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Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.
Weihl CC, Ghadge GD, Kennedy SG, Hay N, Miller RJ, Roos RP. Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB. J Neurosci. 1999 Jul 01; 19(13):5360-9.
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PubMed
subject areas
Adenoviridae
Alzheimer Disease
Animals
Apoptosis
beta Catenin
Calcium-Calmodulin-Dependent Protein Kinases
Carrier Proteins
Cells, Cultured
Cytoskeletal Proteins
Down-Regulation
Enzyme Activation
Glycogen Synthase Kinase 3
Glycogen Synthase Kinases
Hippocampus
JNK Mitogen-Activated Protein Kinases
Membrane Proteins
Mitogen-Activated Protein Kinases
Mutation
Nerve Growth Factors
Neurons
PC12 Cells
Phosphatidylinositol 3-Kinases
Presenilin-1
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-akt
Rats
Receptor, trkA
Ribosomal Protein S6 Kinases
Signal Transduction
Trans-Activators
Transfection
Wnt Proteins
Zebrafish Proteins
authors with profiles
Ghanashyam Ghadge
Raymond P. Roos
Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.