Retinoblastoma-Like Protein p130
"Retinoblastoma-Like Protein p130" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negative regulator of the CELL CYCLE that undergoes PHOSPHORYLATION by CYCLIN-DEPENDENT KINASES. RBL2 contains a conserved pocket region that binds E2F4 TRANSCRIPTION FACTOR and E2F5 TRANSCRIPTION FACTOR. RBL2 also interacts with viral ONCOPROTEINS such as POLYOMAVIRUS TUMOR ANTIGENS; ADENOVIRUS E1A PROTEINS; and PAPILLOMAVIRUS E7 PROTEINS.
| Descriptor ID |
D050717
|
| MeSH Number(s) |
D12.776.624.776.735 D12.776.660.794 D12.776.744.755
|
| Concept/Terms |
Retinoblastoma-Like Protein p130- Retinoblastoma-Like Protein p130
- p130, Retinoblastoma-Like Protein
- Retinoblastoma Like Protein p130
- Retinoblastoma-Like Protein 2
- Retinoblastoma Like Protein 2
- RBL2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Retinoblastoma-Like Protein p130".
Below are MeSH descriptors whose meaning is more specific than "Retinoblastoma-Like Protein p130".
This graph shows the total number of publications written about "Retinoblastoma-Like Protein p130" by people in this website by year, and whether "Retinoblastoma-Like Protein p130" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Retinoblastoma-Like Protein p130" by people in Profiles.
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RBL2 bi-allelic truncating variants cause severe motor and cognitive impairment without evidence for abnormalities in DNA methylation or telomeric function. J Hum Genet. 2021 Nov; 66(11):1101-1112.
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Pathways of proliferation: new targets to inhibit the growth of vascular smooth muscle cells. Circ Res. 2008 Nov 07; 103(10):1047-9.
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miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):2889-94.
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Increased expression of p130 in Alzheimer disease. Neurochem Res. 2007 Apr-May; 32(4-5):639-44.
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Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells. J Biol Chem. 1997 Feb 14; 272(7):4230-6.
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p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene. J Biol Chem. 1996 Oct 11; 271(41):25198-203.