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Stephen Archer

TitleProfessor
InstitutionUniversity of Chicago
DepartmentMedicine
AddressChicago IL 60637
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Piao L, Fang YH, Hamanaka RB, Mutlu GM, Dezfulian C, Archer SL, Sharp WW. Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes. Crit Care Med. 2019 Nov 13. PMID: 31725436.
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    2. Appireddy R, Khan S, Leaver C, Martin C, Jin A, Durafourt BA, Archer SL. Home Virtual Visits for Outpatient Follow-Up Stroke Care: Cross-Sectional Study. J Med Internet Res. 2019 Oct 07; 21(10):e13734. PMID: 31593536.
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    3. Dunham-Snary KJ, Archer SL. Response by Dunham-Snary and Archer to Letter Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction". Circ Res. 2019 Sep 27; 125(8):e35-e36. PMID: 31557123.
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    4. Ranchoux B, Nadeau V, Bourgeois A, Provencher S, Tremblay É, Omura J, Coté N, Abu-Alhayja'a R, Dumais V, Nachbar RT, Tastet L, Dahou A, Breuils-Bonnet S, Marette A, Pibarot P, Dupuis J, Paulin R, Boucherat O, Archer SL, Bonnet S, Potus F. Metabolic Syndrome Exacerbates Pulmonary Hypertension due to Left Heart Disease. Circ Res. 2019 Aug 02; 125(4):449-466. PMID: 31154939.
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    5. Dunham-Snary KJ, Wu D, Potus F, Sykes EA, Mewburn JD, Charles RL, Eaton P, Sultanian RA, Archer SL. Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction. Circ Res. 2019 Jun 07; 124(12):1727-1746. PMID: 30922174.
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    6. Xiong PY, Tian L, Dunham-Snary KJ, Chen KH, Mewburn JD, Neuber-Hess M, Martin A, Dasgupta A, Potus F, Archer SL. Biventricular Increases in Mitochondrial Fission Mediator (MiD51) and Proglycolytic Pyruvate Kinase (PKM2) Isoform in Experimental Group 2 Pulmonary Hypertension-Novel Mitochondrial Abnormalities. Front Cardiovasc Med. 2018; 5:195. PMID: 30740395.
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    7. Prins KW, Rose L, Archer SL, Pritzker M, Weir EK, Olson MD, Thenappan T. Clinical Determinants and Prognostic Implications of Right Ventricular Dysfunction in Pulmonary Hypertension Caused by Chronic Lung Disease. J Am Heart Assoc. 2019 01 22; 8(2):e011464. PMID: 30646788.
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    8. Prins KW, Thenappan T, Weir EK, Kalra R, Pritzker M, Archer SL. Repurposing Medications for Treatment of Pulmonary Arterial Hypertension: What's Old Is New Again. J Am Heart Assoc. 2019 01 08; 8(1):e011343. PMID: 30590974.
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    9. Cirulis MM, Ryan JJ, Archer SL. Pathophysiology, incidence, management, and consequences of cardiac arrhythmia in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Pulm Circ. 2019 Jan-Mar; 9(1):2045894019834890. PMID: 30747032.
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    10. Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, MacKenzie Ross RV, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, Vonk Noordegraaf A, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Trégouët DA, Prokopenko I, Kittles R, Gräf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR. Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. Lancet Respir Med. 2019 Mar; 7(3):227-238. PMID: 30527956.
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    11. Xiong PY, Baba S, Nishioka N, Fujimoto Y, Archer SL, Minamisawa S. Left Atrial Stenosis Induced Pulmonary Venous Arterialization and Group 2 Pulmonary Hypertension in Rat. J Vis Exp. 2018 11 18; (141). PMID: 30507912.
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    12. Rose L, Prins KW, Archer SL, Pritzker M, Weir EK, Misialek JR, Thenappan T. Survival in pulmonary hypertension due to chronic lung disease: Influence of low diffusion capacity of the lungs for carbon monoxide. J Heart Lung Transplant. 2019 Feb; 38(2):145-155. PMID: 30391191.
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    13. Potus F, Hindmarch CCT, Dunham-Snary KJ, Stafford J, Archer SL. Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities. Int J Mol Sci. 2018 Sep 12; 19(9). PMID: 30213070.
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    14. Lahm T, Douglas IS, Archer SL, Bogaard HJ, Chesler NC, Haddad F, Hemnes AR, Kawut SM, Kline JA, Kolb TM, Mathai SC, Mercier O, Michelakis ED, Naeije R, Tuder RM, Ventetuolo CE, Vieillard-Baron A, Voelkel NF, Vonk-Noordegraaf A, Hassoun PM. Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med. 2018 08 15; 198(4):e15-e43. PMID: 30109950.
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    15. D'Arsigny CL, Archer SL. A Step Closer to Understanding How Riociguat Results in Remodelling of the Right Ventricle in Chronic Thromboembolic Pulmonary Hypertension. Can J Cardiol. 2018 09; 34(9):1098-1101. PMID: 30170664.
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    16. Tian L, Potus F, Wu D, Dasgupta A, Chen KH, Mewburn J, Lima P, Archer SL. Increased Drp1-Mediated Mitochondrial Fission Promotes Proliferation and Collagen Production by Right Ventricular Fibroblasts in Experimental Pulmonary Arterial Hypertension. Front Physiol. 2018; 9:828. PMID: 30042687.
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    17. Kuebler WM, Nicolls MR, Olschewski A, Abe K, Rabinovitch M, Stewart D, Chan SY, Morrell NW, Archer SL, Spiekerkoetter E. A pro-con debate: current controversies in PAH pathogenesis at the American Thoracic Society International Conference in 2017. Am J Physiol Lung Cell Mol Physiol. 2018 10 01; 315(4):L502-L516. PMID: 29877097.
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    18. Prins KW, Rose L, Archer SL, Pritzker M, Weir EK, Kazmirczak F, Misialek JR, Thenappan T. Disproportionate Right Ventricular Dysfunction and Poor Survival in Group 3 Pulmonary Hypertension. Am J Respir Crit Care Med. 2018 06 01; 197(11):1496-1499. PMID: 29360393.
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    19. Provencher S, Archer SL, Ramirez FD, Hibbert B, Paulin R, Boucherat O, Lacasse Y, Bonnet S. Standards and Methodological Rigor in Pulmonary Arterial Hypertension Preclinical and Translational Research. Circ Res. 2018 03 30; 122(7):1021-1032. PMID: 29599278.
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    20. Thenappan T, Ormiston ML, Ryan JJ, Archer SL. Pulmonary arterial hypertension: pathogenesis and clinical management. BMJ. 2018 03 14; 360:j5492. PMID: 29540357.
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    21. Chen KH, Dasgupta A, Lin J, Potus F, Bonnet S, Iremonger J, Fu J, Mewburn J, Wu D, Dunham-Snary K, Theilmann AL, Jing ZC, Hindmarch C, Ormiston ML, Lawrie A, Archer SL. Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications. Circulation. 2018 07 17; 138(3):287-304. PMID: 29431643.
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    22. Wijeratne DT, Lajkosz K, Brogly SB, Lougheed MD, Jiang L, Housin A, Barber D, Johnson A, Doliszny KM, Archer SL. Increasing Incidence and Prevalence of World Health Organization Groups 1 to 4 Pulmonary Hypertension: A Population-Based Cohort Study in Ontario, Canada. Circ Cardiovasc Qual Outcomes. 2018 02; 11(2):e003973. PMID: 29444925.
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    23. Archer SL. Pyruvate Kinase and Warburg Metabolism in Pulmonary Arterial Hypertension: Uncoupled Glycolysis and the Cancer-Like Phenotype of Pulmonary Arterial Hypertension. Circulation. 2017 12 19; 136(25):2486-2490. PMID: 29255124.
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    24. Xiong PY, Potus F, Chan W, Archer SL. Models and Molecular Mechanisms of World Health Organization Group 2 to 4 Pulmonary Hypertension. Hypertension. 2018 01; 71(1):34-55. PMID: 29158355.
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    25. Selvam SN, Casey LJ, Bowman ML, Hawke LG, Longmore AJ, Mewburn J, Ormiston ML, Archer SL, Maurice DH, James P. Abnormal angiogenesis in blood outgrowth endothelial cells derived from von Willebrand disease patients. Blood Coagul Fibrinolysis. 2017 Oct; 28(7):521-533. PMID: 28362648.
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    26. Prins KW, Archer SL, Pritzker M, Rose L, Weir EK, Sharma A, Thenappan T. Interleukin-6 is independently associated with right ventricular function in pulmonary arterial hypertension. J Heart Lung Transplant. 2018 03; 37(3):376-384. PMID: 28893516.
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    27. Prins KW, Tian L, Wu D, Thenappan T, Metzger JM, Archer SL. Colchicine Depolymerizes Microtubules, Increases Junctophilin-2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension. J Am Heart Assoc. 2017 May 31; 6(6). PMID: 28566298.
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    28. Tian L, Neuber-Hess M, Mewburn J, Dasgupta A, Dunham-Snary K, Wu D, Chen KH, Hong Z, Sharp WW, Kutty S, Archer SL. Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension. J Mol Med (Berl). 2017 04; 95(4):381-393. PMID: 28265681.
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    29. Hong Z, Chen KH, DasGupta A, Potus F, Dunham-Snary K, Bonnet S, Tian L, Fu J, Breuils-Bonnet S, Provencher S, Wu D, Mewburn J, Ormiston ML, Archer SL. MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype. Am J Respir Crit Care Med. 2017 Feb 15; 195(4):515-529. PMID: 27648837.
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    30. Thenappan T, Archer SL, Weir EK. Resistance over compliance describes right ventricular afterload better than resistance-compliance time: a friendly amendment. Pulm Circ. 2017 Mar; 7(1):275. PMID: 28680587.
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    31. Anand V, Roy SS, Archer SL, Weir EK, Garg SK, Duval S, Thenappan T. Trends and Outcomes of Pulmonary Arterial Hypertension-Related Hospitalizations in the United States: Analysis of the Nationwide Inpatient Sample Database From 2001 Through 2012. JAMA Cardiol. 2016 Dec 01; 1(9):1021-1029. PMID: 27851838.
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    32. Prins KW, Weir EK, Archer SL, Markowitz J, Rose L, Pritzker M, Madlon-Kay R, Thenappan T. Pulmonary pulse wave transit time is associated with right ventricular-pulmonary artery coupling in pulmonary arterial hypertension. Pulm Circ. 2016 Dec; 6(4):576-585. PMID: 28090301.
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    33. Atkins K, Dasgupta A, Chen KH, Mewburn J, Archer SL. The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease. Clin Sci (Lond). 2016 11 01; 130(21):1861-74. PMID: 27660309.
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    34. Abman SH, Ivy DD, Archer SL, Wilson K. Executive Summary of the American Heart Association and American Thoracic Society Joint Guidelines for Pediatric Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 Oct 01; 194(7):898-906. PMID: 27689707.
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    35. Dunham-Snary KJ, Wu D, Sykes EA, Thakrar A, Parlow LRG, Mewburn JD, Parlow JL, Archer SL. Hypoxic Pulmonary Vasoconstriction: From Molecular Mechanisms to Medicine. Chest. 2017 Jan; 151(1):181-192. PMID: 27645688.
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    36. Hemnes AR, Zhao M, West J, Newman JH, Rich S, Archer SL, Robbins IM, Blackwell TS, Cogan J, Loyd JE, Zhao Z, Gaskill C, Jetter C, Kropski JA, Majka SM, Austin ED. Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2016 08 15; 194(4):464-75. PMID: 26926454.
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    37. Wu D, Archer SL. Pulmonary hypertension begets pulmonary hypertension: mutually reinforcing roles for haemodynamics, inflammation, and cancer-like phenotypes. Cardiovasc Res. 2016 07 01; 111(1):1-4. PMID: 27216865.
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    38. Archer SL. Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications. Adv Exp Med Biol. 2016; 903:29-53. PMID: 27343087.
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    39. Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL. Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society. Circulation. 2015 Nov 24; 132(21):2037-99. PMID: 26534956.
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    40. Dasgupta A, Chen KH, Tian L, Archer SL. Gone fission: an asymptomatic STAT2 mutation elongates mitochondria and causes human disease following viral infection. Brain. 2015 Oct; 138(Pt 10):2802-6. PMID: 26408653.
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    41. Dunham-Snary KJ, Hong ZG, Xiong PY, Del Paggio JC, Herr JE, Johri AM, Archer SL. A mitochondrial redox oxygen sensor in the pulmonary vasculature and ductus arteriosus. Pflugers Arch. 2016 Jan; 468(1):43-58. PMID: 26395471.
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    42. Ryan JJ, Archer SL. Emerging concepts in the molecular basis of pulmonary arterial hypertension: part I: metabolic plasticity and mitochondrial dynamics in the pulmonary circulation and right ventricle in pulmonary arterial hypertension. Circulation. 2015 May 12; 131(19):1691-702. PMID: 25964279.
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    43. Ryan J, Dasgupta A, Huston J, Chen KH, Archer SL. Mitochondrial dynamics in pulmonary arterial hypertension. J Mol Med (Berl). 2015 Mar; 93(3):229-42. PMID: 25672499.
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    44. Sharp WW, Archer SL. Mitochondrial dynamics in cardiovascular disease: fission and fusion foretell form and function. J Mol Med (Berl). 2015 Mar; 93(3):225-8. PMID: 25669447.
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    45. Sharp WW, Beiser DG, Fang YH, Han M, Piao L, Varughese J, Archer SL. Inhibition of the mitochondrial fission protein dynamin-related protein 1 improves survival in a murine cardiac arrest model. Crit Care Med. 2015 Feb; 43(2):e38-47. PMID: 25599491.
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    46. Ryan JJ, Huston J, Kutty S, Hatton ND, Bowman L, Tian L, Herr JE, Johri AM, Archer SL. Right ventricular adaptation and failure in pulmonary arterial hypertension. Can J Cardiol. 2015 Apr; 31(4):391-406. PMID: 25840092.
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    47. Dasgupta A, Bowman L, D'Arsigny CL, Archer SL. Soluble guanylate cyclase: a new therapeutic target for pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Clin Pharmacol Ther. 2015 Jan; 97(1):88-102. PMID: 25670386.
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    48. Hemnes AR, Trammell AW, Archer SL, Rich S, Yu C, Nian H, Penner N, Funke M, Wheeler L, Robbins IM, Austin ED, Newman JH, West J. Peripheral blood signature of vasodilator-responsive pulmonary arterial hypertension. Circulation. 2015 Jan 27; 131(4):401-9; discussion 409. PMID: 25361553.
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    49. Tuder RM, Archer SL, Dorfmüller P, Erzurum SC, Guignabert C, Michelakis E, Rabinovitch M, Schermuly R, Stenmark KR, Morrell NW. [Relevant issues in the pathology and pathobiology of pulmonary hypertension]. Turk Kardiyol Dern Ars. 2014 Oct; 42 Suppl 1:5-16. PMID: 25697030.
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    50. Ryan JJ, Archer SL. The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure. Circ Res. 2014 Jun 20; 115(1):176-88. PMID: 24951766.
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    51. Hong Z, Cabrera JA, Mahapatra S, Kutty S, Weir EK, Archer SL. Activation of the EGFR/p38/JNK pathway by mitochondrial-derived hydrogen peroxide contributes to oxygen-induced contraction of ductus arteriosus. J Mol Med (Berl). 2014 Sep; 92(9):995-1007. PMID: 24906456.
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    52. Archer SL. Mitochondrial fission and fusion in human diseases. N Engl J Med. 2014 03 13; 370(11):1074. PMID: 24620884.
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    53. Dweik RA, Rounds S, Erzurum SC, Archer S, Fagan K, Hassoun PM, Hill NS, Humbert M, Kawut SM, Krowka M, Michelakis E, Morrell NW, Stenmark K, Tuder RM, Newman J. An official American Thoracic Society Statement: pulmonary hypertension phenotypes. Am J Respir Crit Care Med. 2014 Feb 01; 189(3):345-55. PMID: 24484330.
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    54. Tuder RM, Archer SL, Dorfmüller P, Erzurum SC, Guignabert C, Michelakis E, Rabinovitch M, Schermuly R, Stenmark KR, Morrell NW. Relevant issues in the pathology and pathobiology of pulmonary hypertension. J Am Coll Cardiol. 2013 Dec 24; 62(25 Suppl):D4-12. PMID: 24355640.
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    55. Samant SA, Zhang HJ, Hong Z, Pillai VB, Sundaresan NR, Wolfgeher D, Archer SL, Chan DC, Gupta MP. SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress. Mol Cell Biol. 2014 Mar; 34(5):807-19. PMID: 24344202.
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    56. Archer SL. Mitochondrial dynamics--mitochondrial fission and fusion in human diseases. N Engl J Med. 2013 Dec 05; 369(23):2236-51. PMID: 24304053.
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    57. Sharp WW, Fang YH, Han M, Zhang HJ, Hong Z, Banathy A, Morrow E, Ryan JJ, Archer SL. Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission. FASEB J. 2014 Jan; 28(1):316-26. PMID: 24076965.
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    58. Prochaska MT, Bergl PA, Patel AR, Moss JD, Archer SL. Atrioventricular heart block and syncope coincident with diagnosis of systemic lupus erythematosus. Can J Cardiol. 2013 Oct; 29(10):1330.e5-1330.e7. PMID: 23916739.
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    59. Archer SL. Riociguat for pulmonary hypertension--a glass half full. N Engl J Med. 2013 Jul 25; 369(4):386-8. PMID: 23883383.
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    60. Piao L, Fang YH, Parikh K, Ryan JJ, Toth PT, Archer SL. Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension. J Mol Med (Berl). 2013 Oct; 91(10):1185-97. PMID: 23794090.
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    61. Ryan JJ, Marsboom G, Fang YH, Toth PT, Morrow E, Luo N, Piao L, Hong Z, Ericson K, Zhang HJ, Han M, Haney CR, Chen CT, Sharp WW, Archer SL. PGC1a-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension. Am J Respir Crit Care Med. 2013 Apr 15; 187(8):865-78. PMID: 23449689.
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    62. von Gise A, Archer SL, Maclean MR, Hansmann G. The first Keystone Symposia Conference on pulmonary vascular isease and right ventricular dysfunction: Current concepts and future therapies. Pulm Circ. 2013 Apr; 3(2):275-7. PMID: 24015328.
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    63. Kim GH, Ryan JJ, Archer SL. The role of redox signaling in epigenetics and cardiovascular disease. Antioxid Redox Signal. 2013 May 20; 18(15):1920-36. PMID: 23480168.
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    64. Hong Z, Kutty S, Toth PT, Marsboom G, Hammel JM, Chamberlain C, Ryan JJ, Zhang HJ, Sharp WW, Morrow E, Trivedi K, Weir EK, Archer SL. Role of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus. Circ Res. 2013 Mar 01; 112(5):802-15. PMID: 23334860.
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    65. Archer SL, Fang YH, Ryan JJ, Piao L. Metabolism and bioenergetics in the right ventricle and pulmonary vasculature in pulmonary hypertension. Pulm Circ. 2013 Jan; 3(1):144-52. PMID: 23662191.
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    66. Ryan JJ, Marsboom G, Archer SL. Rodent models of group 1 pulmonary hypertension. Handb Exp Pharmacol. 2013; 218:105-49. PMID: 24092338.
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    67. Morrell NW, Archer SL, Defelice A, Evans S, Fiszman M, Martin T, Saulnier M, Rabinovitch M, Schermuly R, Stewart D, Truebel H, Walker G, Stenmark KR. Anticipated classes of new medications and molecular targets for pulmonary arterial hypertension. Pulm Circ. 2013 Jan; 3(1):226-44. PMID: 23662201.
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    68. Piao L, Sidhu VK, Fang YH, Ryan JJ, Parikh KS, Hong Z, Toth PT, Morrow E, Kutty S, Lopaschuk GD, Archer SL. FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate. J Mol Med (Berl). 2013 Mar; 91(3):333-46. PMID: 23247844.
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    69. Piao L, Fang YH, Parikh KS, Ryan JJ, D'Souza KM, Theccanat T, Toth PT, Pogoriler J, Paul J, Blaxall BC, Akhter SA, Archer SL. GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension. Circulation. 2012 Dec 11; 126(24):2859-69. PMID: 23124027.
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    70. Rich JD, Archer SL, Rich S. Noninvasive cardiac output measurements in patients with pulmonary hypertension. Eur Respir J. 2013 Jul; 42(1):125-33. PMID: 23100501.
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    71. Thenappan T, Ryan JJ, Archer SL. Evolving epidemiology of pulmonary arterial hypertension. Am J Respir Crit Care Med. 2012 Oct 15; 186(8):707-9. PMID: 23071187.
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    72. Pogoriler JE, Rich S, Archer SL, Husain AN. Persistence of complex vascular lesions despite prolonged prostacyclin therapy of pulmonary arterial hypertension. Histopathology. 2012 Oct; 61(4):597-609. PMID: 22748137.
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    73. Marsboom G, Toth PT, Ryan JJ, Hong Z, Wu X, Fang YH, Thenappan T, Piao L, Zhang HJ, Pogoriler J, Chen Y, Morrow E, Weir EK, Rehman J, Archer SL. Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. Circ Res. 2012 May 25; 110(11):1484-97. PMID: 22511751.
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    74. Rich JD, Thenappan T, Freed B, Patel AR, Thisted RA, Childers R, Archer SL. QTc prolongation is associated with impaired right ventricular function and predicts mortality in pulmonary hypertension. Int J Cardiol. 2013 Aug 10; 167(3):669-76. PMID: 22459397.
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    75. Rehman J, Zhang HJ, Toth PT, Zhang Y, Marsboom G, Hong Z, Salgia R, Husain AN, Wietholt C, Archer SL. Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer. FASEB J. 2012 May; 26(5):2175-86. PMID: 22321727.
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    76. Freed BH, Gomberg-Maitland M, Chandra S, Mor-Avi V, Rich S, Archer SL, Jamison EB, Lang RM, Patel AR. Late gadolinium enhancement cardiovascular magnetic resonance predicts clinical worsening in patients with pulmonary hypertension. J Cardiovasc Magn Reson. 2012 Feb 01; 14:11. PMID: 22296860.
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    77. Marsboom G, Wietholt C, Haney CR, Toth PT, Ryan JJ, Morrow E, Thenappan T, Bache-Wiig P, Piao L, Paul J, Chen CT, Archer SL. Lung ¹8F-fluorodeoxyglucose positron emission tomography for diagnosis and monitoring of pulmonary arterial hypertension. Am J Respir Crit Care Med. 2012 Mar 15; 185(6):670-9. PMID: 22246173.
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    78. Ryan JJ, Thenappan T, Luo N, Ha T, Patel AR, Rich S, Archer SL. The WHO classification of pulmonary hypertension: A case-based imaging compendium. Pulm Circ. 2012 Jan-Mar; 2(1):107-21. PMID: 22558526.
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    79. Ryan JJ, Rich S, Archer SL. Pulmonary endarterectomy surgery--a technically demanding cure for WHO Group IV Pulmonary Hypertension: requirements for centres of excellence and availability in Canada. Can J Cardiol. 2011 Nov-Dec; 27(6):671-4. PMID: 22019277.
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    80. Ryan JJ, Kalscheur M, Dellefave L, McNally E, Archer SL. A KCNE1 missense variant (V47I) causing exercise-induced long QT syndrome (Romano Ward). Int J Cardiol. 2012 Apr 19; 156(2):e33-5. PMID: 21907427.
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    81. Fang YH, Piao L, Hong Z, Toth PT, Marsboom G, Bache-Wiig P, Rehman J, Archer SL. Therapeutic inhibition of fatty acid oxidation in right ventricular hypertrophy: exploiting Randle's cycle. J Mol Med (Berl). 2012 Jan; 90(1):31-43. PMID: 21874543.
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    82. Ryan JJ, Rehman J, Archer SL. Paracrine proliferative signaling by senescent cells in world health organization group 3 pulmonary hypertension: age corrupting youth? Circ Res. 2011 Aug 19; 109(5):476-9. PMID: 21852552.
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    83. Patel AR, Klein MR, Chandra S, Spencer KT, Decara JM, Lang RM, Burke MC, Garrity ER, Hogarth DK, Archer SL, Sweiss NJ, Beshai JF. Myocardial damage in patients with sarcoidosis and preserved left ventricular systolic function: an observational study. Eur J Heart Fail. 2011 Nov; 13(11):1231-7. PMID: 21810833.
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    84. Ryan J, Bloch K, Archer SL. Rodent models of pulmonary hypertension: harmonisation with the world health organisation's categorisation of human PH. Int J Clin Pract Suppl. 2011 Aug; (172):15-34. PMID: 21736677.
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    85. Kim GH, Ryan JJ, Marsboom G, Archer SL. Epigenetic mechanisms of pulmonary hypertension. Pulm Circ. 2011 Jul-Sep; 1(3):347-56. PMID: 22140624.
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    86. Luong C, Rey-Perra J, Vadivel A, Gilmour G, Sauve Y, Koonen D, Walker D, Todd KG, Gressens P, Kassiri Z, Nadeem K, Morgan B, Eaton F, Dyck JR, Archer SL, Thébaud B. Antenatal sildenafil treatment attenuates pulmonary hypertension in experimental congenital diaphragmatic hernia. Circulation. 2011 May 17; 123(19):2120-31. PMID: 21537000.
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    87. Jaff MR, McMurtry MS, Archer SL, Cushman M, Goldenberg N, Goldhaber SZ, Jenkins JS, Kline JA, Michaels AD, Thistlethwaite P, Vedantham S, White RJ, Zierler BK. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation. 2011 Apr 26; 123(16):1788-830. PMID: 21422387.
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    88. Thenappan T, Goel A, Marsboom G, Fang YH, Toth PT, Zhang HJ, Kajimoto H, Hong Z, Paul J, Wietholt C, Pogoriler J, Piao L, Rehman J, Archer SL. A central role for CD68(+) macrophages in hepatopulmonary syndrome. Reversal by macrophage depletion. Am J Respir Crit Care Med. 2011 Apr 15; 183(8):1080-91. PMID: 21148721.
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    89. Rich S, Pogoriler J, Husain AN, Toth PT, Gomberg-Maitland M, Archer SL. Long-term effects of epoprostenol on the pulmonary vasculature in idiopathic pulmonary arterial hypertension. Chest. 2010 Nov; 138(5):1234-9. PMID: 21051399.
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    90. Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer SL, Asosingh K, Balaban R, Bauer N, Bhattacharya J, Bogaard H, Choudhary G, Dorn GW, Dweik R, Fagan K, Fallon M, Finkel T, Geraci M, Gladwin MT, Hassoun PM, Humbert M, Kaminski N, Kawut SM, Loscalzo J, McDonald D, McMurtry IF, Newman J, Nicolls M, Rabinovitch M, Shizuru J, Oka M, Polgar P, Rodman D, Schumacker P, Stenmark K, Tuder R, Voelkel N, Sullivan E, Weinshilboum R, Yoder MC, Zhao Y, Gail D, Moore TM. Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report. Am J Respir Crit Care Med. 2010 Dec 15; 182(12):1554-62. PMID: 20833821.
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    91. Piao L, Marsboom G, Archer SL. Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure. J Mol Med (Berl). 2010 Oct; 88(10):1011-20. PMID: 20820751.
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    92. Weir EK, Archer SL. The role of redox changes in oxygen sensing. Respir Physiol Neurobiol. 2010 Dec 31; 174(3):182-91. PMID: 20801237.
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    93. Archer SL. The mitochondrion as a Swiss army knife: implications for cardiovascular disease. J Mol Med (Berl). 2010 Oct; 88(10):963-5. PMID: 20711556.
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    94. Lin E, Boire A, Hemmige V, Husain AN, Sorrentino M, Nathan S, Akhter SA, Dickstein J, Archer SL. Cardiac tamponade mimicking tuberculous pericarditis as the initial presentation of chronic lymphocytic leukemia in a 58-year-old woman: a case report. J Med Case Rep. 2010 Aug 04; 4:246. PMID: 20684780.
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    95. Urboniene D, Haber I, Fang YH, Thenappan T, Archer SL. Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2010 Sep; 299(3):L401-12. PMID: 20581101.
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    96. Archer SL, Marsboom G, Kim GH, Zhang HJ, Toth PT, Svensson EC, Dyck JR, Gomberg-Maitland M, Thébaud B, Husain AN, Cipriani N, Rehman J. Epigenetic attenuation of mitochondrial superoxide dismutase 2 in pulmonary arterial hypertension: a basis for excessive cell proliferation and a new therapeutic target. Circulation. 2010 Jun 22; 121(24):2661-71. PMID: 20529999.
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    97. Nijjar RS, Watson DI, Jamieson GG, Archer S, Bessell JR, Booth M, Cade R, Cullingford GL, Devitt PG, Fletcher DR, Hurley J, Kiroff G, Martin IJ, Nathanson LK, Windsor JA. Five-year follow-up of a multicenter, double-blind randomized clinical trial of laparoscopic Nissen vs anterior 90 degrees partial fundoplication. Arch Surg. 2010 Jun; 145(6):552-7. PMID: 20566975.
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    98. Levy DI, Cepaitis E, Wanderling S, Toth PT, Archer SL, Goldstein SA. The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner. J Physiol. 2010 Jul 15; 588(Pt 14):2657-68. PMID: 20498229.
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    99. Archer SL, Weir EK, Wilkins MR. Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies. Circulation. 2010 May 11; 121(18):2045-66. PMID: 20458021.
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    100. Sweiss NJ, Hushaw L, Thenappan T, Sawaqed R, Machado RF, Patel AR, Gomberg-Maitland M, Husain AN, Archer SL. Diagnosis and management of pulmonary hypertension in systemic sclerosis. Curr Rheumatol Rep. 2010 Feb; 12(1):8-18. PMID: 20425528.
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    101. Rehman J, Archer SL. A proposed mitochondrial-metabolic mechanism for initiation and maintenance of pulmonary arterial hypertension in fawn-hooded rats: the Warburg model of pulmonary arterial hypertension. Adv Exp Med Biol. 2010; 661:171-85. PMID: 20204730.
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    102. Thenappan T, Shah SJ, Rich S, Tian L, Archer SL, Gomberg-Maitland M. Survival in pulmonary arterial hypertension: a reappraisal of the NIH risk stratification equation. Eur Respir J. 2010 May; 35(5):1079-87. PMID: 20032020.
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    103. Gomberg-Maitland M, Maitland ML, Barst RJ, Sugeng L, Coslet S, Perrino TJ, Bond L, Lacouture ME, Archer SL, Ratain MJ. A dosing/cross-development study of the multikinase inhibitor sorafenib in patients with pulmonary arterial hypertension. Clin Pharmacol Ther. 2010 Mar; 87(3):303-10. PMID: 20010555.
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    104. Piao L, Fang YH, Cadete VJ, Wietholt C, Urboniene D, Toth PT, Marsboom G, Zhang HJ, Haber I, Rehman J, Lopaschuk GD, Archer SL. The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle. J Mol Med (Berl). 2010 Jan; 88(1):47-60. PMID: 19949938.
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    105. Bungard TJ, Smigorowsky MJ, Lalonde LD, Hogan T, Doliszny KM, Gebreyesus G, Garg S, Archer SL. Cardiac EASE (Ensuring Access and Speedy Evaluation) - the impact of a single-point-of-entry multidisciplinary outpatient cardiology consultation program on wait times in Canada. Can J Cardiol. 2009 Dec; 25(12):697-702. PMID: 19960130.
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    106. Archer SL, Michelakis ED. Phosphodiesterase type 5 inhibitors for pulmonary arterial hypertension. N Engl J Med. 2009 Nov 05; 361(19):1864-71. PMID: 19890129.
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    107. Chandra S, Shah SJ, Thenappan T, Archer SL, Rich S, Gomberg-Maitland M. Carbon monoxide diffusing capacity and mortality in pulmonary arterial hypertension. J Heart Lung Transplant. 2010 Feb; 29(2):181-7. PMID: 19783169.
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    108. van Haaften T, Byrne R, Bonnet S, Rochefort GY, Akabutu J, Bouchentouf M, Rey-Parra GJ, Galipeau J, Haromy A, Eaton F, Chen M, Hashimoto K, Abley D, Korbutt G, Archer SL, Thébaud B. Airway delivery of mesenchymal stem cells prevents arrested alveolar growth in neonatal lung injury in rats. Am J Respir Crit Care Med. 2009 Dec 01; 180(11):1131-42. PMID: 19713449.
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    109. Morrell NW, Adnot S, Archer SL, Dupuis J, Jones PL, MacLean MR, McMurtry IF, Stenmark KR, Thistlethwaite PA, Weissmann N, Yuan JX, Weir EK. Cellular and molecular basis of pulmonary arterial hypertension. J Am Coll Cardiol. 2009 Jun 30; 54(1 Suppl):S20-31. PMID: 19555855.
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    110. Polonsky TS, Taillon LA, Sheth H, Min JK, Archer SL, Ward RP. The association between erectile dysfunction and peripheral arterial disease as determined by screening ankle-brachial index testing. Atherosclerosis. 2009 Dec; 207(2):440-4. PMID: 19501825.
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    111. Shah SJ, Thenappan T, Rich S, Sur J, Archer SL, Gomberg-Maitland M. Value of exercise treadmill testing in the risk stratification of patients with pulmonary hypertension. Circ Heart Fail. 2009 Jul; 2(4):278-86. PMID: 19808350.
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    112. McLaughlin VV, Archer SL, Badesch DB, Barst RJ, Farber HW, Lindner JR, Mathier MA, McGoon MD, Park MH, Rosenson RS, Rubin LJ, Tapson VF, Varga J. ACCF/AHA 2009 expert consensus document on pulmonary hypertension a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association. J Am Coll Cardiol. 2009 Apr 28; 53(17):1573-619. PMID: 19389575.
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    113. McLaughlin VV, Archer SL, Badesch DB, Barst RJ, Farber HW, Lindner JR, Mathier MA, McGoon MD, Park MH, Rosenson RS, Rubin LJ, Tapson VF, Varga J, Harrington RA, Anderson JL, Bates ER, Bridges CR, Eisenberg MJ, Ferrari VA, Grines CL, Hlatky MA, Jacobs AK, Kaul S, Lichtenberg RC, Lindner JR, Moliterno DJ, Mukherjee D, Pohost GM, Rosenson RS, Schofield RS, Shubrooks SJ, Stein JH, Tracy CM, Weitz HH, Wesley DJ. ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association: developed in collaboration with the American College of Chest Physicians, American Thoracic Society, Inc., and the Pulmonary Hypertension Association. Circulation. 2009 Apr 28; 119(16):2250-94. PMID: 19332472.
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    114. Marsboom G, Archer SL. Pathways of proliferation: new targets to inhibit the growth of vascular smooth muscle cells. Circ Res. 2008 Nov 07; 103(10):1047-9. PMID: 18988899.
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    115. Rey-Parra GJ, Archer SL, Bland RD, Albertine KH, Carlton DP, Cho SC, Kirby B, Haromy A, Eaton F, Wu X, Thébaud B. Blunted hypoxic pulmonary vasoconstriction in experimental neonatal chronic lung disease. Am J Respir Crit Care Med. 2008 Aug 15; 178(4):399-406. PMID: 18511704.
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    116. Shah SJ, Thenappan T, Rich S, Tian L, Archer SL, Gomberg-Maitland M. Association of serum creatinine with abnormal hemodynamics and mortality in pulmonary arterial hypertension. Circulation. 2008 May 13; 117(19):2475-83. PMID: 18458173.
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    117. Archer SL. Dilated cardiomyopathy and left bundle branch block associated with ingestion of colloidal gold and silver is reversed by British antiLewisite and vitamin E: the potential toxicity of metals used as health supplements. Can J Cardiol. 2008 May; 24(5):397-9. PMID: 18464946.
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    118. Thébaud B, Wu XC, Kajimoto H, Bonnet S, Hashimoto K, Michelakis ED, Archer SL. Developmental absence of the O2 sensitivity of L-type calcium channels in preterm ductus arteriosus smooth muscle cells impairs O2 constriction contributing to patent ductus arteriosus. Pediatr Res. 2008 Feb; 63(2):176-81. PMID: 18091358.
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    119. Archer SL, Gomberg-Maitland M, Maitland ML, Rich S, Garcia JG, Weir EK. Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer. Am J Physiol Heart Circ Physiol. 2008 Feb; 294(2):H570-8. PMID: 18083891.
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    120. McMurtry MS, Bonnet S, Michelakis ED, Bonnet S, Haromy A, Archer SL. Statin therapy, alone or with rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin study. Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L933-40. PMID: 17675370.
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    121. Nagendran J, Archer SL, Soliman D, Gurtu V, Moudgil R, Haromy A, St Aubin C, Webster L, Rebeyka IM, Ross DB, Light PE, Dyck JR, Michelakis ED. Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation. 2007 Jul 17; 116(3):238-48. PMID: 17606845.
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    122. Bonnet S, Rochefort G, Sutendra G, Archer SL, Haromy A, Webster L, Hashimoto K, Bonnet SN, Michelakis ED. The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. Proc Natl Acad Sci U S A. 2007 Jul 03; 104(27):11418-23. PMID: 17596340.
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    123. Bonnet S, Archer SL. Potassium channel diversity in the pulmonary arteries and pulmonary veins: implications for regulation of the pulmonary vasculature in health and during pulmonary hypertension. Pharmacol Ther. 2007 Jul; 115(1):56-69. PMID: 17583356.
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    124. Kajimoto H, Hashimoto K, Bonnet SN, Haromy A, Harry G, Moudgil R, Nakanishi T, Rebeyka I, Thébaud B, Michelakis ED, Archer SL. Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction. Circulation. 2007 Apr 03; 115(13):1777-88. PMID: 17353442.
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    125. Bonnet S, Archer SL, Allalunis-Turner J, Haromy A, Beaulieu C, Thompson R, Lee CT, Lopaschuk GD, Puttagunta L, Bonnet S, Harry G, Hashimoto K, Porter CJ, Andrade MA, Thebaud B, Michelakis ED. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell. 2007 Jan; 11(1):37-51. PMID: 17222789.
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    126. Moudgil R, Michelakis ED, Archer SL. The role of k+ channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension. Microcirculation. 2006 Dec; 13(8):615-32. PMID: 17085423.
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    127. McMurtry MS, Moudgil R, Hashimoto K, Bonnet S, Michelakis ED, Archer SL. Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2007 Apr; 292(4):L872-8. PMID: 17142350.
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    128. Weir EK, Archer SL. Counterpoint: Hypoxic pulmonary vasoconstriction is not mediated by increased production of reactive oxygen species. J Appl Physiol (1985). 2006 Sep; 101(3):995-8; discussion 998. PMID: 16902070.
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    129. Archer SL, Michelakis ED. An evidence-based approach to the management of pulmonary arterial hypertension. Curr Opin Cardiol. 2006 Jul; 21(4):385-92. PMID: 16755209.
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    130. Stewart DJ, Hilton JD, Arnold JM, Gregoire J, Rivard A, Archer SL, Charbonneau F, Cohen E, Curtis M, Buller CE, Mendelsohn FO, Dib N, Page P, Ducas J, Plante S, Sullivan J, Macko J, Rasmussen C, Kessler PD, Rasmussen HS. Angiogenic gene therapy in patients with nonrevascularizable ischemic heart disease: a phase 2 randomized, controlled trial of AdVEGF(121) (AdVEGF121) versus maximum medical treatment. Gene Ther. 2006 Nov; 13(21):1503-11. PMID: 16791287.
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    131. Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thébaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS, Weir EK, Archer SL. An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation. 2006 Jun 06; 113(22):2630-41. PMID: 16735674.
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    132. Archer SL, Paterson I, Francis GA. Images in cardiovascular medicine. Untreated 37-year-old homozygous familial hypercholesterolemic smoker. Circulation. 2006 May 30; 113(21):e777. PMID: 16735680.
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    133. Archer SL, Michelakis ED, Thébaud B, Bonnet S, Moudgil R, Wu XC, Weir EK. A central role for oxygen-sensitive K+ channels and mitochondria in the specialized oxygen-sensing system. Novartis Found Symp. 2006; 272:157-71; discussion 171-5, 214-7. PMID: 16686435.
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    134. Weir EK, López-Barneo J, Buckler KJ, Archer SL. Acute oxygen-sensing mechanisms. N Engl J Med. 2005 Nov 10; 353(19):2042-55. PMID: 16282179.
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    135. Thébaud B, Ladha F, Michelakis ED, Sawicka M, Thurston G, Eaton F, Hashimoto K, Harry G, Haromy A, Korbutt G, Archer SL. Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization. Circulation. 2005 Oct 18; 112(16):2477-86. PMID: 16230500.
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    136. Langleben D, Archer S, Granton J, Hirsch AM, Levy RD, Mehta S, Michelakis E, Stewart DJ. Canadian Cardiovascular Society and Canadian Thoracic Society position statement on pulmonary arterial hypertension. Can Respir J. 2005 Sep; 12(6):303-15. PMID: 16247528.
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    137. Langleben D, Archer S, Granton J, Hirsch AM, Levy RD, Mehta S, Michelakis E, Stewart DJ. Canadian Cardiovascular Society and Canadian Thoracic Society position statement on pulmonary arterial hypertension. Can J Cardiol. 2005 Sep; 21(11):909-14. PMID: 16239973.
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    138. Hong Z, Smith AJ, Archer SL, Wu XC, Nelson DP, Peterson D, Johnson G, Weir EK. Pergolide is an inhibitor of voltage-gated potassium channels, including Kv1.5, and causes pulmonary vasoconstriction. Circulation. 2005 Sep 06; 112(10):1494-9. PMID: 16129789.
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    139. Archer SL. Pre-B-cell colony-enhancing factor regulates vascular smooth muscle maturation through a NAD+-dependent mechanism: recognition of a new mechanism for cell diversity and redox regulation of vascular tone and remodeling. Circ Res. 2005 Jul 08; 97(1):4-7. PMID: 16002754.
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    140. McMurtry MS, Archer SL, Altieri DC, Bonnet S, Haromy A, Harry G, Bonnet S, Puttagunta L, Michelakis ED. Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J Clin Invest. 2005 Jun; 115(6):1479-91. PMID: 15931388.
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    141. Moudgil R, Michelakis ED, Archer SL. Hypoxic pulmonary vasoconstriction. J Appl Physiol (1985). 2005 Jan; 98(1):390-403. PMID: 15591309.
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    142. Archer SL, Gragasin FS, Webster L, Bochinski D, Michelakis ED. Aetiology and management of male erectile dysfunction and female sexual dysfunction in patients with cardiovascular disease. Drugs Aging. 2005; 22(10):823-44. PMID: 16245957.
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    143. Michelakis ED, Thébaud B, Weir EK, Archer SL. Hypoxic pulmonary vasoconstriction: redox regulation of O2-sensitive K+ channels by a mitochondrial O2-sensor in resistance artery smooth muscle cells. J Mol Cell Cardiol. 2004 Dec; 37(6):1119-36. PMID: 15572043.
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    144. Archer SL, Greenlund KJ, Valdez R, Casper ML, Rith-Najarian S, Croft JB. Differences in food habits and cardiovascular disease risk factors among Native Americans with and without diabetes: the Inter-Tribal Heart Project. Public Health Nutr. 2004 Dec; 7(8):1025-32. PMID: 15548340.
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    145. Thébaud B, Michelakis ED, Wu XC, Moudgil R, Kuzyk M, Dyck JR, Harry G, Hashimoto K, Haromy A, Rebeyka I, Archer SL. Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus. Circulation. 2004 Sep 14; 110(11):1372-9. PMID: 15353504.
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    146. Gragasin FS, Michelakis ED, Hogan A, Moudgil R, Hashimoto K, Wu X, Bonnet S, Haromy A, Archer SL. The neurovascular mechanism of clitoral erection: nitric oxide and cGMP-stimulated activation of BKCa channels. FASEB J. 2004 Sep; 18(12):1382-91. PMID: 15333581.
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    147. Archer SL, Wu XC, Thébaud B, Nsair A, Bonnet S, Tyrrell B, McMurtry MS, Hashimoto K, Harry G, Michelakis ED. Preferential expression and function of voltage-gated, O2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells. Circ Res. 2004 Aug 06; 95(3):308-18. PMID: 15217912.
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    148. Newman JH, Fanburg BL, Archer SL, Badesch DB, Barst RJ, Garcia JG, Kao PN, Knowles JA, Loyd JE, McGoon MD, Morse JH, Nichols WC, Rabinovitch M, Rodman DM, Stevens T, Tuder RM, Voelkel NF, Gail DB. Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop. Circulation. 2004 Jun 22; 109(24):2947-52. PMID: 15210611.
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    149. Humbert M, Morrell NW, Archer SL, Stenmark KR, MacLean MR, Lang IM, Christman BW, Weir EK, Eickelberg O, Voelkel NF, Rabinovitch M. Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol. 2004 Jun 16; 43(12 Suppl S):13S-24S. PMID: 15194174.
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    150. Webster LJ, Michelakis ED, Davis T, Archer SL. Use of sildenafil for safe improvement of erectile function and quality of life in men with New York Heart Association classes II and III congestive heart failure: a prospective, placebo-controlled, double-blind crossover trial. Arch Intern Med. 2004 Mar 08; 164(5):514-20. PMID: 15006828.
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    151. Archer SL, Wu XC, Thébaud B, Moudgil R, Hashimoto K, Michelakis ED. O2 sensing in the human ductus arteriosus: redox-sensitive K+ channels are regulated by mitochondria-derived hydrogen peroxide. Biol Chem. 2004 Mar-Apr; 385(3-4):205-16. PMID: 15134333.
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    152. Armstrong PW, Ezekowitz C, Michelakis E, Anderson T, Archer S, Ghali W, Hayward R, Jensen L, Lopaschuk G, Sheldon R. Innovative strategic Canadian research training from TomorrOw's Research Cardiovascular Health Care Professionals (TORCH). Clin Invest Med. 2004 Feb; 27(1):33-41. PMID: 15061584.
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    153. Michelakis ED, Tymchak W, Noga M, Webster L, Wu XC, Lien D, Wang SH, Modry D, Archer SL. Long-term treatment with oral sildenafil is safe and improves functional capacity and hemodynamics in patients with pulmonary arterial hypertension. Circulation. 2003 Oct 28; 108(17):2066-9. PMID: 14568893.
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    154. Archer SL, Hilner JE, Dyer AR, Greenlund KJ, Colangelo LA, Kiefe CI, Liu K. Association of education with dietary intake among young adults in the bi-ethnic Coronary Artery Risk Development in Young Adults (CARDIA) cohort. Public Health Nutr. 2003 Oct; 6(7):689-95. PMID: 14552670.
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    155. Lara N, Chrapko WE, Archer SL, Bellavance F, Mayers I, Le Mellédo JM. Pulmonary and systemic nitric oxide measurements during CCK-5-induced panic attacks. Neuropsychopharmacology. 2003 Oct; 28(10):1840-5. PMID: 12865901.
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    156. Pozeg ZI, Michelakis ED, McMurtry MS, Thébaud B, Wu XC, Dyck JR, Hashimoto K, Wang S, Moudgil R, Harry G, Sultanian R, Koshal A, Archer SL. In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats. Circulation. 2003 Apr 22; 107(15):2037-44. PMID: 12695303.
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    157. Archer SL, Gragasin FS, Wu X, Wang S, McMurtry S, Kim DH, Platonov M, Koshal A, Hashimoto K, Campbell WB, Falck JR, Michelakis ED. Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels. Circulation. 2003 Feb 11; 107(5):769-76. PMID: 12578883.
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    158. Michelakis ED, McMurtry MS, Sonnenberg B, Archer SL. The NO - K+ channel axis in pulmonary arterial hypertension. Activation by experimental oral therapies. Adv Exp Med Biol. 2003; 543:293-322. PMID: 14713130.
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    159. Michelakis ED, Rebeyka I, Wu X, Nsair A, Thébaud B, Hashimoto K, Dyck JR, Haromy A, Harry G, Barr A, Archer SL. O2 sensing in the human ductus arteriosus: regulation of voltage-gated K+ channels in smooth muscle cells by a mitochondrial redox sensor. Circ Res. 2002 Sep 20; 91(6):478-86. PMID: 12242265.
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    160. Hampl V, Bíbová J, Stranák Z, Wu X, Michelakis ED, Hashimoto K, Archer SL. Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition. Am J Physiol Heart Circ Physiol. 2002 Dec; 283(6):H2440-9. PMID: 12388256.
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    161. Archer S, Michelakis E. The mechanism(s) of hypoxic pulmonary vasoconstriction: potassium channels, redox O(2) sensors, and controversies. News Physiol Sci. 2002 Aug; 17:131-7. PMID: 12136039.
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    162. Thébaud B, Michelakis E, Wu XC, Harry G, Hashimoto K, Archer SL. Sildenafil reverses O2 constriction of the rabbit ductus arteriosus by inhibiting type 5 phosphodiesterase and activating BK(Ca) channels. Pediatr Res. 2002 Jul; 52(1):19-24. PMID: 12084842.
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    163. Michelakis ED, Hampl V, Nsair A, Wu X, Harry G, Haromy A, Gurtu R, Archer SL. Diversity in mitochondrial function explains differences in vascular oxygen sensing. Circ Res. 2002 Jun 28; 90(12):1307-15. PMID: 12089069.
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    164. Michelakis E, Tymchak W, Lien D, Webster L, Hashimoto K, Archer S. Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide. Circulation. 2002 May 21; 105(20):2398-403. PMID: 12021227.
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    165. Michelakis ED, McMurtry MS, Wu XC, Dyck JR, Moudgil R, Hopkins TA, Lopaschuk GD, Puttagunta L, Waite R, Archer SL. Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels. Circulation. 2002 Jan 15; 105(2):244-50. PMID: 11790708.
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    166. Archer SL, London B, Hampl V, Wu X, Nsair A, Puttagunta L, Hashimoto K, Waite RE, Michelakis ED. Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5. FASEB J. 2001 Aug; 15(10):1801-3. PMID: 11481235.
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    167. Michelakis ED, Weir EK, Wu X, Nsair A, Waite R, Hashimoto K, Puttagunta L, Knaus HG, Archer SL. Potassium channels regulate tone in rat pulmonary veins. Am J Physiol Lung Cell Mol Physiol. 2001 Jun; 280(6):L1138-47. PMID: 11350792.
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    168. Reeve HL, Michelakis E, Nelson DP, Weir EK, Archer SL. Alterations in a redox oxygen sensing mechanism in chronic hypoxia. J Appl Physiol (1985). 2001 Jun; 90(6):2249-56. PMID: 11356790.
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    169. Reeve HL, Tolarova S, Nelson DP, Archer S, Weir EK. Redox control of oxygen sensing in the rabbit ductus arteriosus. J Physiol. 2001 May 15; 533(Pt 1):253-61. PMID: 11351032.
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    170. Peterson DA, Reeve HL, Nelson D, Archer SL, Weir EK. Triple-bonded unsaturated fatty acids are redox active compounds. Lipids. 2001 Apr; 36(4):431-3. PMID: 11383698.
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    171. Michelakis ED, Dyck JR, McMurtry MS, Wang S, Wu XC, Moudgil R, Hashimoto K, Puttagunta L, Archer SL. Gene transfer and metabolic modulators as new therapies for pulmonary hypertension. Increasing expression and activity of potassium channels in rat and human models. Adv Exp Med Biol. 2001; 502:401-18. PMID: 11950153.
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    172. Archer S, Rich S. Primary pulmonary hypertension: a vascular biology and translational research "Work in progress". Circulation. 2000 Nov 28; 102(22):2781-91. PMID: 11094047.
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    173. Michelakis E, Tymchak W, Archer S. Sildenafil: from the bench to the bedside. CMAJ. 2000 Oct 31; 163(9):1171-5. PMID: 11079066.
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    174. Tanser P, Archer S, Feldman R. Case 2. Recurrence of myocardial infarction. Can J Cardiol. 2000 Aug; 16 Suppl E:24E-26E. PMID: 10906622.
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    175. Michelakis E, Rebeyka I, Bateson J, Olley P, Puttagunta L, Archer S. Voltage-gated potassium channels in human ductus arteriosus. Lancet. 2000 Jul 08; 356(9224):134-7. PMID: 10963252.
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    176. Traverse JH, Wang YL, Du R, Nelson D, Lindstrom P, Archer SL, Gong G, Bache RJ. Coronary nitric oxide production in response to exercise and endothelium-dependent agonists. Circulation. 2000 May 30; 101(21):2526-31. PMID: 10831528.
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    177. Archer SL. In memoriam : Francis X. Witkowski. Circ Res. 2000 Apr 28; 86(8):823. PMID: 10785500.
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    178. Archer SL, Weir EK, Reeve HL, Michelakis E. Molecular identification of O2 sensors and O2-sensitive potassium channels in the pulmonary circulation. Adv Exp Med Biol. 2000; 475:219-40. PMID: 10849663.
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    179. Michelakis ED, Weir EK, Nelson DP, Reeve HL, Tolarova S, Archer SL. Dexfenfluramine elevates systemic blood pressure by inhibiting potassium currents in vascular smooth muscle cells. J Pharmacol Exp Ther. 1999 Dec; 291(3):1143-9. PMID: 10565835.
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    180. Cornfield DN, Martin EB, Hampl V, Archer SL. Aerosol delivery of diethylenetriamine/nitric oxide, a nitric oxide adduct, causes selective pulmonary vasodilation in perinatal lambs. J Lab Clin Med. 1999 Oct; 134(4):419-25. PMID: 10521090.
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    181. Reeve HL, Archer SL, Soper M, Weir EK. Dexfenfluramine increases pulmonary artery smooth muscle intracellular Ca2+, independent of membrane potential. Am J Physiol. 1999 09; 277(3):L662-6. PMID: 10484475.
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    182. Thébaud B, Tibboel D, Rambaud C, Mercier JC, Bourbon JR, Dinh-Xuan AT, Archer SL. Vitamin A decreases the incidence and severity of nitrofen-induced congenital diaphragmatic hernia in rats. Am J Physiol. 1999 08; 277(2):L423-9. PMID: 10444537.
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    183. Archer SL, Reeve HL, Michelakis E, Puttagunta L, Waite R, Nelson DP, Dinauer MC, Weir EK. O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):7944-9. PMID: 10393927.
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    184. Reeve HL, Nelson DP, Archer SL, Weir EK. Effects of fluoxetine, phentermine, and venlafaxine on pulmonary arterial pressure and electrophysiology. Am J Physiol. 1999 02; 276(2):L213-9. PMID: 9950882.
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    185. Peterson DA, Peterson DC, Reeve HL, Archer SL, Weir EK. GTP (gammaS) and GDP (betaS) as electron donors: new wine in old bottles. Life Sci. 1999; 65(11):1135-40. PMID: 10503929.
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    186. Reeve HL, Weir EK, Archer SL, Cornfield DN. A maturational shift in pulmonary K+ channels, from Ca2+ sensitive to voltage dependent. Am J Physiol. 1998 12; 275(6):L1019-25. PMID: 9843837.
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    187. Archer SL, Djaballah K, Humbert M, Weir KE, Fartoukh M, Dall'ava-Santucci J, Mercier JC, Simonneau G, Dinh-Xuan AT. Nitric oxide deficiency in fenfluramine- and dexfenfluramine-induced pulmonary hypertension. Am J Respir Crit Care Med. 1998 Oct; 158(4):1061-7. PMID: 9769261.
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    188. Archer SL, Liu K, Dyer AR, Ruth KJ, Jacobs DR, Van Horn L, Hilner JE, Savage PJ. Relationship between changes in dietary sucrose and high density lipoprotein cholesterol: the CARDIA study. Coronary Artery Risk Development in Young Adults. Ann Epidemiol. 1998 Oct; 8(7):433-8. PMID: 9738689.
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    189. Weir EK, Reeve HL, Johnson G, Michelakis ED, Nelson DP, Archer SL. A role for potassium channels in smooth muscle cells and platelets in the etiology of primary pulmonary hypertension. Chest. 1998 Sep; 114(3 Suppl):200S-204S. PMID: 9741569.
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    190. Weir EK, Reeve HL, Peterson DA, Michelakis ED, Nelson DP, Archer SL. Pulmonary vasoconstriction, oxygen sensing, and the role of ion channels: Thomas A. Neff lecture. Chest. 1998 Jul; 114(1 Suppl):17S-22S. PMID: 9676606.
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    191. Archer SL, Green D, Chamberlain M, Dyer AR, Liu K. Association of dietary fish and n-3 fatty acid intake with hemostatic factors in the coronary artery risk development in young adults (CARDIA) study. Arterioscler Thromb Vasc Biol. 1998 Jul; 18(7):1119-23. PMID: 9672072.
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    192. Archer SL, Souil E, Dinh-Xuan AT, Schremmer B, Mercier JC, El Yaagoubi A, Nguyen-Huu L, Reeve HL, Hampl V. Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes. J Clin Invest. 1998 Jun 01; 101(11):2319-30. PMID: 9616203.
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    193. Tristani-Firouzi M, DeMaster EG, Quast BJ, Nelson DP, Archer SL. Utility of a nitric oxide electrode for monitoring the administration of nitric oxide in biologic systems. J Lab Clin Med. 1998 Mar; 131(3):281-5. PMID: 9523853.
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    194. Michelakis ED, Archer SL. The measurement of NO in biological systems using chemiluminescence. Methods Mol Biol. 1998; 100:111-27. PMID: 10906999.
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    195. Reeve HL, Archer SL, Weir EK. Ion channels in the pulmonary vasculature. Pulm Pharmacol Ther. 1997 Oct-Dec; 10(5-6):243-52. PMID: 9778487.
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    196. Michelakis ED, Reeve HL, Huang JM, Tolarova S, Nelson DP, Weir EK, Archer SL. Potassium channel diversity in vascular smooth muscle cells. Can J Physiol Pharmacol. 1997 Jul; 75(7):889-97. PMID: 9315358.
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    197. Weir EK, Reeve HL, Cornfield DN, Tristani-Firouzi M, Peterson DA, Archer SL. Diversity of response in vascular smooth muscle cells to changes in oxygen tension. Kidney Int. 1997 Feb; 51(2):462-6. PMID: 9027722.
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    198. Tristani-Firouzi M, Martin EB, Tolarova S, Weir EK, Archer SL, Cornfield DN. Ventilation-induced pulmonary vasodilation at birth is modulated by potassium channel activity. Am J Physiol. 1996 Dec; 271(6 Pt 2):H2353-9. PMID: 8997293.
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    199. Tristani-Firouzi M, Reeve HL, Tolarova S, Weir EK, Archer SL. Oxygen-induced constriction of rabbit ductus arteriosus occurs via inhibition of a 4-aminopyridine-, voltage-sensitive potassium channel. J Clin Invest. 1996 Nov 01; 98(9):1959-65. PMID: 8903313.
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    200. Weir EK, Reeve HL, Huang JM, Michelakis E, Nelson DP, Hampl V, Archer SL. Anorexic agents aminorex, fenfluramine, and dexfenfluramine inhibit potassium current in rat pulmonary vascular smooth muscle and cause pulmonary vasoconstriction. Circulation. 1996 Nov 01; 94(9):2216-20. PMID: 8901674.
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    201. Dillon WC, Hampl V, Shultz PJ, Rubins JB, Archer SL. Origins of breath nitric oxide in humans. Chest. 1996 Oct; 110(4):930-8. PMID: 8874248.
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    202. Sidney EJ, Hampl V, Nelson DP, Archer SL, Foegh ML, Cathapermal SS, Weir EK. The somatostatin analog angiopeptin does not reduce chronic hypoxic pulmonary hypertension in rats. Proc Soc Exp Biol Med. 1996 Oct; 213(1):43-9. PMID: 8820822.
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    203. Peterson DA, Peterson DC, Archer SL, Weir EK. Accelerated disulfide reduction with polyunsaturated fatty acids: a mechanism of ionic channel modulation? Redox Rep. 1996 Aug; 2(4):263-5. PMID: 27406276.
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    204. Cornfield DN, Reeve HL, Tolarova S, Weir EK, Archer S. Oxygen causes fetal pulmonary vasodilation through activation of a calcium-dependent potassium channel. Proc Natl Acad Sci U S A. 1996 Jul 23; 93(15):8089-94. PMID: 8755608.
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    205. Hampl V, Tristani-Firouzi M, Nelson DP, Archer SL. Chronic infusion of nitric oxide in experimental pulmonary hypertension: pulmonary pressure-flow analysis. Eur Respir J. 1996 Jul; 9(7):1475-81. PMID: 8836662.
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    206. Archer SL. Diversity of phenotype and function of vascular smooth muscle cells. J Lab Clin Med. 1996 Jun; 127(6):524-9. PMID: 8648256.
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    207. Archer SL, Huang JM, Reeve HL, Hampl V, Tolarová S, Michelakis E, Weir EK. Differential distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia. Circ Res. 1996 Mar; 78(3):431-42. PMID: 8593702.
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    208. Archer SL, Mike D, Crow J, Long W, Weir EK. A placebo-controlled trial of prostacyclin in acute respiratory failure in COPD. Chest. 1996 Mar; 109(3):750-5. PMID: 8617086.
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    209. Hampl V, Tristani-Firouzi M, Hutsell TC, Archer SL. Nebulized nitric oxide/nucleophile adduct reduces chronic pulmonary hypertension. Cardiovasc Res. 1996 Jan; 31(1):55-62. PMID: 8849589.
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    210. Reeve HL, Weir EK, Nelson DP, Peterson DA, Archer SL. Opposing effects of oxidants and antioxidants on K+ channel activity and tone in rat vascular tissue. Exp Physiol. 1995 Sep; 80(5):825-34. PMID: 8546871.
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    211. Archer SL, Hampl V, Nelson DP, Sidney E, Peterson DA, Weir EK. Dithionite increases radical formation and decreases vasoconstriction in the lung. Evidence that dithionite does not mimic alveolar hypoxia. Circ Res. 1995 Jul; 77(1):174-81. PMID: 7788875.
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    212. Archer SL, Freude KA, Shultz PJ. Effect of graded hypoxia on the induction and function of inducible nitric oxide synthase in rat mesangial cells. Circ Res. 1995 Jul; 77(1):21-8. PMID: 7540515.
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    213. Hampl V, Cornfield DN, Cowan NJ, Archer SL. Hypoxia potentiates nitric oxide synthesis and transiently increases cytosolic calcium levels in pulmonary artery endothelial cells. Eur Respir J. 1995 Apr; 8(4):515-22. PMID: 7664847.
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    214. Weir EK, Archer SL. The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels. FASEB J. 1995 Feb; 9(2):183-9. PMID: 7781921.
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    215. Lawrence DM, Archer S, Bidlack JM. Identification of opioid receptors in the immune system using a novel combination of selective opioid ligands and indirect phycoerythrin immunofluorescence. Adv Exp Med Biol. 1995; 373:17-21. PMID: 7668148.
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    216. Hampl V, Huang JM, Weir EK, Archer SL. Activation of the cGMP-dependent protein kinase mimics the stimulatory effect of nitric oxide and cGMP on calcium-gated potassium channels. Physiol Res. 1995; 44(1):39-44. PMID: 8789298.
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    217. Michelakis ED, Archer SL, Weir EK. Acute hypoxic pulmonary vasoconstriction: a model of oxygen sensing. Physiol Res. 1995; 44(6):361-7. PMID: 8798271.
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    218. Archer SL, Huang JM, Hampl V, Nelson DP, Shultz PJ, Weir EK. Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1994 Aug 02; 91(16):7583-7. PMID: 7519783.
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    219. Weir EK, Wyatt CN, Reeve HL, Huang J, Archer SL, Peers C. Diphenyleneiodonium inhibits both potassium and calcium currents in isolated pulmonary artery smooth muscle cells. J Appl Physiol (1985). 1994 Jun; 76(6):2611-5. PMID: 7928890.
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    220. Peterson DA, Archer SL, Weir EK. Superoxide reduction of a disulfide: a model of intracellular redox modulation? Biochem Biophys Res Commun. 1994 May 16; 200(3):1586-91. PMID: 8185613.
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    221. Archer SL, Mike DK, Hetland MB, Kostamo KL, Shafer RB, Chesler E. Usefulness of mean aortic valve gradient and left ventricular diastolic filling pattern for distinguishing symptomatic from asymptomatic patients. Am J Cardiol. 1994 Feb 01; 73(4):275-81. PMID: 8296759.
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    222. Isaacson TC, Hampl V, Weir EK, Nelson DP, Archer SL. Increased endothelium-derived NO in hypertensive pulmonary circulation of chronically hypoxic rats. J Appl Physiol (1985). 1994 Feb; 76(2):933-40. PMID: 7513687.
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    223. Archer SL, Huang J, Henry T, Peterson D, Weir EK. A redox-based O2 sensor in rat pulmonary vasculature. Circ Res. 1993 Dec; 73(6):1100-12. PMID: 8222081.
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    224. Hampl V, Archer SL, Bach R, Nelson DP, Weir EK. Chronic hypoxic pulmonary hypertension. Is thrombin involved? Am Rev Respir Dis. 1993 Oct; 148(4 Pt 1):1043-8. PMID: 8214923.
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    225. Hampl V, Archer SL, Nelson DP, Weir EK. Chronic EDRF inhibition and hypoxia: effects on pulmonary circulation and systemic blood pressure. J Appl Physiol (1985). 1993 Oct; 75(4):1748-57. PMID: 7506706.
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    226. Toher C, Krug H, Archer SL. Diagnosis of pulmonary vein varix by transesophageal echocardiography. Chest. 1993 Jun; 103(6):1901-3. PMID: 8404126.
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    227. Peterson DA, Peterson DC, Archer SL, Weir EK. Superoxide dismutase: an antireductant enzyme? Biochem Soc Trans. 1993 May; 21(2):88S. PMID: 8395430.
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    228. Henry TD, Archer SL, Nelson D, Weir EK, From AH. Postischemic oxygen radical production varies with duration of ischemia. Am J Physiol. 1993 May; 264(5 Pt 2):H1478-84. PMID: 8498563.
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    229. Archer S. Measurement of nitric oxide in biological models. FASEB J. 1993 Feb 01; 7(2):349-60. PMID: 8440411.
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    230. Archer SL, Hampl V. NG-monomethyl-L-arginine causes nitric oxide synthesis in isolated arterial rings: trouble in paradise. Biochem Biophys Res Commun. 1992 Oct 30; 188(2):590-6. PMID: 1445303.
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    231. Rice KL, Duane PG, Archer SL, Gilboe DP, Niewoehner DE. H2O2 injury causes Ca(2+)-dependent and -independent hydrolysis of phosphatidylcholine in alveolar epithelial cells. Am J Physiol. 1992 Oct; 263(4 Pt 1):L430-8. PMID: 1415720.
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    232. Peterson DA, Peterson DC, Archer S, Weir EK. The non specificity of specific nitric oxide synthase inhibitors. Biochem Biophys Res Commun. 1992 Sep 16; 187(2):797-801. PMID: 1382421.
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    233. Post JM, Hume JR, Archer SL, Weir EK. Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am J Physiol. 1992 Apr; 262(4 Pt 1):C882-90. PMID: 1566816.
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    234. Archer SL, Cowan NJ. Measurement of endothelial cytosolic calcium concentration and nitric oxide production reveals discrete mechanisms of endothelium-dependent pulmonary vasodilatation. Circ Res. 1991 Jun; 68(6):1569-81. PMID: 2036711.
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    235. Henry TD, Archer SL, Nelson D, Weir EK, From AH. Enhanced chemiluminescence as a measure of oxygen-derived free radical generation during ischemia and reperfusion. Circ Res. 1990 Dec; 67(6):1453-61. PMID: 2245505.
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    236. Archer SL, Rist K, Nelson DP, DeMaster EG, Cowan N, Weir EK. Comparison of the hemodynamic effects of nitric oxide and endothelium-dependent vasodilators in intact lungs. J Appl Physiol (1985). 1990 Feb; 68(2):735-47. PMID: 2156794.
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    237. Archer SL, Tolins JP, Raij L, Weir EK. Hypoxic pulmonary vasoconstriction is enhanced by inhibition of the synthesis of an endothelium derived relaxing factor. Biochem Biophys Res Commun. 1989 Nov 15; 164(3):1198-205. PMID: 2480112.
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    238. Archer SL, Nelson DP, Weir EK. Simultaneous measurement of O2 radicals and pulmonary vascular reactivity in rat lung. J Appl Physiol (1985). 1989 Nov; 67(5):1903-11. PMID: 2532193.
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    239. Archer SL, Nelson DP, Weir EK. Detection of activated O2 species in vitro and in rat lungs by chemiluminescence. J Appl Physiol (1985). 1989 Nov; 67(5):1912-21. PMID: 2532194.
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    240. DeMaster EG, Raij L, Archer SL, Weir EK. Hydroxylamine is a vasorelaxant and a possible intermediate in the oxidative conversion of L-arginine to nitric oxide. Biochem Biophys Res Commun. 1989 Aug 30; 163(1):527-33. PMID: 2505770.
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    241. Archer SL, Johnson GJ, Gebhard RL, Castleman WL, Levine AS, Westcott JY, Voelkel NF, Nelson DP, Weir EK. Effect of dietary fish oil on lung lipid profile and hypoxic pulmonary hypertension. J Appl Physiol (1985). 1989 Apr; 66(4):1662-73. PMID: 2732158.
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    242. Archer SL, Nelson DP, Zimmer S, From AH, Weir EK. Hypoxic pulmonary vasoconstriction is unaltered by creatine depletion induced by dietary beta-guanidino propionic acid. Life Sci. 1989; 45(12):1081-8. PMID: 2796598.
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    243. Archer SL, Peterson D, Nelson DP, DeMaster EG, Kelly B, Eaton JW, Weir EK. Oxygen radicals and antioxidant enzymes alter pulmonary vascular reactivity in the rat lung. J Appl Physiol (1985). 1989 Jan; 66(1):102-11. PMID: 2917913.
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    244. Weir EK, Archer SL, Edwards JE. Chronic primary and secondary thromboembolic pulmonary hypertension. Chest. 1988 Mar; 93(3 Suppl):149S-154S. PMID: 3277816.
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    245. Archer S, Nelson D, Gebhard R, Levine AS, Prigge W, Weir EK. Effects of dietary fish oil on lung phospholipid fatty acid composition and intrinsic pulmonary vascular reactivity. Cardiovasc Res. 1987 Dec; 21(12):928-32. PMID: 3455359.
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    246. Archer S, Gornick C, Grund F, Shafer R, Weir EK. Exercise thallium testing in ventricular preexcitation. Am J Cardiol. 1987 May 01; 59(12):1103-6. PMID: 3578050.
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    247. Archer SL, Chesler E, Cohn JN, Weir EK. ZK 36-374, a stable analog of prostacyclin, prevents acute hypoxic pulmonary hypertension in the dog. J Am Coll Cardiol. 1986 Nov; 8(5):1189-94. PMID: 2428854.
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    248. Archer SL, Kulik TJ, Chesler E, Weir EK. The effects of substance P on the preconstricted pulmonary vasculature of the anesthetized dog. Proc Soc Exp Biol Med. 1986 Oct; 183(1):19-27. PMID: 2428048.
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    249. Archer SL, Will JA, Weir EK. Redox status in the control of pulmonary vascular tone. Herz. 1986 Jun; 11(3):127-41. PMID: 3017827.
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    250. Archer SL, Yankovich RD, Chesler E, Weir EK. Comparative effects of nisoldipine, nifedipine and bepridil on experimental pulmonary hypertension. J Pharmacol Exp Ther. 1985 Apr; 233(1):12-7. PMID: 3872360.
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