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Savas Tay

TitleAssociate Professor
InstitutionUniversity of Chicago
DepartmentBiochem/Mol Bio
AddressChicago IL 60637
Email
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Patel P, Drayman N, Liu P, Bilgic M, Tay S. Computer vision reveals hidden variables underlying NF-?B activation in single cells. Sci Adv. 2021 Oct 22; 7(43):eabg4135. PMID: 34678061.
      View in: PubMed
    2. Phan HV, van Gent M, Drayman N, Basu A, Gack MU, Tay S. High-throughput RNA sequencing of paraformaldehyde-fixed single cells. Nat Commun. 2021 09 24; 12(1):5636. PMID: 34561439.
      View in: PubMed
    3. Drayman N, DeMarco JK, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Muñoz-Alía MÁ, Schuster B, Nair V, Han KY, O'Brien A, Tomatsidou A, Meyer B, Vignuzzi M, Missiakas D, Botten JW, Brooke CB, Lee H, Baker SC, Mounce BC, Heaton NS, Severson WE, Palmer KE, Dickinson BC, Joachimiak A, Randall G, Tay S. Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2. Science. 2021 08 20; 373(6557):931-936. PMID: 34285133.
      View in: PubMed
    4. Naumov V, Putin E, Pushkov S, Kozlova E, Romantsov K, Kalashnikov A, Galkin F, Tihonova N, Shneyderman A, Galkin E, Zinkevich A, Cope SM, Sethuraman R, Oprea TI, Pearson AT, Tay S, Agrawal N, Dubovenko A, Vanhaelen Q, Ozerov I, Aliper A, Izumchenko E, Zhavoronkov A. COVIDomic: A multi-modal cloud-based platform for identification of risk factors associated with COVID-19 severity. PLoS Comput Biol. 2021 07; 17(7):e1009183. PMID: 34260589.
      View in: PubMed
    5. Morris A, McCorkindale W, Consortium TCM, Drayman N, Chodera JD, Tay S, London N, Lee AA. Discovery of SARS-CoV-2 main protease inhibitors using a synthesis-directed de novo design model. Chem Commun (Camb). 2021 Jun 15; 57(48):5909-5912. PMID: 34008627.
      View in: PubMed
    6. Abasiyanik MF, Flood B, Lin J, Ozcan S, Rouhani SJ, Pyzer A, Trujillo J, Zhen C, Wu P, Jumic S, Wang A, Gajewski TF, Wang P, Hartley M, Ameti B, Niemiec R, Fernando M, Mishra V, Savage P, Aydogan B, Bethel C, Matushek S, Beavis KG, Agrawal N, Segal J, Tay S, Izumchenko E. Sensitive detection and quantification of SARS-CoV-2 in saliva. Sci Rep. 2021 06 14; 11(1):12425. PMID: 34127708.
      View in: PubMed
    7. Nguyen LC, Yang D, Nicolaescu V, Best TJ, Ohtsuki T, Chen SN, Friesen JB, Drayman N, Mohamed A, Dann C, Silva D, Gula H, Jones KA, Millis JM, Dickinson BC, Tay S, Oakes SA, Pauli GF, Meltzer DO, Randall G, Rosner MR. Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response. bioRxiv. 2021 Mar 10. PMID: 33758843.
      View in: PubMed
    8. Vistain LF, Tay S. Single-Cell Proteomics. Trends Biochem Sci. 2021 08; 46(8):661-672. PMID: 33653632.
      View in: PubMed
    9. Van Phan H, van Gent M, Drayman N, Basu A, Gack MU, Tay S. Fixed single-cell RNA sequencing for understanding virus infection and host response. bioRxiv. 2021 Jan 21. PMID: 32995793.
      View in: PubMed
    10. Son M, Wang AG, Tu HL, Metzig MO, Patel P, Husain K, Lin J, Murugan A, Hoffmann A, Tay S. NF-?B responds to absolute differences in cytokine concentrations. Sci Signal. 2021 Jan 19; 14(666). PMID: 34211635.
      View in: PubMed
    11. Abasiyanik MF, Flood B, Lin J, Ozcan S, Rouhani SJ, Pyzer A, Trujillo J, Zhen C, Wu P, Jumic S, Wang A, Gajewski TF, Wang P, Hartley M, Ameti B, Niemiec R, Fernando M, Aydogan B, Bethel C, Matushek S, Beavis KG, Agrawal N, Segal J, Tay S, Izumchenko E. Sensitive detection and quantification of SARS-CoV-2 in saliva. medRxiv. 2020 Dec 07. PMID: 33330880.
      View in: PubMed
    12. Schuster B, Junkin M, Kashaf SS, Romero-Calvo I, Kirby K, Matthews J, Weber CR, Rzhetsky A, White KP, Tay S. Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids. Nat Commun. 2020 10 19; 11(1):5271. PMID: 33077832.
      View in: PubMed
    13. Drayman N, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Muñoz-Alía MÁ, Schuster B, Nair V, Botten JW, Brooke CB, Baker SC, Mounce BC, Heaton NS, Dickinson BC, Jaochimiak A, Randall G, Tay S. Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro. bioRxiv. 2020 Sep 01. PMID: 32908976.
      View in: PubMed
    14. Watterson WJ, Tanyeri M, Watson AR, Cham CM, Shan Y, Chang EB, Eren AM, Tay S. Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes. Elife. 2020 06 17; 9. PMID: 32553109.
      View in: PubMed
    15. Abasiyanik MF, Wolfe K, Van Phan H, Lin J, Laxman B, White SR, Verhoef PA, Mutlu GM, Patel B, Tay S. Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomes. Nat Commun. 2020 05 25; 11(1):2607. PMID: 32451375.
      View in: PubMed
    16. Lin J, Jordi C, Son M, Van Phan H, Drayman N, Abasiyanik MF, Vistain L, Tu HL, Tay S. Ultra-sensitive digital quantification of proteins and mRNA in single cells. Nat Commun. 2019 08 07; 10(1):3544. PMID: 31391463.
      View in: PubMed
    17. Drayman N, Patel P, Vistain L, Tay S. HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populations. Elife. 2019 05 15; 8. PMID: 31090537.
      View in: PubMed
    18. Zhang C, Tu HL, Jia G, Mukhtar T, Taylor V, Rzhetsky A, Tay S. Ultra-multiplexed analysis of single-cell dynamics reveals logic rules in differentiation. Sci Adv. 2019 04; 5(4):eaav7959. PMID: 30949582.
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    19. Tanyeri M, Tay S. Viable cell culture in PDMS-based microfluidic devices. Methods Cell Biol. 2018; 148:3-33. PMID: 30473072.
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    20. Dettinger P, Frank T, Etzrodt M, Ahmed N, Reimann A, Trenzinger C, Loeffler D, Kokkaliaris KD, Schroeder T, Tay S. Automated Microfluidic System for Dynamic Stimulation and Tracking of Single Cells. Anal Chem. 2018 09 18; 90(18):10695-10700. PMID: 30059208.
      View in: PubMed
    21. Kaestli AJ, Junkin M, Tay S. Integrated platform for cell culture and dynamic quantification of cell secretion. Lab Chip. 2017 11 21; 17(23):4124-4133. PMID: 29094740.
      View in: PubMed
    22. Piehler A, Ghorashian N, Zhang C, Tay S. Universal signal generator for dynamic cell stimulation. Lab Chip. 2017 06 27; 17(13):2218-2224. PMID: 28573304.
      View in: PubMed
    23. Kellogg RA, Tian C, Etzrodt M, Tay S. Cellular Decision Making by Non-Integrative Processing of TLR Inputs. Cell Rep. 2017 04 04; 19(1):125-135. PMID: 28380352.
      View in: PubMed
    24. Schwarz J, Bierbaum V, Merrin J, Frank T, Hauschild R, Bollenbach T, Tay S, Sixt M, Mehling M. A microfluidic device for measuring cell migration towards substrate-bound and soluble chemokine gradients. Sci Rep. 2016 11 07; 6:36440. PMID: 27819270.
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    25. Junkin M, Kaestli AJ, Cheng Z, Jordi C, Albayrak C, Hoffmann A, Tay S. High-Content Quantification of Single-Cell Immune Dynamics. Cell Rep. 2016 Apr 12; 15(2):411-22. PMID: 27050527.
      View in: PubMed
    26. Albayrak C, Jordi CA, Zechner C, Lin J, Bichsel CA, Khammash M, Tay S. Digital Quantification of Proteins and mRNA in Single Mammalian Cells. Mol Cell. 2016 Mar 17; 61(6):914-24. PMID: 26990994.
      View in: PubMed
    27. Kellogg RA, Tian C, Lipniacki T, Quake SR, Tay S. Digital signaling decouples activation probability and population heterogeneity. Elife. 2015 Oct 21; 4:e08931. PMID: 26488364.
      View in: PubMed
    28. Tay S. Single-Cell Analysis: The Differences That Kill. Cell. 2015 Sep 10; 162(6):1208-10. PMID: 26359980.
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    29. Frank T, Tay S. Automated co-culture system for spatiotemporal analysis of cell-to-cell communication. Lab Chip. 2015 May 21; 15(10):2192-200. PMID: 25892510.
      View in: PubMed
    30. Mehling M, Frank T, Albayrak C, Tay S. Real-time tracking, retrieval and gene expression analysis of migrating human T cells. Lab Chip. 2015 Mar 07; 15(5):1276-83. PMID: 25512266.
      View in: PubMed
    31. Kellogg RA, Tay S. Noise facilitates transcriptional control under dynamic inputs. Cell. 2015 Jan 29; 160(3):381-92. PMID: 25635454.
      View in: PubMed
    32. Alsteens D, Tay S, Müller DJ. Toward high-throughput biomechanical phenotyping of single molecules. Nat Methods. 2015 Jan; 12(1):45-6. PMID: 25549270.
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    33. Kellogg RA, Gómez-Sjöberg R, Leyrat AA, Tay S. High-throughput microfluidic single-cell analysis pipeline for studies of signaling dynamics. Nat Protoc. 2014 Jul; 9(7):1713-26. PMID: 24967621.
      View in: PubMed
    34. Junkin M, Tay S. Microfluidic single-cell analysis for systems immunology. Lab Chip. 2014 Apr 07; 14(7):1246-60. PMID: 24503696.
      View in: PubMed
    35. Mehling M, Tay S. Microfluidic cell culture. Curr Opin Biotechnol. 2014 Feb; 25:95-102. PMID: 24484886.
      View in: PubMed
    36. Pekalski J, Zuk PJ, Kochanczyk M, Junkin M, Kellogg R, Tay S, Lipniacki T. Spontaneous NF-?B activation by autocrine TNFa signaling: a computational analysis. PLoS One. 2013; 8(11):e78887. PMID: 24324544.
      View in: PubMed
    37. Frank T, Tay S. Flow-switching allows independently programmable, extremely stable, high-throughput diffusion-based gradients. Lab Chip. 2013 Apr 07; 13(7):1273-81. PMID: 23386049.
      View in: PubMed
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