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Raymond E Moellering

TitleAssociate Professor
InstitutionUniversity of Chicago
AddressChicago IL 60637
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    DP2GM128199     (MOELLERING, RAYMOND E)Sep 30, 2017 - May 31, 2022
    Targeting Transcription with Synthetic Biologics
    Role: Principal Investigator

    R00CA175399     (MOELLERING, RAYMOND E)Aug 7, 2015 - Jul 31, 2018
    Distribution, regulation and function of a novel lysine PTM in metabolic disease
    Role: Principal Investigator

    K99CA175399     (MOELLERING, RAYMOND E)Aug 1, 2014 - Mar 15, 2015
    Distribution, regulation and function of a novel lysine PTM in metabolic disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Coukos JS, Lee CW, Pillai KS, Shah H, Moellering RE. PARK7 Catalyzes Stereospecific Detoxification of Methylglyoxal Consistent with Glyoxalase and Not Deglycase Function. Biochemistry. 2023 11 07; 62(21):3126-3133. PMID: 37884446; PMCID: PMC10634309.
      Citations:    Fields:    Translation:Humans
    2. Stein BD, Ferrarone JR, Gardner EE, Chang JW, Wu D, Hollstein PE, Liang RJ, Yuan M, Chen Q, Coukos JS, Sindelar M, Ngo B, Gross SS, Shaw RJ, Zhang C, Asara JM, Moellering RE, Varmus H, Cantley LC. LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma. Cancer Discov. 2023 04 03; 13(4):1002-1025. PMID: 36715544; PMCID: PMC10068449.
      Citations: 2     Fields:    Translation:HumansAnimals
    3. Swenson CS, Pillai KS, Carlos AJ, Moellering RE. Spatial Chemoproteomics for Mapping the Active Proteome. Isr J Chem. 2023 Mar; 63(3-4). PMID: 38046285; PMCID: PMC10688764.
    4. Coukos JS, Lee CW, Pillai KS, Liu KJ, Moellering RE. Widespread, Reversible Cysteine Modification by Methylglyoxal Regulates Metabolic Enzyme Function. ACS Chem Biol. 2023 01 20; 18(1):91-101. PMID: 36562291; PMCID: PMC9872086.
      Citations: 3     Fields:    
    5. Speltz TE, Qiao Z, Swenson CS, Shangguan X, Coukos JS, Lee CW, Thomas DM, Santana J, Fanning SW, Greene GL, Moellering RE. Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains. Nat Biotechnol. 2023 04; 41(4):541-551. PMID: 36302987; PMCID: PMC10392954.
      Citations: 3     Fields:    Translation:Cells
    6. Nguyen LC, Renner DM, Silva D, Yang D, Parenti NA, Medina KM, Nicolaescu V, Gula H, Drayman N, Valdespino A, Mohamed A, Dann C, Wannemo K, Robinson-Mailman L, Gonzalez A, Cao M, Qiao Z, Moellering RE, Tay S, Randall G, Beers MF, Rosner MR, Oakes SA, Weiss SR, Stock L. SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells. mBio. 2022 10 26; 13(5):e0241522. PMID: 36125275; PMCID: PMC9600248.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    7. Nguyen LC, Renner DM, Silva D, Yang D, Parenti N, Medina KM, Nicolaescu V, Gula H, Drayman N, Valdespino A, Mohamed A, Dann C, Wannemo K, Robinson-Mailman L, Gonzalez A, Cao M, Qiao Z, Moellering RE, Tay S, Randall G, Beers MF, Rosner MR, Oakes SA, Weiss SR, Stock L. SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1a/XBP1 ER stress pathway in human lung-derived cells. bioRxiv. 2022 Jun 13. PMID: 35821981; PMCID: PMC9275661.
    8. Montgomery JE, Moellering RE. Diels-Alder Cycloadditions for Peptide Macrocycle Formation. Methods Mol Biol. 2022; 2371:159-174. PMID: 34596848.
      Citations:    Fields:    Translation:Cells
    9. Coukos JS, Moellering RE. Methylglyoxal Forms Diverse Mercaptomethylimidazole Crosslinks with Thiol and Guanidine Pairs in Endogenous Metabolites and Proteins. ACS Chem Biol. 2021 11 19; 16(11):2453-2461. PMID: 34581579; PMCID: PMC8609522.
      Citations: 4     Fields:    Translation:HumansCells
    10. Huang JX, Wu D, Stein BD, Moellering RE. Huang et al. reply. Nat Methods. 2021 07; 18(7):763-767. PMID: 34140701.
      Citations: 1     Fields:    
    11. Huang JX, Coukos JS, Moellering RE. Corrigendum to "Interaction profiling methods to map protein and pathway targets of bioactive ligands", [Curr Opin Chem Biol 54 (February 2020) 76-84]. Curr Opin Chem Biol. 2021 Aug; 63:230. PMID: 33223432.
      Citations:    Fields:    
    12. Speltz TE, Moellering RE. Protein targeting with SAF(er) electrophiles. Nat Chem. 2020 10; 12(10):885-887. PMID: 32978603.
      Citations: 1     Fields:    Translation:Cells
    13. Chang JW, Bhuiyan M, Tsai HM, Zhang HJ, Li G, Fathi S, McCutcheon DC, Leoni L, Freifelder R, Chen CT, Moellering RE. In Vivo Imaging of the Tumor-Associated Enzyme NCEH1 with a Covalent PET Probe. Angew Chem Int Ed Engl. 2020 08 24; 59(35):15161-15165. PMID: 32415874; PMCID: PMC7748380.
      Citations: 7     Fields:    Translation:HumansAnimals
    14. Huang JX, Coukos JS, Moellering RE. Interaction profiling methods to map protein and pathway targets of bioactive ligands. Curr Opin Chem Biol. 2020 02; 54:76-84. PMID: 32146330; PMCID: PMC7745198.
      Citations: 2     Fields:    
    15. Moellering RE. Editorial Overview: Tracking the ties that bind: Emerging technologies to profile biomolecular interactions in native environments. Curr Opin Chem Biol. 2020 02; 54:A1-A4. PMID: 32245537.
      Citations:    Fields:    Translation:Humans
    16. McCutcheon DC, Lee G, Carlos A, Montgomery JE, Moellering RE. Photoproximity Profiling of Protein-Protein Interactions in Cells. J Am Chem Soc. 2020 01 08; 142(1):146-153. PMID: 31820968; PMCID: PMC7484951.
      Citations: 11     Fields:    Translation:HumansCells
    17. Li G, Eckert MA, Chang JW, Montgomery JE, Chryplewicz A, Lengyel E, Moellering RE. Ultrasensitive, multiplexed chemoproteomic profiling with soluble activity-dependent proximity ligation. Proc Natl Acad Sci U S A. 2019 10 22; 116(43):21493-21500. PMID: 31591248; PMCID: PMC6815137.
      Citations: 6     Fields:    Translation:HumansCells
    18. Montgomery JE, Donnelly JA, Fanning SW, Speltz TE, Shangguan X, Coukos JS, Greene GL, Moellering RE. Versatile Peptide Macrocyclization with Diels-Alder Cycloadditions. J Am Chem Soc. 2019 10 16; 141(41):16374-16381. PMID: 31523967; PMCID: PMC7745206.
      Citations: 11     Fields:    Translation:Cells
    19. Huang JX, Lee G, Cavanaugh KE, Chang JW, Gardel ML, Moellering RE. High throughput discovery of functional protein modifications by Hotspot Thermal Profiling. Nat Methods. 2019 09; 16(9):894-901. PMID: 31384043; PMCID: PMC7238970.
      Citations: 40     Fields:    Translation:HumansCells
    20. Chang JW, Moellering RE. No Bones About It: Small Molecules for Bone Regeneration. Cell Chem Biol. 2019 07 18; 26(7):911-912. PMID: 31323220.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    21. Li G, Moellering RE. Chemical probes for spatially resolved measurement of active enzymes in single cells. Methods Enzymol. 2019; 628:243-262. PMID: 31668232; PMCID: PMC7745195.
      Citations: 2     Fields:    Translation:HumansCells
    22. Li G, Moellering RE. A Concise, Modular Antibody-Oligonucleotide Conjugation Strategy Based on Disuccinimidyl Ester Activation Chemistry. Chembiochem. 2019 06 14; 20(12):1599-1605. PMID: 30767357; PMCID: PMC6773266.
      Citations: 9     Fields:    
    23. Eckert MA, Coscia F, Chryplewicz A, Chang JW, Hernandez KM, Pan S, Tienda SM, Nahotko DA, Li G, Lastra RR, Curtis M, Yamada SD, Perets R, McGregor SM, Andrade J, Fiehn O, Moellering RE, Mann M, Lengyel E, Blaženovic I. Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts. Nature. 2019 05; 569(7758):723-728. PMID: 31043742; PMCID: PMC6690743.
      Citations: 185     Fields:    Translation:HumansCells
    24. Chang JW, Montgomery JE, Lee G, Moellering RE. Chemoproteomic Profiling of Phosphoaspartate Modifications in Prokaryotes. Angew Chem Int Ed Engl. 2018 11 26; 57(48):15712-15716. PMID: 30231186; PMCID: PMC6760989.
      Citations: 9     Fields:    Translation:Cells
    25. Bollong MJ, Lee G, Coukos JS, Yun H, Zambaldo C, Chang JW, Chin EN, Ahmad I, Chatterjee AK, Lairson LL, Schultz PG, Moellering RE. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling. Nature. 2018 10; 562(7728):600-604. PMID: 30323285; PMCID: PMC6444936.
      Citations: 110     Fields:    Translation:HumansAnimalsCells
    26. Yang H, Swartz AM, Park HJ, Srivastava P, Ellis-Guardiola K, Upp DM, Lee G, Belsare K, Gu Y, Zhang C, Moellering RE, Lewis JC. Evolving artificial metalloenzymes via random mutagenesis. Nat Chem. 2018 03; 10(3):318-324. PMID: 29461523; PMCID: PMC5891097.
      Citations: 26     Fields:    Translation:Cells
    27. Li G, Montgomery JE, Eckert MA, Chang JW, Tienda SM, Lengyel E, Moellering RE. An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells. Nat Commun. 2017 11 24; 8(1):1775. PMID: 29176560; PMCID: PMC5701173.
      Citations: 11     Fields:    Translation:HumansCells
    28. KleinJan A, Tindemans I, Montgomery JE, Lukkes M, de Bruijn MJW, van Nimwegen M, Bergen I, Moellering RE, Hoogsteden HC, Boon L, Amsen D, Hendriks RW. The Notch pathway inhibitor stapled a-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma. J Allergy Clin Immunol. 2018 07; 142(1):76-85.e8. PMID: 29111218; PMCID: PMC7488091.
      Citations: 14     Fields:    Translation:Animals
    29. Mitra S, Montgomery JE, Kolar MJ, Li G, Jeong KJ, Peng B, Verdine GL, Mills GB, Moellering RE. Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer. Nat Commun. 2017 09 22; 8(1):660. PMID: 28939823; PMCID: PMC5610242.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    30. Chang JW, Lee G, Coukos JS, Moellering RE. Profiling Reactive Metabolites via Chemical Trapping and Targeted Mass Spectrometry. Anal Chem. 2016 07 05; 88(13):6658-61. PMID: 27314642; PMCID: PMC4998964.
      Citations: 10     Fields:    Translation:HumansCells
    31. Moellering RE, Cravatt BF. Functional lysine modification by an intrinsically reactive primary glycolytic metabolite. Science. 2013 Aug 02; 341(6145):549-53. PMID: 23908237; PMCID: PMC4005992.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    32. Grossmann TN, Yeh JT, Bowman BR, Chu Q, Moellering RE, Verdine GL. Inhibition of oncogenic Wnt signaling through direct targeting of ß-catenin. Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44):17942-7. PMID: 23071338; PMCID: PMC3497784.
      Citations: 99     Fields:    Translation:HumansCells
    33. Moellering RE, Cravatt BF. How chemoproteomics can enable drug discovery and development. Chem Biol. 2012 Jan 27; 19(1):11-22. PMID: 22284350; PMCID: PMC3312051.
      Citations: 55     Fields:    Translation:Humans
    34. Chang JW, Moellering RE, Cravatt BF. An activity-based imaging probe for the integral membrane hydrolase KIAA1363. Angew Chem Int Ed Engl. 2012 Jan 23; 51(4):966-70. PMID: 22162147; PMCID: PMC3425385.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    35. Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, Bradner JE. Direct inhibition of the NOTCH transcription factor complex. Nature. 2009 Nov 12; 462(7270):182-8. PMID: 19907488; PMCID: PMC2951323.
      Citations: 355     Fields:    Translation:HumansAnimalsCells
    36. Moellering RE, Black KC, Krishnamurty C, Baggett BK, Stafford P, Rain M, Gatenby RA, Gillies RJ. Acid treatment of melanoma cells selects for invasive phenotypes. Clin Exp Metastasis. 2008; 25(4):411-25. PMID: 18301995.
      Citations: 98     Fields:    Translation:HumansCells
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