Positive Regulatory Domain I-Binding Factor 1
"Positive Regulatory Domain I-Binding Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcriptional repressor protein that contains an N-terminal PR-SET domain, four C-terminal CYS2-HIS2 ZINC FINGERS, and binds the PRDI element in the INTERFERON-BETA gene. It has methyltransferase activity and mediates gene transcription in tissue-specific innate and adaptive immune lymphocyte T-CELLS, repressing expression of proteins that promote exit of these tissue-specific T-cell populations from non-lymphoid organs.
| Descriptor ID |
D000074462
|
| MeSH Number(s) |
D08.811.913.555.500.800.700 D12.776.260.703.650 D12.776.930.780.904
|
| Concept/Terms |
Positive Regulatory Domain I-Binding Factor 1- Positive Regulatory Domain I-Binding Factor 1
- Positive Regulatory Domain I Binding Factor 1
- PRDI-BF1 Protein
- PRDI BF1 Protein
- B Lymphocyte-Induced Maturation Protein 1
- B Lymphocyte Induced Maturation Protein 1
- PRDM1 Protein
- BLIMP1 Protein
|
Below are MeSH descriptors whose meaning is more general than "Positive Regulatory Domain I-Binding Factor 1".
Below are MeSH descriptors whose meaning is more specific than "Positive Regulatory Domain I-Binding Factor 1".
This graph shows the total number of publications written about "Positive Regulatory Domain I-Binding Factor 1" by people in this website by year, and whether "Positive Regulatory Domain I-Binding Factor 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Positive Regulatory Domain I-Binding Factor 1" by people in Profiles.
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T-bet Transcription Factor Promotes Antibody-Secreting Cell Differentiation by Limiting the Inflammatory Effects of IFN-? on B Cells. Immunity. 2019 05 21; 50(5):1172-1187.e7.
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Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection. Nat Immunol. 2017 Nov; 18(11):1249-1260.
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Transcriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4. Immunity. 2013 May 23; 38(5):918-29.
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Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia. Am J Clin Pathol. 2013 Feb; 139(2):210-9.
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Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nat Immunol. 2012 Mar 11; 13(4):405-11.
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Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma. Nat Med. 2011 Jul 24; 17(8):941-3.
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Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity. 2006 Aug; 25(2):225-36.
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The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse. Development. 2005 Mar; 132(6):1315-25.
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Blimp-1; immunoglobulin secretion and the switch to plasma cells. Curr Top Microbiol Immunol. 2005; 290:201-24.
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Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation. J Immunol. 2004 May 01; 172(9):5427-40.