Pre-B-Cell Leukemia Transcription Factor 1
"Pre-B-Cell Leukemia Transcription Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A TALE-type homeodomain protein and transcription factor that binds the DNA sequence 5'-ATCAATCAA-3'. It forms a heterodimer with MEIS1 TRANSCRIPTION FACTOR and functions as a transcriptional activator of HOMEOBOX PROTEIN NKX-2.5 and ELONGIN A, and as a transcriptional repressor of CDKN2B PROTEIN, in the regulation of developmental and morphogenetic processes such as spleen and limb development. Chromosome translocations involving the PBX1 and TCF3 genes occur in cases of pre-B-cell ACUTE LYMPHOID LEUKEMIA.
| Descriptor ID |
D000075062
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| MeSH Number(s) |
D12.776.260.400.836 D12.776.624.664.700.163 D12.776.930.712
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| Concept/Terms |
Pre-B-Cell Leukemia Transcription Factor 1- Pre-B-Cell Leukemia Transcription Factor 1
- Pre B Cell Leukemia Transcription Factor 1
- PBX1 Homeobox Protein
- Homeobox Protein, PBX1
- Pre-B-Cell Leukemia Homeobox 1 Protein
- Pre B Cell Leukemia Homeobox 1 Protein
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This graph shows the total number of publications written about "Pre-B-Cell Leukemia Transcription Factor 1" by people in this website by year, and whether "Pre-B-Cell Leukemia Transcription Factor 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
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Below are the most recent publications written about "Pre-B-Cell Leukemia Transcription Factor 1" by people in Profiles.
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PBX3 is an important cofactor of HOXA9 in leukemogenesis. Blood. 2013 Feb 21; 121(8):1422-31.
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Deregulation of a Hox protein regulatory network spanning prostate cancer initiation and progression. Clin Cancer Res. 2012 Aug 15; 18(16):4291-302.
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Fibroblast growth factor-8 expression is regulated by intronic engrailed and Pbx1-binding sites. J Biol Chem. 1999 Feb 26; 274(9):6020-6.