"Proprotein Convertase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine endopeptidase that has specificity for cleavage at ARGININE. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN, proluteinizing-hormone-releasing hormone, proenkephalins, prodynorphin, and PROINSULIN.
| Descriptor ID |
D045706
|
| MeSH Number(s) |
D08.811.277.656.300.760.646 D08.811.277.656.837.562 D08.811.277.656.959.350.646
|
| Concept/Terms |
Proprotein Convertase 2- Proprotein Convertase 2
- PC2 Prohormone Convertase
- PC2 Protein
- Endopeptidase PC2
- PC2, Endopeptidase
- Prohormone Convertase 2
- Convertase 2, Prohormone
- Prohormone Convertase PC2
- Convertase PC2, Prohormone
- Proinsulin Convertase 2
- Convertase 2, Proinsulin
- Prohormone Convertase, PC2
- Convertase, PC2 Prohormone
- PC2 Endoprotease
- Endoprotease, PC2
- Neuroendocrine Convertase PC2
- Convertase PC2, Neuroendocrine
|
Below are MeSH descriptors whose meaning is more general than "Proprotein Convertase 2".
Below are MeSH descriptors whose meaning is more specific than "Proprotein Convertase 2".
This graph shows the total number of publications written about "Proprotein Convertase 2" by people in this website by year, and whether "Proprotein Convertase 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 2 | 2 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proprotein Convertase 2" by people in Profiles.
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The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead? Diabetes Obes Metab. 2007 Nov; 9 Suppl 2:56-66.
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Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death. Diabetes. 2006 Aug; 55(8):2192-201.
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Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon interdomain site, Lys70-Arg71, to generate glucagon. Endocrinology. 2005 Feb; 146(2):713-27.
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Regulatory roles of the P domain of the subtilisin-like prohormone convertases. J Biol Chem. 1998 May 01; 273(18):11107-14.
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Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells. Biochem J. 1996 Jan 01; 313 ( Pt 1):259-68.
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Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line. Diabetes. 1996 Jan; 45(1):37-43.
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Molecular modeling of the substrate specificity of prohormone convertases SPC2 and SPC3. J Biol Chem. 1995 Jun 02; 270(22):13277-84.
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Proprotein convertases in amphioxus: predicted structure and expression of proteases SPC2 and SPC3. Proc Natl Acad Sci U S A. 1995 Apr 11; 92(8):3591-5.
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Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus. J Clin Invest. 1995 Mar; 95(3):1032-9.
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Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2. Genomics. 1993 Sep; 17(3):785-6.