Polycomb Repressive Complex 1
"Polycomb Repressive Complex 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multisubunit polycomb protein complex with affinity for CHROMATIN that contains methylated HISTONE H3. It contains an E3 ubiquitin ligase activity that is specific for HISTONE H2A and works in conjunction with POLYCOMB REPRESSIVE COMPLEX 2 to effect EPIGENETIC REPRESSION.
| Descriptor ID |
D063150
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| MeSH Number(s) |
D05.500.781.100 D08.811.464.938.750.280 D12.776.660.235.600.100 D12.776.664.235.800.100 D12.776.930.780.890.100
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Polycomb Repressive Complex 1".
Below are MeSH descriptors whose meaning is more specific than "Polycomb Repressive Complex 1".
This graph shows the total number of publications written about "Polycomb Repressive Complex 1" by people in this website by year, and whether "Polycomb Repressive Complex 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Polycomb Repressive Complex 1" by people in Profiles.
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The IL-6R and Bmi-1 axis controls self-renewal and chemoresistance of head and neck cancer stem cells. Cell Death Dis. 2021 10 23; 12(11):988.
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A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci. Cancer Epidemiol Biomarkers Prev. 2016 12; 25(12):1609-1618.
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Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus. Sci Signal. 2012 Oct 23; 5(247):ra77.
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Impaired cell adhesion, apoptosis, and signaling in WASP gene-disrupted Nalm-6 pre-B cells and recovery of cell adhesion using a transducible form of WASp. Int J Hematol. 2012 Mar; 95(3):299-310.
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The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors. Cell Cycle. 2010 Jul 01; 9(13):2663-73.
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ELF4/MEF activates MDM2 expression and blocks oncogene-induced p16 activation to promote transformation. Mol Cell Biol. 2009 Jul; 29(13):3687-99.
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Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS. FASEB J. 2009 Mar; 23(3):783-94.
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Chromosomal distribution of PcG proteins during Drosophila development. PLoS Biol. 2006 Jun; 4(6):e170.
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Transformation by the Bmi-1 oncoprotein correlates with its subnuclear localization but not its transcriptional suppression activity. Mol Cell Biol. 1996 Oct; 16(10):5527-35.