Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
"Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcriptional co-activator for NUCLEAR RECEPTORS. It is characterized by an N-terminal LxxLL sequence, a region that interacts with PPAR GAMMA, and a C-terminal RNA RECOGNITION MOTIF. It increases expression of MITOCHONDRIAL UNCOUPLING PROTEIN to regulate genes involved in metabolic reprogramming in response to dietary restriction and the integration of CIRCADIAN RHYTHMS with ENERGY METABOLISM.
| Descriptor ID |
D000071248
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| MeSH Number(s) |
D12.644.360.024.314.650 D12.776.157.057.080.650 D12.776.157.725.813.875 D12.776.476.024.394.650 D12.776.660.675.650 D12.776.664.962.813.875 D12.776.930.617.650
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha".
Below are MeSH descriptors whose meaning is more specific than "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha".
This graph shows the total number of publications written about "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" by people in this website by year, and whether "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 2 | 2 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha" by people in Profiles.
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Tartary Buckwheat Extract Attenuated the Obesity-Induced Inflammation and Increased Muscle PGC-1a/SIRT1 Expression in High Fat Diet-Induced Obese Rats. Nutrients. 2019 Mar 18; 11(3).
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Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. Nat Med. 2018 01; 24(1):39-49.
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AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species. Cell Rep. 2017 Oct 03; 21(1):1-9.
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Thyroid hormone activation by type 2 deiodinase mediates exercise-induced peroxisome proliferator-activated receptor-? coactivator-1a expression in skeletal muscle. J Physiol. 2016 09 15; 594(18):5255-69.
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Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats. Nutrients. 2015 Sep 22; 7(9):8152-69.
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Cardioprotective Signature of Short-Term Caloric Restriction. PLoS One. 2015; 10(6):e0130658.
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The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation. J Clin Invest. 2014 Jun; 124(6):2640-50.
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Endothelial PGC-1a mediates vascular dysfunction in diabetes. Cell Metab. 2014 Feb 04; 19(2):246-58.
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The role of thyroid hormone and brown adipose tissue in energy homoeostasis. Lancet Diabetes Endocrinol. 2013 Nov; 1(3):250-8.
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PGC1a-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension. Am J Respir Crit Care Med. 2013 Apr 15; 187(8):865-78.