 Fibrinolysin
"Fibrinolysin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.
| Descriptor ID |
D005341
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| MeSH Number(s) |
D08.811.277.656.300.760.330 D08.811.277.656.959.350.330
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| Concept/Terms |
Fibrinolysin- Fibrinolysin
- Protease F
- Glu-Plasmin
- Glu Plasmin
- Plasmin
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Below are MeSH descriptors whose meaning is more general than "Fibrinolysin".
Below are MeSH descriptors whose meaning is more specific than "Fibrinolysin".
This graph shows the total number of publications written about "Fibrinolysin" by people in this website by year, and whether "Fibrinolysin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1986 | 1 | 0 | 1 | | 1988 | 0 | 1 | 1 | | 1992 | 0 | 1 | 1 | | 2001 | 2 | 0 | 2 | | 2002 | 1 | 1 | 2 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 2 | 1 | 3 | | 2013 | 2 | 0 | 2 | | 2017 | 0 | 2 | 2 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Fibrinolysin" by people in Profiles.
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Singh SR, Hariprasad SM, Narayanan R. Current Management of Macular Hole. Ophthalmic Surg Lasers Imaging Retina. 2019 02 01; 50(2):61-68.
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Ishihara J, Fukunaga K, Ishihara A, Larsson HM, Potin L, Hosseinchi P, Galliverti G, Swartz MA, Hubbell JA. Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events. Sci Transl Med. 2017 Nov 08; 9(415).
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Briquez PS, Lorentz KM, Larsson HM, Frey P, Hubbell JA. Human Kunitz-type protease inhibitor engineered for enhanced matrix retention extends longevity of fibrin biomaterials. Biomaterials. 2017 Aug; 135:1-9.
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Hoffmann DC, Willenborg S, Koch M, Zwolanek D, Müller S, Becker AK, Metzger S, Ehrbar M, Kurschat P, Hellmich M, Hubbell JA, Eming SA. Proteolytic processing regulates placental growth factor activities. J Biol Chem. 2013 Jun 21; 288(25):17976-89.
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Ober MD, Hariprasad SM. Ocriplasmin: nonsurgical option for VMA and macular hole, but with potential barriers to practical use. Ophthalmic Surg Lasers Imaging Retina. 2013 Mar-Apr; 44(2):113-6; discussion p.113.
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Patterson J, Hubbell JA. SPARC-derived protease substrates to enhance the plasmin sensitivity of molecularly engineered PEG hydrogels. Biomaterials. 2011 Feb; 32(5):1301-10.
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Lorentz KM, Kontos S, Frey P, Hubbell JA. Engineered aprotinin for improved stability of fibrin biomaterials. Biomaterials. 2011 Jan; 32(2):430-8.
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Jo YS, Rizzi SC, Ehrbar M, Weber FE, Hubbell JA, Lutolf MP. Biomimetic PEG hydrogels crosslinked with minimal plasmin-sensitive tri-amino acid peptides. J Biomed Mater Res A. 2010 Jun 01; 93(3):870-7.
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Arrighi I, Mark S, Alvisi M, von Rechenberg B, Hubbell JA, Schense JC. Bone healing induced by local delivery of an engineered parathyroid hormone prodrug. Biomaterials. 2009 Mar; 30(9):1763-71.
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Ehrbar M, Metters A, Zammaretti P, Hubbell JA, Zisch AH. Endothelial cell proliferation and progenitor maturation by fibrin-bound VEGF variants with differential susceptibilities to local cellular activity. J Control Release. 2005 Jan 03; 101(1-3):93-109.
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