AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
"AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dioxygenase and alkylation repair homolog that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. It can also repair alkylated DNA containing 1-ethenoadenine in vitro. It has highest affinity for double-stranded DNA.
| Descriptor ID |
D000071499
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| MeSH Number(s) |
D08.811.074.062.750 D08.811.682.690.416.139.750
|
| Concept/Terms |
AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase- AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
- AlkB Homolog 2, Alpha Ketoglutarate Dependent Dioxygenase
- Alkylated DNA Repair Protein AlkB Homolog 2
- Oxy DC1 Protein
- DNA Oxidative Demethylase ALKBH2
- Alpha-ketoglutarate-Dependent Dioxygenase AlkB Homolog 2
- Alpha ketoglutarate Dependent Dioxygenase AlkB Homolog 2
|
Below are MeSH descriptors whose meaning is more general than "AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase".
Below are MeSH descriptors whose meaning is more specific than "AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase".
This graph shows the total number of publications written about "AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase" by people in this website by year, and whether "AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase" by people in Profiles.
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Duplex interrogation by a direct DNA repair protein in search of base damage. Nat Struct Mol Biol. 2012 Jun 03; 19(7):671-6.
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Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase. Nature. 2010 Nov 11; 468(7321):330-3.
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Structure determination of DNA methylation lesions N1-meA and N3-meC in duplex DNA using a cross-linked protein-DNA system. Nucleic Acids Res. 2010 Jul; 38(13):4415-25.
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A non-heme iron-mediated chemical demethylation in DNA and RNA. Acc Chem Res. 2009 Apr 21; 42(4):519-29.
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Chemical methods to study protein-nucleic acid interactions. Nucleic Acids Symp Ser (Oxf). 2009; (53):43.
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Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. Nature. 2008 Apr 24; 452(7190):961-5.
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Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies. Nucleic Acids Res. 2004; 32(4):1548-54.