Transforming Growth Factor beta
"Transforming Growth Factor beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
| Descriptor ID |
D016212
|
| MeSH Number(s) |
D12.644.276.374.687 D12.644.276.954.775 D12.776.467.374.687 D12.776.467.942.775 D23.529.374.687 D23.529.942.775
|
| Concept/Terms |
Transforming Growth Factor beta- Transforming Growth Factor beta
- Milk Growth Factor
- Factor, Milk Growth
- Growth Factor, Milk
- TGF-beta
- TGFbeta
- Platelet Transforming Growth Factor
- Bone-Derived Transforming Growth Factor
- Bone Derived Transforming Growth Factor
|
Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor beta".
Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor beta".
This graph shows the total number of publications written about "Transforming Growth Factor beta" by people in this website by year, and whether "Transforming Growth Factor beta" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1996 | 1 | 2 | 3 |
| 1997 | 4 | 4 | 8 |
| 1998 | 5 | 1 | 6 |
| 1999 | 3 | 2 | 5 |
| 2000 | 3 | 1 | 4 |
| 2001 | 6 | 7 | 13 |
| 2002 | 3 | 2 | 5 |
| 2003 | 5 | 5 | 10 |
| 2004 | 9 | 4 | 13 |
| 2005 | 8 | 11 | 19 |
| 2006 | 6 | 2 | 8 |
| 2007 | 7 | 4 | 11 |
| 2008 | 5 | 6 | 11 |
| 2009 | 8 | 5 | 13 |
| 2010 | 5 | 3 | 8 |
| 2011 | 10 | 5 | 15 |
| 2012 | 8 | 3 | 11 |
| 2013 | 4 | 8 | 12 |
| 2014 | 4 | 3 | 7 |
| 2015 | 3 | 9 | 12 |
| 2016 | 8 | 3 | 11 |
| 2017 | 4 | 5 | 9 |
| 2018 | 2 | 5 | 7 |
| 2019 | 2 | 7 | 9 |
| 2020 | 4 | 2 | 6 |
| 2021 | 0 | 5 | 5 |
| 2022 | 0 | 3 | 3 |
| 2023 | 4 | 5 | 9 |
| 2024 | 3 | 2 | 5 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Transforming Growth Factor beta" by people in Profiles.
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mTOR signaling regulates multiple metabolic pathways in human lung fibroblasts after TGF-ß and in pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2025 Feb 01; 328(2):L215-L228.
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Ga12 and Ga13 proteins are required for transforming growth factor-ß-induced myofibroblast differentiation. Biochem J. 2024 12 18; 481(24):1937-1948.
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Exploring the potential of TGFß as a diagnostic marker and therapeutic target against cancer. Biochem Pharmacol. 2025 01; 231:116646.
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Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment. Nat Cancer. 2024 Jul; 5(7):1045-1062.
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IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFß. Front Immunol. 2024; 15:1293883.
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The safety and efficacy of systemic delivery of a new liver-de-targeted TGFß signaling inhibiting adenovirus in an immunocompetent triple negative mouse mammary tumor model. Cancer Gene Ther. 2024 Apr; 31(4):574-585.
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Epitranscriptional regulation of TGF-ß pseudoreceptor BAMBI by m6A/YTHDF2 drives extrinsic radioresistance. J Clin Invest. 2023 12 15; 133(24).
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Anoctamin-1 is induced by TGF-ß and contributes to lung myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol. 2024 01 01; 326(1):L111-L123.
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Granzyme K- and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease. J Allergy Clin Immunol. 2024 Apr; 153(4):1095-1112.
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TGF-ß Promotes the Postselection Thymic Development and Peripheral Function of IFN-?-Producing Invariant NKT cells. J Immunol. 2023 11 01; 211(9):1376-1384.