Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity.

Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):321-9.

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subject areas

Animals
Cells, Cultured
Endothelial Cells
Enzyme Activation
Gene Expression Regulation
Human Umbilical Vein Endothelial Cells
Humans
Inflammation
Inflammation Mediators
Intracellular Signaling Peptides and Proteins
Kruppel-Like Transcription Factors
Leukocyte Rolling
Mice
Mice, Inbred C57BL
NF-kappa B
Nitric Oxide Synthase Type III
Phosphorylation
Protein Inhibitors of Activated STAT
RNA Interference
Skin
Skin Transplantation
Small Ubiquitin-Related Modifier Proteins
Sumoylation
Time Factors
Transfection
Transplantation, Autologous
Tumor Necrosis Factor-alpha
Tumor Suppressor Protein p53
Ubiquitin-Protein Ligases

authors with profiles

Eugene B. Chang