Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity.

Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity. J Biol Chem. 2005 Dec 30; 280(52):43121-30.

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subject areas

Animals
Aorta
Blotting, Western
Calcium
Catalytic Domain
Cell Death
Cells, Cultured
COS Cells
DNA
Enzyme Activation
Gene Expression Regulation, Enzymologic
Heart Failure
Heart Ventricles
Histone Deacetylases
Humans
Immunoprecipitation
Models, Biological
Muscle Cells
Myocytes, Cardiac
NAD
Oxidative Stress
Plasmids
Poly(ADP-ribose) Polymerases
Protein Processing, Post-Translational
Protein Structure, Tertiary
Rats
RNA, Small Interfering
Signal Transduction
Sirtuin 1
Sirtuins
Time Factors
Transfection
Tumor Suppressor Protein p53

authors with profiles

Mahesh P. Gupta