"Allosteric Site" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A site on an enzyme which upon binding of a modulator, causes the enzyme to undergo a conformational change that may alter its catalytic or binding properties.
| Descriptor ID |
D000495
|
| MeSH Number(s) |
G02.111.570.120.147
|
| Concept/Terms |
Allosteric Site- Allosteric Site
- Allosteric Sites
- Site, Allosteric
- Sites, Allosteric
|
Below are MeSH descriptors whose meaning is more general than "Allosteric Site".
Below are MeSH descriptors whose meaning is more specific than "Allosteric Site".
This graph shows the total number of publications written about "Allosteric Site" by people in this website by year, and whether "Allosteric Site" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 3 | 3 |
| 2018 | 1 | 2 | 3 |
| 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Allosteric Site" by people in Profiles.
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Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase. Protein Sci. 2020 03; 29(3):779-788.
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Identification and characterization of fragment binding sites for allosteric ligand design using the site identification by ligand competitive saturation hotspots approach (SILCS-Hotspots). Biochim Biophys Acta Gen Subj. 2020 04; 1864(4):129519.
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Engineering allosteric regulation in protein kinases. Sci Signal. 2018 11 06; 11(555).
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Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity. Cell Syst. 2018 10 24; 7(4):371-383.e4.
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An evolutionary hotspot defines functional differences between CRYPTOCHROMES. Nat Commun. 2018 03 19; 9(1):1138.
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Inhibition of RAS function through targeting an allosteric regulatory site. Nat Chem Biol. 2017 Jan; 13(1):62-68.
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Computational allosteric ligand binding site identification on Ras proteins. Acta Biochim Biophys Sin (Shanghai). 2016 Jan; 48(1):3-10.
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Substrate-Induced Allosteric Change in the Quaternary Structure of the Spermidine N-Acetyltransferase SpeG. J Mol Biol. 2015 Nov 06; 427(22):3538-3553.
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A novel polyamine allosteric site of SpeG from Vibrio cholerae is revealed by its dodecameric structure. J Mol Biol. 2015 Mar 27; 427(6 Pt B):1316-1334.
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Allosteric inhibition of the neuropeptidase neurolysin. J Biol Chem. 2014 Dec 19; 289(51):35605-19.