F-Box-WD Repeat-Containing Protein 7
"F-Box-WD Repeat-Containing Protein 7" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES.
| Descriptor ID |
D000073979
|
| MeSH Number(s) |
D08.811.464.938.750.750.750 D12.776.157.169.750 D12.776.167.242
|
| Concept/Terms |
F-Box-WD Repeat-Containing Protein 7- F-Box-WD Repeat-Containing Protein 7
- F Box WD Repeat Containing Protein 7
- F-Box and WD-40 Domain-Containing Protein 7
- F Box and WD 40 Domain Containing Protein 7
- FBXW7 Protein
|
Below are MeSH descriptors whose meaning is more general than "F-Box-WD Repeat-Containing Protein 7".
Below are MeSH descriptors whose meaning is more specific than "F-Box-WD Repeat-Containing Protein 7".
This graph shows the total number of publications written about "F-Box-WD Repeat-Containing Protein 7" by people in this website by year, and whether "F-Box-WD Repeat-Containing Protein 7" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "F-Box-WD Repeat-Containing Protein 7" by people in Profiles.
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Chromosome instability underlies hematopoietic stem cell dysfunction and lymphoid neoplasia associated with impaired Fbw7-mediated cyclin E regulation. Mol Cell Biol. 2014 Sep; 34(17):3244-58.
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An integrated view of cyclin E function and regulation. Cell Cycle. 2012 Jan 01; 11(1):57-64.
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Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science. 2011 Aug 26; 333(6046):1154-7.
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hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53. Cancer Sci. 2003 May; 94(5):431-6.