High-Temperature Requirement A Serine Peptidase 1
"High-Temperature Requirement A Serine Peptidase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A secreted serine protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL).
| Descriptor ID |
D000074289
|
| MeSH Number(s) |
D08.811.277.656.300.760.420 D08.811.277.656.959.350.420
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "High-Temperature Requirement A Serine Peptidase 1".
Below are MeSH descriptors whose meaning is more specific than "High-Temperature Requirement A Serine Peptidase 1".
This graph shows the total number of publications written about "High-Temperature Requirement A Serine Peptidase 1" by people in this website by year, and whether "High-Temperature Requirement A Serine Peptidase 1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "High-Temperature Requirement A Serine Peptidase 1" by people in Profiles.
-
BMP-Responsive Protease HtrA1 Is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury Response. J Neurosci. 2018 04 11; 38(15):3840-3857.
-
The inhibitory effect of IFN-? on protease HTRA1 expression in rheumatoid arthritis. J Immunol. 2014 Jul 01; 193(1):130-8.
-
Lipopolysaccharide increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA-1 expression. Arthritis Rheum. 2013 Nov; 65(11):2835-46.
-
Genetic variation in IGF2 and HTRA1 and breast cancer risk among BRCA1 and BRCA2 carriers. Cancer Epidemiol Biomarkers Prev. 2011 Aug; 20(8):1690-702.