"Phencyclidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.
| Descriptor ID |
D010622
|
| MeSH Number(s) |
D03.383.621.699
|
| Concept/Terms |
Phencyclidine- Phencyclidine
- 1-(1-Phenylcyclohexyl)piperidine
- Angel Dust
- Dust, Angel
|
Below are MeSH descriptors whose meaning is more general than "Phencyclidine".
Below are MeSH descriptors whose meaning is more specific than "Phencyclidine".
This graph shows the total number of publications written about "Phencyclidine" by people in this website by year, and whether "Phencyclidine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Phencyclidine" by people in Profiles.
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Hippocampal GABAA antagonism reverses the novel object recognition deficit in sub-chronic phencyclidine-treated rats. Behav Brain Res. 2018 04 16; 342:11-18.
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Muscarinic receptor signaling contributes to atypical antipsychotic drug reversal of the phencyclidine-induced deficit in novel object recognition in rats. J Psychopharmacol. 2017 12; 31(12):1588-1604.
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?9-tetrahydrocannabinol (?9-THC) administration after neonatal exposure to phencyclidine potentiates schizophrenia-related behavioral phenotypes in mice. Pharmacol Biochem Behav. 2017 08; 159:6-11.
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Dopamine D4 receptor stimulation contributes to novel object recognition: Relevance to cognitive impairment in schizophrenia. J Psychopharmacol. 2017 04; 31(4):442-452.
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Nicotinic receptors and lurasidone-mediated reversal of phencyclidine-induced deficit in novel object recognition. Behav Brain Res. 2016 Mar 15; 301:204-12.
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Prolonged reversal of the phencyclidine-induced impairment in novel object recognition by a serotonin (5-HT)1A-dependent mechanism. Behav Brain Res. 2016 Mar 15; 301:132-41.
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Primate phencyclidine model of schizophrenia: sex-specific effects on cognition, brain derived neurotrophic factor, spine synapses, and dopamine turnover in prefrontal cortex. Int J Neuropsychopharmacol. 2014 Oct 31; 18(6).
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Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration. Neuropharmacology. 2012 Mar; 62(3):1442-52.
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Psychopharmacology of prepulse inhibition in mice. Chin J Physiol. 1996; 39(3):139-46.
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Behavioral dependence on caffeine and phencyclidine in rhesus monkeys: interactive effects. Pharmacol Biochem Behav. 1988 Dec; 31(4):927-32.