 Hepatocyte Nuclear Factor 1
"Hepatocyte Nuclear Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcription factor that regulates the expression of a large set of hepatic proteins including SERUM ALBUMIN; beta-fibrinogen; and ALPHA 1-ANTITRYPSIN. It is composed of hetero- or homo-dimers of HEPATOCYTE NUCLEAR FACTOR 1-ALPHA and HEPATOCYTE NUCLEAR FACTOR 1-BETA.
| Descriptor ID |
D051537
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| MeSH Number(s) |
D12.776.260.262.500 D12.776.660.352.500 D12.776.930.323.500
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| Concept/Terms |
Hepatocyte Nuclear Factor 1- Hepatocyte Nuclear Factor 1
- HNF-1 Protein
- HNF 1 Protein
- HNF1 Transcription Factor
- Transcription Factor, HNF1
- Hepatic Nuclear Factor 1
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Below are MeSH descriptors whose meaning is more general than "Hepatocyte Nuclear Factor 1".
Below are MeSH descriptors whose meaning is more specific than "Hepatocyte Nuclear Factor 1".
This graph shows the total number of publications written about "Hepatocyte Nuclear Factor 1" by people in this website by year, and whether "Hepatocyte Nuclear Factor 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 0 | 1 | 1 | | 1993 | 0 | 1 | 1 | | 1996 | 0 | 2 | 2 | | 1997 | 0 | 6 | 6 | | 1998 | 0 | 2 | 2 | | 2000 | 0 | 2 | 2 | | 2001 | 0 | 2 | 2 | | 2004 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Hepatocyte Nuclear Factor 1" by people in Profiles.
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Browne JA, Yang R, Eggener SE, Leir SH, Harris A. HNF1 regulates critical processes in the human epididymis epithelium. Mol Cell Endocrinol. 2016 Apr 15; 425:94-102.
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O'Brien VP, Bokelmann K, Ramírez J, Jobst K, Ratain MJ, Brockmöller J, Tzvetkov MV. Hepatocyte nuclear factor 1 regulates the expression of the organic cation transporter 1 via binding to an evolutionary conserved region in intron 1 of the OCT1 gene. J Pharmacol Exp Ther. 2013 Oct; 347(1):181-92.
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Court MH, Hazarika S, Krishnaswamy S, Finel M, Williams JA. Novel polymorphic human UDP-glucuronosyltransferase 2A3: cloning, functional characterization of enzyme variants, comparative tissue expression, and gene induction. Mol Pharmacol. 2008 Sep; 74(3):744-54.
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Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA. Control of pancreas and liver gene expression by HNF transcription factors. Science. 2004 Feb 27; 303(5662):1378-81.
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Shih DQ, Screenan S, Munoz KN, Philipson L, Pontoglio M, Yaniv M, Polonsky KS, Stoffel M. Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism. Diabetes. 2001 Nov; 50(11):2472-80.
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Lee JC, Smith SB, Watada H, Lin J, Scheel D, Wang J, Mirmira RG, German MS. Regulation of the pancreatic pro-endocrine gene neurogenin3. Diabetes. 2001 May; 50(5):928-36.
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Ng MC, Li JK, So WY, Critchley JA, Cockram CS, Bell GI, Chan JC. Nature or nurture: an insightful illustration from a Chinese family with hepatocyte nuclear factor-1 alpha diabetes (MODY3) Diabetologia. 2000 Jun; 43(6):816-8.
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Bjørkhaug L, Søvik O, Bell GI, Njølstad PR, Molven A. A simple test for the high-frequency P291fsinsC mutation in the HNF1 alpha/MODY3 gene. Diabetologia. 2000 Jun; 43(6):818-9.
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Dukes ID, Sreenan S, Roe MW, Levisetti M, Zhou YP, Ostrega D, Bell GI, Pontoglio M, Yaniv M, Philipson L, Polonsky KS. Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice. J Biol Chem. 1998 Sep 18; 273(38):24457-64.
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Pontoglio M, Sreenan S, Roe M, Pugh W, Ostrega D, Doyen A, Pick AJ, Baldwin A, Velho G, Froguel P, Levisetti M, Bonner-Weir S, Bell GI, Yaniv M, Polonsky KS. Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice. J Clin Invest. 1998 May 15; 101(10):2215-22.
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