AlkB Homolog 5, RNA Demethylase
"AlkB Homolog 5, RNA Demethylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A dioxygenase and alkylation repair homolog that demethylates RNA by oxidative demethylation. It specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA in higher eukaryotes. It can also demethylate N(6)-methyladenosine in SINGLE-STRANDED DNA.
| Descriptor ID |
D000071502
|
| MeSH Number(s) |
D08.811.074.062.937 D08.811.682.662.582.207 D08.811.682.690.416.139.968
|
| Concept/Terms |
AlkB Homolog 5, RNA Demethylase- AlkB Homolog 5, RNA Demethylase
- Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 5
- Alpha Ketoglutarate Dependent Dioxygenase AlkB Homolog 5
- RNA Demethylase ALKBH5
- ALKBH5, RNA Demethylase
- Demethylase ALKBH5, RNA
- Alkylated DNA Repair Protein AlkB Homolog 5
|
Below are MeSH descriptors whose meaning is more general than "AlkB Homolog 5, RNA Demethylase".
Below are MeSH descriptors whose meaning is more specific than "AlkB Homolog 5, RNA Demethylase".
This graph shows the total number of publications written about "AlkB Homolog 5, RNA Demethylase" by people in this website by year, and whether "AlkB Homolog 5, RNA Demethylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "AlkB Homolog 5, RNA Demethylase" by people in Profiles.
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Base-resolution quantitative DAMM-seq for mapping RNA methylations in tRNA and mitochondrial polycistronic RNA. Methods Enzymol. 2023; 692:39-54.
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Preparation of Human Nuclear RNA m6A Methyltransferases and Demethylases and Biochemical Characterization of Their Catalytic Activity. Methods Enzymol. 2015; 560:117-30.
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Crystal structure of the RNA demethylase ALKBH5 from zebrafish. FEBS Lett. 2014 Mar 18; 588(6):892-8.
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ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol Cell. 2013 Jan 10; 49(1):18-29.