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Hans Schreiber

InstitutionUniversity of Chicago
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    The main focus of this laboratory is to study the fundamental mechanisms that govern the interaction of cancer cells with the immune system. In particular, our laboratory is trying to exploit the fact that cancer cells usually carry cancer-specific mutations and antigens, and that under certain conditions, the immune system can destroy cancer cells even after they have disseminated in the body. We are trying to understand the mechanisms that often allow immunogenic cancer cells to escape immune destruction, and we want to develop new strategies and principles on which to base novel therapeutic approaches. We are also studying the signals needed for the immune system to be alerted be cancer cells, and then to destroy these cells. Finally, we combine immunology with genetics and biochemistry, which provides us with a powerful tool to search for cancer-specific changes in malignant cells in order to identify critical mechanisms and immunological targets that can be used to destroy the cancer.

    Collapse Biography 
    Collapse education and training
    University of Freiburg, GermanyMD1969
    University of Freiburg, GermanyD.M.Sc.1969Experimental Pathology, Radiation Biology
    Oak Ridge National Laboratory/Atomic Energy Comission, Biology DivisionPost Doctoral1970-73Experimental Carcinogenesis, Microbiology, and Cytology
    Educational Council for Foreign Medical GraduatesDiploma1973
    Charite University Medicine, Berlin, GermanyInternship1973-74
    State of Baden-Wuerttemberg, GermanyMedical License1974
    The University of Chicago, ChicagoPh.D1977
    Pritzer School of MedicineResidencyAnatomic Pathology

    Collapse Research 
    Collapse research activities and funding
    S10RR016978     (SCHREIBER, HANS)Apr 1, 2003 - Mar 31, 2005
    Three Laser BD Digital LSR
    Role: Principal Investigator

    P01CA097296     (SCHREIBER, HANS)Jul 1, 2002 - May 31, 2014
    CD8+ T cells and Immunological Tumor Regression
    Role: Principal Investigator

    P01CA074182     (SCHREIBER, HANS)Jul 10, 1998 - Apr 30, 2003
    Role: Principal Investigator

    R01CA037156     (SCHREIBER, HANS)Jul 1, 1984 - Aug 31, 2019
    Immunology of Unique Tumor Specific Antigens
    Role: Principal Investigator

    T32AI007090     (SAVAGE, PETER AIDAN)Jul 1, 1979 - Jun 30, 2024
    Interdisciplinary Training Program in Immunology
    Role: Co-Principal Investigator

    R01CA022677     (SCHREIBER, HANS)Feb 1, 1978 - Jun 30, 2025
    Manipulation of Tumor Specific Immunity
    Role: Principal Investigator

    R37CA022677     (SCHREIBER, HANS)Feb 1, 1978 - Jan 31, 1994
    Role: Principal Investigator

    P01CA019266     (SCHREIBER, HANS)Jun 1, 1976 - Mar 31, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Nakamura Y, Wolf SP, Anastasopoulou V, Drousch K, Diehl MI, Engels B, Yew PY, Kiyotani K, Schreiber K, Schreiber H, Leisegang M. One CD4+TCR and One CD8+TCR Targeting Autochthonous Neoantigens Are Essential and Sufficient for Tumor Eradication. Clin Cancer Res. 2024 Apr 15; 30(8):1642-1654. PMID: 38190111.
      Citations:    Fields:    
    2. Shin SC, Vickman RE, Filimon B, Yang Y, Hu Z, Mangold KA, Prabhakar BS, Schreiber H, Xu W. The safety and efficacy of systemic delivery of a new liver-de-targeted TGFß signaling inhibiting adenovirus in an immunocompetent triple negative mouse mammary tumor model. Cancer Gene Ther. 2024 Apr; 31(4):574-585. PMID: 38267626.
      Citations:    Fields:    
    3. Shin SC, Vickman R, Filimon B, Hu Z, Mangold K, Xu W, Yang Y, Prabhakar B, Schreiber H. The Safety and Efficacy of Systemic Delivery of a New Liver-de-targeted TGFß Signaling Inhibiting Adenovirus in an Immunocompetent Triple Negative Mouse Mammary Tumor Model. Res Sq. 2023 Sep 14. PMID: 37790556; PMCID: PMC10543255.
    4. Ranoa DRE, Sharma P, Schane CP, Lewis AN, Valdez E, Marada VVVR, Hager MV, Montgomery W, Wolf SP, Schreiber K, Schreiber H, Bailey K, Fan TM, Hergenrother PJ, Roy EJ, Kranz DM. Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model. J Immunother Cancer. 2023 05; 11(5). PMID: 37258040; PMCID: PMC10255004.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Hu Y, Cao G, Chen X, Huang X, Asby N, Ankenbruck N, Rahman A, Thusu A, He Y, Riedell PA, Bishop MR, Schreiber H, Kline JP, Huang J. Antigen-Multimers: Specific, Sensitive, Precise, and Multifunctional High-Avidity CAR-Staining Reagents. Matter. 2021 Dec 01; 4(12):3917-3940. PMID: 34901832; PMCID: PMC8654235.
      Citations: 2     
    6. Wolf SP, Wen FT, Schreiber H. Criteria to make animal studies more relevant to treating human cancer. Curr Opin Immunol. 2022 02; 74:25-31. PMID: 34619458; PMCID: PMC8901458.
      Citations: 1     Fields:    Translation:HumansAnimals
    7. Schreiber K, Hyjek E, Krausz T, Spiotto MT, Steiner M, Idel C, Booras H, Beck-Engeser G, Riederer J, Wolf SP, Karrison T, Jensen E, Weichselbaum RR, Nakamura Y, Yew PY, Lambert PF, Kurita T, Kiyotani K, Schreiber H, Böttinger P, Willimsky G, Leisegang M. Cooperation of genes in HPV16 E6/E7-dependent cervicovaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens. Carcinogenesis. 2020 11 13; 41(11):1605-1615. PMID: 32221533; PMCID: PMC7896110.
      Citations: 5     Fields:    Translation:AnimalsCells
    8. Sharma P, Marada VVVR, Cai Q, Kizerwetter M, He Y, Wolf SP, Schreiber K, Clausen H, Schreiber H, Kranz DM. Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides. Proc Natl Acad Sci U S A. 2020 06 30; 117(26):15148-15159. PMID: 32541028; PMCID: PMC7334454.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    9. Xu W, Yang Y, Hu Z, Head M, Mangold KA, Sullivan M, Wang E, Saha P, Gulukota K, Helseth DL, Guise T, Prabhkar BS, Kaul K, Schreiber H, Seth P. LyP-1-Modified Oncolytic Adenoviruses Targeting Transforming Growth Factor ß Inhibit Tumor Growth and Metastases and Augment Immune Checkpoint Inhibitor Therapy in Breast Cancer Mouse Models. Hum Gene Ther. 2020 08; 31(15-16):863-880. PMID: 32394753; PMCID: PMC7462024.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    10. Diehl MI, Bindokas VP, Schreiber H, Wolf SP. Automated cell cluster analysis provides insight into multi-cell-type interactions between immune cells and their targets. Exp Cell Res. 2020 08 15; 393(2):112014. PMID: 32439494; PMCID: PMC7415733.
      Citations: 2     Fields:    Translation:AnimalsCells
    11. Schreiber K, Karrison TG, Wolf SP, Kiyotani K, Steiner M, Littmann ER, Pamer EG, Schreiber H, Kammertoens T, Leisegang M. Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors. Cancer Immunol Res. 2020 02; 8(2):192-202. PMID: 31831634; PMCID: PMC7007920.
      Citations: 11     Fields:    Translation:AnimalsCells
    12. He Y, Schreiber K, Wolf SP, Wen F, Steentoft C, Zerweck J, Steiner M, Sharma P, Shepard HM, Posey A, June CH, Mandel U, Clausen H, Leisegang M, Meredith SC, Kranz DM, Schreiber H. Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell. JCI Insight. 2019 Dec 05; 4(23). PMID: 31801912; PMCID: PMC6962012.
      Citations: 7     Fields:    
    13. He Y, Schreiber K, Wolf SP, Wen F, Steentoft C, Zerweck J, Steiner M, Sharma P, Shepard HM, Posey A, June CH, Mandel U, Clausen H, Meredith SC, Kranz DM, Schreiber H, Leisegang M. Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell. JCI Insight. 2019 11 01; 4(21). PMID: 31672936; PMCID: PMC6948763.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    14. Friedman J, Moore EC, Zolkind P, Robbins Y, Clavijo PE, Sun L, Greene S, Morisada MV, Mydlarz WK, Schmitt N, Hodge JW, Schreiber H, Van Waes C, Uppaluri R, Allen C. Neoadjuvant PD-1 Immune Checkpoint Blockade Reverses Functional Immunodominance among Tumor Antigen-Specific T Cells. Clin Cancer Res. 2020 02 01; 26(3):679-689. PMID: 31645352; PMCID: PMC7002203.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    15. Sasmal DK, Feng W, Roy S, Leung P, He Y, Cai C, Cao G, Lian H, Qin J, Hui E, Schreiber H, Adams EJ, Huang J. TCR-pMHC bond conformation controls TCR ligand discrimination. Cell Mol Immunol. 2020 03; 17(3):203-217. PMID: 31530899; PMCID: PMC7052167.
      Citations: 16     Fields:    Translation:AnimalsCells
    16. Steentoft C, Fuhrmann M, Battisti F, Van Coillie J, Madsen TD, Halim A, Vakhrushev SY, Joshi HJ, Schreiber H, Mandel U, Narimatsu Y, Campos D. A strategy for generating cancer-specific monoclonal antibodies to aberrant O-glycoproteins: identification of a novel dysadherin-Tn antibody. Glycobiology. 2019 04 01; 29(4):307-319. PMID: 30726901; PMCID: PMC6430981.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    17. Schreiber H. Fibroblasts: Dangerous travel companions. J Exp Med. 2019 03 04; 216(3):479-481. PMID: 30710056; PMCID: PMC6400545.
      Citations: 3     Fields:    Translation:HumansCells
    18. Arina A, Idel C, Ivanov A, Fehling HJ, Fruttiger M, Lohoff M, Herrmann A, Yu H, Weichselbaum R, Kammertoens T, Friese C, Briesemeister D, Rothe M, Szymborska A, Patone G, Kunz S, Sommermeyer D, Engels B, Leisegang M, Textor A, Uckert W, Hübner N, Gerhardt H, Beule D, Schreiber H, Blankenstein T. Tumour ischaemia by interferon-? resembles physiological blood vessel regression. Nature. 2017 05 04; 545(7652):98-102. PMID: 28445461; PMCID: PMC5567674.
      Citations: 135     Fields:    Translation:AnimalsCells
    19. Arina A, Karrison T, Galka E, Schreiber K, Weichselbaum RR, Schreiber H. Transfer of Allogeneic CD4+ T Cells Rescues CD8+ T Cells in Anti-PD-L1-Resistant Tumors Leading to Tumor Eradication. Cancer Immunol Res. 2017 02; 5(2):127-136. PMID: 28077434; PMCID: PMC5354300.
      Citations: 9     Fields:    Translation:AnimalsCells
    20. Engels B, Chervin AS, Sant AJ, Kranz DM, Schreiber H. Long-term Persistence of CD4+ but Rapid Disappearance of CD8+ T Cells Expressing an MHC Class I-restricted TCR of Nanomolar Affinity. Mol Ther. 2012 Mar; 20(3):652-660. PMID: 28160633.
    21. Posey AD, Schwab RD, Boesteanu AC, Steentoft C, Mandel U, Engels B, Stone JD, Madsen TD, Schreiber K, Haines KM, Cogdill AP, Chen TJ, Song D, Scholler J, Kranz DM, Feldman MD, Young R, Keith B, Schreiber H, Clausen H, Johnson LA, June CH. Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma. Immunity. 2016 06 21; 44(6):1444-54. PMID: 27332733; PMCID: PMC5358667.
      Citations: 274     Fields:    Translation:HumansAnimalsCells
    22. Arina A, Idel C, Hyjek EM, Alegre ML, Wang Y, Bindokas VP, Weichselbaum RR, Schreiber H. Tumor-associated fibroblasts predominantly come from local and not circulating precursors. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):7551-6. PMID: 27317748; PMCID: PMC4941507.
      Citations: 98     Fields:    Translation:AnimalsCells
    23. Binder DC, Arina A, Wen F, Tu T, Zhao M, Hoffman RM, Wainwright DA, Schreiber H. Tumor relapse prevented by combining adoptive T cell therapy with Salmonella typhimurium. Oncoimmunology. 2016 Jun; 5(6):e1130207. PMID: 27471609; PMCID: PMC4938310.
      Citations: 10     Fields:    
    24. Engels B, Schreiber K, Yew PY, Kiyotani K, Idel C, Arina A, Duraiswamy J, Weichselbaum RR, Nakamura Y, Leisegang M, Uckert W, Schreiber H. Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation. Clin Cancer Res. 2016 06 01; 22(11):2734-43. PMID: 26667491; PMCID: PMC4891260.
      Citations: 40     Fields:    Translation:AnimalsCells
    25. Schreiber H, Greenberg P. Editorial overview: tumour immunology. Curr Opin Immunol. 2015 Apr; 33:ix-xi. PMID: 25823946.
      Citations:    Fields:    Translation:HumansAnimals
    26. Blankenstein T, Leisegang M, Uckert W, Schreiber H. Targeting cancer-specific mutations by T cell receptor gene therapy. Curr Opin Immunol. 2015 Apr; 33:112-9. PMID: 25728991; PMCID: PMC4557613.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    27. Binder DC, Schreiber H. Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors--letter. Cancer Res. 2014 Jan 15; 74(2):632; discussion 635. PMID: 24408925; PMCID: PMC3905982.
      Citations: 9     Fields:    Translation:AnimalsCells
    28. Arina A, Schreiber K, Binder DC, Karrison TG, Liu RB, Schreiber H. Adoptively transferred immune T cells eradicate established tumors despite cancer-induced immune suppression. J Immunol. 2014 Feb 01; 192(3):1286-93. PMID: 24367029; PMCID: PMC4084557.
      Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    29. Schietinger A, Arina A, Liu RB, Wells S, Huang J, Engels B, Bindokas V, Bartkowiak T, Lee D, Herrmann A, Piston DW, Pittet MJ, Lin PC, Zal T, Schreiber H. Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer. Oncoimmunology. 2013 Nov 01; 2(11):e26677. PMID: 24482750; PMCID: PMC3895414.
      Citations: 26     Fields:    
    30. Binder DC, Schreiber H. High-affinity peptide-based anticancer vaccination to overcome resistance to immunostimulatory antibodies. Oncoimmunology. 2013 Dec 01; 2(12):e26704. PMID: 24563823; PMCID: PMC3923789.
      Citations: 2     Fields:    
    31. Gajewski TF, Schreiber H, Fu YX. Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol. 2013 Oct; 14(10):1014-22. PMID: 24048123; PMCID: PMC4118725.
      Citations: 1853     Fields:    Translation:HumansAnimalsCells
    32. Binder DC, Engels B, Arina A, Yu P, Slauch JM, Fu YX, Karrison T, Burnette B, Zhao M, Hoffman RM, Munn DH, Rowley DA, Schreiber H, Idel C. Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer. Cancer Immunol Res. 2013 Aug; 1(2):123-33. PMID: 24455752; PMCID: PMC3895468.
      Citations: 43     Fields:    Translation:AnimalsCells
    33. Liu RB, Engels B, Schreiber K, Ciszewski C, Schietinger A, Schreiber H, Jabri B. IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8158-63. PMID: 23637340; PMCID: PMC3657809.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    34. Engels B, Engelhard VH, Sidney J, Sette A, Binder DC, Liu RB, Kranz DM, Meredith SC, Rowley DA, Schreiber H. Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity. Cancer Cell. 2013 Apr 15; 23(4):516-26. PMID: 23597565; PMCID: PMC3658176.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    35. Stone JD, Chervin AS, Schreiber H, Kranz DM. Design and characterization of a protein superagonist of IL-15 fused with IL-15Ra and a high-affinity T cell receptor. Biotechnol Prog. 2012 Nov-Dec; 28(6):1588-97. PMID: 22961781; PMCID: PMC3514595.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    36. Stone JD, Aggen DH, Schietinger A, Schreiber H, Kranz DM. A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs). Oncoimmunology. 2012 Sep 01; 1(6):863-873. PMID: 23162754; PMCID: PMC3489742.
      Citations: 51     Fields:    
    37. Soto CM, Stone JD, Chervin AS, Engels B, Schreiber H, Roy EJ, Kranz DM. MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR. Cancer Immunol Immunother. 2013 Feb; 62(2):359-69. PMID: 22926060; PMCID: PMC3570684.
      Citations: 18     Fields:    Translation:AnimalsCells
    38. Schreiber K, Arina A, Engels B, Spiotto MT, Sidney J, Sette A, Karrison TG, Weichselbaum RR, Rowley DA, Schreiber H. Spleen cells from young but not old immunized mice eradicate large established cancers. Clin Cancer Res. 2012 May 01; 18(9):2526-33. PMID: 22415314; PMCID: PMC5354938.
      Citations: 17     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    39. Wen FT, Thisted RA, Rowley DA, Schreiber H. A systematic analysis of experimental immunotherapies on tumors differing in size and duration of growth. Oncoimmunology. 2012 Mar 01; 1(2):172-178. PMID: 22720238; PMCID: PMC3377001.
      Citations: 33     Fields:    
    40. Liu RB, Engels B, Arina A, Schreiber K, Hyjek E, Schietinger A, Binder DC, Butz E, Krausz T, Rowley DA, Jabri B, Schreiber H. Densely granulated murine NK cells eradicate large solid tumors. Cancer Res. 2012 Apr 15; 72(8):1964-74. PMID: 22374983; PMCID: PMC3680344.
      Citations: 31     Fields:    Translation:AnimalsCells
    41. Engels B, Chervin AS, Sant AJ, Kranz DM, Schreiber H. Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity. Mol Ther. 2012 Mar; 20(3):652-60. PMID: 22233579; PMCID: PMC3293607.
      Citations: 27     Fields:    Translation:AnimalsCells
    42. Engels B, Rowley DA, Schreiber H. Targeting stroma to treat cancers. Semin Cancer Biol. 2012 Feb; 22(1):41-9. PMID: 22212863; PMCID: PMC3321387.
      Citations: 40     Fields:    Translation:HumansCells
    43. Schreiber H, Rowley JD, Rowley DA. Targeting mutations predictably. Blood. 2011 Jul 28; 118(4):830-1. PMID: 21799095.
      Citations: 3     Fields:    
    44. Wu TH, Schreiber K, Arina A, Khodarev NN, Efimova EV, Rowley DA, Weichselbaum RR, Schreiber H. Progression of cancer from indolent to aggressive despite antigen retention and increased expression of interferon-gamma inducible genes. Cancer Immun. 2011 Jun 30; 11:2. PMID: 21714479; PMCID: PMC3127375.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    45. Schreiber H, Rowley DA. Cancer. Awakening immunity. Science. 2010 Nov 05; 330(6005):761-2. PMID: 21051618.
      Citations: 18     Fields:    Translation:AnimalsCells
    46. Schietinger A, Philip M, Liu RB, Schreiber K, Schreiber H. Bystander killing of cancer requires the cooperation of CD4(+) and CD8(+) T cells during the effector phase. J Exp Med. 2010 Oct 25; 207(11):2469-77. PMID: 20921286; PMCID: PMC2964573.
      Citations: 80     Fields:    Translation:AnimalsCells
    47. Brooks CL, Schietinger A, Borisova SN, Kufer P, Okon M, Hirama T, Mackenzie CR, Wang LX, Schreiber H, Evans SV. Antibody recognition of a unique tumor-specific glycopeptide antigen. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):10056-61. PMID: 20479270; PMCID: PMC2890472.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    48. Philip M, Schietinger A, Schreiber H. Ribosomal versus non-ribosomal cellular antigens: factors determining efficiency of indirect presentation to CD4+ T cells. Immunology. 2010 Aug; 130(4):494-503. PMID: 20331471; PMCID: PMC2913260.
      Citations: 6     Fields:    Translation:AnimalsCells
    49. Thomas DL, Kim M, Bowerman NA, Narayanan S, Kranz DM, Schreiber H, Roy EJ. Recurrence of intracranial tumors following adoptive T cell therapy can be prevented by direct and indirect killing aided by high levels of tumor antigen cross-presented on stromal cells. J Immunol. 2009 Aug 01; 183(3):1828-37. PMID: 19592642.
      Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    50. Chopra N, Gan W, Schreiber H, Kurutz JW, Meredith SC. Versatile cyclic templates for assembly of axially oriented ligands. Bioconjug Chem. 2009 Feb; 20(2):231-40. PMID: 19159293.
      Citations: 1     Fields:    Translation:Cells
    51. Schreiber H. Tumor-specific immune responses. Semin Immunol. 2008 Oct; 20(5):265-6. PMID: 18977672; PMCID: PMC3644555.
      Citations: 1     Fields:    Translation:HumansAnimals
    52. Shepard HM, Brdlik CM, Schreiber H. Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family. J Clin Invest. 2008 Nov; 118(11):3574-81. PMID: 18982164; PMCID: PMC2575712.
      Citations: 47     Fields:    Translation:HumansCells
    53. Schietinger A, Philip M, Schreiber H. Specificity in cancer immunotherapy. Semin Immunol. 2008 Oct; 20(5):276-85. PMID: 18684640; PMCID: PMC3644553.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    54. Zhang B, Karrison T, Rowley DA, Schreiber H. IFN-gamma- and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers. J Clin Invest. 2008 Apr; 118(4):1398-404. PMID: 18317595; PMCID: PMC2262029.
      Citations: 87     Fields:    Translation:AnimalsCells
    55. Zhang B, Zhang Y, Bowerman NA, Schietinger A, Fu YX, Kranz DM, Rowley DA, Schreiber H. Equilibrium between host and cancer caused by effector T cells killing tumor stroma. Cancer Res. 2008 Mar 01; 68(5):1563-71. PMID: 18316622.
      Citations: 36     Fields:    Translation:AnimalsCells
    56. Schreiber H, Rowley DA. Cancer. Quo vadis, specificity? Science. 2008 Jan 11; 319(5860):164-5. PMID: 18187644.
      Citations:    Fields:    Translation:HumansAnimalsCells
    57. Yu P, Lee Y, Wang Y, Liu X, Auh S, Gajewski TF, Schreiber H, You Z, Kaynor C, Wang X, Fu YX. Targeting the primary tumor to generate CTL for the effective eradication of spontaneous metastases. J Immunol. 2007 Aug 01; 179(3):1960-8. PMID: 17641063; PMCID: PMC2387226.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    58. Zhang B, Bowerman NA, Salama JK, Schmidt H, Spiotto MT, Schietinger A, Yu P, Fu YX, Weichselbaum RR, Rowley DA, Kranz DM, Schreiber H. Induced sensitization of tumor stroma leads to eradication of established cancer by T cells. J Exp Med. 2007 Jan 22; 204(1):49-55. PMID: 17210731; PMCID: PMC2118433.
      Citations: 189     Fields:    Translation:AnimalsCellsPHPublic Health
    59. Gabrilovich DI, Bronte V, Chen SH, Colombo MP, Ochoa A, Ostrand-Rosenberg S, Schreiber H. The terminology issue for myeloid-derived suppressor cells. Cancer Res. 2007 Jan 01; 67(1):425; author reply 426. PMID: 17210725; PMCID: PMC1941787.
      Citations: 360     Fields:    Translation:AnimalsCells
    60. Schietinger A, Philip M, Yoshida BA, Azadi P, Liu H, Meredith SC, Schreiber H. A mutant chaperone converts a wild-type protein into a tumor-specific antigen. Science. 2006 Oct 13; 314(5797):304-8. PMID: 17038624.
      Citations: 73     Fields:    Translation:AnimalsCells
    61. Schreiber K, Rowley DA, Schreiber H, Riethmüller G. Cancer immunotherapy and preclinical studies: why we are not wasting our time with animal experiments. Hematol Oncol Clin North Am. 2006 Jun; 20(3):567-84. PMID: 16762725.
      Citations: 28     Fields:    Translation:HumansAnimals
    62. Spiotto MT, Schreiber H. Floxed reporter genes: Flow-cytometric selection of clonable cells expressing high levels of a target gene after tamoxifen-regulated Cre-loxP recombination. J Immunol Methods. 2006 May 30; 312(1-2):201-8. PMID: 16674971.
      Citations: 2     Fields:    Translation:AnimalsCells
    63. Lodge A, Yu P, Nicholl MB, Brown IE, Jackson CC, Schreiber K, Sugg SL, Schreiber H, Shilyansky J. CD40 ligation restores cytolytic T lymphocyte response and eliminates fibrosarcoma in the peritoneum of mice lacking CD4+ T cells. Cancer Immunol Immunother. 2006 Dec; 55(12):1542-52. PMID: 16491399.
      Citations: 3     Fields:    Translation:AnimalsCells
    64. Yu P, Rowley DA, Fu YX, Schreiber H. The role of stroma in immune recognition and destruction of well-established solid tumors. Curr Opin Immunol. 2006 Apr; 18(2):226-31. PMID: 16459066.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    65. Spiotto MT, Schreiber H. Rapid destruction of the tumor microenvironment by CTLs recognizing cancer-specific antigens cross-presented by stromal cells. Cancer Immun. 2005 Jun 06; 5:8. PMID: 15934727.
      Citations: 30     Fields:    Translation:AnimalsCells
    66. Yu P, Lee Y, Liu W, Krausz T, Chong A, Schreiber H, Fu YX. Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. J Exp Med. 2005 Mar 07; 201(5):779-91. PMID: 15753211; PMCID: PMC2212829.
      Citations: 147     Fields:    Translation:AnimalsCells
    67. Kaplan BL, Moore TV, Schreiber K, Callender GG, Schreiber H, Nishimura MI. A new murine tumor model for studying HLA-A2-restricted anti-tumor immunity. Cancer Lett. 2005 Jun 16; 224(1):153-66. PMID: 15911111.
      Citations:    Fields:    Translation:AnimalsCells
    68. Philip M, Rowley DA, Schreiber H. Inflammation as a tumor promoter in cancer induction. Semin Cancer Biol. 2004 Dec; 14(6):433-9. PMID: 15489136.
      Citations: 213     Fields:    Translation:HumansAnimalsCells
    69. Schreiber K, Cannon RE, Karrison T, Beck-Engeser G, Huo D, Tennant RW, Jensen H, Kast WM, Krausz T, Meredith SC, Chen L, Schreiber H. Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors. Oncogene. 2004 May 13; 23(22):3972-9. PMID: 15077191.
      Citations: 18     Fields:    Translation:Animals
    70. Wu TH, Pabin CN, Qin Z, Blankenstein T, Philip M, Dignam J, Schreiber K, Schreiber H. Long-term suppression of tumor growth by TNF requires a Stat1- and IFN regulatory factor 1-dependent IFN-gamma pathway but not IL-12 or IL-18. J Immunol. 2004 Mar 01; 172(5):3243-51. PMID: 14978132.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    71. Spiotto MT, Rowley DA, Schreiber H. Bystander elimination of antigen loss variants in established tumors. Nat Med. 2004 Mar; 10(3):294-8. PMID: 14981514.
      Citations: 115     Fields:    Translation:AnimalsCells
    72. Yu P, Lee Y, Liu W, Chin RK, Wang J, Wang Y, Schietinger A, Philip M, Schreiber H, Fu YX. Priming of naive T cells inside tumors leads to eradication of established tumors. Nat Immunol. 2004 Feb; 5(2):141-9. PMID: 14704792.
      Citations: 146     Fields:    Translation:AnimalsCellsPHPublic Health
    73. Spiotto MT, Fu YX, Schreiber H. Tumor immunity meets autoimmunity: antigen levels and dendritic cell maturation. Curr Opin Immunol. 2003 Dec; 15(6):725-30. PMID: 14630209.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    74. Spiotto MT, Reth MA, Schreiber H. Genetic changes occurring in established tumors rapidly stimulate new antibody responses. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5425-30. PMID: 12702750; PMCID: PMC154361.
      Citations: 3     Fields:    Translation:AnimalsCells
    75. Yu P, Spiotto MT, Lee Y, Schreiber H, Fu YX. Complementary role of CD4+ T cells and secondary lymphoid tissues for cross-presentation of tumor antigen to CD8+ T cells. J Exp Med. 2003 Apr 21; 197(8):985-95. PMID: 12695490; PMCID: PMC2193872.
      Citations: 28     Fields:    Translation:AnimalsCells
    76. Beck C, Schreiber K, Schreiber H, Rowley DA. C-kit+ FcR+ myelocytes are increased in cancer and prevent the proliferation of fully cytolytic T cells in the presence of immune serum. Eur J Immunol. 2003 Jan; 33(1):19-28. PMID: 12594828.
      Citations: 7     Fields:    Translation:AnimalsCells
    77. Spiotto MT, Yu P, Rowley DA, Nishimura MI, Meredith SC, Gajewski TF, Fu YX, Schreiber H. Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells. Immunity. 2002 Dec; 17(6):737-47. PMID: 12479820.
      Citations: 90     Fields:    Translation:AnimalsCells
    78. Eiben GL, Velders MP, Schreiber H, Cassetti MC, Pullen JK, Smith LR, Kast WM, Eiben GL, Velders MP, Schreiber H, Cassetti MC, Pullen JK, Smith LR, Kast WM. Establishment of an HLA-A*0201 human papillomavirus type 16 tumor model to determine the efficacy of vaccination strategies in HLA-A*0201 transgenic mice. Cancer Res. 2002 Oct 15; 62(20):5792-9. PMID: 12384540.
      Citations: 12     Fields:    Translation:AnimalsCells
    79. Schreiber H, Wu TH, Nachman J, Kast WM. Immunodominance and tumor escape. Semin Cancer Biol. 2002 Feb; 12(1):25-31. PMID: 11926408.
      Citations: 30     Fields:    Translation:HumansAnimals
    80. Beck-Engeser GB, Monach PA, Mumberg D, Yang F, Wanderling S, Schreiber K, Espinosa R, Le Beau MM, Meredith SC, Schreiber H. Point mutation in essential genes with loss or mutation of the second allele: relevance to the retention of tumor-specific antigens. J Exp Med. 2001 Aug 06; 194(3):285-300. PMID: 11489948; PMCID: PMC2193475.
      Citations: 24     Fields:    Translation:AnimalsCells
    81. Weijzen S, Meredith SC, Velders MP, Elmishad AG, Schreiber H, Kast WM, Weijzen S, Meredith SC, Velders MP, Elmishad AG, Schreiber H, Kast WM. Pharmacokinetic differences between a T cell-tolerizing and a T cell-activating peptide. J Immunol. 2001 Jun 15; 166(12):7151-7. PMID: 11390461.
      Citations: 5     Fields:    Translation:AnimalsCells
    82. Schreiber K, Wu TH, Kast WM, Schreiber H. Tracking the common ancestry of antigenically distinct cancer variants. Clin Cancer Res. 2001 Mar; 7(3 Suppl):871s-875s. PMID: 11300485.
      Citations: 8     Fields:    Translation:AnimalsCells
    83. Beck C, Schreiber H, Rowley D. Role of TGF-beta in immune-evasion of cancer. Microsc Res Tech. 2001 Feb 15; 52(4):387-95. PMID: 11170297.
      Citations: 29     Fields:    Translation:AnimalsCells
    84. Schreiber H, Wu TH, Nachman J, Rowley DA. Immunological enhancement of primary tumor development and its prevention. Semin Cancer Biol. 2000 Oct; 10(5):351-7. PMID: 11100883.
      Citations: 14     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    85. Siegel CT, Schreiber K, Meredith SC, Beck-Engeser GB, Lancki DW, Lazarski CA, Fu YX, Rowley DA, Schreiber H. Enhanced growth of primary tumors in cancer-prone mice after immunization against the mutant region of an inherited oncoprotein. J Exp Med. 2000 Jun 05; 191(11):1945-56. PMID: 10839809; PMCID: PMC2213520.
      Citations: 15     Fields:    Translation:AnimalsPHPublic Health
    86. Seetharam S, Staba MJ, Schumm LP, Schreiber K, Schreiber H, Kufe DW, Weichselbaum RR. Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation. Int J Oncol. 1999 Oct; 15(4):769-73. PMID: 10493960.
      Citations: 20     Fields:    Translation:AnimalsCells
    87. Mumberg D, Monach PA, Wanderling S, Philip M, Toledano AY, Schreiber RD, Schreiber H. CD4(+) T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma. Proc Natl Acad Sci U S A. 1999 Jul 20; 96(15):8633-8. PMID: 10411927; PMCID: PMC17568.
      Citations: 130     Fields:    Translation:AnimalsCells
    88. Velders MP, Schreiber H, Kast WM. Active immunization against cancer cells: impediments and advances. Semin Oncol. 1998 Dec; 25(6):697-706. PMID: 9865683.
      Citations: 2     Fields:    Translation:HumansAnimals
    89. Dubey P, Meredith SC, Siegel CT, Schreiber H. Tumor cells induce cytolytic T cells to a single immunodominant mutant peptide. J Immunother. 1998 Jul; 21(4):277-82. PMID: 9672849.
      Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
    90. Schott A, Vogel I, Krueger U, Kalthoff H, Schreiber HW, Schmiegel W, Henne-Bruns D, Kremer B, Juhl H. Isolated tumor cells are frequently detectable in the peritoneal cavity of gastric and colorectal cancer patients and serve as a new prognostic marker. Ann Surg. 1998 Mar; 227(3):372-9. PMID: 9527060; PMCID: PMC1191275.
      Citations: 32     Fields:    Translation:Humans
    91. Wick M, Dubey P, Koeppen H, Siegel CT, Fields PE, Chen L, Bluestone JA, Schreiber H. Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy. J Exp Med. 1997 Jul 21; 186(2):229-38. PMID: 9221752; PMCID: PMC2198977.
      Citations: 47     Fields:    Translation:AnimalsCellsPHPublic Health
    92. Dubey P, Hendrickson RC, Meredith SC, Siegel CT, Shabanowitz J, Skipper JC, Engelhard VH, Hunt DF, Schreiber H. The immunodominant antigen of an ultraviolet-induced regressor tumor is generated by a somatic point mutation in the DEAD box helicase p68. J Exp Med. 1997 Feb 17; 185(4):695-705. PMID: 9034148; PMCID: PMC2196148.
      Citations: 55     Fields:    Translation:AnimalsCells
    93. Seung LP, Weichselbaum RR, Toledano A, Schreiber K, Schreiber H. Radiation can inhibit tumor growth indirectly while depleting circulating leukocytes. Radiat Res. 1996 Dec; 146(6):612-8. PMID: 8955710.
      Citations: 5     Fields:    Translation:AnimalsCells
    94. Mumberg D, Wick M, Schreiber H. Unique tumor antigens redefined as mutant tumor-specific antigens. Semin Immunol. 1996 Oct; 8(5):289-93. PMID: 8956457.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    95. Van Waes C, Monach PA, Urban JL, Wortzel RD, Schreiber H. Immunodominance deters the response to other tumor antigens thereby favoring escape: prevention by vaccination with tumor variants selected with cloned cytolytic T cells in vitro. Tissue Antigens. 1996 May; 47(5):399-407. PMID: 8795140.
      Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
    96. Seung LP, Seung SK, Schreiber H. Antigenic cancer cells that escape immune destruction are stimulated by host cells. Cancer Res. 1995 Nov 01; 55(21):5094-100. PMID: 7585557.
      Citations: 12     Fields:    Translation:AnimalsCells
    97. Seung LP, Rowley DA, Dubey P, Schreiber H. Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection. Proc Natl Acad Sci U S A. 1995 Jul 03; 92(14):6254-8. PMID: 7603979; PMCID: PMC41496.
      Citations: 67     Fields:    Translation:AnimalsCells
    98. Pekarek LA, Starr BA, Toledano AY, Schreiber H. Inhibition of tumor growth by elimination of granulocytes. J Exp Med. 1995 Jan 01; 181(1):435-40. PMID: 7807024; PMCID: PMC2191807.
      Citations: 133     Fields:    Translation:AnimalsCells
    99. Monach PA, Meredith SC, Siegel CT, Schreiber H. A unique tumor antigen produced by a single amino acid substitution. Immunity. 1995 Jan; 2(1):45-59. PMID: 7600302.
      Citations: 101     Fields:    Translation:AnimalsCellsPHPublic Health
    100. Kalthoff H, Schott A, Schreiber HW, Henne-Bruns D, Kremer B, Juhl H, Krüger U. [Immunocytologic detection of disseminated tumor cells in the peritoneal cavity and bone marrow in patients with pancreatic carcinoma]. Chirurg. 1994 Dec; 65(12):1111-5. PMID: 7851144.
      Citations: 2     Fields:    Translation:Humans
    101. Juhl H, Stritzel M, Wroblewski A, Henne-Bruns D, Kremer B, Schmiegel W, Neumaier M, Wagener C, Schreiber HW, Kalthoff H. Immunocytological detection of micrometastatic cells: comparative evaluation of findings in the peritoneal cavity and the bone marrow of gastric, colorectal and pancreatic cancer patients. Int J Cancer. 1994 May 01; 57(3):330-5. PMID: 8168992.
      Citations: 42     Fields:    Translation:Humans
    102. Juhl H, Kalthoff H, Schreiber HW, Wagener C, Neumaier M, Gerhard M. Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction. J Clin Oncol. 1994 Apr; 12(4):725-9. PMID: 7512130.
      Citations: 58     Fields:    Translation:HumansCells
    103. Koeppen H, Acena M, Drolet A, Rowley DA, Schreiber H. Tumors with reduced expression of a cytotoxic T lymphocyte recognized antigen lack immunogenicity but retain sensitivity to lysis by cytotoxic T lymphocytes. Eur J Immunol. 1993 Nov; 23(11):2770-6. PMID: 8223853.
      Citations: 5     Fields:    Translation:AnimalsCells
    104. Teng MN, Turksen K, Jacobs CA, Fuchs E, Schreiber H. Prevention of runting and cachexia by a chimeric TNF receptor-Fc protein. Clin Immunol Immunopathol. 1993 Nov; 69(2):215-22. PMID: 8403559.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    105. Seung S, Urban JL, Schreiber H. A tumor escape variant that has lost one major histocompatibility complex class I restriction element induces specific CD8+ T cells to an antigen that no longer serves as a target. J Exp Med. 1993 Sep 01; 178(3):933-40. PMID: 8394406; PMCID: PMC2191160.
      Citations: 17     Fields:    Translation:AnimalsCells
    106. Koeppen H, Singh S, Schreiber H. Genetically engineered vaccines. Comparison of active versus passive immunotherapy against solid tumors. Ann N Y Acad Sci. 1993 Aug 12; 690:244-55. PMID: 8368742.
      Citations: 2     Fields:    Translation:AnimalsCells
    107. Koeppen HK, Singh S, Stauss HJ, Park BH, Rowley DA, Schreiber H. CD4-positive and B lymphocytes in transplantation immunity. I. Promotion of tumor allograft rejection through elimination of CD4-positive lymphocytes. Transplantation. 1993 Jun; 55(6):1349-55. PMID: 8100089.
      Citations: 2     Fields:    Translation:AnimalsCells
    108. Monach PA, Schreiber H, Rowley DA. CD4+ and B lymphocytes in transplantation immunity. II. Augmented rejection of tumor allografts by mice lacking B cells. Transplantation. 1993 Jun; 55(6):1356-61. PMID: 8100090.
      Citations: 21     Fields:    Translation:AnimalsCells
    109. Pekarek LA, Weichselbaum RR, Beckett MA, Nachman J, Schreiber H. Footprinting of individual tumors and their variants by constitutive cytokine expression patterns. Cancer Res. 1993 May 01; 53(9):1978-81. PMID: 8481898.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    110. Seung S, Urban JL, Schreiber H. DNA sequence analysis of T-cell receptor genes reveals an oligoclonal T-cell response to a tumor with multiple target antigens. Cancer Res. 1993 Feb 15; 53(4):840-5. PMID: 8381330.
      Citations: 1     Fields:    Translation:AnimalsCells
    111. Cheng J, Turksen K, Yu QC, Schreiber H, Teng M, Fuchs E. Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice. Genes Dev. 1992 Aug; 6(8):1444-56. PMID: 1379563.
      Citations: 39     Fields:    Translation:AnimalsCells
    112. Urban JL, Schreiber H. Tumor antigens. Annu Rev Immunol. 1992; 10:617-44. PMID: 1590998.
      Citations: 35     Fields:    Translation:Humans
    113. Singh S, Ross SR, Acena M, Rowley DA, Schreiber H. Stroma is critical for preventing or permitting immunological destruction of antigenic cancer cells. J Exp Med. 1992 Jan 01; 175(1):139-46. PMID: 1309851; PMCID: PMC2119086.
      Citations: 51     Fields:    Translation:AnimalsCells
    114. Ward PL, Schreiber H. MHC class I restricted T cells and immune surveillance against transplanted ultraviolet light-induced tumors. Semin Cancer Biol. 1991 Oct; 2(5):321-8. PMID: 1837738.
      Citations: 5     Fields:    Translation:AnimalsCells
    115. Teng MN, Park BH, Koeppen HK, Tracey KJ, Fendly BM, Schreiber H. Long-term inhibition of tumor growth by tumor necrosis factor in the absence of cachexia or T-cell immunity. Proc Natl Acad Sci U S A. 1991 May 01; 88(9):3535-9. PMID: 2023898; PMCID: PMC51486.
      Citations: 22     Fields:    Translation:AnimalsCells
    116. Ward PL, Koeppen HK, Hurteau T, Rowley DA, Schreiber H. Major histocompatibility complex class I and unique antigen expression by murine tumors that escaped from CD8+ T-cell-dependent surveillance. Cancer Res. 1990 Jul 01; 50(13):3851-8. PMID: 2112981.
      Citations: 26     Fields:    Translation:AnimalsCells
    117. Ellenhorn JD, Schreiber H, Bluestone JA. Mechanism of tumor rejection in anti-CD3 monoclonal antibody-treated mice. J Immunol. 1990 Apr 01; 144(7):2840-6. PMID: 1969454.
      Citations: 13     Fields:    Translation:AnimalsCells
    118. Perdrizet GA, Ross SR, Stauss HJ, Singh S, Koeppen H, Schreiber H. Animals bearing malignant grafts reject normal grafts that express through gene transfer the same antigen. J Exp Med. 1990 Apr 01; 171(4):1205-20. PMID: 2324687; PMCID: PMC2187845.
      Citations: 6     Fields:    Translation:Animals
    119. Torre-Amione G, Beauchamp RD, Koeppen H, Park BH, Schreiber H, Moses HL, Rowley DA. A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance. Proc Natl Acad Sci U S A. 1990 Feb; 87(4):1486-90. PMID: 2137615; PMCID: PMC53500.
      Citations: 87     Fields:    Translation:AnimalsCells
    120. Ward PL, Koeppen H, Hurteau T, Schreiber H. Tumor antigens defined by cloned immunological probes are highly polymorphic and are not detected on autologous normal cells. J Exp Med. 1989 Jul 01; 170(1):217-32. PMID: 2787379; PMCID: PMC2189372.
      Citations: 42     Fields:    Translation:AnimalsCells
    121. Mullen CA, Rowley DA, Schreiber H. Highly immunogenic regressor tumor cells can prevent development of postsurgical tumor immunity. Cell Immunol. 1989 Mar; 119(1):101-13. PMID: 2522025.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    122. Schreiber H, Koeppen H, Ward PL. Tumor-specific antigens and tumor-specific mutant proteins in mouse and man. Haematol Blood Transfus. 1989; 32:284-8. PMID: 2483150.
      Citations:    Fields:    Translation:HumansAnimals
    123. Rothstein JL, Lint TF, Schreiber H. Tumor necrosis factor/cachectin. Induction of hemorrhagic necrosis in normal tissue requires the fifth component of complement (C5). J Exp Med. 1988 Dec 01; 168(6):2007-21. PMID: 3199066; PMCID: PMC2189157.
      Citations: 13     Fields:    Translation:AnimalsCells
    124. Ellenhorn JD, Hirsch R, Schreiber H, Bluestone JA. In vivo administration of anti-CD3 prevents malignant progressor tumor growth. Science. 1988 Oct 28; 242(4878):569-71. PMID: 2902689.
      Citations: 18     Fields:    Translation:AnimalsCells
    125. Caesar J, Kalthoff H, Greten H, Schreiber HW, Thiele HG, Schmiegel WH. Antiproliferative effects exerted by recombinant human tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on human pancreatic tumor cell lines. Pancreas. 1988; 3(2):180-8. PMID: 3131759.
      Citations: 14     Fields:    Translation:HumansCells
    126. Schreiber H, Ward PL, Rowley DA, Stauss HJ. Unique tumor-specific antigens. Annu Rev Immunol. 1988; 6:465-83. PMID: 3289573.
      Citations: 27     Fields:    Translation:HumansAnimals
    127. Rothstein JL, Schreiber H. Synergy between tumor necrosis factor and bacterial products causes hemorrhagic necrosis and lethal shock in normal mice. Proc Natl Acad Sci U S A. 1988 Jan; 85(2):607-11. PMID: 3422444; PMCID: PMC279600.
      Citations: 69     Fields:    Translation:Animals
    128. Meyer-Pannwitt U, Rose R, Gundlach K, Schreiber HW, Hellner D. [Clinical aspects and therapy of Merkel cell tumor--report of 4 personal cases and review of the literature]. Langenbecks Arch Chir. 1988; 373(3):173-81. PMID: 3288829.
      Citations:    Fields:    Translation:Humans
    129. Stauss HJ, Fink MA, Starr B, Schreiber H. Identification of a gene encoding a tumor-specific antigen that causes tumor rejection. Haematol Blood Transfus. 1987; 31:308-13. PMID: 3443398.
      Citations:    Fields:    Translation:Animals
    130. Rothstein JL, Schreiber H. Relationship of tumour necrosis factor and endotoxin to macrophage cytotoxicity, haemorrhagic necrosis and lethal shock. Ciba Found Symp. 1987; 131:124-39. PMID: 3330008.
      Citations: 3     Fields:    Translation:Animals
    131. Klapdor R, Klapdor U, Bahlo M, Dallek M, Kremer B, van Ackeren H, Schreiber HW, Greten H. [CA 12-5 in cancer of the digestive tract. A comparison with CA 19-9 and CEA in cancer of the pancreas and colon]. Dtsch Med Wochenschr. 1984 Dec 21; 109(51-52):1949-54. PMID: 6595110.
      Citations: 3     Fields:    Translation:HumansAnimals
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