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Gokhan M. Mutlu

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine
AddressChicago IL 60637
Email
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    Collapse Overview 
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    Dr. Mutlu is Professor of Medicine and Chief of the Section of Pulmonary and Critical Care Medicine at the University of Chicago. He is also the principal investigator/director of the NIH T32 Research training in respiratory biology. Dr. Mutlu's research focuses on the mechanisms of acute lung injury, and pulmonary fibrosis. Specifically, his laboratory is interested in understanding the role of macrophage and fibroblast metabolism including mitochondria in the pathogenesis of acute lung injury and pulmonary fibrosis. Dr. Mutlu's laboratory has extensive expertise with in vitro cell based methods including bioenergetics and in vivo models of acute lung injury (influenza, LPS, bacterial pneumonia and particulate matter) and pulmonary fibrosis (bleomycin).
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    P01HL144454     (PRABHAKAR, NANDURI R)Apr 15, 2019 - Mar 31, 2024
    NIH
    Integrative Consequences of Intermittent Hypoxia
    Role: PI, Project 3
    P30ES027792     (AHSAN, HABIBUL)Sep 30, 2017 - Mar 31, 2027
    NIH
    ChicAgo Center for Health and EnvironmenT (CACHET)
    Role: Director, Pilot Project Program
    U01ES026718     (MUTLU, GOKHAN M.)Jun 1, 2016 - Apr 30, 2020
    NIH
    Particulate matter-induced changes in DNA methylome and transcriptome
    Role: Principal Investigator
    R21ES025644     (MUTLU, GOKHAN M.)May 1, 2015 - Apr 30, 2017
    NIH
    Regulation of IL-6 and DNA and RNA methylation by PM-induced mitochondrial ROS
    Role: Principal Investigator
    R01ES015024     (MUTLU, GOKHAN M.)Sep 1, 2006 - May 31, 2023
    NIH
    Role of alveolar macrophages in particulate matter-induced cardiopulmonary disease
    Role: Principal Investigator
    T32HL007605     (MUTLU, GOKHAN M)Aug 1, 1985 - Jun 30, 2025
    NIH
    Research training in respiratory biology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Selvan K, Mutlu G. Geotrichum infection in an immunocompetent host with SARS-CoV-2 infection. Tuberk Toraks. 2021 Sep; 69(3):421-424. PMID: 34581166.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    2. Wu D, Lee TH, Huang RT, D Guzy R, Schoettler N, Adegunsoye A, Mueller J, Husain A, I Sperling A, Fang Y, Mutlu GM. SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy. Am J Respir Cell Mol Biol. 2021 08; 65(2):222-226. PMID: 33971111; PMCID: PMC8399572.
      Citations: 5     Fields:    Translation:HumansCells
    3. Cetin-Atalay R, Meliton AY, Wu D, Woods PS, Sun KA, Peng YJ, Nanduri J, Su X, Fang Y, Hamanaka RB, Prabhakar N, Mutlu GM. Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release. Front Physiol. 2021; 12:701995. PMID: 34322038; PMCID: PMC8311436.
      Citations: 4     
    4. Wu D, Harrison DL, Szasz T, Yeh CF, Shentu TP, Meliton A, Huang RT, Zhou Z, Huang J, Fang Y, Mutlu GM. Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells. Nat Metab. 2021 05; 3(5):714-727. PMID: 34031595; PMCID: PMC8362837.
      Citations: 27     Fields:    Translation:HumansCells
    5. Hamanaka RB, Mutlu GM. The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production by myofibroblasts: implications for organ fibrosis and cancer. Amino Acids. 2021 Dec; 53(12):1851-1862. PMID: 33963932; PMCID: PMC8914507.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    6. Zhang Y, Wang L, Cai H, Mutlu GM. More to Explore: Further Definition of Risk Factors for COPD - Differential Gender Difference, Modest Elevation in PM2.5, and e-Cigarette Use. Front Physiol. 2021; 12:669152. PMID: 34025456; PMCID: PMC8131967.
      Citations: 2     
    7. Khemani RG, Lee JT, Wu D, Schenck EJ, Hayes MM, Kritek PA, Gershengorn HB, Mutlu GM, Coudroy R. Update in Critical Care 2020. Am J Respir Crit Care Med. 2021 05 01; 203(9):1088-1098. PMID: 33734938; PMCID: PMC8314915.
      Citations:    Fields:    Translation:Humans
    8. McQuattie-Pimentel AC, Ren Z, Joshi N, Watanabe S, Stoeger T, Chi M, Lu Z, Sichizya L, Aillon RP, Chen CI, Soberanes S, Chen Z, Reyfman PA, Walter JM, Anekalla KR, Davis JM, Helmin KA, Runyan CE, Abdala-Valencia H, Nam K, Meliton AY, Winter DR, Morimoto RI, Bharat A, Perlman H, Gottardi CJ, Ridge KM, Chandel NS, Sznajder JI, Balch WE, Singer BD, Misharin AV, Budinger GRS, Mutlu GM. The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging. J Clin Invest. 2021 02 15; 131(4). PMID: 33586677; PMCID: PMC7919859.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    9. Lee TH, Wu D, Guzy R, Schoettler N, Adegunsoye A, Mueller J, Hussein A, Sperling A, Mutlu GM, Fang Y. SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy. bioRxiv. 2021 Jan 18. PMID: 33469586; PMCID: PMC7814823.
      Citations:    
    10. Hamanaka RB, Mutlu GM. Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism. FEBS J. 2021 11; 288(22):6331-6352. PMID: 33393204; PMCID: PMC8253875.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    11. O'Leary EM, Tian Y, Nigdelioglu R, Witt LJ, Cetin-Atalay R, Meliton AY, Woods PS, Kimmig LM, Sun KA, Hamanaka RB, Gökalp GA, Mutlu GM. TGF-ß Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation. Am J Respir Cell Mol Biol. 2020 11; 63(5):601-612. PMID: 32668192; PMCID: PMC7605163.
      Citations: 36     Fields:    Translation:HumansCells
    12. Kimmig LM, Wu D, Gold M, Pettit NN, Pitrak D, Mueller J, Husain AN, Mutlu EA, Mutlu GM. IL-6 Inhibition in Critically Ill COVID-19 Patients Is Associated With Increased Secondary Infections. Front Med (Lausanne). 2020; 7:583897. PMID: 33195334; PMCID: PMC7655919.
      Citations: 97     
    13. Kimmig LM, Wu D, Gold M, Pettit NN, Pitrak D, Mueller J, Husain AN, Mutlu EA, Mutlu GM. IL6 inhibition in critically ill COVID-19 patients is associated with increased secondary infections. medRxiv. 2020 Sep 12. PMID: 32935118; PMCID: PMC7491533.
      Citations: 2     
    14. Pettit NN, Nguyen CT, Wu D, Kimmig L, Pitrak D, Pursell K, Mutlu GM. Late onset infectious complications and safety of tocilizumab in the management of COVID-19. J Med Virol. 2021 03; 93(3):1459-1464. PMID: 32790075; PMCID: PMC7436682.
      Citations: 45     Fields:    Translation:Humans
    15. Hamanaka RB, Mutlu GM. The Airway Epithelial Response to Air Pollution: It's Not Just Inflammation. Am J Respir Cell Mol Biol. 2020 08; 63(2):139-140. PMID: 32311285; PMCID: PMC7397764.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    16. Sun KA, Li Y, Meliton AY, Woods PS, Kimmig LM, Hamanaka RB, Cetin-Atalay R, Mutlu GM. Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response. Elife. 2020 04 07; 9. PMID: 32255424; PMCID: PMC7185992.
      Citations: 24     Fields:    Translation:AnimalsCells
    17. Woods PS, Kimmig LM, Meliton AY, Sun KA, Tian Y, O'Leary EM, Hamanaka RB, Gökalp GA, Mutlu GM. Tissue-Resident Alveolar Macrophages Do Not Rely on Glycolysis for LPS-induced Inflammation. Am J Respir Cell Mol Biol. 2020 02; 62(2):243-255. PMID: 31469581; PMCID: PMC6993551.
      Citations: 58     Fields:    Translation:AnimalsCells
    18. Piao L, Fang YH, Hamanaka RB, Dezfulian C, Archer SL, Sharp WW, Mutlu GM. Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes. Crit Care Med. 2020 02; 48(2):e133-e140. PMID: 31939812; PMCID: PMC6964871.
      Citations: 13     Fields:    Translation:AnimalsCells
    19. Hamanaka RB, O'Leary EM, Witt LJ, Tian Y, Meliton AY, Dulin NO, Gökalp GA, Mutlu GM. Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts. Am J Respir Cell Mol Biol. 2019 11; 61(5):597-606. PMID: 30973753; PMCID: PMC6827066.
      Citations: 64     Fields:    Translation:HumansCells
    20. Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV, Mutlu GM. Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 06 15; 199(12):1517-1536. PMID: 30554520; PMCID: PMC6580683.
      Citations: 564     Fields:    Translation:HumansAnimalsCells
    21. Labaki WW, Kimmig LM, Han MK, Bhatt SP, Mutlu GM. Update in Chronic Obstructive Pulmonary Disease 2018. Am J Respir Crit Care Med. 2019 06 15; 199(12):1462-1470. PMID: 30958976; PMCID: PMC6835078.
      Citations: 2     Fields:    Translation:Humans
    22. Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Budinger GRS, Mutlu GM. Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis. Cell Metab. 2019 Feb 05; 29(2):503. PMID: 30726761; PMCID: PMC6377562.
      Citations: 8     Fields:    
    23. Hamanaka RB, Mutlu GM. Alveolar Epithelial Cells Burn Fat to Survive Acute Lung Injury. Am J Respir Cell Mol Biol. 2019 02; 60(2):135-136. PMID: 30278142; PMCID: PMC6835041.
      Citations: 1     Fields:    Translation:HumansCells
    24. Duan FF, Barron G, Meliton A, Mutlu GM, Dulin NO, Schuger L. P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-ß1, -ß2, and -ß3 Translation. Am J Respir Cell Mol Biol. 2019 02; 60(2):221-231. PMID: 30230348; PMCID: PMC6376409.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    25. Radigan KA, Nicholson TT, Welch LC, Chi M, Amarelle L, Shigemura M, Shigemura A, Runyan CE, Morales-Nebreda L, Perlman H, Ceco E, Lecuona E, Dada LA, Misharin AV, Mutlu GM, Sznajder JI, Budinger GRS, Angulo M. Influenza A Virus Infection Induces Muscle Wasting via IL-6 Regulation of the E3 Ubiquitin Ligase Atrogin-1. J Immunol. 2019 01 15; 202(2):484-493. PMID: 30530483; PMCID: PMC6324970.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    26. Hamanaka RB, Mutlu GM. Particulate Matter Air Pollution: Effects on the Cardiovascular System. Front Endocrinol (Lausanne). 2018; 9:680. PMID: 30505291; PMCID: PMC6250783.
      Citations: 130     Fields:    
    27. Soberanes S, Misharin AV, Jairaman A, Morales-Nebreda L, McQuattie-Pimentel AC, Cho T, Hamanaka RB, Meliton AY, Reyfman PA, Walter JM, Chen CI, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Antalek M, Abdala-Valencia H, Chiarella SE, Sun KA, Woods PS, Ghio AJ, Jain M, Perlman H, Ridge KM, Morimoto RI, Sznajder JI, Balch WE, Bhorade SM, Bharat A, Prakriya M, Chandel NS, Budinger GRS, Mutlu GM. Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis. Cell Metab. 2019 02 05; 29(2):335-347.e5. PMID: 30318339; PMCID: PMC6365216.
      Citations: 45     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    28. Wu D, Woods PS, Duong HT, Mutlu GM. Role of Cellular Metabolism in Pulmonary Diseases. Am J Respir Cell Mol Biol. 2018 07; 59(1):127-129. PMID: 29634283; PMCID: PMC6039875.
      Citations:    Fields:    Translation:HumansCells
    29. Adegunsoye A, Oldham JM, Bellam SK, Chung JH, Chung PA, Biblowitz KM, Montner S, Lee C, Hsu S, Husain AN, Vij R, Mutlu G, Noth I, Churpek MM, Strek ME. African-American race and mortality in interstitial lung disease: a multicentre propensity-matched analysis. Eur Respir J. 2018 06; 51(6). PMID: 29724923; PMCID: PMC6089357.
      Citations: 21     Fields:    Translation:Humans
    30. Mutlu EA, Comba IY, Cho T, Engen PA, Yazici C, Soberanes S, Hamanaka RB, Nigdelioglu R, Meliton AY, Ghio AJ, Budinger GRS, Mutlu GM. Inhalational exposure to particulate matter air pollution alters the composition of the gut microbiome. Environ Pollut. 2018 Sep; 240:817-830. PMID: 29783199; PMCID: PMC6400491.
      Citations: 89     Fields:    Translation:AnimalsPHPublic Health
    31. Hamanaka RB, Nigdelioglu R, Meliton AY, Tian Y, Witt LJ, O'Leary E, Sun KA, Woods PS, Wu D, Ansbro B, Ard S, Rohde JM, Dulin NO, Guzy RD, Mutlu GM. Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2018 05; 58(5):585-593. PMID: 29019702; PMCID: PMC5946329.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    32. Budinger GRS, Mutlu GM. Letter by Mutlu and Budinger Regarding Article, "Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification". Circulation. 2018 03 13; 137(11):1203-1204. PMID: 29530899; PMCID: PMC6368954.
      Citations:    Fields:    Translation:PHPublic Health
    33. Wang T, Pehrsson EC, Purushotham D, Li D, Zhuo X, Zhang B, Lawson HA, Province MA, Krapp C, Lan Y, Coarfa C, Katz TA, Tang WY, Wang Z, Biswal S, Rajagopalan S, Colacino JA, Tsai ZT, Sartor MA, Neier K, Dolinoy DC, Pinto J, Hamanaka RB, Mutlu GM, Patisaul HB, Aylor DL, Crawford GE, Wiltshire T, Chadwick LH, Duncan CG, Garton AE, McAllister KA, TaRGET II Consortium, Bartolomei MS, Walker CL, Tyson FL. The NIEHS TaRGET II Consortium and environmental epigenomics. Nat Biotechnol. 2018 03 06; 36(3):225-227. PMID: 29509741; PMCID: PMC5991835.
      Citations: 52     Fields:    Translation:HumansPHPublic Health
    34. Wu D, Hamanaka RB, Fang Y, Mutlu GM. Letter by Wu et al Regarding Article, "Mechanical Activation of Hypoxia-Inducible Factor 1a Drives Endothelial Dysfunction at Atheroprone Sites". Arterioscler Thromb Vasc Biol. 2017 12; 37(12):e197-e198. PMID: 29162600; PMCID: PMC5777320.
      Citations:    Fields:    Translation:Humans
    35. Misharin AV, Morales-Nebreda L, Reyfman PA, Cuda CM, Walter JM, McQuattie-Pimentel AC, Chen CI, Anekalla KR, Joshi N, Williams KJN, Abdala-Valencia H, Yacoub TJ, Chi M, Chiu S, Gonzalez-Gonzalez FJ, Gates K, Lam AP, Nicholson TT, Homan PJ, Soberanes S, Dominguez S, Morgan VK, Saber R, Shaffer A, Hinchcliff M, Marshall SA, Bharat A, Berdnikovs S, Bhorade SM, Bartom ET, Morimoto RI, Balch WE, Sznajder JI, Chandel NS, Jain M, Gottardi CJ, Singer BD, Ridge KM, Bagheri N, Shilatifard A, Budinger GRS, Perlman H, Mutlu GM. Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span. J Exp Med. 2017 Aug 07; 214(8):2387-2404. PMID: 28694385; PMCID: PMC5551573.
      Citations: 527     Fields:    Translation:HumansAnimalsCells
    36. Wu D, Huang RT, Hamanaka RB, Krause M, Oh MJ, Kuo CH, Nigdelioglu R, Meliton AY, Witt L, Dai G, Civelek M, Prabhakar NR, Fang Y, Mutlu GM. HIF-1a is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium. Elife. 2017 05 30; 6. PMID: 28556776; PMCID: PMC5495571.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    37. Gileles-Hillel A, Almendros I, Khalyfa A, Nigdelioglu R, Qiao Z, Hamanaka RB, Akbarpour M, Gozal D, Mutlu GM. Prolonged Exposures to Intermittent Hypoxia Promote Visceral White Adipose Tissue Inflammation in a Murine Model of Severe Sleep Apnea: Effect of Normoxic Recovery. Sleep. 2017 03 01; 40(3). PMID: 28329220.
      Citations: 29     Fields:    Translation:AnimalsCells
    38. Huang RT, Wu D, Meliton A, Oh MJ, Krause M, Lloyd JA, Nigdelioglu R, Hamanaka RB, Jain MK, Birukova A, Kress JP, Birukov KG, Fang Y, Mutlu GM. Experimental Lung Injury Reduces Krüppel-like Factor 2 to Increase Endothelial Permeability via Regulation of RAPGEF3-Rac1 Signaling. Am J Respir Crit Care Med. 2017 03 01; 195(5):639-651. PMID: 27855271; PMCID: PMC5363977.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    39. Hamanaka RB, Mutlu GM. PFKFB3, a Direct Target of p63, Is Required for Proliferation and Inhibits Differentiation in Epidermal Keratinocytes. J Invest Dermatol. 2017 06; 137(6):1267-1276. PMID: 28108301; PMCID: PMC5441935.
      Citations: 24     Fields:    Translation:HumansCells
    40. La J, Reed E, Chan L, Smolyaninova LV, Akomova OA, Orlov SN, Dulin NO, Mutlu GM. Downregulation of TGF-ß Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase. PLoS One. 2016; 11(12):e0168363. PMID: 28006004; PMCID: PMC5179089.
      Citations: 12     Fields:    Translation:HumansCells
    41. Nigdelioglu R, Hamanaka RB, Meliton AY, O'Leary E, Witt LJ, Cho T, Sun K, Bonham C, Wu D, Woods PS, Husain AN, Wolfgeher D, Dulin NO, Chandel NS, Mutlu GM. Transforming Growth Factor (TGF)-ß Promotes de Novo Serine Synthesis for Collagen Production. J Biol Chem. 2016 12 30; 291(53):27239-27251. PMID: 27836973; PMCID: PMC5207151.
      Citations: 73     Fields:    Translation:HumansCells
    42. Bindu S, Pillai VB, Kanwal A, Samant S, Verdin E, Dulin N, Gupta MP, Mutlu GM. SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage. Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L68-L78. PMID: 27815257; PMCID: PMC5283928.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    43. Nicholson TT, Raparia K, Sporn PH, Bharat A, Mutlu GM. Wandering Pleural Mesothelial Fatty Cyst. Am J Respir Crit Care Med. 2016 Nov 01; 194(9):1164-1165. PMID: 27556583; PMCID: PMC5440972.
      Citations:    Fields:    Translation:Humans
    44. Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Morty RE, Schmoldt C, Bespalowa J, Wolff T, Pleschka S, Mayer K, Gattenloehner S, Fink L, Lohmeyer J, Seeger W, Sznajder JI, Budinger GR, Herold S, Vadász I, Mutlu GM. Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection. J Clin Invest. 2016 Apr 01; 126(4):1566-80. PMID: 26999599; PMCID: PMC4811131.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    45. La J, Reed EB, Koltsova S, Akimova O, Hamanaka RB, Orlov SN, Dulin NO, Mutlu GM. Regulation of myofibroblast differentiation by cardiac glycosides. Am J Physiol Lung Cell Mol Physiol. 2016 05 01; 310(9):L815-23. PMID: 26851261; PMCID: PMC4867347.
      Citations: 14     Fields:    Translation:HumansCells
    46. Nicholson TT, Mutlu GM. Pneumothorax following bronchoalveolar lavage for the diagnosis of non-tuberculous mycobacterial infection. An «atypical» complication of bronchoscopy? Arch Bronconeumol. 2016 May; 52(5):278-9. PMID: 26574159.
      Citations: 3     Fields:    Translation:Humans
    47. Ghio AJ, Soukup JM, Dailey LA, Tong H, Kesic MJ, Budinger GR, Mutlu GM. Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect. Chem Res Toxicol. 2015 Nov 16; 28(11):2104-11. PMID: 26462088; PMCID: PMC4838017.
      Citations: 19     Fields:    Translation:HumansCells
    48. Soveg F, Abdala-Valencia H, Campbell J, Morales-Nebreda L, Cook-Mills JM, Mutlu GM. Regulation of allergic lung inflammation by endothelial cell transglutaminase 2. Am J Physiol Lung Cell Mol Physiol. 2015 Sep 15; 309(6):L573-83. PMID: 26209276; PMCID: PMC4572420.
      Citations: 6     Fields:    Translation:AnimalsCells
    49. Morales-Nebreda LI, Rogel MR, Eisenberg JL, Hamill KJ, Soberanes S, Nigdelioglu R, Chi M, Cho T, Radigan KA, Ridge KM, Misharin AV, Woychek A, Hopkinson S, Perlman H, Mutlu GM, Pardo A, Selman M, Jones JC, Budinger GR. Lung-specific loss of a3 laminin worsens bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2015 Apr; 52(4):503-12. PMID: 25188360; PMCID: PMC4491119.
      Citations: 17     Fields:    Translation:HumansAnimals
    50. Boe AE, Eren M, Morales-Nebreda L, Murphy SB, Budinger GR, Miyata T, Vaughan DE, Mutlu GM. Nitric oxide prevents alveolar senescence and emphysema in a mouse model. PLoS One. 2015; 10(3):e0116504. PMID: 25756287; PMCID: PMC4355068.
      Citations: 6     Fields:    Translation:Animals
    51. Meliton AY, Meng F, Tian Y, Sarich N, Mutlu GM, Birukova AA, Birukov KG. Oxidized phospholipids protect against lung injury and endothelial barrier dysfunction caused by heat-inactivated Staphylococcus aureus. Am J Physiol Lung Cell Mol Physiol. 2015 Mar 15; 308(6):L550-62. PMID: 25575515; PMCID: PMC4360062.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    52. Cheresh P, Morales-Nebreda L, Kim SJ, Yeldandi A, Williams DB, Cheng Y, Budinger GR, Ridge K, Schumacker PT, Bohr VA, Kamp DW, Mutlu GM. Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice. Am J Respir Cell Mol Biol. 2015 Jan; 52(1):25-36. PMID: 24918270; PMCID: PMC4370253.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    53. Meng F, Meliton A, Moldobaeva N, Mutlu G, Kawasaki Y, Akiyama T, Birukova AA. Asef mediates HGF protective effects against LPS-induced lung injury and endothelial barrier dysfunction. Am J Physiol Lung Cell Mol Physiol. 2015 Mar 01; 308(5):L452-63. PMID: 25539852; PMCID: PMC4346776.
      Citations: 24     Fields:    Translation:HumansCells
    54. Chiarella SE, Budinger GR, Mutlu GM. ß2-Agonist therapy may contribute to the air pollution and IL-6-associated risk of developing severe asthma with dual-positive TH2/TH17 cells. J Allergy Clin Immunol. 2015 Jan; 135(1):290-1. PMID: 25445822; PMCID: PMC4386576.
      Citations: 5     Fields:    Translation:HumansCells
    55. Misharin AV, Cuda CM, Saber R, Turner JD, Gierut AK, Haines GK, Berdnikovs S, Filer A, Clark AR, Buckley CD, Budinger GR, Perlman H, Mutlu GM. Nonclassical Ly6C(-) monocytes drive the development of inflammatory arthritis in mice. Cell Rep. 2014 Oct 23; 9(2):591-604. PMID: 25373902; PMCID: PMC4223808.
      Citations: 171     Fields:    Translation:AnimalsCells
    56. Radigan KA, Morales-Nebreda L, Soberanes S, Nicholson T, Nigdelioglu R, Cho T, Chi M, Hamanaka RB, Misharin AV, Perlman H, Budinger GR, Mutlu GM. Impaired clearance of influenza A virus in obese, leptin receptor deficient mice is independent of leptin signaling in the lung epithelium and macrophages. PLoS One. 2014; 9(9):e108138. PMID: 25232724; PMCID: PMC4169489.
      Citations: 36     Fields:    Translation:AnimalsCells
    57. Morales-Nebreda L, Chi M, Lecuona E, Chandel NS, Dada LA, Ridge K, Soberanes S, Nigdelioglu R, Sznajder JI, Budinger GR, Radigan KA, Mutlu GM. Intratracheal administration of influenza virus is superior to intranasal administration as a model of acute lung injury. J Virol Methods. 2014 Dec; 209:116-20. PMID: 25239366; PMCID: PMC4315182.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    58. Lam AP, Herazo-Maya JD, Sennello JA, Flozak AS, Russell S, Budinger GR, DasGupta R, Varga J, Kaminski N, Gottardi CJ, Mutlu GM. Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2014 Jul 15; 190(2):185-95. PMID: 24921217; PMCID: PMC4226053.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    59. Budinger GR, Mutlu GM. Reply: ß2-agonists and acute respiratory distress syndrome. Am J Respir Crit Care Med. 2014 Jun 01; 189(11):1448. PMID: 24881949; PMCID: PMC4098089.
      Citations: 1     Fields:    Translation:Humans
    60. Chiarella SE, Soberanes S, Urich D, Morales-Nebreda L, Nigdelioglu R, Green D, Young JB, Gonzalez A, Rosario C, Misharin AV, Ghio AJ, Wunderink RG, Donnelly HK, Radigan KA, Perlman H, Chandel NS, Budinger GR, Mutlu GM. ß2-Adrenergic agonists augment air pollution-induced IL-6 release and thrombosis. J Clin Invest. 2014 Jul; 124(7):2935-46. PMID: 24865431; PMCID: PMC4071386.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    61. Radigan KA, Mutlu GM. Markers of prognosis specific to influenza infection: are we there yet? Am J Respir Crit Care Med. 2014 May 15; 189(10):1159-60. PMID: 24832741.
      Citations: 2     Fields:    Translation:HumansCells
    62. Morales-Nebreda L, Scott Budinger GR, Radigan KA, Mutlu GM. Loss of TLR4 does not prevent influenza A-induced mortality. Am J Respir Crit Care Med. 2014 May 15; 189(10):1280-1. PMID: 24832747; PMCID: PMC4225852.
      Citations: 7     Fields:    Translation:HumansAnimals
    63. Wheaton WW, Weinberg SE, Hamanaka RB, Soberanes S, Sullivan LB, Anso E, Glasauer A, Dufour E, Mutlu GM, Budigner GS, Chandel NS. Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis. Elife. 2014 May 13; 3:e02242. PMID: 24843020; PMCID: PMC4017650.
      Citations: 559     Fields:    Translation:HumansCells
    64. Eren M, Boe AE, Murphy SB, Place AT, Nagpal V, Morales-Nebreda L, Urich D, Quaggin SE, Budinger GR, Miyata T, Vaughan DE, Mutlu GM. PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. Proc Natl Acad Sci U S A. 2014 May 13; 111(19):7090-5. PMID: 24778222; PMCID: PMC4024885.
      Citations: 91     Fields:    Translation:AnimalsCells
    65. Budinger GR, Mutlu GM. ß2-agonists and acute respiratory distress syndrome. Am J Respir Crit Care Med. 2014 Mar 15; 189(6):624-5. PMID: 24628310; PMCID: PMC3983843.
      Citations: 3     Fields:    Translation:Humans
    66. Wiese KM, Mutlu GM. Babesiosis. Am J Respir Crit Care Med. 2014 Mar 01; 189(5):602. PMID: 24579836.
      Citations: 1     Fields:    Translation:Humans
    67. Misharin AV, Morales-Nebreda L, Budinger GR, Perlman H, Mutlu GM. Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung. Am J Respir Cell Mol Biol. 2013 Oct; 49(4):503-10. PMID: 23672262; PMCID: PMC3824047.
      Citations: 457     Fields:    Translation:AnimalsCells
    68. Ghio AJ, Tong H, Soukup JM, Dailey LA, Cheng WY, Samet JM, Kesic MJ, Bromberg PA, Turi JL, Upadhyay D, Scott Budinger GR, Mutlu GM. Sequestration of mitochondrial iron by silica particle initiates a biological effect. Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15; 305(10):L712-24. PMID: 23997175.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    69. Budinger GRS, Mutlu GM. Balancing the risks and benefits of oxygen therapy in critically III adults. Chest. 2013 Apr; 143(4):1151-1162. PMID: 23546490; PMCID: PMC3616683.
      Citations: 20     Fields:    Translation:Humans
    70. Do-Umehara HC, Chen C, Urich D, Zhou L, Qiu J, Jang S, Zander A, Baker MA, Eilers M, Sporn PH, Ridge KM, Sznajder JI, Budinger GR, Lin A, Liu J, Mutlu GM. Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-d. Nat Immunol. 2013 May; 14(5):461-9. PMID: 23525087; PMCID: PMC3631447.
      Citations: 50     Fields:    Translation:AnimalsCells
    71. Jain M, Rivera S, Monclus EA, Synenki L, Zirk A, Eisenbart J, Feghali-Bostwick C, Mutlu GM, Budinger GR, Chandel NS. Mitochondrial reactive oxygen species regulate transforming growth factor-ß signaling. J Biol Chem. 2013 Jan 11; 288(2):770-7. PMID: 23204521; PMCID: PMC3543026.
      Citations: 195     Fields:    Translation:HumansCells
    72. Bhattacharyya S, Kelley K, Melichian DS, Tamaki Z, Fang F, Su Y, Feng G, Pope RM, Budinger GR, Lafyatis R, Radstake T, Feghali-Bostwick C, Varga J, Mutlu GM. Toll-like receptor 4 signaling augments transforming growth factor-ß responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma. Am J Pathol. 2013 Jan; 182(1):192-205. PMID: 23141927; PMCID: PMC3538029.
      Citations: 129     Fields:    Translation:HumansAnimalsCells
    73. Abdala-Valencia H, Berdnikovs S, McCary CA, Urick D, Mahadevia R, Marchese ME, Swartz K, Wright L, Cook-Mills JM, Mutlu GM. Inhibition of allergic inflammation by supplementation with 5-hydroxytryptophan. Am J Physiol Lung Cell Mol Physiol. 2012 Oct 15; 303(8):L642-60. PMID: 22842218; PMCID: PMC3469632.
      Citations: 12     Fields:    Translation:AnimalsCells
    74. Radigan KA, Urich D, Misharin AV, Chiarella SE, Soberanes S, Gonzalez A, Perlman H, Wunderink RG, Budinger GR, Mutlu GM. The effect of rosuvastatin in a murine model of influenza A infection. PLoS One. 2012; 7(4):e35788. PMID: 22536437; PMCID: PMC3335012.
      Citations: 26     Fields:    Translation:AnimalsCells
    75. Soberanes S, Gonzalez A, Urich D, Chiarella SE, Radigan KA, Osornio-Vargas A, Joseph J, Kalyanaraman B, Ridge KM, Chandel NS, De Vizcaya-Ruiz A, Budinger GR, Mutlu GM. Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway. Sci Rep. 2012; 2:275. PMID: 22355787; PMCID: PMC3281276.
      Citations: 37     Fields:    
    76. Dada L, Gonzalez AR, Urich D, Soberanes S, Manghi TS, Chiarella SE, Chandel NS, Budinger GR, Mutlu GM. Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 receptor. PLoS One. 2012; 7(1):e30448. PMID: 22272351; PMCID: PMC3260305.
      Citations: 9     Fields:    Translation:AnimalsCells
    77. Duch MC, Budinger GR, Liang YT, Soberanes S, Urich D, Chiarella SE, Campochiaro LA, Gonzalez A, Chandel NS, Hersam MC, Mutlu GM. Minimizing oxidation and stable nanoscale dispersion improves the biocompatibility of graphene in the lung. Nano Lett. 2011 Dec 14; 11(12):5201-7. PMID: 22023654; PMCID: PMC3237757.
      Citations: 127     Fields:    Translation:AnimalsCells
    78. Budinger GR, Wu M, Lam AP, Zirk A, Rivera S, Urich D, Chiarella SE, Go LH, Ghosh AK, Selman M, Pardo A, Varga J, Kamp DW, Chandel NS, Sznajder JI, Jain M, Mutlu GM. Proteasomal inhibition after injury prevents fibrosis by modulating TGF-ß(1) signalling. Thorax. 2012 Feb; 67(2):139-46. PMID: 21921091; PMCID: PMC3595535.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    79. Urich D, Eisenberg JL, Hamill KJ, Takawira D, Chiarella SE, Soberanes S, Gonzalez A, Koentgen F, Manghi T, Hopkinson SB, Misharin AV, Perlman H, Mutlu GM, Budinger GR, Jones JC. Lung-specific loss of the laminin a3 subunit confers resistance to mechanical injury. J Cell Sci. 2011 Sep 01; 124(Pt 17):2927-37. PMID: 21878500; PMCID: PMC3166037.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    80. Bryce PJ, Budinger GR, Mutlu GM. Linking air pollution exposure with thrombosis. Blood. 2011 Sep 01; 118(9):2636-7. PMID: 21885614; PMCID: PMC3167365.
      Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
    81. Gusarova GA, Trejo HE, Dada LA, Briva A, Welch LC, Hamanaka RB, Chandel NS, Prakriya M, Sznajder JI, Mutlu GM. Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation. Mol Cell Biol. 2011 Sep; 31(17):3546-56. PMID: 21730292; PMCID: PMC3165547.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    82. Budinger GR, Mutlu GM. Update in environmental and occupational medicine 2010. Am J Respir Crit Care Med. 2011 Jun 15; 183(12):1614-9. PMID: 21693716; PMCID: PMC3136990.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    83. Mutlu EA, Engen PA, Soberanes S, Urich D, Forsyth CB, Nigdelioglu R, Chiarella SE, Radigan KA, Gonzalez A, Jakate S, Keshavarzian A, Budinger GR, Mutlu GM. Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice. Part Fibre Toxicol. 2011 Jun 09; 8:19. PMID: 21658250; PMCID: PMC3132719.
      Citations: 82     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    84. Budinger GR, McKell JL, Urich D, Foiles N, Weiss I, Chiarella SE, Gonzalez A, Soberanes S, Ghio AJ, Nigdelioglu R, Mutlu EA, Radigan KA, Green D, Kwaan HC, Mutlu GM. Particulate matter-induced lung inflammation increases systemic levels of PAI-1 and activates coagulation through distinct mechanisms. PLoS One. 2011 Apr 11; 6(4):e18525. PMID: 21494547; PMCID: PMC3073968.
      Citations: 46     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    85. Lam AP, Flozak AS, Russell S, Wei J, Jain M, Budinger GR, Feghali-Bostwick CA, Varga J, Gottardi CJ, Mutlu GM. Nuclear ß-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation. Am J Respir Cell Mol Biol. 2011 Nov; 45(5):915-22. PMID: 21454805; PMCID: PMC3262680.
      Citations: 74     Fields:    Translation:HumansCells
    86. Jain M, Budinger GR, Lo A, Urich D, Rivera SE, Ghosh AK, Gonzalez A, Chiarella SE, Marks K, Donnelly HK, Soberanes S, Varga J, Radigan KA, Chandel NS, Mutlu GM. Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-?. Am J Respir Crit Care Med. 2011 Jun 01; 183(11):1490-8. PMID: 21317313; PMCID: PMC3266063.
      Citations: 62     Fields:    Translation:HumansAnimals
    87. Budinger GR, Urich D, Soberanes S, Buccellato LJ, Hawkins K, Chiarella SE, Radigan KA, Eisenbart J, Agrawal H, Berkelhamer S, Hekimi S, Zhang J, Perlman H, Schumacker PT, Jain M, Chandel NS, Mutlu GM. Epithelial cell death is an important contributor to oxidant-mediated acute lung injury. Am J Respir Crit Care Med. 2011 Apr 15; 183(8):1043-54. PMID: 20959557; PMCID: PMC3086743.
      Citations: 60     Fields:    Translation:AnimalsCells
    88. Kuzniar TJ, Balagani R, Radigan KA, Factor P, Mutlu GM. Coma with absent brainstem reflexes resulting from zolpidem overdose. Am J Ther. 2010 Sep-Oct; 17(5):e172-4. PMID: 20862780.
      Citations: 5     Fields:    Translation:Humans
    89. Wolfe L, Lakadamyali H, Mutlu GM. Joubert syndrome associated with severe central sleep apnea. J Clin Sleep Med. 2010 Aug 15; 6(4):384-8. PMID: 20726289; PMCID: PMC2919671.
      Citations: 13     Fields:    Translation:Humans
    90. Van Hee VC, Kaufman JD, Budinger GR, Mutlu GM. Update in environmental and occupational medicine 2009. Am J Respir Crit Care Med. 2010 Jun 01; 181(11):1174-80. PMID: 20516491; PMCID: PMC3081277.
      Citations: 1     Fields:    Translation:HumansAnimalsPHPublic Health
    91. Budinger GR, Green AA, Urich D, Soberanes S, Chiarella SE, Alheid GF, McCrimmon DR, Szleifer I, Hersam MC, Mutlu GM. Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity. Nano Lett. 2010 May 12; 10(5):1664-70. PMID: 20377197; PMCID: PMC2869384.
      Citations: 54     Fields:    Translation:AnimalsCells
    92. Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Budinger GR, Chandel NS, Mutlu GM. Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8788-93. PMID: 20421486; PMCID: PMC2889315.
      Citations: 865     Fields:    Translation:HumansAnimalsCells
    93. Weiss CH, Budinger GR, Jain M, Mutlu GM. Proteasomal regulation of pulmonary fibrosis. Proc Am Thorac Soc. 2010 Feb; 7(1):77-83. PMID: 20160152; PMCID: PMC3137153.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    94. Budinger GR, Mutlu GM. Not much turbulence: addition of heliox to noninvasive ventilation fails to improve outcomes in patients with exacerbations of chronic obstructive pulmonary disease. Crit Care Med. 2010 Jan; 38(1):319-20. PMID: 20023482.
      Citations: 2     Fields:    Translation:Humans
    95. Mork T, Kuzniar TJ, Mutlu GM. Dysphonia and chest pain as presenting symptoms of pneumomediastinum. Tuberk Toraks. 2010; 58(2):184-7. PMID: 20865573.
      Citations: 1     Fields:    Translation:Humans
    96. Lin Z, Yin P, Reierstad S, O'Halloran M, Coon VJ, Pearson EK, Mutlu GM, Bulun SE. Adenosine A1 receptor, a target and regulator of estrogen receptoralpha action, mediates the proliferative effects of estradiol in breast cancer. Oncogene. 2010 Feb 25; 29(8):1114-22. PMID: 19935720; PMCID: PMC2829108.
      Citations: 28     Fields:    Translation:HumansCells
    97. Flozak AS, Lam AP, Russell S, Jain M, Peled ON, Sheppard KA, Beri R, Budinger GR, Gottardi CJ, Mutlu GM. Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells. J Biol Chem. 2010 Jan 29; 285(5):3157-67. PMID: 19933277; PMCID: PMC2823449.
      Citations: 67     Fields:    Translation:AnimalsCells
    98. Balachandran JS, Jaleel M, Jain M, Mahajan N, Kalhan R, Balagani R, Donnelly HK, Greenstein E, Mutlu GM. Head CT is of limited diagnostic value in critically ill patients who remain unresponsive after discontinuation of sedation. BMC Anesthesiol. 2009 May 07; 9:3. PMID: 19422697; PMCID: PMC2685364.
      Citations: 2     Fields:    
    99. Chandel NS, Budinger GR, Varga J, Synenki L, Donnelly HK, Zirk A, Eisenbart J, Jovanovic B, Jain M, Mutlu GM. Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways. Crit Care Med. 2009 May; 37(5):1678-84. PMID: 19325470.
      Citations: 9     Fields:    Translation:HumansCells
    100. Emerling BM, Weinberg F, Snyder C, Burgess Z, Viollet B, Budinger GR, Chandel NS, Mutlu GM. Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio. Free Radic Biol Med. 2009 May 15; 46(10):1386-91. PMID: 19268526; PMCID: PMC3326346.
      Citations: 147     Fields:    Translation:AnimalsCells
    101. Urich D, Soberanes S, Burgess Z, Chiarella SE, Ghio AJ, Ridge KM, Kamp DW, Chandel NS, Budinger GR, Mutlu GM. Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation. FASEB J. 2009 Jul; 23(7):2055-64. PMID: 19237507; PMCID: PMC2704586.
      Citations: 20     Fields:    Translation:AnimalsCells
    102. Soberanes S, Urich D, Baker CM, Burgess Z, Chiarella SE, Bell EL, Ghio AJ, De Vizcaya-Ruiz A, Liu J, Ridge KM, Kamp DW, Chandel NS, Schumacker PT, Budinger GR, Mutlu GM. Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution. J Biol Chem. 2009 Jan 23; 284(4):2176-86. PMID: 19033436; PMCID: PMC2629089.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    103. Budinger GR, Urich D, DeBiase PJ, Chiarella SE, Burgess ZO, Baker CM, Soberanes S, Jones JC, Mutlu GM. Stretch-induced activation of AMP kinase in the lung requires dystroglycan. Am J Respir Cell Mol Biol. 2008 Dec; 39(6):666-72. PMID: 18556591; PMCID: PMC2586043.
      Citations: 17     Fields:    Translation:AnimalsCells
    104. Green D, Bellmeyer A, Baker CM, Burgess Z, Rajamannan N, Christman JW, Foiles N, Kamp DW, Ghio AJ, Chandel NS, Dean DA, Sznajder JI, Budinger GR, Mutlu GM. Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway. J Clin Invest. 2007 Oct; 117(10):2952-61. PMID: 17885684; PMCID: PMC1978421.
      Citations: 124     Fields:    Translation:AnimalsCells
    105. Factor P, Mutlu GM. Alveolar epithelial beta2-adrenergic receptors. Am J Respir Cell Mol Biol. 2008 Feb; 38(2):127-34. PMID: 17709598; PMCID: PMC2214676.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    106. Wang HL, Akinci IO, Baker CM, Urich D, Bellmeyer A, Jain M, Chandel NS, Budinger GR, Mutlu GM. The intrinsic apoptotic pathway is required for lipopolysaccharide-induced lung endothelial cell death. J Immunol. 2007 Aug 01; 179(3):1834-41. PMID: 17641050.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    107. Machado-Aranda D, Norton JE, Bellmeyer A, Urich D, Zhou R, Dean DA, Mutlu GM. Electroporation-mediated gene transfer of the Na+,K+ -ATPase rescues endotoxin-induced lung injury. Am J Respir Crit Care Med. 2007 Sep 15; 176(6):582-90. PMID: 17556717; PMCID: PMC1994223.
      Citations: 38     Fields:    Translation:Animals
    108. Factor P, Chen L, Mohameed J, Akhmedov AT, Meng FJ, Jilling T, Lewis ER, Johnson MD, Xu A, Kass D, Martino JM, Bellmeyer A, Albazi JS, Emala C, Lee HT, Dobbs LG, Matalon S, Mutlu GM. Adenosine regulation of alveolar fluid clearance. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):4083-8. PMID: 17360481; PMCID: PMC1820712.
      Citations: 46     Fields:    Translation:AnimalsCells
    109. Bellmeyer A, Martino JM, Chandel NS, Scott Budinger GR, Dean DA, Mutlu GM. Leptin resistance protects mice from hyperoxia-induced acute lung injury. Am J Respir Crit Care Med. 2007 Mar 15; 175(6):587-94. PMID: 17185651; PMCID: PMC1899284.
      Citations: 66     Fields:    Translation:AnimalsCells
    110. Kuzniar TJ, Blum MG, Kasibowska-Kuzniar K, Mutlu GM. Predictors of acute lung injury and severe hypoxemia in patients undergoing operative talc pleurodesis. Ann Thorac Surg. 2006 Dec; 82(6):1976-81. PMID: 17126094.
      Citations: 5     Fields:    Translation:Humans
    111. Wunderink RG, Mutlu GM. Severe pseudomonal infections. Curr Opin Crit Care. 2006 Oct; 12(5):458-63. PMID: 16943726.
      Citations: 6     Fields:    Translation:Humans
    112. Soberanes S, Panduri V, Ghio A, Bundinger GR, Kamp DW, Mutlu GM. p53 mediates particulate matter-induced alveolar epithelial cell mitochondria-regulated apoptosis. Am J Respir Crit Care Med. 2006 Dec 01; 174(11):1229-38. PMID: 16946128; PMCID: PMC2648105.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    113. Mutlu EA, Bellmeyer A, Rubinstein I, Mutlu GM. Pulmonary adverse events of anti-tumor necrosis factor-alpha antibody therapy. Am J Med. 2006 Aug; 119(8):639-46. PMID: 16887405.
      Citations: 9     Fields:    Translation:Humans
    114. Rubinstein I, Mutlu GM. Clinical manifestations of sarcoidosis among inner-city African-American dwellers. J Natl Med Assoc. 2006 Jul; 98(7):1140-3. PMID: 16895285; PMCID: PMC2569462.
      Citations:    Fields:    Translation:Humans
    115. Factor P, Mutlu GM. Pulmonary tumor embolism of unknown origin. Mayo Clin Proc. 2006 Jun; 81(6):721. PMID: 16770969.
      Citations:    Fields:    Translation:HumansCells
    116. Mutlu EA, Keshavarzian A, Mutlu GM. Hyperalbuminemia and elevated transaminases associated with high-protein diet. Scand J Gastroenterol. 2006 Jun; 41(6):759-60. PMID: 16716979.
      Citations: 10     Fields:    Translation:Humans
    117. Bellmeyer A, Budinger GR, Mutlu GM. Air pollution impairs lung's ability to clear edema fluid. Am J Cardiol. 2006 Aug 01; 98(3):423-4. PMID: 16860038.
      Citations: 1     Fields:    Translation:HumansAnimals
    118. Budinger GR, Eisenbart J, Fuller AC, Bellmeyer AA, Baker CM, Wilson M, Ridge K, Barrett TA, Lee VY, Chandel NS, Mutlu GM. Proapoptotic Bid is required for pulmonary fibrosis. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4604-9. PMID: 16537427; PMCID: PMC1401229.
      Citations: 64     Fields:    Translation:AnimalsCells
    119. Quesada N, Mutlu GM. Images in cardiovascular medicine. Pulmonary embolization of acrylic cement during vertebroplasty. Circulation. 2006 Feb 28; 113(8):e295-6. PMID: 16505181.
      Citations: 11     Fields:    Translation:Humans
    120. Snyder C, Bellmeyer A, Wang H, Hawkins K, Soberanes S, Welch LC, Ghio AJ, Chandel NS, Kamp D, Sznajder JI, Budinger GR, Mutlu GM. Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generation. Am J Respir Cell Mol Biol. 2006 Jun; 34(6):670-6. PMID: 16439801; PMCID: PMC2644228.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    121. Mutlu GM, Budinger GR. Incidence and outcomes of acute lung injury. N Engl J Med. 2006 Jan 26; 354(4):416-7; author reply 416-7. PMID: 16436776.
      Citations: 11     Fields:    Translation:Humans
    122. Topin J, Mutlu GM. Images in clinical medicine. Splenic and mediastinal calcifications in histoplasmosis. N Engl J Med. 2006 Jan 12; 354(2):179. PMID: 16407513.
      Citations: 2     Fields:    Translation:HumansAnimals
    123. Sznajder JI, Mutlu GM. Mechanisms of pulmonary edema clearance. Am J Physiol Lung Cell Mol Physiol. 2005 Nov; 289(5):L685-95. PMID: 16214819.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    124. Kuzniar TJ, Gruber B, Mutlu GM. Cerebrospinal fluid leak and meningitis associated with nasal continuous positive airway pressure therapy. Chest. 2005 Sep; 128(3):1882-4. PMID: 16162800.
      Citations: 5     Fields:    Translation:Humans
    125. Adir Y, Jameel M, Akhmedov AT, Welch L, Dumasius V, Meng FJ, Zabner J, Koenig C, Lewis ER, Balagani R, Traver G, Sznajder JI, Factor P, Mutlu GM. Interdependency of beta-adrenergic receptors and CFTR in regulation of alveolar active Na+ transport. Circ Res. 2005 May 13; 96(9):999-1005. PMID: 15802612.
      Citations: 43     Fields:    Translation:HumansAnimals
    126. Rubinstein I, Mutlu GM. The saga of obstructive sleep apnea syndrome and daytime hypercapnia: work in progress. Chest. 2005 Mar; 127(3):698-9. PMID: 15764742.
      Citations: 3     Fields:    Translation:Humans
    127. Akinci OI, Celik M, Martino JM, Tugrul S, Ozcan PE, Yilmazbayhan D, Yeldandi AV, Turkoz KH, Kiran B, Cakar N, Mutlu GM, Telci L. Effects of body temperature on ventilator-induced lung injury. J Crit Care. 2005 Mar; 20(1):66-73. PMID: 16015518.
      Citations: 9     Fields:    Translation:Animals
    128. Sznajder JI, Mutlu GM. Pseudohypoxemia: interpretation of discrepancies between SaO(2) and SpO(2). Tuberk Toraks. 2005; 53(2):185-9. PMID: 16100658.
      Citations: 1     Fields:    Translation:Humans
    129. Kuzniar T, Factor P, Mutlu GM. A 41-year-old man with altered mental status and acute flaccid paralysis. Chest. 2005 Jan; 127(1):391-4. PMID: 15654004.
      Citations:    Fields:    Translation:Humans
    130. Ahkmedov AT, Lum H, Factor P, Mutlu GM. Potential genetic therapies for acute lung injury. Curr Gene Ther. 2004 Dec; 4(4):487-95. PMID: 15578996.
      Citations: 2     Fields:    Translation:HumansAnimals
    131. Koch WJ, Factor P, Mutlu GM. Alveolar epithelial beta 2-adrenergic receptors: their role in regulation of alveolar active sodium transport. Am J Respir Crit Care Med. 2004 Dec 15; 170(12):1270-5. PMID: 15447942.
      Citations: 23     Fields:    Translation:Humans
    132. Sznajder JI, Mutlu GM. beta(2)-Agonists for treatment of pulmonary edema: ready for clinical studies? Crit Care Med. 2004 Jul; 32(7):1607-8. PMID: 15241111.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    133. Factor P, Mutlu GM. Role of vasopressin in the management of septic shock. Intensive Care Med. 2004 Jul; 30(7):1276-91. PMID: 15103461.
      Citations: 39     Fields:    Translation:HumansCells
    134. Dumasius V, Burhop J, McShane PJ, Meng FJ, Welch L, Dumasius A, Mohebahmadi N, Thakuria G, Hardiman K, Matalon S, Hollenberg S, Factor P, Mutlu GM. Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling. Circ Res. 2004 Apr 30; 94(8):1091-100. PMID: 15016730.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    135. Dematte D'Amico JE, Donnelly HK, Feinglass J, Jovanovic BD, Ndukwu IM, Mutlu GM. Risk assessment for inpatient survival in the long-term acute care setting after prolonged critical illness. Chest. 2003 Sep; 124(3):1039-45. PMID: 12970035.
      Citations: 5     Fields:    Translation:Humans
    136. Akinci IO, Cakar N, Tugrul S, Ozcan PE, Gitmez M, Esen F, Telci L, Mutlu GM. Gastric intramucosal pH is stable during titration of positive end-expiratory pressure to improve oxygenation in acute respiratory distress syndrome. Crit Care. 2003 Jun; 7(3):R17-23. PMID: 12793886; PMCID: PMC270676.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    137. Mutlu EA, Factor P, Mutlu GM. Prevention and treatment of gastrointestinal complications in patients on mechanical ventilation. Am J Respir Med. 2003; 2(5):395-411. PMID: 14719992.
      Citations: 6     Fields:    Translation:Humans
    138. Factor P, Adir Y, Burhop J, Dumasius V, Mutlu GM. Effects of beta2-adrenergic receptor overexpression on alveolar epithelial active transport. J Allergy Clin Immunol. 2002 Dec; 110(6 Suppl):S242-6. PMID: 12464931.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    139. Leikin JB, Oh K, Factor P, Mutlu GM. An unresponsive biochemistry professor in the bathtub. Chest. 2002 Sep; 122(3):1073-6. PMID: 12226056.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    140. Weiss DJ, Bonneau L, Mendez M, Wang Y, Dumasius V, Factor P, Mutlu GM. Comparison of surfactant and perfluorochemical liquid enhanced adenovirus-mediated gene transfer in normal rat lung. Mol Ther. 2002 Jul; 6(1):43-9. PMID: 12095302.
      Citations: 3     Fields:    Translation:AnimalsCells
    141. Factor P, Mutlu GM. Acute-onset quadriplegia, respiratory failure, and ventricular tachycardia in a 21-year-old man following a soccer match. Chest. 2002 Jun; 121(6):2036-9. PMID: 12065374.
      Citations:    Fields:    Translation:Humans
    142. Factor P, Azzam ZA, Sznajder JI, Dumasius V, Mutlu GM. Enhancement of alveolar epithelial beta(2)-adrenergic receptor function via gene transfer. Chest. 2002 Mar; 121(3 Suppl):45S-46S. PMID: 11893682.
      Citations:    Fields:    Translation:AnimalsCells
    143. Dumasius V, Mendez M, Factor P, Mutlu GM. Acute lung injury does not impair adenoviral-mediated gene transfer to the alveolar epithelium. Chest. 2002 Mar; 121(3 Suppl):33S-34S. PMID: 11893674.
      Citations: 3     Fields:    Translation:AnimalsCells
    144. Factor P, Mendez M, Mutlu GM, Dumasius V. Acute hyperoxic lung injury does not impede adenoviral-mediated alveolar gene transfer. Am J Respir Crit Care Med. 2002 Feb 15; 165(4):521-6. PMID: 11850346.
      Citations: 6     Fields:    Translation:AnimalsCells
    145. Factor P, Schwartz DE, Sznajder JI, Mutlu GM. Severe status asthmaticus: management with permissive hypercapnia and inhalation anesthesia. Crit Care Med. 2002 Feb; 30(2):477-80. PMID: 11889333.
      Citations: 15     Fields:    Translation:Humans
    146. Dumasius V, Sznajder JI, Azzam ZS, Boja J, Mutlu GM, Maron MB, Factor P. beta(2)-adrenergic receptor overexpression increases alveolar fluid clearance and responsiveness to endogenous catecholamines in rats. Circ Res. 2001 Nov 09; 89(10):907-14. PMID: 11701618.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    147. Mutlu GM, Garey KW, Robbins RA, Danziger LH, Rubinstein I. Collection and analysis of exhaled breath condensate in humans. Am J Respir Crit Care Med. 2001 Sep 01; 164(5):731-7. PMID: 11549524.
      Citations: 63     Fields:    Translation:Humans
    148. Mutlu GM, Mutlu EA, Factor P. GI complications in patients receiving mechanical ventilation. Chest. 2001 Apr; 119(4):1222-41. PMID: 11296191.
      Citations: 98     Fields:    Translation:Humans
    149. Mutlu GM, Rubinstein I. Obstructive sleep apnea syndrome-associated nocturnal myocardial ischemia. Chest. 2000 Jun; 117(6):1534-5. PMID: 10858377.
      Citations:    Fields:    Translation:Humans
    150. Mutlu GM, Factor P. Complications of mechanical ventilation. Respir Care Clin N Am. 2000 Jun; 6(2):213-52,v. PMID: 10757962.
      Citations: 13     Fields:    Translation:Humans
    151. Mutlu GM, Moonjelly E, Chan L, Olopade CO. Laryngospasm and paradoxical bronchoconstriction after repeated doses of beta 2-agonists containing edetate disodium. Mayo Clin Proc. 2000 Mar; 75(3):285-7. PMID: 10725956.
      Citations: 7     Fields:    Translation:Humans
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