Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis.

Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis. Circ Res. 2020 06 05; 126(12):1723-1745.

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subject areas

Animals
Cells, Cultured
DNA (Cytosine-5-)-Methyltransferase 1
Epigenesis, Genetic
Fibrosis
Heart Ventricles
Hypertension, Pulmonary
Hypoxia-Inducible Factor 1, alpha Subunit
Male
Mitochondria, Heart
Mitochondrial Dynamics
Monocrotaline
Myofibroblasts
Rats
Rats, Sprague-Dawley
Transforming Growth Factor beta

authors with profiles

Stephen Archer