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Jayasri Nanduri

TitleResearch Professor
InstitutionUniversity of Chicago
DepartmentMedicine-Emergency Medicine
AddressChicago IL 60637
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Makarenko VV, Peng YJ, Khan SA, Nanduri J, Fox AP, Prabhakar NR. Long-term facilitation of catecholamine secretion from adrenal chromaffin cells of neonatal rats by chronic intermittent hypoxia. J Neurophysiol. 2019 Nov 01; 122(5):1874-1883. PMID: 31483699.
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    2. Vaddi DR, Piao L, Khan SA, Wang N, Prabhakar NR, Nanduri J. Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells. PLoS One. 2019; 14(4):e0215905. PMID: 31017964.
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    3. Prabhakar NR, Peng YJ, Nanduri J. Recent advances in understanding the physiology of hypoxic sensing by the carotid body. F1000Res. 2018; 7. PMID: 30631432.
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    4. Nanduri J, Peng YJ, Wang N, Prabhakar NR. Neural Activation of Molecular Circuitry in Intermittent Hypoxia. Curr Opin Physiol. 2019 Feb; 7:9-14. PMID: 31544168.
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    5. Prabhakar NR, Peng YJ, Yuan G, Nanduri J. Reactive oxygen radicals and gaseous transmitters in carotid body activation by intermittent hypoxia. Cell Tissue Res. 2018 05; 372(2):427-431. PMID: 29470646.
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    6. Nanduri J, Peng YJ, Wang N, Khan SA, Semenza GL, Prabhakar NR. DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity. J Physiol. 2018 08; 596(15):3087-3100. PMID: 29148180.
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    7. Nanduri J, Prabhakar NR. Immunohistochemistry of the Carotid Body. Methods Mol Biol. 2018; 1742:155-166. PMID: 29330798.
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    8. Peng YJ, Zhang X, Nanduri J, Prabhakar NR. Therapeutic Targeting of the Carotid Body for Treating Sleep Apnea in a Pre-clinical Mouse Model. Adv Exp Med Biol. 2018; 1071:109-114. PMID: 30357741.
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    9. Nanduri J, Semenza GL, Prabhakar NR. Epigenetic changes by DNA methylation in chronic and intermittent hypoxia. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L1096-L1100. PMID: 28839104.
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    10. Peng YJ, Zhang X, Gridina A, Chupikova I, McCormick DL, Thomas RJ, Scammell TE, Kim G, Vasavda C, Nanduri J, Kumar GK, Semenza GL, Snyder SH, Prabhakar NR. Complementary roles of gasotransmitters CO and H2S in sleep apnea. Proc Natl Acad Sci U S A. 2017 02 07; 114(6):1413-1418. PMID: 28115703.
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    11. Nanduri J, Peng YJ, Wang N, Khan SA, Semenza GL, Kumar GK, Prabhakar NR. Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia. J Physiol. 2017 01 01; 595(1):63-77. PMID: 27506145.
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    12. Yuan G, Peng YJ, Khan SA, Nanduri J, Singh A, Vasavda C, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR. H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea. Sci Signal. 2016 08 16; 9(441):ra80. PMID: 27531649.
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    13. Wang N, Kang HS, Ahmmed G, Khan SA, Makarenko VV, Prabhakar NR, Nanduri J. Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia. Am J Physiol Cell Physiol. 2016 Mar 01; 310(5):C329-36. PMID: 26659724.
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    14. Makarenko VV, Ahmmed GU, Peng YJ, Khan SA, Nanduri J, Kumar GK, Fox AP, Prabhakar NR. CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia. J Neurophysiol. 2016 Jan 01; 115(1):345-54. PMID: 26561606.
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    15. Yuan G, Vasavda C, Peng YJ, Makarenko VV, Raghuraman G, Nanduri J, Gadalla MM, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR. Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal. 2015 Apr 21; 8(373):ra37. PMID: 25900831.
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    16. Prabhakar NR, Peng YJ, Kumar GK, Nanduri J. Peripheral chemoreception and arterial pressure responses to intermittent hypoxia. Compr Physiol. 2015 Apr; 5(2):561-77. PMID: 25880505.
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    17. Nanduri J, Peng YJ, Yuan G, Kumar GK, Prabhakar NR. Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome. J Mol Med (Berl). 2015 May; 93(5):473-80. PMID: 25772710.
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    18. Nanduri J, Vaddi DR, Khan SA, Wang N, Makarenko V, Semenza GL, Prabhakar NR. HIF-1a activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase. PLoS One. 2015; 10(3):e0119762. PMID: 25751622.
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    19. Kumar GK, Nanduri J, Peng YJ, Prabhakar NR. Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla. Respir Physiol Neurobiol. 2015 Apr; 209:115-9. PMID: 25583660.
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    20. Nanduri J, Prabhakar NR. Epigenetic Regulation of Carotid Body Oxygen Sensing: Clinical Implications. Adv Exp Med Biol. 2015; 860:1-8. PMID: 26303461.
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    21. Kumar GK, Peng YJ, Nanduri J, Prabhakar NR. Carotid Body Chemoreflex Mediates Intermittent Hypoxia-Induced Oxidative Stress in the Adrenal Medulla. Adv Exp Med Biol. 2015; 860:195-9. PMID: 26303481.
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    22. Makarenko VV, Peng YJ, Yuan G, Fox AP, Kumar GK, Nanduri J, Prabhakar NR. CaV3.2 T-type Ca²? channels in H2S-mediated hypoxic response of the carotid body. Am J Physiol Cell Physiol. 2015 Jan 15; 308(2):C146-54. PMID: 25377087.
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    23. Peng YJ, Yuan G, Khan S, Nanduri J, Makarenko VV, Reddy VD, Vasavda C, Kumar GK, Semenza GL, Prabhakar NR. Regulation of hypoxia-inducible factor-a isoforms and redox state by carotid body neural activity in rats. J Physiol. 2014 Sep 01; 592(17):3841-58. PMID: 24973414.
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    24. Mariani CJ, Vasanthakumar A, Madzo J, Yesilkanal A, Bhagat T, Yu Y, Bhattacharyya S, Wenger RH, Cohn SL, Nanduri J, Verma A, Prabhakar NR, Godley LA. TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma. Cell Rep. 2014 Jun 12; 7(5):1343-1352. PMID: 24835990.
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    25. Makarenko VV, Usatyuk PV, Yuan G, Lee MM, Nanduri J, Natarajan V, Kumar GK, Prabhakar NR. Intermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation. Am J Physiol Cell Physiol. 2014 Apr 15; 306(8):C745-52. PMID: 24477234.
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    26. Peng YJ, Makarenko VV, Nanduri J, Vasavda C, Raghuraman G, Yuan G, Gadalla MM, Kumar GK, Snyder SH, Prabhakar NR. Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1174-9. PMID: 24395806.
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    27. Nanduri J, Vaddi DR, Khan SA, Wang N, Makerenko V, Prabhakar NR. Xanthine oxidase mediates hypoxia-inducible factor-2a degradation by intermittent hypoxia. PLoS One. 2013; 8(10):e75838. PMID: 24124516.
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    28. Peng YJ, Nanduri J, Raghuraman G, Wang N, Kumar GK, Prabhakar NR. Role of oxidative stress-induced endothelin-converting enzyme activity in the alteration of carotid body function by chronic intermittent hypoxia. Exp Physiol. 2013 Nov; 98(11):1620-30. PMID: 23913764.
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    29. Wang N, Khan SA, Prabhakar NR, Nanduri J. Impairment of pancreatic ß-cell function by chronic intermittent hypoxia. Exp Physiol. 2013 Sep; 98(9):1376-85. PMID: 23709585.
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    30. Yuan G, Peng YJ, Reddy VD, Makarenko VV, Nanduri J, Khan SA, Garcia JA, Kumar GK, Semenza GL, Prabhakar NR. Mutual antagonism between hypoxia-inducible factors 1a and 2a regulates oxygen sensing and cardio-respiratory homeostasis. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):E1788-96. PMID: 23610397.
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    31. Nanduri J, Prabhakar NR. Developmental programming of O(2) sensing by neonatal intermittent hypoxia via epigenetic mechanisms. Respir Physiol Neurobiol. 2013 Jan 01; 185(1):105-9. PMID: 22846496.
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    32. Makarenko VV, Nanduri J, Raghuraman G, Fox AP, Gadalla MM, Kumar GK, Snyder SH, Prabhakar NR. Endogenous H2S is required for hypoxic sensing by carotid body glomus cells. Am J Physiol Cell Physiol. 2012 Nov 01; 303(9):C916-23. PMID: 22744006.
      View in: PubMed
    33. Nanduri J, Makarenko V, Reddy VD, Yuan G, Pawar A, Wang N, Khan SA, Zhang X, Kinsman B, Peng YJ, Kumar GK, Fox AP, Godley LA, Semenza GL, Prabhakar NR. Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2515-20. PMID: 22232674.
      View in: PubMed
    34. Yuan G, Khan SA, Luo W, Nanduri J, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia. J Cell Physiol. 2011 Nov; 226(11):2925-33. PMID: 21302291.
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    35. Peng YJ, Nanduri J, Zhang X, Wang N, Raghuraman G, Seagard J, Kumar GK, Prabhakar NR. Endothelin-1 mediates attenuated carotid baroreceptor activity by intermittent hypoxia. J Appl Physiol (1985). 2012 Jan; 112(1):187-96. PMID: 22016368.
      View in: PubMed
    36. Peng YJ, Nanduri J, Khan SA, Yuan G, Wang N, Kinsman B, Vaddi DR, Kumar GK, Garcia JA, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 2a (HIF-2a) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):3065-70. PMID: 21288809.
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    37. Khan SA, Nanduri J, Yuan G, Kinsman B, Kumar GK, Joseph J, Kalyanaraman B, Prabhakar NR. NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in rats. Antioxid Redox Signal. 2011 Feb 15; 14(4):533-42. PMID: 20618070.
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    38. Prabhakar NR, Kumar GK, Nanduri J. Intermittent hypoxia augments acute hypoxic sensing via HIF-mediated ROS. Respir Physiol Neurobiol. 2010 Dec 31; 174(3):230-4. PMID: 20804864.
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    39. Souvannakitti D, Nanduri J, Yuan G, Kumar GK, Fox AP, Prabhakar NR. NADPH oxidase-dependent regulation of T-type Ca2+ channels and ryanodine receptors mediate the augmented exocytosis of catecholamines from intermittent hypoxia-treated neonatal rat chromaffin cells. J Neurosci. 2010 Aug 11; 30(32):10763-72. PMID: 20705601.
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    40. Peng YJ, Nanduri J, Raghuraman G, Souvannakitti D, Gadalla MM, Kumar GK, Snyder SH, Prabhakar NR. H2S mediates O2 sensing in the carotid body. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10719-24. PMID: 20556885.
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    41. Prabhakar NR, Kumar GK, Nanduri J. Intermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2. Ann N Y Acad Sci. 2009 Oct; 1177:162-8. PMID: 19845618.
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    42. Nanduri J, Bergson P, Wang N, Ficker E, Prabhakar NR. Hypoxia inhibits maturation and trafficking of hERG K(+) channel protein: Role of Hsp90 and ROS. Biochem Biophys Res Commun. 2009 Oct 16; 388(2):212-6. PMID: 19654002.
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    43. Peng YJ, Nanduri J, Yuan G, Wang N, Deneris E, Pendyala S, Natarajan V, Kumar GK, Prabhakar NR. NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia. J Neurosci. 2009 Apr 15; 29(15):4903-10. PMID: 19369559.
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    44. Nanduri J, Wang N, Yuan G, Khan SA, Souvannakitti D, Peng YJ, Kumar GK, Garcia JA, Prabhakar NR. Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities. Proc Natl Acad Sci U S A. 2009 Jan 27; 106(4):1199-204. PMID: 19147445.
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    45. Prabhakar NR, Peng YJ, Kumar GK, Nanduri J, Di Giulio C, Lahiri S. Long-term regulation of carotid body function: acclimatization and adaptation--invited article. Adv Exp Med Biol. 2009; 648:307-17. PMID: 19536494.
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    46. Pawar A, Nanduri J, Yuan G, Khan SA, Wang N, Kumar GK, Prabhakar NR. Reactive oxygen species-dependent endothelin signaling is required for augmented hypoxic sensory response of the neonatal carotid body by intermittent hypoxia. Am J Physiol Regul Integr Comp Physiol. 2009 Mar; 296(3):R735-42. PMID: 19109370.
      View in: PubMed
    47. Nanduri J, Yuan G, Kumar GK, Semenza GL, Prabhakar NR. Transcriptional responses to intermittent hypoxia. Respir Physiol Neurobiol. 2008 Dec 10; 164(1-2):277-81. PMID: 18692603.
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    48. Yuan G, Nanduri J, Khan S, Semenza GL, Prabhakar NR. Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR. J Cell Physiol. 2008 Dec; 217(3):674-85. PMID: 18651560.
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    49. Nanduri J, Wang N, Bergson P, Yuan G, Ficker E, Prabhakar NR. Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein. Biochem Biophys Res Commun. 2008 Aug 22; 373(2):309-14. PMID: 18570888.
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    50. Prabhakar NR, Kumar GK, Nanduri J, Semenza GL. ROS signaling in systemic and cellular responses to chronic intermittent hypoxia. Antioxid Redox Signal. 2007 Sep; 9(9):1397-403. PMID: 17627465.
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    51. Nanduri J, Nanduri RP. Cellular mechanisms associated with intermittent hypoxia. Essays Biochem. 2007; 43:91-104. PMID: 17705795.
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    52. Prabhakar NR, Dick TE, Nanduri J, Kumar GK. Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia. Exp Physiol. 2007 Jan; 92(1):39-44. PMID: 17124274.
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    53. Low SH, Vasanji A, Nanduri J, He M, Sharma N, Koo M, Drazba J, Weimbs T. Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. Mol Biol Cell. 2006 Feb; 17(2):977-89. PMID: 16339081.
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    54. Yuan G, Nanduri J, Bhasker CR, Semenza GL, Prabhakar NR. Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia. J Biol Chem. 2005 Feb 11; 280(6):4321-8. PMID: 15569687.
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    55. Nanduri J, Tartakoff AM. The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell. 2001 Aug; 8(2):281-9. PMID: 11545731.
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    56. Nanduri J, Tartakoff AM. Perturbation of the nucleus: a novel Hog1p-independent, Pkc1p-dependent consequence of hypertonic shock in yeast. Mol Biol Cell. 2001 Jun; 12(6):1835-41. PMID: 11408589.
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    57. Tartakoff AM, Lichtenstein M, Nanduri J, Tsao HM. Review: dynamic stability of the interphase nucleus in health and disease. J Struct Biol. 2000 Apr; 129(2-3):144-58. PMID: 10806065.
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    58. Nanduri J, Mitra S, Andrei C, Liu Y, Yu Y, Hitomi M, Tartakoff AM. An unexpected link between the secretory path and the organization of the nucleus. J Biol Chem. 1999 Nov 19; 274(47):33785-9. PMID: 10559272.
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    59. Nanduri J, Williams S, Aji T, Flanigan TP. Characterization of an immunogenic glycocalyx on the surfaces of Cryptosporidium parvum oocysts and sporozoites. Infect Immun. 1999 Apr; 67(4):2022-4. PMID: 10085053.
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    60. Nanduri J, Vroegop SM, Buxser SE, Neet KE. Immunological determinants of nerve growth factor involved in p140trk (Trk) receptor binding. J Neurosci Res. 1994 Mar 01; 37(4):433-44. PMID: 7517456.
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    61. Nanduri J, Dennis JE, Rosenberry TL, Mahmoud AA, Tartakoff AM. Glycocalyx of bodies versus tails of Schistosoma mansoni cercariae. Lectin-binding, size, charge, and electron microscopic characterization. J Biol Chem. 1991 Jan 15; 266(2):1341-7. PMID: 1985952.
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    62. Nanduri J, Kazura JW. Paramyosin-enhanced clearance of Brugia malayi microfilaremia in mice. J Immunol. 1989 Nov 15; 143(10):3359-63. PMID: 2809205.
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    63. Flanigan TP, King CH, Lett RR, Nanduri J, Mahmoud AA. Induction of resistance to Schistosoma mansoni infection in mice by purified parasite paramyosin. J Clin Invest. 1989 Mar; 83(3):1010-4. PMID: 2493482.
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    64. Nanduri J, Kazura JW. Clinical and laboratory aspects of filariasis. Clin Microbiol Rev. 1989 Jan; 2(1):39-50. PMID: 2644023.
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    65. Nilsen TW, Maroney PA, Goodwin RG, Perrine KG, Denker JA, Nanduri J, Kazura JW. Cloning and characterization of a potentially protective antigen in lymphatic filariasis. Proc Natl Acad Sci U S A. 1988 May; 85(10):3604-7. PMID: 3368467.
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    66. King CH, Lett RR, Nanduri J, el Ibiary S, Peters PA, Olds GR, Mahmoud AA. Isolation and characterization of a protective antigen for adjuvant-free immunization against Schistosoma mansoni. J Immunol. 1987 Dec 15; 139(12):4218-24. PMID: 3121733.
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    67. Davis AH, Nanduri J, Watson DC. Cloning and gene expression of Schistosoma mansoni protease. J Biol Chem. 1987 Sep 15; 262(26):12851-5. PMID: 3305515.
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