"DCC Receptor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells.
- DCC Receptor
- Receptor, DCC
- DCC Tumor Suppressor Protein
- Deleted in Colorectal Carcinoma Protein
- DCC-Netrin-1 Receptor
- DCC Netrin 1 Receptor
- Receptor, DCC-Netrin-1
Below are MeSH descriptors whose meaning is more general than "DCC Receptor".
Below are MeSH descriptors whose meaning is more specific than "DCC Receptor".
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Below are the most recent publications written about "DCC Receptor" by people in Profiles.
A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration. Hypertension. 2016 09; 68(3):621-9.
A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population. J Hum Genet. 2012 Apr; 57(4):235-7.
Presenilin attenuates receptor-mediated signaling and synaptic function. J Neurosci. 2005 Feb 09; 25(6):1540-9.
Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC). J Biol Chem. 2003 Aug 15; 278(33):30425-8.