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Christopher Weber

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentPathology
AddressChicago IL 60637
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    Collapse Overview 
    Collapse overview
    Dr. Weber is an expert in the biophysical properties of the tight junctions and focuses on defining mechanisms of claudin barrier regulation in health and disease.

    A second focus of Dr. Weber's lab is cardiac cellular electrophysiology, with an emphasis on mechanisms of abnormal cellular calcium handling in disease.

    Collapse Biography 
    Collapse education and training
    Loyola University Chicago, Stritch School of MedicineMD, PhD2004Physiology
    University of Chicago MedicineResidency2007Anatomic Pathology
    University of Chicago MedicineFellowship2010Gastrointestinal Pathology

    Collapse Research 
    Collapse research activities and funding
    R01DK131542     (KHALILI-ARAGHI, FATEMEH ;WEBER, CHRISTOPHER)Sep 30, 2021 - Jul 31, 2026
    NIH
    Structure, function, and modulation of claudin cation channels in the GI tract
    Role: Principal Investigator
    R03DK103007     (WEBER, CHRISTOPHER)Jul 1, 2014 - Apr 30, 2016
    NIH
    Mechanisms of tight junction pore and leak pathway regulation in intestinal mucos
    Role: Principal Investigator
    K08DK088953     (WEBER, CHRISTOPHER)Jul 1, 2010 - Jun 30, 2015
    NIH
    Mechanisms and pathways of trans-tight junction conductance
    Role: Principal Investigator
    F32DK082134     (WEBER, CHRISTOPHER)Jul 1, 2008 - Jun 30, 2011
    NIH
    Mechanisms of epithelial barrier dysfunction mediated by inflammatory cytokines
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cohen NA, Weber CR, Cheng JX, Choi D, Garcia NM, Choi NK, Rubin DT. Ozanimod-Exposed Patients with Ulcerative Colitis Undergoing Total Colectomy Exhibit Unique Lymph Node Histologic Changes. J Crohns Colitis. 2023 Oct 25. PMID: 37879626.
      Citations:    Fields:    
    2. Jamil OK, Shaw D, Deng Z, Dinardi N, Fillman N, Khanna S, Krugliak Cleveland N, Sakuraba A, Weber CR, Cohen RD, Dalal S, Jabri B, Rubin DT, Pekow J. Inflammation in the proximal colon is a risk factor for the development of colorectal neoplasia in inflammatory bowel disease patients with primary sclerosing cholangitis. Therap Adv Gastroenterol. 2023; 16:17562848231184985. PMID: 37692199; PMCID: PMC10486214.
      Citations:    
    3. Li P, Li Y, Sajjadi S, Sidahmed M, Li Y, McGuinness S, Fuladi S, Konar S, Shen L, Araghi FK, Weber CR. Molecular dynamics analyses of CLDN15 pore size and charge selectivity. bioRxiv. 2023 Aug 17. PMID: 37645840; PMCID: PMC10461993.
      Citations:    
    4. Shaw DG, Aguirre-Gamboa R, Vieira MC, Gona S, DiNardi N, Wang A, Dumaine A, Gelderloos-Arends J, Earley ZM, Meckel KR, Ciszewski C, Castillo A, Monroe K, Torres J, Shah SC, Colombel JF, Itzkowitz S, Newberry R, Cohen RD, Rubin DT, Quince C, Cobey S, Jonkers IH, Weber CR, Pekow J, Wilson PC, Barreiro LB, Jabri B. Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis. Nat Med. 2023 Jun; 29(6):1520-1529. PMID: 37322120; PMCID: PMC10287559.
      Citations: 1     Fields:    Translation:Humans
    5. Matthews JM, Schuster B, Kashaf SS, Liu P, Ben-Yishay R, Ishay-Ronen D, Izumchenko E, Shen L, Weber CR, Bielski M, Kupfer SS, Bilgic M, Rzhetsky A, Tay S. OrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics. PLoS Comput Biol. 2022 11; 18(11):e1010584. PMID: 36350878; PMCID: PMC9645660.
      Citations: 7     Fields:    
    6. Fuladi S, McGuinness S, Shen L, Weber CR, Khalili-Araghi F. Molecular mechanism of claudin-15 strand flexibility: A computational study. J Gen Physiol. 2022 12 05; 154(12). PMID: 36318156; PMCID: PMC9629798.
      Citations: 5     Fields:    Translation:Cells
    7. Ferrarotto R, Mishra V, Herz E, Yaacov A, Solomon O, Rauch R, Mondshine A, Motin M, Leibovich-Rivkin T, Davis M, Kaye J, Weber CR, Shen L, Pearson AT, Rosenberg AJ, Chen X, Singh A, Aster JC, Agrawal N, Izumchenko E. AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling. Cell Death Dis. 2022 08 05; 13(8):678. PMID: 35931701; PMCID: PMC9355983.
      Citations: 4     Fields:    Translation:HumansCells
    8. Akiyama S, Ollech JE, Traboulsi C, Rai V, Glick LR, Yi Y, Runde J, Olivas AD, Weber CR, Cohen RD, Olortegui KBS, Hurst RD, Umanskiy K, Shogan BD, Rubin MA, Dalal SR, Sakuraba A, Pekow J, Chang EB, Hart J, Hyman NH, Rubin DT. Histopathology of Colectomy Specimens Predicts Endoscopic Pouch Phenotype in Patients with Ulcerative Colitis. Dig Dis Sci. 2022 08; 67(8):4020-4031. PMID: 35288827.
      Citations:    Fields:    Translation:Humans
    9. Marchelletta RR, Krishnan M, Spalinger MR, Placone TW, Alvarez R, Sayoc-Becerra A, Canale V, Shawki A, Park YS, Bernts LH, Myers S, Barrett KE, Krystofiak E, Kachar B, McGovern DP, Weber CR, Hanson EM, Eckmann L, McCole DF, Tremblay ML. T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling. J Clin Invest. 2021 09 01; 131(17). PMID: 34623320; PMCID: PMC8409587.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    10. Boylan KE, Patrey S, McMullen PD, Tesic V, Weber CR, Hart J, Setia N. Objective Visual Analog Scale for Biopsy Diagnosis of Helicobacter pylori Infection in Clinical Practice. Am J Surg Pathol. 2021 05 01; 45(5):672-679. PMID: 33534221.
      Citations:    Fields:    Translation:HumansCells
    11. Quandt J, Arnovitz S, Haghi L, Woehlk J, Mohsin A, Okoreeh M, Mathur PS, Emmanuel AO, Osman A, Krishnan M, Morin SB, Pearson AT, Sweis RF, Pekow J, Weber CR, Khazaie K, Gounari F. Wnt-ß-catenin activation epigenetically reprograms Treg cells in inflammatory bowel disease and dysplastic progression. Nat Immunol. 2021 04; 22(4):471-484. PMID: 33664518; PMCID: PMC8262575.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    12. Schuster B, Junkin M, Kashaf SS, Romero-Calvo I, Kirby K, Matthews J, Weber CR, Rzhetsky A, White KP, Tay S. Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids. Nat Commun. 2020 10 19; 11(1):5271. PMID: 33077832; PMCID: PMC7573629.
      Citations: 68     Fields:    Translation:Humans
    13. Manzella CR, Jayawardena D, Pagani W, Li Y, Alrefai WA, Bauer J, Jung B, Weber CR, Gill RK. Serum Serotonin Differentiates Between Disease Activity States in Crohn's Patients. Inflamm Bowel Dis. 2020 09 18; 26(10):1607-1618. PMID: 32844174; PMCID: PMC7500525.
      Citations: 14     Fields:    Translation:Humans
    14. Olivas AD, Setia N, Weber CR, Xiao SY, Villa E, Chapman CG, Siddiqui UD, Waxman I, Hart J, Alpert L. Histologic changes caused by injection of a novel submucosal lifting agent for endoscopic resection in GI lesions. Gastrointest Endosc. 2021 02; 93(2):470-476. PMID: 32593688.
      Citations: 4     Fields:    Translation:Humans
    15. Dai W, Nadadur RD, Brennan JA, Smith HL, Shen KM, Gadek M, Laforest B, Wang M, Gemel J, Li Y, Zhang J, Ziman BD, Yan J, Ai X, Beyer EC, Lakata EG, Kasthuri N, Efimov IR, Broman MT, Moskowitz IP, Shen L, Weber CR. ZO-1 Regulates Intercalated Disc Composition and Atrioventricular Node Conduction. Circ Res. 2020 07 03; 127(2):e28-e43. PMID: 32347164; PMCID: PMC7334106.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    16. Zou J, Li Y, Yu J, Dong L, Husain AN, Shen L, Weber CR. Idiopathic pulmonary fibrosis is associated with tight junction protein alterations. Biochim Biophys Acta Biomembr. 2020 05 01; 1862(5):183205. PMID: 32001212.
      Citations: 14     Fields:    Translation:HumansCells
    17. Fuladi S, Jannat RW, Shen L, Weber CR, Khalili-Araghi F. Computational Modeling of Claudin Structure and Function. Int J Mol Sci. 2020 Jan 23; 21(3). PMID: 31979311; PMCID: PMC7037046.
      Citations: 8     Fields:    Translation:AnimalsCells
    18. Wei S, Li Y, Polster SP, Weber CR, Awad IA, Shen L. Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation. Int J Mol Sci. 2020 Jan 20; 21(2). PMID: 31968585; PMCID: PMC7013531.
      Citations: 10     Fields:    Translation:HumansCells
    19. Laforest B, Dai W, Tyan L, Lazarevic S, Shen KM, Gadek M, Broman MT, Weber CR, Moskowitz IP. Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis. J Clin Invest. 2019 11 01; 129(11):4937-4950. PMID: 31609246; PMCID: PMC6819107.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    20. Alpert L, Yassan L, Poon R, Kadri S, Niu N, Patil SA, Mujacic I, Montes D, Galbo F, Wurst MN, Zhen CJ, Cohen RD, Rubin DT, Pekow JR, Weber CR, Xiao SY, Hart J, Segal J, Setia N. Targeted mutational analysis of inflammatory bowel disease-associated colorectal cancers. Hum Pathol. 2019 07; 89:44-50. PMID: 31054900.
      Citations: 11     Fields:    Translation:Humans
    21. Dai W, Laforest B, Tyan L, Shen KM, Nadadur RD, Alvarado FJ, Mazurek SR, Lazarevic S, Gadek M, Wang Y, Li Y, Valdivia HH, Shen L, Broman MT, Moskowitz IP, Weber CR. A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice. Elife. 2019 03 21; 8. PMID: 30896405; PMCID: PMC6428569.
      Citations: 16     Fields:    Translation:AnimalsCells
    22. Wang Y, Li Y, Zou J, Polster SP, Lightle R, Moore T, Dimaano M, He TC, Weber CR, Awad IA, Shen L. The cerebral cavernous malformation disease causing gene KRIT1 participates in intestinal epithelial barrier maintenance and regulation. FASEB J. 2019 02; 33(2):2132-2143. PMID: 30252535; PMCID: PMC6338648.
      Citations: 8     Fields:    Translation:HumansCells
    23. Romero-Calvo I, Weber CR, Ray M, Brown M, Kirby K, Nandi RK, Long TM, Sparrow SM, Ugolkov A, Qiang W, Zhang Y, Brunetti T, Kindler H, Segal JP, Rzhetsky A, Mazar AP, Buschmann MM, Weichselbaum R, Roggin K, White KP. Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma Tumors. Mol Cancer Res. 2019 01; 17(1):70-83. PMID: 30171177; PMCID: PMC6647028.
      Citations: 49     Fields:    Translation:HumansAnimals
    24. Overstreet AM, LaTorre DL, Abernathy-Close L, Murphy SF, Rhee L, Boger AM, Adlaka KR, Iverson AM, Bakke DS, Weber CR, Boone DL. The JAK inhibitor ruxolitinib reduces inflammation in an ILC3-independent model of innate immune colitis. Mucosal Immunol. 2018 09; 11(5):1454-1465. PMID: 29988117; PMCID: PMC6162142.
      Citations: 4     Fields:    Translation:AnimalsCells
    25. Sofia MA, Ciorba MA, Meckel K, Lim CK, Guillemin GJ, Weber CR, Bissonnette M, Pekow JR. Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis. Inflamm Bowel Dis. 2018 06 08; 24(7):1471-1480. PMID: 29796641; PMCID: PMC6196764.
      Citations: 47     Fields:    Translation:Humans
    26. Meisel M, Hinterleitner R, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N, Bouziat R, Ringus DL, Wang Y, Li Y, Dinh V, Kim SM, McDonald BD, Zurenski MA, Musch MW, Furtado GC, Lira SA, Baier G, Chang EB, Eren AM, Weber CR, Godley LA, Barreiro LB, Jabri B, Buscarlet M, Busque L, Verdú EF. Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature. 2018 05; 557(7706):580-584. PMID: 29769727; PMCID: PMC6238954.
      Citations: 170     Fields:    Translation:AnimalsCells
    27. Christensen B, Gibson PR, Micic D, Colman RJ, Goeppinger SR, Kassim O, Yarur A, Weber CR, Cohen RD, Rubin DT. Safety and Efficacy of Combination Treatment With Calcineurin Inhibitors and Vedolizumab in Patients With Refractory Inflammatory Bowel Disease. Clin Gastroenterol Hepatol. 2019 02; 17(3):486-493. PMID: 29751166; PMCID: PMC7034423.
      Citations: 34     Fields:    Translation:Humans
    28. Christensen B, Colman RJ, Micic D, Gibson PR, Goeppinger SR, Yarur A, Weber CR, Cohen RD, Rubin DT. Vedolizumab as Induction and Maintenance for Inflammatory Bowel Disease: 12-month Effectiveness and Safety. Inflamm Bowel Dis. 2018 03 19; 24(4):849-860. PMID: 29562271; PMCID: PMC6196763.
      Citations: 12     Fields:    Translation:Humans
    29. Yang XH, Nadadur RD, Hilvering CR, Bianchi V, Werner M, Mazurek SR, Gadek M, Shen KM, Goldman JA, Tyan L, Bekeny J, Hall JM, Lee N, Perez-Cervantes C, Burnicka-Turek O, Poss KD, Weber CR, de Laat W, Ruthenburg AJ, Moskowitz IP. Transcription-factor-dependent enhancer transcription defines a gene regulatory network for cardiac rhythm. Elife. 2017 12 27; 6. PMID: 29280435; PMCID: PMC5745077.
      Citations: 26     Fields:    Translation:AnimalsCells
    30. Uraizee I, Hart J, Waxman I, Weber CR, Setia N. Unusual gastric subepithelial tumor: primary mixed acinar-endocrine neoplasm in an anemic woman. Gastrointest Endosc. 2018 May; 87(5):1355-1356. PMID: 29102730.
      Citations: 1     Fields:    Translation:HumansCells
    31. Krugliak Cleveland N, Rubin DT, Hart J, Weber CR, Meckel K, Tran AL, Aelvoet AS, Pan I, Gonsalves A, Gaetano JN, Williams KM, Wroblewski K, Jabri B, Pekow J. Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis Frequently Have Subclinical Inflammation in the Proximal Colon. Clin Gastroenterol Hepatol. 2018 Jan; 16(1):68-74. PMID: 28756053; PMCID: PMC5735030.
      Citations: 17     Fields:    Translation:Humans
    32. Weber CR, Turner JR. Dynamic modeling of the tight junction pore pathway. Ann N Y Acad Sci. 2017 06; 1397(1):209-218. PMID: 28605031; PMCID: PMC5488723.
      Citations: 15     Fields:    Translation:AnimalsCells
    33. Dalal S, Antonopoulos D, Hubert N, Raffals LH, Dolan K, Weber C, Messer JS, Jabri B, Bendelac A, Eren AM, Rubin DT, Sogin M, Chang EB, Huang Y. Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. Inflamm Bowel Dis. 2017 03; 23(3):366-378. PMID: 28221248; PMCID: PMC5988644.
      Citations: 9     Fields:    Translation:HumansCells
    34. Huang Y, Dalal S, Antonopoulos D, Hubert N, Raffals LH, Dolan K, Weber C, Messer JS, Jabri B, Bendelac A, Eren AM, Rubin DT, Sogin M, Chang EB. Early Transcriptomic Changes in the Ileal Pouch Provide Insight into the Molecular Pathogenesis of Pouchitis and Ulcerative Colitis. Inflamm Bowel Dis. 2017 Feb 13. PMID: 28248733.
      Citations:    
    35. Meisel M, Mayassi T, Fehlner-Peach H, Koval JC, O'Brien SL, Hinterleitner R, Lesko K, Kim S, Bouziat R, Chen L, Weber CR, Mazmanian SK, Jabri B, Antonopoulos DA. Interleukin-15 promotes intestinal dysbiosis with butyrate deficiency associated with increased susceptibility to colitis. ISME J. 2017 01; 11(1):15-30. PMID: 27648810; PMCID: PMC5315477.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    36. Nadadur RD, Broman MT, Boukens B, Mazurek SR, Yang X, van den Boogaard M, Bekeny J, Gadek M, Ward T, Zhang M, Qiao Y, Martin JF, Seidman CE, Seidman J, Christoffels V, Efimov IR, McNally EM, Weber CR, Moskowitz IP. Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm. Sci Transl Med. 2016 08 31; 8(354):354ra115. PMID: 27582060; PMCID: PMC5266594.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    37. Wali RK, Momi N, Dela Cruz M, Calderwood AH, Stypula-Cyrus Y, Almassalha L, Chhaparia A, Weber CR, Radosevich A, Tiwari AK, Latif B, Backman V, Roy HK. Higher Order Chromatin Modulator Cohesin SA1 Is an Early Biomarker for Colon Carcinogenesis: Race-Specific Implications. Cancer Prev Res (Phila). 2016 Nov; 9(11):844-854. PMID: 27549371; PMCID: PMC5093027.
      Citations: 6     Fields:    Translation:HumansCells
    38. Ward MA, Pierre JF, Leal RF, Huang Y, Shogan B, Dalal SR, Weber CR, Leone VA, Musch MW, An GC, Rao MC, Rubin DT, Raffals LE, Antonopoulos DA, Sogin ML, Hyman NH, Alverdy JC, Chang EB. Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility. Am J Physiol Gastrointest Liver Physiol. 2016 06 01; 310(11):G973-88. PMID: 27079612; PMCID: PMC4935476.
      Citations: 11     Fields:    Translation:HumansAnimals
    39. Weber CR, Liang GH, Wang Y, Das S, Shen L, Yu AS, Nelson DJ, Turner JR. Claudin-2-dependent paracellular channels are dynamically gated. Elife. 2015 Nov 14; 4:e09906. PMID: 26568313; PMCID: PMC4755754.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    40. Roy HK, Turzhitsky V, Wali R, Radosevich AJ, Jovanovic B, Della'Zanna G, Umar A, Rubin DT, Goldberg MJ, Bianchi L, De La Cruz M, Bogojevic A, Helenowski IB, Rodriguez L, Chatterton R, Skripkauskas S, Page K, Weber CR, Huang X, Richmond E, Bergan RC, Backman V. Spectral biomarkers for chemoprevention of colonic neoplasia: a placebo-controlled double-blinded trial with aspirin. Gut. 2017 02; 66(2):285-292. PMID: 26503631; PMCID: PMC5108693.
      Citations: 20     Fields:    Translation:Humans
    41. Chen P, Bakke D, Kolodziej L, Lodolce J, Weber CR, Boone DL, Toback FG. Antrum Mucosal Protein-18 Peptide Targets Tight Junctions to Protect and Heal Barrier Structure and Function in Models of Inflammatory Bowel Disease. Inflamm Bowel Dis. 2015 Oct; 21(10):2393-2402. PMID: 26197453; PMCID: PMC4567513.
      Citations: 8     Fields:    Translation:AnimalsCells
    42. Staruschenko A, Weber CR, Pochynyuk O, McCole DF. S&R Foundation 15th Anniversary. Physiologist. 2015 Sep; 58(5):241-2. PMID: 26442383.
      Citations:    Fields:    Translation:Humans
    43. Grimm WA, Messer JS, Murphy SF, Nero T, Lodolce JP, Weber CR, Logsdon MF, Bartulis S, Sylvester BE, Springer A, Dougherty U, Niewold TB, Kupfer SS, Ellis N, Huo D, Bissonnette M, Boone DL. The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon. Gut. 2016 Mar; 65(3):456-64. PMID: 25645662; PMCID: PMC4789828.
      Citations: 40     Fields:    Translation:HumansCells
    44. Murphy SF, Rhee L, Grimm WA, Weber CR, Messer JS, Lodolce JP, Chang JE, Bartulis SJ, Nero T, Kukla RA, MacDougall G, Binghay C, Kolodziej LE, Boone DL. Intestinal epithelial expression of TNFAIP3 results in microbial invasion of the inner mucus layer and induces colitis in IL-10-deficient mice. Am J Physiol Gastrointest Liver Physiol. 2014 Nov 01; 307(9):G871-82. PMID: 25234043; PMCID: PMC4216993.
      Citations: 12     Fields:    Translation:Animals
    45. Liang GH, Weber CR. Molecular aspects of tight junction barrier function. Curr Opin Pharmacol. 2014 Dec; 19:84-9. PMID: 25128899; PMCID: PMC4330960.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    46. Singh P, Bello B, Weber C, Umanskiy K. Rectal leiomyosarcoma in association with ulcerative colitis: a rare condition with an unusual presentation. Int J Colorectal Dis. 2014 Jul; 29(7):887-8. PMID: 24777350.
      Citations: 9     Fields:    Translation:Humans
    47. Keerthivasan S, Aghajani K, Dose M, Molinero L, Khan MW, Venkateswaran V, Weber C, Emmanuel AO, Sun T, Bentrem DJ, Mulcahy M, Keshavarzian A, Ramos EM, Blatner N, Khazaie K, Gounari F. ß-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells. Sci Transl Med. 2014 Feb 26; 6(225):225ra28. PMID: 24574339; PMCID: PMC4020714.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    48. Weber CR, Rubin DT. Chronic pouchitis versus recurrent Crohn's disease: a diagnostic challenge. Dig Dis Sci. 2013 Oct; 58(10):2748-50. PMID: 23925821; PMCID: PMC3805823.
      Citations: 1     Fields:    Translation:Humans
    49. Buschmann MM, Shen L, Rajapakse H, Raleigh DR, Wang Y, Wang Y, Lingaraju A, Zha J, Abbott E, McAuley EM, Breskin LA, Wu L, Anderson K, Turner JR, Weber CR. Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux. Mol Biol Cell. 2013 Oct; 24(19):3056-68. PMID: 23924897; PMCID: PMC3784380.
      Citations: 88     Fields:    Translation:HumansCells
    50. Qi W, Fitchev PS, Cornwell ML, Greenberg J, Cabe M, Weber CR, Roy HK, Crawford SE, Savkovic SD. FOXO3 growth inhibition of colonic cells is dependent on intraepithelial lipid droplet density. J Biol Chem. 2013 Jun 07; 288(23):16274-16281. PMID: 23603907; PMCID: PMC3675566.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    51. Bergmann KR, Liu SX, Tian R, Kushnir A, Turner JR, Li HL, Chou PM, Weber CR, De Plaen IG. Bifidobacteria stabilize claudins at tight junctions and prevent intestinal barrier dysfunction in mouse necrotizing enterocolitis. Am J Pathol. 2013 May; 182(5):1595-606. PMID: 23470164; PMCID: PMC3644725.
      Citations: 108     Fields:    Translation:HumansAnimalsCells
    52. Ginsburg KS, Weber CR, Bers DM. Cardiac Na+-Ca2+ exchanger: dynamics of Ca2+-dependent activation and deactivation in intact myocytes. J Physiol. 2013 Apr 15; 591(8):2067-86. PMID: 23401616; PMCID: PMC3634520.
      Citations: 18     Fields:    Translation:AnimalsCells
    53. Bouyer PG, Tang X, Weber CR, Shen L, Turner JR, Matthews JB. Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15; 304(2):G142-56. PMID: 23139219; PMCID: PMC3543646.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    54. Wali RK, Kunte DP, De La Cruz M, Tiwari AK, Brasky J, Weber CR, Gibson TP, Patel A, Savkovic SD, Brockstein BE, Roy HK. Topical polyethylene glycol as a novel chemopreventive agent for oral cancer via targeting of epidermal growth factor response. PLoS One. 2012; 7(6):e38047. PMID: 22675506; PMCID: PMC3366973.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    55. Weber CR. Dynamic properties of the tight junction barrier. Ann N Y Acad Sci. 2012 Jun; 1257:77-84. PMID: 22671592; PMCID: PMC3687038.
      Citations: 41     Fields:    Translation:HumansCells
    56. Rhee L, Murphy SF, Kolodziej LE, Grimm WA, Weber CR, Lodolce JP, Chang JE, Bartulis SJ, Messer JS, Schneider JR, Paski S, Nero TM, Boone DL. Expression of TNFAIP3 in intestinal epithelial cells protects from DSS- but not TNBS-induced colitis. Am J Physiol Gastrointest Liver Physiol. 2012 Jul 15; 303(2):G220-7. PMID: 22595989; PMCID: PMC3404569.
      Citations: 17     Fields:    Translation:Animals
    57. Edelblum KL, Shen L, Weber CR, Marchiando AM, Clay BS, Wang Y, Prinz I, Malissen B, Sperling AI, Turner JR. Dynamic migration of ?d intraepithelial lymphocytes requires occludin. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):7097-102. PMID: 22511722; PMCID: PMC3345021.
      Citations: 92     Fields:    Translation:AnimalsCells
    58. Frantz AL, Rogier EW, Weber CR, Shen L, Cohen DA, Fenton LA, Bruno ME, Kaetzel CS. Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides. Mucosal Immunol. 2012 Sep; 5(5):501-12. PMID: 22491177; PMCID: PMC3422608.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    59. Qi W, Joshi S, Weber CR, Wali RK, Roy HK, Savkovic SD. Polyethylene glycol diminishes pathological effects of Citrobacter rodentium infection by blocking bacterial attachment to the colonic epithelia. Gut Microbes. 2011 Sep 01; 2(5):267-73. PMID: 22067938; PMCID: PMC3242793.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    60. Qi W, Weber CR, Wasland K, Savkovic SD. Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity. BMC Cancer. 2011 Jun 03; 11:219. PMID: 21639915; PMCID: PMC3134425.
      Citations: 49     Fields:    Translation:HumansCells
    61. Raleigh DR, Boe DM, Yu D, Weber CR, Marchiando AM, Bradford EM, Wang Y, Wu L, Schneeberger EE, Shen L, Turner JR. Occludin S408 phosphorylation regulates tight junction protein interactions and barrier function. J Cell Biol. 2011 May 02; 193(3):565-82. PMID: 21536752; PMCID: PMC3087007.
      Citations: 120     Fields:    Translation:HumansCells
    62. Shen L, Weber CR, Raleigh DR, Yu D, Turner JR. Tight junction pore and leak pathways: a dynamic duo. Annu Rev Physiol. 2011; 73:283-309. PMID: 20936941; PMCID: PMC4655434.
      Citations: 377     Fields:    Translation:HumansAnimalsCells
    63. Qi W, Weber CR, Wasland K, Roy H, Wali R, Joshi S, Savkovic SD. Tumor suppressor FOXO3 mediates signals from the EGF receptor to regulate proliferation of colonic cells. Am J Physiol Gastrointest Liver Physiol. 2011 Feb; 300(2):G264-72. PMID: 21109589; PMCID: PMC3043652.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    64. Lee G, Goretsky T, Managlia E, Dirisina R, Singh AP, Brown JB, May R, Yang GY, Ragheb JW, Evers BM, Weber CR, Turner JR, He XC, Katzman RB, Li L, Barrett TA. Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology. 2010 Sep; 139(3):869-81, 881.e1-9. PMID: 20580720; PMCID: PMC2930080.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    65. Yu D, Marchiando AM, Weber CR, Raleigh DR, Wang Y, Shen L, Turner JR. MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function. Proc Natl Acad Sci U S A. 2010 May 04; 107(18):8237-41. PMID: 20404178; PMCID: PMC2889526.
      Citations: 126     Fields:    Translation:HumansAnimalsCells
    66. Marchiando AM, Shen L, Graham WV, Weber CR, Schwarz BT, Austin JR, Raleigh DR, Guan Y, Watson AJ, Montrose MH, Turner JR. Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. J Cell Biol. 2010 Apr 05; 189(1):111-26. PMID: 20351069; PMCID: PMC2854371.
      Citations: 254     Fields:    Translation:AnimalsCells
    67. Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR. Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. J Biol Chem. 2010 Apr 16; 285(16):12037-46. PMID: 20177070; PMCID: PMC2852941.
      Citations: 148     Fields:    Translation:HumansAnimalsCells
    68. Snoeks L, Weber CR, Wasland K, Turner JR, Vainder C, Qi W, Savkovic SD. Tumor suppressor FOXO3 participates in the regulation of intestinal inflammation. Lab Invest. 2009 Sep; 89(9):1053-62. PMID: 19636295; PMCID: PMC3048782.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    69. Mukherjee A, Morosky SA, Shen L, Weber CR, Turner JR, Kim KS, Wang T, Coyne CB. Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions. J Biol Chem. 2009 Mar 06; 284(10):6486-94. PMID: 19122199; PMCID: PMC5405323.
      Citations: 31     Fields:    Translation:HumansCells
    70. Weber CR, Nalle SC, Tretiakova M, Rubin DT, Turner JR. Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab Invest. 2008 Oct; 88(10):1110-20. PMID: 18711353; PMCID: PMC2586671.
      Citations: 168     Fields:    Translation:HumansCells
    71. Snoeks L, Weber CR, Turner JR, Bhattacharyya M, Wasland K, Savkovic SD. Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells. Infect Immun. 2008 Oct; 76(10):4677-85. PMID: 18678662; PMCID: PMC2546851.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    72. Shen L, Weber CR, Turner JR. The tight junction protein complex undergoes rapid and continuous molecular remodeling at steady state. J Cell Biol. 2008 May 19; 181(4):683-95. PMID: 18474622; PMCID: PMC2386107.
      Citations: 171     Fields:    Translation:HumansAnimalsCells
    73. Sun Q, Weber CR, Sohail A, Bernardo MM, Toth M, Zhao H, Turner JR, Fridman R. MMP25 (MT6-MMP) is highly expressed in human colon cancer, promotes tumor growth, and exhibits unique biochemical properties. J Biol Chem. 2007 Jul 27; 282(30):21998-2010. PMID: 17513868; PMCID: PMC1978545.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    74. Weber CR, Turner JR. Inflammatory bowel disease: is it really just another break in the wall? Gut. 2007 Jan; 56(1):6-8. PMID: 17172583; PMCID: PMC1856658.
      Citations: 61     Fields:    Translation:HumansCells
    75. Jacobson DA, Weber CR, Bao S, Turk J, Philipson LH. Modulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyunsaturated fatty acid arachidonate. J Biol Chem. 2007 Mar 09; 282(10):7442-9. PMID: 17197450; PMCID: PMC2044499.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    76. Weber CR, Piacentino V, Houser SR, Bers DM. Dynamic regulation of sodium/calcium exchange function in human heart failure. Circulation. 2003 Nov 04; 108(18):2224-9. PMID: 14557358.
      Citations: 55     Fields:    Translation:HumansCells
    77. Weber CR, Ginsburg KS, Bers DM. Cardiac submembrane [Na+] transients sensed by Na+-Ca2+ exchange current. Circ Res. 2003 May 16; 92(9):950-2. PMID: 12702644.
      Citations: 14     Fields:    Translation:AnimalsCells
    78. Piacentino V, Weber CR, Chen X, Weisser-Thomas J, Margulies KB, Bers DM, Houser SR. Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res. 2003 Apr 04; 92(6):651-8. PMID: 12600875.
      Citations: 197     Fields:    Translation:HumansCells
    79. Ginsburg KS, Weber CR, Despa S, Bers DM. Simultaneous measurement of [Na]i, [Ca]i, and I(NCX) in intact cardiac myocytes. Ann N Y Acad Sci. 2002 Nov; 976:157-8. PMID: 12502556.
      Citations:    Fields:    Translation:Animals
    80. Piacentino V, Weber CR, Gaughan JP, Margulies KB, Bers DM, Houser SR. Modulation of contractility in failing human myocytes by reverse-mode Na/Ca exchange. Ann N Y Acad Sci. 2002 Nov; 976:466-71. PMID: 12502596.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    81. Bers DM, Weber CR. Na/Ca exchange function in intact ventricular myocytes. Ann N Y Acad Sci. 2002 Nov; 976:500-12. PMID: 12502604.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    82. Weber CR, Piacentino V, Margulies KB, Bers DM, Houser SR. Calcium influx via I(NCX) is favored in failing human ventricular myocytes. Ann N Y Acad Sci. 2002 Nov; 976:478-9. PMID: 12502599.
      Citations: 3     Fields:    Translation:HumansCells
    83. Despa S, Islam MA, Weber CR, Pogwizd SM, Bers DM. Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged. Circulation. 2002 May 28; 105(21):2543-8. PMID: 12034663.
      Citations: 142     Fields:    Translation:AnimalsCells
    84. Weber CR, Piacentino V, Ginsburg KS, Houser SR, Bers DM, Weber CR, Piacentino V, Ginsburg KS, Houser SR, Bers DM. Na(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential. Circ Res. 2002 Feb 08; 90(2):182-9. PMID: 11834711.
      Citations: 77     Fields:    Translation:AnimalsCells
    85. Weber CR, Ginsburg KS, Philipson KD, Shannon TR, Bers DM. Allosteric regulation of Na/Ca exchange current by cytosolic Ca in intact cardiac myocytes. J Gen Physiol. 2001 Feb; 117(2):119-31. PMID: 11158165; PMCID: PMC2217247.
      Citations: 64     Fields:    Translation:AnimalsCells
    86. Ginsburg KS, Weber CR, Bers DM. Control of maximum sarcoplasmic reticulum Ca load in intact ferret ventricular myocytes. Effects Of thapsigargin and isoproterenol. J Gen Physiol. 1998 Apr; 111(4):491-504. PMID: 9524134; PMCID: PMC2217121.
      Citations: 15     Fields:    Translation:AnimalsCells
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