 Dynamins
"Dynamins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport. They associate with microtubule bundles (MICROTUBULES) and are believed to produce mechanical force via a process linked to GTP hydrolysis. This enzyme was formerly listed as EC 3.6.1.50.
| Descriptor ID |
D034281
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| MeSH Number(s) |
D08.811.277.040.330.200 D12.776.220.600.450.200 D12.776.543.990.400
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| Concept/Terms |
GTPase-Deficient Dynamin- GTPase-Deficient Dynamin
- Dynamin, GTPase-Deficient
- GTPase Deficient Dynamin
- Dynamin, Alanine44 Substituted With Lysine
- Dynamin, Mutated Form, K44A
- Dynamin K44A
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Below are MeSH descriptors whose meaning is more general than "Dynamins".
Below are MeSH descriptors whose meaning is more specific than "Dynamins".
This graph shows the total number of publications written about "Dynamins" by people in this website by year, and whether "Dynamins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 2 | 3 | | 2005 | 2 | 1 | 3 | | 2010 | 0 | 1 | 1 | | 2012 | 1 | 1 | 2 | | 2013 | 1 | 0 | 1 | | 2014 | 0 | 2 | 2 | | 2015 | 1 | 0 | 1 | | 2017 | 1 | 1 | 2 | | 2018 | 2 | 1 | 3 | | 2019 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dynamins" by people in Profiles.
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Zhang R, Lee DM, Jimah JR, Gerassimov N, Yang C, Kim S, Luvsanjav D, Winkelman J, Mettlen M, Abrams ME, Kalia R, Keene P, Pandey P, Ravaux B, Kim JH, Ditlev JA, Zhang G, Rosen MK, Frost A, Alto NM, Gardel M, Schmid SL, Svitkina TM, Hinshaw JE, Chen EH. Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein. Nat Cell Biol. 2020 06; 22(6):674-688.
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Wu D, Dasgupta A, Chen KH, Neuber-Hess M, Patel J, Hurst TE, Mewburn JD, Lima PDA, Alizadeh E, Martin A, Wells M, Snieckus V, Archer SL. Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury. FASEB J. 2020 01; 34(1):1447-1464.
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Odenwald MA, Choi W, Kuo WT, Singh G, Sailer A, Wang Y, Shen L, Fanning AS, Turner JR. The scaffolding protein ZO-1 coordinates actomyosin and epithelial apical specializations in vitro and in vivo. J Biol Chem. 2018 11 09; 293(45):17317-17335.
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Kim YM, Youn SW, Sudhahar V, Das A, Chandhri R, Cuervo Grajal H, Kweon J, Leanhart S, He L, Toth PT, Kitajewski J, Rehman J, Yoon Y, Cho J, Fukai T, Ushio-Fukai M. Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence. Cell Rep. 2018 06 19; 23(12):3565-3578.
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Kar UP, Dey H, Rahaman A. Tetrahymena dynamin-related protein 6 self-assembles independent of membrane association. J Biosci. 2018 Mar; 43(1):139-148.
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Nan J, Zhu W, Rahman MS, Liu M, Li D, Su S, Zhang N, Hu X, Yu H, Gupta MP, Wang J. Molecular regulation of mitochondrial dynamics in cardiac disease. Biochim Biophys Acta Mol Cell Res. 2017 Jul; 1864(7):1260-1273.
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Tian L, Neuber-Hess M, Mewburn J, Dasgupta A, Dunham-Snary K, Wu D, Chen KH, Hong Z, Sharp WW, Kutty S, Archer SL. Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension. J Mol Med (Berl). 2017 04; 95(4):381-393.
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Sharp WW, Beiser DG, Fang YH, Han M, Piao L, Varughese J, Archer SL. Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model. Crit Care Med. 2015 Feb; 43(2):e38-47.
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Greene AC, Lord SJ, Tian A, Rhodes C, Kai H, Groves JT. Spatial organization of EphA2 at the cell-cell interface modulates trans-endocytosis of ephrinA1. Biophys J. 2014 May 20; 106(10):2196-205.
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Briguglio JS, Turkewitz AP. Tetrahymena thermophila: a divergent perspective on membrane traffic. J Exp Zool B Mol Dev Evol. 2014 Nov; 322(7):500-16.
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