 Tissue Plasminogen Activator
"Tissue Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
| Descriptor ID |
D010959
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| MeSH Number(s) |
D08.811.277.656.300.760.875 D08.811.277.656.959.350.875 D12.776.124.125.662.768 D23.119.970
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| Concept/Terms |
Tissue Plasminogen Activator- Tissue Plasminogen Activator
- Plasminogen Activator, Tissue
- Tissue Activator D-44
- Tissue Activator D 44
- Tisokinase
- Tissue-Type Plasminogen Activator
- Tissue Type Plasminogen Activator
- TTPA
- T-Plasminogen Activator
- T Plasminogen Activator
- Alteplase
- Plasminogen Activator, Tissue-Type
- Plasminogen Activator, Tissue Type
Activase- Activase
- Hoffmann-La Roche Brand of Alteplase
- Hoffmann La Roche Brand of Alteplase
- Genentech Brand of Alteplase
- Alteplase Genentech Brand
Actilyse- Actilyse
- Boehringer Ingelheim Brand of Alteplase
- Lysatec rt-PA
- Lysatec rt PA
- Lysatec rtPA
- Promeco Brand of Alteplase
- Alteplase Promeco Brand
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Below are MeSH descriptors whose meaning is more general than "Tissue Plasminogen Activator".
Below are MeSH descriptors whose meaning is more specific than "Tissue Plasminogen Activator".
This graph shows the total number of publications written about "Tissue Plasminogen Activator" by people in this website by year, and whether "Tissue Plasminogen Activator" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1988 | 1 | 0 | 1 | | 1989 | 2 | 0 | 2 | | 1990 | 2 | 0 | 2 | | 1991 | 2 | 1 | 3 | | 1992 | 1 | 0 | 1 | | 1993 | 2 | 0 | 2 | | 1995 | 3 | 0 | 3 | | 1996 | 1 | 1 | 2 | | 1998 | 2 | 0 | 2 | | 1999 | 1 | 1 | 2 | | 2001 | 3 | 0 | 3 | | 2002 | 0 | 1 | 1 | | 2003 | 1 | 1 | 2 | | 2004 | 0 | 2 | 2 | | 2005 | 1 | 1 | 2 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2008 | 3 | 1 | 4 | | 2009 | 2 | 1 | 3 | | 2010 | 6 | 1 | 7 | | 2011 | 3 | 3 | 6 | | 2012 | 8 | 2 | 10 | | 2013 | 7 | 1 | 8 | | 2014 | 0 | 4 | 4 | | 2015 | 7 | 3 | 10 | | 2016 | 4 | 1 | 5 | | 2017 | 2 | 1 | 3 | | 2018 | 4 | 1 | 5 | | 2019 | 1 | 1 | 2 |
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Below are the most recent publications written about "Tissue Plasminogen Activator" by people in Profiles.
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Papavasileiou V, Goldstein LB. Thrombolysis in young adults with acute ischemic stroke: Quicker may be better. Neurology. 2019 06 11; 92(24):1129-1130.
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Ziai WC, McBee N, Lane K, Lees KR, Dawson J, Vespa P, Thompson RE, Mendelow AD, Kase CS, Carhuapoma JR, Thompson CB, Mayo SW, Reilly P, Janis S, Anderson CS, Harrigan MR, Camarata PJ, Caron JL, Zuccarello M, Awad IA, Hanley DF. A randomized 500-subject open-label phase 3 clinical trial of minimally invasive surgery plus alteplase in intracerebral hemorrhage evacuation (MISTIE III). Int J Stroke. 2019 07; 14(5):548-554.
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Fam MD, Stadnik A, Zeineddine HA, Girard R, Mayo S, Dlugash R, McBee N, Lane K, Mould WA, Ziai W, Hanley D, Awad IA. Symptomatic Hemorrhagic Complications in Clot Lysis: Evaluation of Accelerated Resolution of Intraventricular Hemorrhage Phase III Clinical Trial (CLEAR III): A Posthoc Root-Cause Analysis. Neurosurgery. 2018 12 01; 83(6):1260-1268.
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Khatib R, Arevalo YA, Berendsen MA, Prabhakaran S, Huffman MD. Presentation, Evaluation, Management, and Outcomes of Acute Stroke in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis. Neuroepidemiology. 2018; 51(1-2):104-112.
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Mendelson SJ, Courtney DM, Gordon EJ, Thomas LF, Holl JL, Prabhakaran S. National Practice Patterns of Obtaining Informed Consent for Stroke Thrombolysis. Stroke. 2018 03; 49(3):765-767.
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Richards CT, Huebinger R, Tataris KL, Weber JM, Eggers L, Markul E, Stein-Spencer L, Pearlman KS, Holl JL, Prabhakaran S. Cincinnati Prehospital Stroke Scale Can Identify Large Vessel Occlusion Stroke. Prehosp Emerg Care. 2018 May-Jun; 22(3):312-318.
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Mendelson SJ, Aggarwal NT, Richards C, O'Neill K, Holl JL, Prabhakaran S. Racial disparities in refusal of stroke thrombolysis in Chicago. Neurology. 2018 01 30; 90(5):e359-e364.
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Fam MD, Hanley D, Stadnik A, Zeineddine HA, Girard R, Jesselson M, Cao Y, Money L, McBee N, Bistran-Hall AJ, Mould WA, Lane K, Camarata PJ, Zuccarello M, Awad IA. Surgical Performance in Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation Phase III Clinical Trial. Neurosurgery. 2017 Nov 01; 81(5):860-866.
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Murthy SB, Awad I, Harnof S, Aldrich F, Harrigan M, Jallo J, Caron JL, Huang J, Camarata P, Lara LR, Dlugash R, McBee N, Eslami V, Hanley DF, Ziai WC. Permanent CSF shunting after intraventricular hemorrhage in the CLEAR III trial. Neurology. 2017 Jul 25; 89(4):355-362.
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Hanley DF, Lane K, McBee N, Ziai W, Tuhrim S, Lees KR, Dawson J, Gandhi D, Ullman N, Mould WA, Mayo SW, Mendelow AD, Gregson B, Butcher K, Vespa P, Wright DW, Kase CS, Carhuapoma JR, Keyl PM, Diener-West M, Muschelli J, Betz JF, Thompson CB, Sugar EA, Yenokyan G, Janis S, John S, Harnof S, Lopez GA, Aldrich EF, Harrigan MR, Ansari S, Jallo J, Caron JL, LeDoux D, Adeoye O, Zuccarello M, Adams HP, Rosenblum M, Thompson RE, Awad IA. Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial. Lancet. 2017 02 11; 389(10069):603-611.
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