Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension.

Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. Circ Res. 2012 May 25; 110(11):1484-97.

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subject areas

Animals
Antihypertensive Agents
Case-Control Studies
CDC2 Protein Kinase
Cell Cycle Checkpoints
Cell Proliferation
Cells, Cultured
Cobalt
Cyclin B1
Disease Models, Animal
Dynamins
Enzyme Activation
Familial Primary Pulmonary Hypertension
Genetic Therapy
Glycolysis
GTP Phosphohydrolases
Humans
Hypertension, Pulmonary
Hypoxia
Hypoxia-Inducible Factor 1, alpha Subunit
Male
Microtubule-Associated Proteins
Mitochondria, Muscle
Mitochondrial Proteins
Mitosis
Monocrotaline
Muscle, Smooth, Vascular
Myocytes, Smooth Muscle
Phosphorylation
Pulmonary Artery
Quinazolinones
Rats
Rats, Sprague-Dawley
RNA Interference
Serine
Time Factors
Transfection

authors with profiles

Lin Piao
Stephen Archer