Tumor Suppressor Protein p53
"Tumor Suppressor Protein p53" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
| Descriptor ID |
D016159
|
| MeSH Number(s) |
D12.776.157.687.650 D12.776.260.820 D12.776.624.776.775 D12.776.660.720.650 D12.776.744.845
|
| Concept/Terms |
Tumor Suppressor Protein p53- Tumor Suppressor Protein p53
- p53 Antigen
- TP53 Protein
- TRP53 Protein
- p53 Tumor Suppressor Protein
- pp53 Phosphoprotein
- Phosphoprotein, pp53
- Cellular Tumor Antigen p53
- Oncoprotein p53
|
Below are MeSH descriptors whose meaning is more general than "Tumor Suppressor Protein p53".
Below are MeSH descriptors whose meaning is more specific than "Tumor Suppressor Protein p53".
This graph shows the total number of publications written about "Tumor Suppressor Protein p53" by people in this website by year, and whether "Tumor Suppressor Protein p53" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 3 | 4 | 7 |
| 1997 | 2 | 3 | 5 |
| 1998 | 2 | 4 | 6 |
| 1999 | 1 | 1 | 2 |
| 2000 | 3 | 4 | 7 |
| 2001 | 4 | 2 | 6 |
| 2002 | 9 | 9 | 18 |
| 2003 | 7 | 3 | 10 |
| 2004 | 9 | 1 | 10 |
| 2005 | 6 | 4 | 10 |
| 2006 | 6 | 5 | 11 |
| 2007 | 3 | 6 | 9 |
| 2008 | 4 | 10 | 14 |
| 2009 | 3 | 2 | 5 |
| 2010 | 11 | 6 | 17 |
| 2011 | 7 | 8 | 15 |
| 2012 | 5 | 9 | 14 |
| 2013 | 5 | 1 | 6 |
| 2014 | 8 | 5 | 13 |
| 2015 | 7 | 7 | 14 |
| 2016 | 6 | 6 | 12 |
| 2017 | 8 | 4 | 12 |
| 2018 | 5 | 9 | 14 |
| 2019 | 7 | 7 | 14 |
| 2020 | 5 | 4 | 9 |
| 2021 | 5 | 3 | 8 |
| 2022 | 5 | 7 | 12 |
| 2023 | 2 | 10 | 12 |
| 2024 | 8 | 5 | 13 |
| 2025 | 14 | 5 | 19 |
| 2026 | 2 | 3 | 5 |
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Below are the most recent publications written about "Tumor Suppressor Protein p53" by people in Profiles.
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Cancer treatment alters mutant selection in normal esophagus. Nat Genet. 2026 Oct; 58(10):2566-2578.
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MDM2 Inhibition with Alrizomadlin (APG-115) in TP53 wild-type salivary gland cancers: a phase I clinical trial. Nat Commun. 2026 Mar 19; 17(1).
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Spectrum, prevalence, and clinical correlates of PPM1D mutations in patients with clonal hematopoiesis and clonal cytopenias. Blood Adv. 2026 Mar 10; 10(5):1746-1755.
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The dynamics of mutational selection in cutaneous squamous carcinogenesis. Commun Biol. 2026 Jan 12; 9(1):127.
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Characterization of chromosome 5 aberrations in TP53 mutated myeloid neoplasms with =5% blasts: An International TP53 Investigators Network (iTiN) study. Cancer. 2026 Jan 01; 132(1):e70210.
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Mutant p53 promotes clonal hematopoiesis by generating a chronic inflammatory microenvironment. J Clin Invest. 2026 02 02; 136(3).
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AGR2 suppresses ferroptosis via the p53/FPN1 regulatory axis and drives therapeutic vulnerabilities in pancreatic cancer. Cell Death Dis. 2025 Dec 01; 16(1):877.
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DNA-hypermethylated human gastric cancer circumvents apoptosis in the absence of TP53 mutation. J Pathol. 2025 Dec; 267(4):435-449.
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Thymic epithelial cells amplify epigenetic noise to promote immune tolerance. Nature. 2025 10; 646(8085):724-733.
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Karyotypic clonal fraction predicts adverse outcome in TP53-mutated myeloid neoplasms: an International TP53 investigators Network (iTiN) study. J Clin Pathol. 2025 Aug 18; 78(9):629-635.