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Robert Grossman

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine-Computational Biomedicine and Biomedical Data Science
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Robert L. Grossman is the Frederick H. Rawson Distinguished Service Professor in Medicine and Computer Science and the Jim and Karen Frank Director of the Center for Translational Data Science at the University of Chicago. He has also served as the chief research informatics officer of the Biological Sciences Division since 2011. He is the Co-Chief in the Section of Computational Biomedicine and Biomedical Data Science in the Department of Medicine.


    Collapse Biography 
    Collapse awards and honors
    2016ACM Fellow
    2013AAAS Fellow
    2013Federal 100 Award Winner
    2011Pritzker Scholar, University of Chicago

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Applebaum MA, Barr EK, Karpus J, Nie J, Zhang Z, Armstrong AE, Uppal S, Sukhanova M, Zhang W, Chlenski A, Salwen HR, Wilkinson E, Dobratic M, Grossman R, Godley LA, Stranger BE, He C, Cohn SL. 5-Hydroxymethylcytosine Profiles Are Prognostic of Outcome in Neuroblastoma and Reveal Transcriptional Networks That Correlate With Tumor Phenotype. JCO Precis Oncol. 2019; 3. PMID: 31179414.
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    2. Jun G, Manning A, Almeida M, Zawistowski M, Wood AR, Teslovich TM, Fuchsberger C, Feng S, Cingolani P, Gaulton KJ, Dyer T, Blackwell TW, Chen H, Chines PS, Choi S, Churchhouse C, Fontanillas P, King R, Lee S, Lincoln SE, Trubetskoy V, DePristo M, Fingerlin T, Grossman R, Grundstad J, Heath A, Kim J, Kim YJ, Laramie J, Lee J, Li H, Liu X, Livne O, Locke AE, Maller J, Mazur A, Morris AP, Pollin TI, Ragona D, Reich D, Rivas MA, Scott LJ, Sim X, Tearle RG, Teo YY, Williams AL, Zöllner S, Curran JE, Peralta J, Akolkar B, Bell GI, Burtt NP, Cox NJ, Florez JC, Hanis CL, McKeon C, Mohlke KL, Seielstad M, Wilson JG, Atzmon G, Below JE, Dupuis J, Nicolae DL, Lehman D, Park T, Won S, Sladek R, Altshuler D, McCarthy MI, Duggirala R, Boehnke M, Frayling TM, Abecasis GR, Blangero J. Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees. Proc Natl Acad Sci U S A. 2018 01 09; 115(2):379-384. PMID: 29279374.
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    3. Stricker TP, Brown CD, Bandlamudi C, McNerney M, Kittler R, Montoya V, Peterson A, Grossman R, White KP. Robust stratification of breast cancer subtypes using differential patterns of transcript isoform expression. PLoS Genet. 2017 03; 13(3):e1006589. PMID: 28263985.
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    4. Volchenboum SL, Cox SM, Heath A, Resnick A, Cohn SL, Grossman R. Data Commons to Support Pediatric Cancer Research. Am Soc Clin Oncol Educ Book. 2017; 37:746-752. PMID: 28561664.
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    5. Grossman RL, Heath AP, Ferretti V, Varmus HE, Lowy DR, Kibbe WA, Staudt LM. Toward a Shared Vision for Cancer Genomic Data. N Engl J Med. 2016 Sep 22; 375(12):1109-12. PMID: 27653561.
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    6. Slattery M, Ma L, Spokony RF, Arthur RK, Kheradpour P, Kundaje A, Nègre N, Crofts A, Ptashkin R, Zieba J, Ostapenko A, Suchy S, Victorsen A, Jameel N, Grundstad AJ, Gao W, Moran JR, Rehm EJ, Grossman RL, Kellis M, White KP. Diverse patterns of genomic targeting by transcriptional regulators in Drosophila melanogaster. Genome Res. 2014 Jul; 24(7):1224-35. PMID: 24985916.
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    7. Heath AP, Greenway M, Powell R, Spring J, Suarez R, Hanley D, Bandlamudi C, McNerney ME, White KP, Grossman RL. Bionimbus: a cloud for managing, analyzing and sharing large genomics datasets. J Am Med Inform Assoc. 2014 Nov-Dec; 21(6):969-75. PMID: 24464852.
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    8. Kolker E, Özdemir V, Martens L, Hancock W, Anderson G, Anderson N, Aynacioglu S, Baranova A, Campagna SR, Chen R, Choiniere J, Dearth SP, Feng WC, Ferguson L, Fox G, Frishman D, Grossman R, Heath A, Higdon R, Hutz MH, Janko I, Jiang L, Joshi S, Kel A, Kemnitz JW, Kohane IS, Kolker N, Lancet D, Lee E, Li W, Lisitsa A, Llerena A, Macnealy-Koch C, Marshall JC, Masuzzo P, May A, Mias G, Monroe M, Montague E, Mooney S, Nesvizhskii A, Noronha S, Omenn G, Rajasimha H, Ramamoorthy P, Sheehan J, Smarr L, Smith CV, Smith T, Snyder M, Rapole S, Srivastava S, Stanberry L, Stewart E, Toppo S, Uetz P, Verheggen K, Voy BH, Warnich L, Wilhelm SW, Yandl G. Toward more transparent and reproducible omics studies through a common metadata checklist and data publications. OMICS. 2014 Jan; 18(1):10-4. PMID: 24456465.
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    9. Madzo J, Liu H, Rodriguez A, Vasanthakumar A, Sundaravel S, Caces DBD, Looney TJ, Zhang L, Lepore JB, Macrae T, Duszynski R, Shih AH, Song CX, Yu M, Yu Y, Grossman R, Raumann B, Verma A, He C, Levine RL, Lavelle D, Lahn BT, Wickrema A, Godley LA. Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis. Cell Rep. 2014 Jan 16; 6(1):231-244. PMID: 24373966.
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    10. Kolker E, Özdemir V, Martens L, Hancock W, Anderson G, Anderson N, Aynacioglu S, Baranova A, Campagna SR, Chen R, Choiniere J, Dearth SP, Feng WC, Ferguson L, Fox G, Frishman D, Grossman R, Heath A, Higdon R, Hutz MH, Janko I, Jiang L, Joshi S, Kel A, Kemnitz JW, Kohane IS, Kolker N, Lancet D, Lee E, Li W, Lisitsa A, Llerena A, MacNealy-Koch C, Marshall JC, Masuzzo P, May A, Mias G, Monroe M, Montague E, Mooney S, Nesvizhskii A, Noronha S, Omenn G, Rajasimha H, Ramamoorthy P, Sheehan J, Smarr L, Smith CV, Smith T, Snyder M, Rapole S, Srivastava S, Stanberry L, Stewart E, Toppo S, Uetz P, Verheggen K, Voy BH, Warnich L, Wilhelm SW, Yandl G. Toward More Transparent and Reproducible Omics Studies Through a Common Metadata Checklist and Data Publications. Big Data. 2013 Dec; 1(4):196-201. PMID: 27447251.
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    11. Blair DR, Lyttle CS, Mortensen JM, Bearden CF, Jensen AB, Khiabanian H, Melamed R, Rabadan R, Bernstam EV, Brunak S, Jensen LJ, Nicolae D, Shah NH, Grossman RL, Cox NJ, White KP, Rzhetsky A. A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk. Cell. 2013 Sep 26; 155(1):70-80. PMID: 24074861.
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    12. Jiang ZF, Xia F, Johnson KW, Brown CD, Bartom E, Tuteja JH, Stevens R, Grossman RL, Brumin M, White KP, Ghanim M. Comparison of the genome sequences of "Candidatus Portiera aleyrodidarum" primary endosymbionts of the whitefly Bemisia tabaci B and Q biotypes. Appl Environ Microbiol. 2013 Mar; 79(5):1757-9. PMID: 23315735.
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    13. McNerney ME, Brown CD, Wang X, Bartom ET, Karmakar S, Bandlamudi C, Yu S, Ko J, Sandall BP, Stricker T, Anastasi J, Grossman RL, Cunningham JM, Le Beau MM, White KP. CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia. Blood. 2013 Feb 07; 121(6):975-83. PMID: 23212519.
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    14. Jiang ZF, Xia F, Johnson KW, Bartom E, Tuteja JH, Stevens R, Grossman RL, Brumin M, White KP, Ghanim M. Genome sequences of the primary endosymbiont "Candidatus Portiera aleyrodidarum" in the whitefly Bemisia tabaci B and Q biotypes. J Bacteriol. 2012 Dec; 194(23):6678-9. PMID: 23144417.
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    15. Grossman RL, White KP. A vision for a biomedical cloud. J Intern Med. 2012 Feb; 271(2):122-30. PMID: 22142244.
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    16. Feng X, Grossman R, Stein L. PeakRanger: a cloud-enabled peak caller for ChIP-seq data. BMC Bioinformatics. 2011 May 09; 12:139. PMID: 21554709.
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    17. Nègre N, Brown CD, Ma L, Bristow CA, Miller SW, Wagner U, Kheradpour P, Eaton ML, Loriaux P, Sealfon R, Li Z, Ishii H, Spokony RF, Chen J, Hwang L, Cheng C, Auburn RP, Davis MB, Domanus M, Shah PK, Morrison CA, Zieba J, Suchy S, Senderowicz L, Victorsen A, Bild NA, Grundstad AJ, Hanley D, MacAlpine DM, Mannervik M, Venken K, Bellen H, White R, Gerstein M, Russell S, Grossman RL, Ren B, Posakony JW, Kellis M, White KP. A cis-regulatory map of the Drosophila genome. Nature. 2011 Mar 24; 471(7339):527-31. PMID: 21430782.
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    18. Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science. 2010 Dec 24; 330(6012):1787-97. PMID: 21177974.
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    19. Karmonik C, Dulay M, Verma A, Grossman RG. Cost function evaluation for the registration of clinical DTI images onto the ICBM DTI81 white matter atlas. Technol Health Care. 2010; 18(2):145-56. PMID: 20495254.
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    20. Gu Y, Grossman RL. Sector and Sphere: the design and implementation of a high-performance data cloud. Philos Trans A Math Phys Eng Sci. 2009 Jun 28; 367(1897):2429-45. PMID: 19451100.
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    21. Tian F, Chen J, Bao S, Shi L, Liu X, Grossman R. A graph model based study on regulatory impacts of transcription factors of Drosophila melanogaster and comparison across species. Biochem Biophys Res Commun. 2009 Sep 04; 386(4):559-62. PMID: 19538943.
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    22. Dulay MF, Levin HS, York MK, Mizrahi EM, Verma A, Goldsmith I, Grossman RG, Yoshor D. Predictors of individual visual memory decline after unilateral anterior temporal lobe resection. Neurology. 2009 May 26; 72(21):1837-42. PMID: 19470966.
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    23. Dulay MF, Levin HS, York MK, Li X, Mizrahi EM, Goldsmith I, Verma A, Goldman A, Grossman RG, Yoshor D. Changes in individual and group spatial and verbal learning characteristics after anterior temporal lobectomy. Epilepsia. 2009 Jun; 50(6):1385-95. PMID: 18657174.
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    24. Ge Y, Zohrabian VM, Grossman RI. Seven-Tesla magnetic resonance imaging: new vision of microvascular abnormalities in multiple sclerosis. Arch Neurol. 2008 Jun; 65(6):812-6. PMID: 18541803.
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    25. Mikheev A, Nevsky G, Govindan S, Grossman R, Rusinek H. Fully automatic segmentation of the brain from T1-weighted MRI using Bridge Burner algorithm. J Magn Reson Imaging. 2008 Jun; 27(6):1235-41. PMID: 18504741.
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    26. Kamoun M, Grossman RA. Kidney-transplant rejection and anti-MICA antibodies. N Engl J Med. 2008 Jan 10; 358(2):195; author reply 196. PMID: 18184968.
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    27. Dulay MF, York MK, Soety EM, Hamilton WJ, Mizrahi EM, Goldsmith IL, Verma A, Grossman RG, Yoshor D, Armstrong DD, Levin HS. Memory, emotional and vocational impairments before and after anterior temporal lobectomy for complex partial seizures. Epilepsia. 2006 Nov; 47(11):1922-30. PMID: 17116033.
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    28. Wilkinson L, Anand A, Grossman R. High-dimensional visual analytics: interactive exploration guided by pairwise views of point distributions. IEEE Trans Vis Comput Graph. 2006 Nov-Dec; 12(6):1363-72. PMID: 17073361.
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    29. Lee RF, Johnson G, Grossman RI, Stoeckel B, Trampel R, McGuinness G. Advantages of parallel imaging in conjunction with hyperpolarized helium--a new approach to MRI of the lung. Magn Reson Med. 2006 May; 55(5):1132-41. PMID: 16586457.
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    30. Grossman R, Kasturi P, Hamelberg D, Liu B. An empirical study of the universal chemical key algorithm for assigning unique keys to chemical compounds. J Bioinform Comput Biol. 2004 Mar; 2(1):155-71. PMID: 15272437.
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    31. Sanghera MK, Grossman RG, Kalhorn CG, Hamilton WJ, Ondo WG, Jankovic J. Basal ganglia neuronal discharge in primary and secondary dystonia. Adv Neurol. 2004; 94:29-36. PMID: 14509651.
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    32. Sanghera MK, Grossman RG, Kalhorn CG, Hamilton WJ, Ondo WG, Jankovic J. Basal ganglia neuronal discharge in primary and secondary dystonia in patients undergoing pallidotomy. Neurosurgery. 2003 Jun; 52(6):1358-70; discussion 1370-3. PMID: 12762881.
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    33. York MK, Rettig GM, Grossman RG, Hamilton WJ, Armstrong DD, Levin HS, Mizrahi EM. Seizure control and cognitive outcome after temporal lobectomy: a comparison of classic Ammon's horn sclerosis, atypical mesial temporal sclerosis, and tumoral pathologies. Epilepsia. 2003 Mar; 44(3):387-98. PMID: 12614395.
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    34. Grossman R, Kasturi P, Hamelberg D, Liu B. Experimental studies of the Universal Chemical Key (UCK) algorithm on the NCI database of chemical compounds. Proc IEEE Comput Soc Bioinform Conf. 2003; 2:244-50. PMID: 16452799.
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    35. Yehuda R, Halligan SL, Grossman R, Golier JA, Wong C. The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and holocaust survivors with and without posttraumatic stress disorder. Biol Psychiatry. 2002 Sep 01; 52(5):393-403. PMID: 12242055.
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    36. Yoshor D, Hamilton WJ, Ondo W, Jankovic J, Grossman RG. Comparison of thalamotomy and pallidotomy for the treatment of dystonia. Neurosurgery. 2001 Apr; 48(4):818-24; discussion 824-6. PMID: 11322442.
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    37. Erdamar S, Zhu ZQ, Hamilton WJ, Armstrong DL, Grossman RG. Corpora amylacea and heat shock protein 27 in Ammon's horn sclerosis. J Neuropathol Exp Neurol. 2000 Aug; 59(8):698-706. PMID: 10952060.
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    38. Trask TW, Trask RP, Aguilar-Cordova E, Shine HD, Wyde PR, Goodman JC, Hamilton WJ, Rojas-Martinez A, Chen SH, Woo SL, Grossman RG. Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors. Mol Ther. 2000 Feb; 1(2):195-203. PMID: 10933931.
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    39. York MK, Levin HS, Grossman RG, Hamilton WJ. Neuropsychological outcome following unilateral pallidotomy. Brain. 1999 Dec; 122 ( Pt 12):2209-20. PMID: 10581217.
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    40. Udupa JK, Wei L, Samarasekera S, Miki Y, van Buchem MA, Grossman RI. Multiple sclerosis lesion quantification using fuzzy-connectedness principles. IEEE Trans Med Imaging. 1997 Oct; 16(5):598-609. PMID: 9368115.
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    41. Zhu ZQ, Armstrong DL, Hamilton WJ, Grossman RG. Disproportionate loss of CA4 parvalbumin-immunoreactive interneurons in patients with Ammon's horn sclerosis. J Neuropathol Exp Neurol. 1997 Sep; 56(9):988-98. PMID: 9291940.
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    42. Jankovic J, Hamilton WJ, Grossman RG. Thalamic surgery for movement disorders. Adv Neurol. 1997; 74:221-33. PMID: 9348417.
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    43. Jaffey PB, Mundt AJ, Baunoch DA, Armstrong DL, Hamilton WJ, Zagaja VG, Grossman RG, Wollmann RL. The clinical significance of extracellular matrix in gangliogliomas. J Neuropathol Exp Neurol. 1996 Dec; 55(12):1246-52. PMID: 8957448.
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    44. Loevner LA, Shapiro RM, Grossman RI, Overhauser J, Kamholz J. White matter changes associated with deletions of the long arm of chromosome 18 (18q- syndrome): a dysmyelinating disorder? AJNR Am J Neuroradiol. 1996 Nov-Dec; 17(10):1843-8. PMID: 8933867.
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    45. Jankovic J, Cardoso F, Grossman RG, Hamilton WJ. Outcome after stereotactic thalamotomy for parkinsonian, essential, and other types of tremor. Neurosurgery. 1995 Oct; 37(4):680-6; discussion 686-7. PMID: 8559296.
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    46. Cardoso F, Jankovic J, Grossman RG, Hamilton WJ. Outcome after stereotactic thalamotomy for dystonia and hemiballismus. Neurosurgery. 1995 Mar; 36(3):501-7; discussion 507-8. PMID: 7753350.
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    47. Krishnan B, Armstrong DL, Grossman RG, Zhu ZQ, Rutecki PA, Mizrahi EM. Glial cell nuclear hypertrophy in complex partial seizures. J Neuropathol Exp Neurol. 1994 Sep; 53(5):502-7. PMID: 8083691.
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    48. Mizrahi EM, Kellaway P, Grossman RG, Rutecki PA, Armstrong D, Rettig G, Loewen S. Anterior temporal lobectomy and medically refractory temporal lobe epilepsy of childhood. Epilepsia. 1990 May-Jun; 31(3):302-12. PMID: 2344847.
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    49. Zhu ZQ, Armstrong DL, Grossman RG, Hamilton WJ. Tyrosine hydroxylase-immunoreactive neurons in the temporal lobe in complex partial seizures. Ann Neurol. 1990 May; 27(5):564-72. PMID: 1972875.
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    50. Yousem DM, Patrone PM, Grossman RI. Leptomeningeal metastases: MR evaluation. J Comput Assist Tomogr. 1990 Mar-Apr; 14(2):255-61. PMID: 2312855.
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    51. Simpson RK, Grossman RG. Seizures after jogging. N Engl J Med. 1989 Sep 21; 321(12):835. PMID: 2770817.
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    52. Rutecki PA, Grossman RG, Armstrong D, Irish-Loewen S. Electrophysiological connections between the hippocampus and entorhinal cortex in patients with complex partial seizures. J Neurosurg. 1989 May; 70(5):667-75. PMID: 2709106.
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    53. Atlas SW, Grossman RI, Gomori JM, Hackney DB, Goldberg HI, Zimmerman RA, Bilaniuk LT. Hemorrhagic intracranial malignant neoplasms: spin-echo MR imaging. Radiology. 1987 Jul; 164(1):71-7. PMID: 3588929.
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    54. Hecht-Leavitt C, Gomori JM, Grossman RI, Goldberg HI, Hackney DB, Zimmerman RA, Bilaniuk LT. High-field MRI of hemorrhagic cortical infarction. AJNR Am J Neuroradiol. 1986 Jul-Aug; 7(4):581-5. PMID: 3088936.
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    55. Zimmerman RA, Bilaniuk LT, Johnson MH, Hershey B, Jaffe S, Gomori JM, Goldberg HI, Grossman RI. MRI of central nervous system: early clinical results. AJNR Am J Neuroradiol. 1986 Jul-Aug; 7(4):587-94. PMID: 3088937.
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    56. Zimmerman RA, Bilaniuk LT, Hackney DB, Goldberg HI, Grossman RI. Magnetic resonance imaging of dural venous sinus invasion, occlusion and thrombosis. Acta Radiol Suppl. 1986; 369:110-2. PMID: 2980425.
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    57. Zimmerman RA, Bilaniuk LT, Packer R, Sutton L, Samuel L, Johnson MH, Grossman RI, Goldberg HI. Resistive NMR of brain stem gliomas. Neuroradiology. 1985; 27(1):21-5. PMID: 3974861.
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    58. Zimmerman RA, Bilaniuk LT, Grossman RI, Goldberg HI, Edelstein W, Bottomley P, Redington RW. Cerebral NMR: diagnostic evaluation of brain tumors by partial saturation technique with resistive NMR. Neuroradiology. 1985; 27(1):9-15. PMID: 3974874.
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    59. Zimmerman RA, Grossman RI, Goldberg HI, Lynch R, Levine R, Samuel L. Comparison of digital subtraction arteriography and conventional film screen subtraction arteriography for neuroradiology. Neuroradiology. 1984; 26(6):457-62. PMID: 6390247.
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    60. Zimmerman RA, Bilaniuk LT, Goldberg HI, Grossman RI, Levine RS, Lynch R, Edelstein W, Bottomley P, Redington R. Cerebral NMR imaging: early results with a 0.12 T resistive system. AJR Am J Roentgenol. 1983 Dec; 141(6):1187-93. PMID: 6606315.
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    61. Grossman RG. Treatment of patients with intracranial hematomas. N Engl J Med. 1981 Jun 18; 304(25):1540-1. PMID: 7231492.
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    62. London WT, Drew JS, Blumberg BS, Lyons P, Grossman R. Hepatitis B infection and kidney-graft survival. N Engl J Med. 1978 Feb 09; 298(6):342. PMID: 340944.
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