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Lucia Rothman-Denes

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMolecular Genetics and Cell Biology
AddressChicago IL 60637
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    Collapse Biography 
    Collapse education and training
    School of Sciences, University of Buenos Aires, Buenos Aires, ArgentinaLicenciado1964Chemistry
    School of Sciences, University of Buenos Aires, Buenos Aires, ArgentinaPhD1967Biochemistry
    NIAMD, NIH, Bethesda, MD, USAnone1970Molecular Biology
    University of Chicago, Chicago, IL, USAnone1974Virology
    Collapse awards and honors
    1988Award for excellence in graduate teaching, University of Chicago
    1992elected fellow, American Academy of Microbiology
    2000elected fellow, American Association for the Advancement of Science
    2001elected member, American Academy of Arts and Sciences
    2014elected member, National Academy of Sciences, USA

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lenneman BR, Rothman-Denes LB. Structural and biochemical investigation of bacteriophage N4-encoded RNA polymerases. Biomolecules. 2015 Apr 27; 5(2):647-67. PMID: 25924224.
      View in: PubMed
    2. Rothman-Denes LB. Structure of Escherichia coli RNA polymerase holoenzyme at last. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):19662-3. PMID: 24272941.
      View in: PubMed
    3. Gleghorn ML, Davydova EK, Basu R, Rothman-Denes LB, Murakami KS. X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides. Proc Natl Acad Sci U S A. 2011 Mar 01; 108(9):3566-71. PMID: 21321236.
      View in: PubMed
    4. Yano ST, Rothman-Denes LB. A phage-encoded inhibitor of Escherichia coli DNA replication targets the DNA polymerase clamp loader. Mol Microbiol. 2011 Mar; 79(5):1325-38. PMID: 21205014.
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    5. Gleghorn ML, Davydova EK, Rothman-Denes LB, Murakami KS. Structural basis for DNA-hairpin promoter recognition by the bacteriophage N4 virion RNA polymerase. Mol Cell. 2008 Dec 05; 32(5):707-17. PMID: 19061645.
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    6. Davydova EK, Kaganman I, Kazmierczak KM, Rothman-Denes LB. Identification of bacteriophage N4 virion RNA polymerase-nucleic acid interactions in transcription complexes. J Biol Chem. 2009 Jan 23; 284(4):1962-70. PMID: 19015264.
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    7. McPartland J, Rothman-Denes LB. The tail sheath of bacteriophage N4 interacts with the Escherichia coli receptor. J Bacteriol. 2009 Jan; 191(2):525-32. PMID: 19011026.
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    8. Murakami KS, Davydova EK, Rothman-Denes LB. X-ray crystal structure of the polymerase domain of the bacteriophage N4 virion RNA polymerase. Proc Natl Acad Sci U S A. 2008 Apr 01; 105(13):5046-51. PMID: 18362338.
      View in: PubMed
    9. Rothman-Denes LB, Parsot C. Cell regulation. Curr Opin Microbiol. 2008 Apr; 11(2):75-7. PMID: 18358764.
      View in: PubMed
    10. Choi KH, McPartland J, Kaganman I, Bowman VD, Rothman-Denes LB, Rossmann MG. Insight into DNA and protein transport in double-stranded DNA viruses: the structure of bacteriophage N4. J Mol Biol. 2008 May 02; 378(3):726-36. PMID: 18374942.
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    11. Davydova EK, Santangelo TJ, Rothman-Denes LB. Bacteriophage N4 virion RNA polymerase interaction with its promoter DNA hairpin. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7033-8. PMID: 17438270.
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    12. Stojkovic EA, Rothman-Denes LB. Coliphage N4 N-acetylmuramidase defines a new family of murein hydrolases. J Mol Biol. 2007 Feb 16; 366(2):406-19. PMID: 17174325.
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    13. Altman S, Bassler BL, Beckwith J, Belfort M, Berg HC, Bloom B, Brenchley JE, Campbell A, Collier RJ, Connell N, Cozzarelli NR, Craig NL, Darst S, Ebright RH, Elledge SJ, Falkow S, Galan JE, Gottesman M, Gourse R, Grindley ND, Gross CA, Grossman A, Hochschild A, Howe M, Hurwitz J, Isberg RR, Kaplan S, Kornberg A, Kustu SG, Landick RC, Landy A, Levy SB, Losick R, Long SR, Maloy SR, Mekalanos JJ, Neidhardt FC, Pace NR, Ptashne M, Roberts JW, Roth JR, Rothman-Denes LB, Salyers A, Schaechter M, Shapiro L, Silhavy TJ, Simon MI, Walker G, Yanofsky C, Zinder N. An open letter to Elias Zerhouni. Science. 2005 Mar 04; 307(5714):1409-10. PMID: 15746409.
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    14. Carter RH, Demidenko AA, Hattingh-Willis S, Rothman-Denes LB. Phage N4 RNA polymerase II recruitment to DNA by a single-stranded DNA-binding protein. Genes Dev. 2003 Sep 15; 17(18):2334-45. PMID: 12975320.
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    15. Davydova EK, Rothman-Denes LB. Escherichia coli single-stranded DNA-binding protein mediates template recycling during transcription by bacteriophage N4 virion RNA polymerase. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9250-5. PMID: 12876194.
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    16. Davydova EK, Kazmierczak KM, Rothman-Denes LB. Bacteriophage N4-coded, virion-encapsulated DNA-dependent RNA polymerase. Methods Enzymol. 2003; 370:83-94. PMID: 14712636.
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    17. Kazmierczak KM, Davydova EK, Mustaev AA, Rothman-Denes LB. The phage N4 virion RNA polymerase catalytic domain is related to single-subunit RNA polymerases. EMBO J. 2002 Nov 01; 21(21):5815-23. PMID: 12411499.
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    18. Willis SH, Kazmierczak KM, Carter RH, Rothman-Denes LB. N4 RNA polymerase II, a heterodimeric RNA polymerase with homology to the single-subunit family of RNA polymerases. J Bacteriol. 2002 Sep; 184(18):4952-61. PMID: 12193610.
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    19. Van Dyk TK, Wei Y, Hanafey MK, Dolan M, Reeve MJ, Rafalski JA, Rothman-Denes LB, LaRossa RA. A genomic approach to gene fusion technology. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2555-60. PMID: 11226277.
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    20. Dai X, Rothman-Denes LB. DNA structure and transcription. Curr Opin Microbiol. 1999 Apr; 2(2):126-30. PMID: 10322174.
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    21. Dai X, Rothman-Denes LB. Sequence and DNA structural determinants of N4 virion RNA polymerase-promoter recognition. Genes Dev. 1998 Sep 01; 12(17):2782-90. PMID: 9732275.
      View in: PubMed
    22. Rothman-Denes LB, Dai X, Davydova E, Carter R, Kazmierczak K. Transcriptional regulation by DNA structural transitions and single-stranded DNA-binding proteins. Cold Spring Harb Symp Quant Biol. 1998; 63:63-73. PMID: 10384271.
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    23. Dai X, Kloster M, Rothman-Denes LB. Sequence-dependent extrusion of a small DNA hairpin at the N4 virion RNA polymerase promoters. J Mol Biol. 1998; 283(1):43-58. PMID: 9761672.
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    24. Dai X, Greizerstein MB, Nadas-Chinni K, Rothman-Denes LB. Supercoil-induced extrusion of a regulatory DNA hairpin. Proc Natl Acad Sci U S A. 1997 Mar 18; 94(6):2174-9. PMID: 9122167.
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    25. Miller A, Wood D, Ebright RH, Rothman-Denes LB. RNA polymerase beta' subunit: a target of DNA binding-independent activation. Science. 1997 Mar 14; 275(5306):1655-7. PMID: 9054361.
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    26. Glucksmann-Kuis MA, Dai X, Markiewicz P, Rothman-Denes LB. E. coli SSB activates N4 virion RNA polymerase promoters by stabilizing a DNA hairpin required for promoter recognition. Cell. 1996 Jan 12; 84(1):147-54. PMID: 8548819.
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    27. Miller A, Dai X, Choi M, Glucksmann-Kuis MA, Rothman-Denes LB. Single-stranded DNA-binding proteins as transcriptional activators. Methods Enzymol. 1996; 274:9-20. PMID: 8902792.
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    28. Choi M, Miller A, Cho NY, Rothman-Denes LB. Identification, cloning, and characterization of the bacteriophage N4 gene encoding the single-stranded DNA-binding protein. A protein required for phage replication, recombination, and late transcription. J Biol Chem. 1995 Sep 22; 270(38):22541-7. PMID: 7673246.
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    29. Cho NY, Choi M, Rothman-Denes LB. The bacteriophage N4-coded single-stranded DNA-binding protein (N4SSB) is the transcriptional activator of Escherichia coli RNA polymerase at N4 late promoters. J Mol Biol. 1995 Mar 03; 246(4):461-71. PMID: 7877167.
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    30. Kiino DR, Singer MS, Rothman-Denes LB. Two overlapping genes encoding membrane proteins required for bacteriophage N4 adsorption. J Bacteriol. 1993 Nov; 175(21):7081-5. PMID: 8226649.
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    31. Kiino DR, Licudine R, Wilt K, Yang DH, Rothman-Denes LB. A cytoplasmic protein, NfrC, is required for bacteriophage N4 adsorption. J Bacteriol. 1993 Nov; 175(21):7074-80. PMID: 8226648.
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    32. Markiewicz P, Malone C, Chase JW, Rothman-Denes LB. Escherichia coli single-stranded DNA-binding protein is a supercoiled template-dependent transcriptional activator of N4 virion RNA polymerase. Genes Dev. 1992 Oct; 6(10):2010-9. PMID: 1383090.
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    33. Glucksmann MA, Markiewicz P, Malone C, Rothman-Denes LB. Specific sequences and a hairpin structure in the template strand are required for N4 virion RNA polymerase promoter recognition. Cell. 1992 Aug 07; 70(3):491-500. PMID: 1643660.
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    34. Abravaya K, Rothman-Denes LB. N4 RNA polymerase II sites of transcription initiation. J Mol Biol. 1990 Jan 20; 211(2):359-72. PMID: 2407852.
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    35. Kiino DR, Rothman-Denes LB. Genetic analysis of bacteriophage N4 adsorption. J Bacteriol. 1989 Sep; 171(9):4595-602. PMID: 2670887.
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    36. Lindberg G, Kowalczykowski SC, Rist JK, Sugino A, Rothman-Denes LB. Purification and characterization of the coliphage N4-coded single-stranded DNA binding protein. J Biol Chem. 1989 Jul 25; 264(21):12700-8. PMID: 2663866.
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    37. Abravaya K, Rothman-Denes LB. In vitro requirements for N4 RNA polymerase II-specific initiation. J Biol Chem. 1989 Jul 25; 264(21):12695-9. PMID: 2663865.
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    38. Hartmann GR, Biebricher C, Glaser SJ, Grosse F, Katzameyer MJ, Lindner AJ, Mosig H, Nasheuer HP, Rothman-Denes LB, Schäffner AR, et al. Twelfth Fritz Lipmann lecture. Initiation of transcription--a general tool for affinity labeling of RNA polymerases by autocatalysis. Biol Chem Hoppe Seyler. 1988 Sep; 369(9):775-88. PMID: 3067733.
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    39. Lindberg GK, Rist JK, Kunkel TA, Sugino A, Rothman-Denes LB. Purification and characterization of bacteriophage N4-induced DNA polymerase. J Biol Chem. 1988 Aug 15; 263(23):11319-26. PMID: 3403528.
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    40. Ohmori H, Haynes LL, Rothman-Denes LB. Structure of the ends of the coliphage N4 genome. J Mol Biol. 1988 Jul 05; 202(1):1-10. PMID: 3172206.
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    41. Markiewicz P, Glucksmann A, Rothman-Denes LB. N4 virion DNA dependent-RNA polymerase: initiation sequences utilized by the enzyme on heterologous templates. Nucleic Acids Res. 1988 Feb 11; 16(3):1011-26. PMID: 3344199.
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    42. Malone C, Spellman S, Hyman D, Rothman-Denes LB. Cloning and generation of a genetic map of bacteriophage N4 DNA. Virology. 1988 Feb; 162(2):328-36. PMID: 3341115.
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    43. Muglia L, Rothman-Denes LB. Cell type-specific negative regulatory element in the control region of the rat alpha-fetoprotein gene. Proc Natl Acad Sci U S A. 1986 Oct; 83(20):7653-7. PMID: 2429314.
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    44. Guinta D, Lindberg G, Rothman-Denes LB. Bacteriophage N4-coded 5'----3' exonuclease. Purification and characterization. J Biol Chem. 1986 Aug 15; 261(23):10736-43. PMID: 3525553.
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    45. Rist JK, Pearle M, Sugino A, Rothman-Denes LB. Development of an in vitro bacteriophage N4 DNA replication system. J Biol Chem. 1986 Aug 15; 261(23):10506-10. PMID: 3525547.
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    46. Guinta D, Stambouly J, Falco SC, Rist JK, Rothman-Denes LB. Host and phage-coded functions required for coliphage N4 DNA replication. Virology. 1986 Apr 15; 150(1):33-44. PMID: 3006344.
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    47. Haynes LL, Rothman-Denes LB. N4 virion RNA polymerase sites of transcription initiation. Cell. 1985 Jun; 41(2):597-605. PMID: 3986911.
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    48. Zehring WA, Rothman-Denes LB. Purification and characterization of coliphage N4 RNA polymerase II activity from infected cell extracts. J Biol Chem. 1983 Jul 10; 258(13):8074-80. PMID: 6345539.
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    49. Zehring WA, Falco SC, Malone C, Rothman-Denes LB. Bacteriophage N4-induced transcribing activities in E. coli. III. A third cistron required for N4 RNA polymerase II activity. Virology. 1983 Apr 30; 126(2):678-87. PMID: 6344415.
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    50. Rothman-Denes L. Transposons. Science. 1982 Jan 01; 215(4528):52-3. PMID: 17790464.
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    51. Zivin R, Zehring W, Rothman-Denes LB. Transcriptional map of bacteriophage N4. Location and polarity of N4 RNAs. J Mol Biol. 1981 Oct 25; 152(2):335-56. PMID: 6276570.
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    52. Zivin R, Malone C, Rothman-Denes LB. Physical map of coliphage N4 DNA. Virology. 1980 Jul 15; 104(1):205-18. PMID: 6249023.
      View in: PubMed
    53. Falco SC, Zehring W, Rothman-Denes LB. DNA-dependent RNA polymerase from bacteriophage N4 virions. Purification and characterization. J Biol Chem. 1980 May 10; 255(9):4339-47. PMID: 6989837.
      View in: PubMed
    54. Falco SC, Rothman-Denes LB. Bacteriophage N4-induced transcribing activities in Escherichia coli. I. Detection and characterization in cell extracts. Virology. 1979 Jun; 95(2):454-65. PMID: 380137.
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    55. Falco SC, Rothman-Denes LB. Bacteriophage N4-induced transcribing activities in Escherichia coli. II. Association of the N4 transcriptional apparatus with the cytoplasmic membrane. Virology. 1979 Jun; 95(2):466-75. PMID: 380138.
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    56. Falco SC, Zivin R, Rothman-Denes LB. Novel template requirements of N4 virion RNA polymerase. Proc Natl Acad Sci U S A. 1978 Jul; 75(7):3220-4. PMID: 356050.
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    57. vander Laan K, Falco SC, Rothman-Denes LB. The program of RNA synthesis in N4-infected Escherichia coli. Virology. 1977 Feb; 76(2):596-601. PMID: 320753.
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    58. Falco SC, Laan KV, Rothman-Denes LB. Virion-associated RNA polymerase required for bacteriophage N4 development. Proc Natl Acad Sci U S A. 1977 Feb; 74(2):520-3. PMID: 322130.
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    59. Hesse JE, Rothman-Denes LB, Epstein W. A convenient erythrocyte membrane cyclic AMP binding assay. Anal Biochem. 1975 Sep; 68(1):202-8. PMID: 171971.
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    60. Epstein W, Rothman-Denes LB, Hesse J. Adenosine 3':5'-cyclic monophosphate as mediator of catabolite repression in Escherichia coli. Proc Natl Acad Sci U S A. 1975 Jun; 72(6):2300-4. PMID: 166384.
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    61. Rothman-Denes LB, Schito GC. Novel transcribing activities in N4-infected Escherichia coli. Virology. 1974 Jul; 60(1):65-72. PMID: 4601458.
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    62. Rothman-Denes LB, Hesse JE, Epstein W. Role of cyclic adenosine 3',5'-monophosphate in the in vivo expression of the galactose operon of Escherichia coli. J Bacteriol. 1973 Jun; 114(3):1040-4. PMID: 4351384.
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    63. Cabib E, Rothman-Denes LB, Huang K. The regulation of glycogen synthesis in yeast. Ann N Y Acad Sci. 1973 Feb 09; 210:192-206. PMID: 4270090.
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    64. Haselkorn R, Rothman-Denes LB. Protein synthesis. Annu Rev Biochem. 1973; 42:397-438. PMID: 4581230.
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    65. Rothman-Denes LB, Haselkorn R, Schito GC. Selective shutoff of catabolite-sensitive host syntheses by bacroxyurea pharmaco mutation genes coliphages growth l virus replication escherichia coli growth l lysogeny crosses genetic coliteriophage N4. Virology. 1972 Oct; 50(1):95-102. PMID: 4343116.
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    66. Rothman-Denes L, Martin RG. Two mutations in the first gene of the histidine operon of Salmonella typhimurium affecting control. J Bacteriol. 1971 Apr; 106(1):227-37. PMID: 4928009.
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    67. Rothman-Denes LB, Cabib E. Glucose 6-phosphate dependent and independent forms of yeast glycogen synthetase. Their properties and interconversions. Biochemistry. 1971 Mar 30; 10(7):1236-42. PMID: 5553327.
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    68. Rothman-Denes LB, Cabib E. Two forms of yeast glycogen synthetase and their role in glycogen accumulation. Proc Natl Acad Sci U S A. 1970 Jul; 66(3):967-74. PMID: 4987630.
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