pulmonary tumor embolism of unknown origin. Mayo Clin Proc. 2006 Jun; 81(6):721. PMID: 16770969.
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    92. Mutlu EA, Keshavarzian A, Mutlu GM. Hyperalbuminemia and elevated transaminases associated with high-protein diet. Scand J Gastroenterol. 2006 Jun; 41(6):759-60. PMID: 16716979.
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    93. Mutlu GM, Bellmeyer A, Budinger GR. Air pollution impairs lung's ability to clear edema fluid. Am J Cardiol. 2006 Aug 01; 98(3):423-4. PMID: 16860038.
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    94. Budinger GR, Mutlu GM, Eisenbart J, Fuller AC, Bellmeyer AA, Baker CM, Wilson M, Ridge K, Barrett TA, Lee VY, Chandel NS. Proapoptotic Bid is required for pulmonary fibrosis. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4604-9. PMID: 16537427.
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    95. Quesada N, Mutlu GM. Images in cardiovascular medicine. Pulmonary embolization of acrylic cement during vertebroplasty. Circulation. 2006 Feb 28; 113(8):e295-6. PMID: 16505181.
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    96. Mutlu GM, Snyder C, Bellmeyer A, Wang H, Hawkins K, Soberanes S, Welch LC, Ghio AJ, Chandel NS, Kamp D, Sznajder JI, Budinger GR. Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generation. Am J Respir Cell Mol Biol. 2006 Jun; 34(6):670-6. PMID: 16439801.
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    97. Mutlu GM, Budinger GR. Incidence and outcomes of acute lung injury. N Engl J Med. 2006 Jan 26; 354(4):416-7; author reply 416-7. PMID: 16436776.
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    98. Topin J, Mutlu GM. Images in clinical medicine. Splenic and mediastinal calcifications in histoplasmosis. N Engl J Med. 2006 Jan 12; 354(2):179. PMID: 16407513.
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    99. Mutlu GM, Sznajder JI. Mechanisms of pulmonary edema clearance. Am J Physiol Lung Cell Mol Physiol. 2005 Nov; 289(5):L685-95. PMID: 16214819.
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    100. Kuzniar TJ, Gruber B, Mutlu GM. Cerebrospinal fluid leak and meningitis associated with nasal continuous positive airway pressure therapy. Chest. 2005 Sep; 128(3):1882-4. PMID: 16162800.
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    101. Mutlu GM, Adir Y, Jameel M, Akhmedov AT, Welch L, Dumasius V, Meng FJ, Zabner J, Koenig C, Lewis ER, Balagani R, Traver G, Sznajder JI, Factor P. Interdependency of beta-adrenergic receptors and CFTR in regulation of alveolar active Na+ transport. Circ Res. 2005 May 13; 96(9):999-1005. PMID: 15802612.
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    102. Mutlu GM, Rubinstein I. The saga of obstructive sleep apnea syndrome and daytime hypercapnia: work in progress. Chest. 2005 Mar; 127(3):698-9. PMID: 15764742.
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    103. Akinci OI, Celik M, Mutlu GM, Martino JM, Tugrul S, Ozcan PE, Yilmazbayhan D, Yeldandi AV, Turkoz KH, Kiran B, Telci L, Cakar N. Effects of body temperature on ventilator-induced lung injury. J Crit Care. 2005 Mar; 20(1):66-73. PMID: 16015518.
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    104. Mutlu GM, Kuzniar T, Factor P. A 41-year-old man with altered mental status and acute flaccid paralysis. Chest. 2005 Jan; 127(1):391-4. PMID: 15654004.
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    105. Mutlu GM, Sznajder JI. Pseudohypoxemia: interpretation of discrepancies between SaO(2) and SpO(2). Tuberk Toraks. 2005; 53(2):185-9. PMID: 16100658.
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    106. Mutlu GM, Ahkmedov AT, Lum H, Factor P. Potential genetic therapies for acute lung injury. Curr Gene Ther. 2004 Dec; 4(4):487-95. PMID: 15578996.
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    107. Mutlu GM, Koch WJ, Factor P. Alveolar epithelial beta 2-adrenergic receptors: their role in regulation of alveolar active sodium transport. Am J Respir Crit Care Med. 2004 Dec 15; 170(12):1270-5. PMID: 15447942.
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    108. Mutlu GM, Sznajder JI. beta(2)-Agonists for treatment of pulmonary edema: ready for clinical studies? Crit Care Med. 2004 Jul; 32(7):1607-8. PMID: 15241111.
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    109. Mutlu GM, Factor P. Role of vasopressin in the management of septic shock. Intensive Care Med. 2004 Jul; 30(7):1276-91. PMID: 15103461.
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    110. Mutlu GM, Dumasius V, Burhop J, McShane PJ, Meng FJ, Welch L, Dumasius A, Mohebahmadi N, Thakuria G, Hardiman K, Matalon S, Hollenberg S, Factor P. Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling. Circ Res. 2004 Apr 30; 94(8):1091-100. PMID: 15016730.
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    111. Dematte D'Amico JE, Donnelly HK, Mutlu GM, Feinglass J, Jovanovic BD, Ndukwu IM. Risk assessment for inpatient survival in the long-term acute care setting after prolonged critical illness. Chest. 2003 Sep; 124(3):1039-45. PMID: 12970035.
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    112. Akinci IO, Cakar N, Mutlu GM, Tugrul S, Ozcan PE, Gitmez M, Esen F, Telci L. Gastric intramucosal pH is stable during titration of positive end-expiratory pressure to improve oxygenation in acute respiratory distress syndrome. Crit Care. 2003 Jun; 7(3):R17-23. PMID: 12793886.
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    113. Mutlu GM, Mutlu EA, Factor P. Prevention and treatment of gastrointestinal complications in patients on mechanical ventilation. Am J Respir Med. 2003; 2(5):395-411. PMID: 14719992.
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    114. Factor P, Adir Y, Mutlu GM, Burhop J, Dumasius V. Effects of beta2-adrenergic receptor overexpression on alveolar epithelial active transport. J Allergy Clin Immunol. 2002 Dec; 110(6 Suppl):S242-6. PMID: 12464931.
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    115. Mutlu GM, Leikin JB, Oh K, Factor P. An unresponsive biochemistry professor in the bathtub. Chest. 2002 Sep; 122(3):1073-6. PMID: 12226056.
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    116. Weiss DJ, Mutlu GM, Bonneau L, Mendez M, Wang Y, Dumasius V, Factor P. Comparison of surfactant and perfluorochemical liquid enhanced adenovirus-mediated gene transfer in normal rat lung. Mol Ther. 2002 Jul; 6(1):43-9. PMID: 12095302.
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    117. Mutlu GM, Factor P. Acute-onset quadriplegia, respiratory failure, and ventricular tachycardia in a 21-year-old man following a soccer match. Chest. 2002 Jun; 121(6):2036-9. PMID: 12065374.
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    118. Factor P, Azzam ZA, Mutlu GM, Sznajder JI, Dumasius V. Enhancement of alveolar epithelial beta(2)-adrenergic receptor function via gene transfer. Chest. 2002 Mar; 121(3 Suppl):45S-46S. PMID: 11893682.
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    119. Dumasius V, Mendez M, Mutlu GM, Factor P. Acute lung injury does not impair adenoviral-mediated gene transfer to the alveolar epithelium. Chest. 2002 Mar; 121(3 Suppl):33S-34S. PMID: 11893674.
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    120. Factor P, Mendez M, Mutlu GM, Dumasius V. Acute hyperoxic lung injury does not impede adenoviral-mediated alveolar gene transfer. Am J Respir Crit Care Med. 2002 Feb 15; 165(4):521-6. PMID: 11850346.
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    121. Mutlu GM, Factor P, Schwartz DE, Sznajder JI. Severe status asthmaticus: management with permissive hypercapnia and inhalation anesthesia. Crit Care Med. 2002 Feb; 30(2):477-80. PMID: 11889333.
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    122. Dumasius V, Sznajder JI, Azzam ZS, Boja J, Mutlu GM, Maron MB, Factor P. beta(2)-adrenergic receptor overexpression increases alveolar fluid clearance and responsiveness to endogenous catecholamines in rats. Circ Res. 2001 Nov 09; 89(10):907-14. PMID: 11701618.
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    123. Mutlu GM, Garey KW, Robbins RA, Danziger LH, Rubinstein I. Collection and analysis of exhaled breath condensate in humans. Am J Respir Crit Care Med. 2001 Sep 01; 164(5):731-7. PMID: 11549524.
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    124. Mutlu GM, Mutlu EA, Factor P. GI complications in patients receiving mechanical ventilation. Chest. 2001 Apr; 119(4):1222-41. PMID: 11296191.
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    125. Mutlu GM, Rubinstein I. Obstructive sleep apnea syndrome-associated nocturnal myocardial ischemia. Chest. 2000 Jun; 117(6):1534-5. PMID: 10858377.
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    126. Mutlu GM, Factor P. Complications of mechanical ventilation. Respir Care Clin N Am. 2000 Jun; 6(2):213-52,v. PMID: 10757962.
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    127. Mutlu GM, Moonjelly E, Chan L, Olopade CO. Laryngospasm and paradoxical bronchoconstriction after repeated doses of beta 2-agonists containing edetate disodium. Mayo Clin Proc. 2000 Mar; 75(3):285-7. PMID: 10725956.
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