Tissue Plasminogen Activator
"Tissue Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
| Descriptor ID |
D010959
|
| MeSH Number(s) |
D08.811.277.656.300.760.875 D08.811.277.656.959.350.875 D12.776.124.125.662.768 D23.119.970
|
| Concept/Terms |
Tissue Plasminogen Activator- Tissue Plasminogen Activator
- Plasminogen Activator, Tissue
- Tissue Activator D-44
- Tissue Activator D 44
- Tisokinase
- Tissue-Type Plasminogen Activator
- Tissue Type Plasminogen Activator
- TTPA
- T-Plasminogen Activator
- T Plasminogen Activator
- Alteplase
- Plasminogen Activator, Tissue-Type
- Plasminogen Activator, Tissue Type
Actilyse- Actilyse
- Lysatec rt-PA
- Lysatec rt PA
- Lysatec rtPA
|
Below are MeSH descriptors whose meaning is more general than "Tissue Plasminogen Activator".
Below are MeSH descriptors whose meaning is more specific than "Tissue Plasminogen Activator".
This graph shows the total number of publications written about "Tissue Plasminogen Activator" by people in this website by year, and whether "Tissue Plasminogen Activator" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 2 | 0 | 2 |
| 1995 | 3 | 0 | 3 |
| 1996 | 1 | 1 | 2 |
| 1998 | 2 | 0 | 2 |
| 1999 | 1 | 1 | 2 |
| 2001 | 3 | 0 | 3 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 0 | 2 | 2 |
| 2005 | 1 | 1 | 2 |
| 2007 | 1 | 1 | 2 |
| 2008 | 2 | 1 | 3 |
| 2009 | 3 | 1 | 4 |
| 2010 | 5 | 1 | 6 |
| 2011 | 5 | 3 | 8 |
| 2012 | 7 | 2 | 9 |
| 2013 | 7 | 2 | 9 |
| 2014 | 0 | 4 | 4 |
| 2015 | 7 | 3 | 10 |
| 2016 | 4 | 2 | 6 |
| 2017 | 2 | 2 | 4 |
| 2018 | 4 | 1 | 5 |
| 2019 | 4 | 1 | 5 |
| 2020 | 2 | 3 | 5 |
| 2021 | 3 | 3 | 6 |
| 2022 | 3 | 2 | 5 |
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Below are the most recent publications written about "Tissue Plasminogen Activator" by people in Profiles.
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One-Year Outcome Trajectories and Factors Associated with Functional Recovery Among Survivors of Intracerebral and Intraventricular Hemorrhage With Initial Severe Disability. JAMA Neurol. 2022 09 01; 79(9):856-868.
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Effect of Thrombin and Incubation Time on Porcine Whole Blood Clot Elasticity and Recombinant Tissue Plasminogen Activator Susceptibility. Ultrasound Med Biol. 2022 08; 48(8):1567-1578.
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Bayesian deep learning outperforms clinical trial estimators of intracerebral and intraventricular hemorrhage volume. J Neuroimaging. 2022 09; 32(5):968-976.
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Race-Ethnic Disparities in Rates of Declination of Thrombolysis for Stroke. Neurology. 2022 04 19; 98(16):e1596-e1604.
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(More than) doubling down: Effective fibrinolysis at a reduced rt-PA dose for catheter-directed thrombolysis combined with histotripsy. PLoS One. 2022; 17(1):e0261567.
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Design and Characterization of an Ultrasound Transducer for Combined Histotripsy-Thrombolytic Therapy. IEEE Trans Ultrason Ferroelectr Freq Control. 2022 01; 69(1):156-165.
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Association Between Intraventricular Alteplase Use and Parenchymal Hematoma Volume in Patients With Spontaneous Intracerebral Hemorrhage and Intraventricular Hemorrhage. JAMA Netw Open. 2021 12 01; 4(12):e2135773.
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Assessment of histological characteristics, imaging markers, and rt-PA susceptibility of ex vivo venous thrombi. Sci Rep. 2021 11 23; 11(1):22805.
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Door-In-Door-Out Process Times at Primary Stroke Centers in Chicago. Ann Emerg Med. 2021 11; 78(5):674-681.
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Association between clot composition and stroke origin in mechanical thrombectomy patients: analysis of the Stroke Thromboembolism Registry of Imaging and Pathology. J Neurointerv Surg. 2021 Jul; 13(7):594-598.