 Cytokines
"Cytokines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
| Descriptor ID |
D016207
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| MeSH Number(s) |
D12.644.276.374 D12.776.467.374 D23.529.374
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cytokines".
Below are MeSH descriptors whose meaning is more specific than "Cytokines".
This graph shows the total number of publications written about "Cytokines" by people in this website by year, and whether "Cytokines" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1987 | 0 | 1 | 1 | | 1989 | 0 | 1 | 1 | | 1990 | 0 | 4 | 4 | | 1991 | 2 | 3 | 5 | | 1992 | 2 | 3 | 5 | | 1993 | 6 | 1 | 7 | | 1994 | 4 | 4 | 8 | | 1995 | 7 | 7 | 14 | | 1996 | 2 | 6 | 8 | | 1997 | 8 | 2 | 10 | | 1998 | 1 | 5 | 6 | | 1999 | 8 | 4 | 12 | | 2000 | 3 | 6 | 9 | | 2001 | 3 | 8 | 11 | | 2002 | 3 | 15 | 18 | | 2003 | 4 | 15 | 19 | | 2004 | 6 | 17 | 23 | | 2005 | 7 | 23 | 30 | | 2006 | 3 | 16 | 19 | | 2007 | 6 | 8 | 14 | | 2008 | 13 | 7 | 20 | | 2009 | 6 | 19 | 25 | | 2010 | 8 | 14 | 22 | | 2011 | 10 | 17 | 27 | | 2012 | 8 | 14 | 22 | | 2013 | 5 | 18 | 23 | | 2014 | 2 | 16 | 18 | | 2015 | 3 | 28 | 31 | | 2016 | 8 | 17 | 25 | | 2017 | 9 | 20 | 29 | | 2018 | 6 | 23 | 29 | | 2019 | 7 | 14 | 21 | | 2020 | 5 | 8 | 13 | | 2021 | 2 | 1 | 3 |
To return to the timeline, click here.
Below are the most recent publications written about "Cytokines" by people in Profiles.
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Liu G, Lee JH, Parker ZM, Acharya D, Chiang JJ, van Gent M, Riedl W, Davis-Gardner ME, Wies E, Chiang C, Gack MU. ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity. Nat Microbiol. 2021 04; 6(4):467-478.
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Ferrara R, Campochiaro C, Garassino MC. Shifting From a "One Size Fits All" to a Tailored Approach for Immune-Related Adverse Events. J Thorac Oncol. 2021 02; 16(2):183-186.
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Chiang C, Liu G, Gack MU. Viral Evasion of RIG-I-Like Receptor-Mediated Immunity through Dysregulation of Ubiquitination and ISGylation. Viruses. 2021 01 26; 13(2).
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Chakraborty S, Gonzalez J, Edwards K, Mallajosyula V, Buzzanco AS, Sherwood R, Buffone C, Kathale N, Providenza S, Xie MM, Andrews JR, Blish CA, Singh U, Dugan H, Wilson PC, Pham TD, Boyd SD, Nadeau KC, Pinsky BA, Zhang S, Memoli MJ, Taubenberger JK, Morales T, Schapiro JM, Tan GS, Jagannathan P, Wang TT. Proinflammatory IgG Fc structures in patients with severe COVID-19. Nat Immunol. 2021 01; 22(1):67-73.
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Diorio C, Henrickson SE, Vella LA, McNerney KO, Chase J, Burudpakdee C, Lee JH, Jasen C, Balamuth F, Barrett DM, Banwell BL, Bernt KM, Blatz AM, Chiotos K, Fisher BT, Fitzgerald JC, Gerber JS, Gollomp K, Gray C, Grupp SA, Harris RM, Kilbaugh TJ, John ARO, Lambert M, Liebling EJ, Paessler ME, Petrosa W, Phillips C, Reilly AF, Romberg ND, Seif A, Sesok-Pizzini DA, Sullivan KE, Vardaro J, Behrens EM, Teachey DT, Bassiri H. Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2. J Clin Invest. 2020 11 02; 130(11):5967-5975.
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Daneshkhah A, Agrawal V, Eshein A, Subramanian H, Roy HK, Backman V. Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients. Aging Clin Exp Res. 2020 Oct; 32(10):2141-2158.
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Alverdy JC, Keskey R, Thewissen R. Can the Cecal Ligation and Puncture Model Be Repurposed To Better Inform Therapy in Human Sepsis? Infect Immun. 2020 08 19; 88(9).
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Sica A, Colombo MP, Trama A, Horn L, Garassino MC, Torri V. Immunometabolic Status of COVID-19 Cancer Patients. Physiol Rev. 2020 10 01; 100(4):1839-1850.
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Liu G, Gack MU. Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity. Immunity. 2020 07 14; 53(1):26-42.
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Abasiyanik MF, Wolfe K, Van Phan H, Lin J, Laxman B, White SR, Verhoef PA, Mutlu GM, Patel B, Tay S. Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomes. Nat Commun. 2020 05 25; 11(1):2607.
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