"Thyroid Nuclear Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. It is critical for maintaining thyroid tissue in a differentiated state and also plays a role in lung development. Mutations in the NKX2-1 gene are associated with CHOREA, BENIGN HEREDITARY.
| Descriptor ID |
D000074482
|
| MeSH Number(s) |
D12.776.260.400.871 D12.776.660.823 D12.776.930.888
|
| Concept/Terms |
Thyroid Nuclear Factor 1- Thyroid Nuclear Factor 1
- Thyroid Transcription Factor 1
- TITF-1 Protein
- TITF 1 Protein
- Homeobox Protein Nkx-2.1
- Homeobox Protein Nkx 2.1
- Nkx-2.1, Homeobox Protein
- NK2 Homeobox 1 Protein
- TITF1 Protein
- TTF-1 Thyroid Nuclear Factor
- TTF 1 Thyroid Nuclear Factor
- Thyroid-Specific Enhancer-Binding Protein
- Enhancer-Binding Protein, Thyroid-Specific
- Thyroid Specific Enhancer Binding Protein
|
Below are MeSH descriptors whose meaning is more general than "Thyroid Nuclear Factor 1".
Below are MeSH descriptors whose meaning is more specific than "Thyroid Nuclear Factor 1".
This graph shows the total number of publications written about "Thyroid Nuclear Factor 1" by people in this website by year, and whether "Thyroid Nuclear Factor 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Thyroid Nuclear Factor 1" by people in Profiles.
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Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice. Thyroid. 2019 10; 29(10):1438-1446.
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Novel Mutations in the NKX2.1 gene and the PAX8 gene in a Boy with Brain-Lung-Thyroid Syndrome. Exp Clin Endocrinol Diabetes. 2018 02; 126(2):85-90.
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Pathfinding of corticothalamic axons relies on a rendezvous with thalamic projections. Neuron. 2013 Feb 06; 77(3):472-84.
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Generation of functional thyroid from embryonic stem cells. Nature. 2012 Nov 01; 491(7422):66-71.
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Thyroid transcription factor 1 rescues PAX8/p300 synergism impaired by a natural PAX8 paired domain mutation with dominant negative activity. Mol Endocrinol. 2005 Jul; 19(7):1779-91.
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Hypothyroidism in thyroid transcription factor 1 haploinsufficiency is caused by reduced expression of the thyroid-stimulating hormone receptor. Mol Endocrinol. 2003 Nov; 17(11):2295-302.
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Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice. J Clin Invest. 2002 Feb; 109(4):469-73.
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Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J). Dev Biol. 2000 Jan 15; 217(2):254-65.