 Tissue Plasminogen Activator
"Tissue Plasminogen Activator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
| Descriptor ID |
D010959
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| MeSH Number(s) |
D08.811.277.656.300.760.875 D08.811.277.656.959.350.875 D12.776.124.125.662.768 D23.119.970
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| Concept/Terms |
Tissue Plasminogen Activator- Tissue Plasminogen Activator
- Plasminogen Activator, Tissue
- Tissue Activator D-44
- Tissue Activator D 44
- Tisokinase
- Tissue-Type Plasminogen Activator
- Tissue Type Plasminogen Activator
- TTPA
- T-Plasminogen Activator
- T Plasminogen Activator
- Alteplase
- Plasminogen Activator, Tissue-Type
- Plasminogen Activator, Tissue Type
Activase- Activase
- Hoffmann-La Roche Brand of Alteplase
- Hoffmann La Roche Brand of Alteplase
- Genentech Brand of Alteplase
- Alteplase Genentech Brand
Actilyse- Actilyse
- Boehringer Ingelheim Brand of Alteplase
- Lysatec rt-PA
- Lysatec rt PA
- Lysatec rtPA
- Promeco Brand of Alteplase
- Alteplase Promeco Brand
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Below are MeSH descriptors whose meaning is more general than "Tissue Plasminogen Activator".
Below are MeSH descriptors whose meaning is more specific than "Tissue Plasminogen Activator".
This graph shows the total number of publications written about "Tissue Plasminogen Activator" by people in this website by year, and whether "Tissue Plasminogen Activator" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1988 | 1 | 0 | 1 | | 1989 | 2 | 0 | 2 | | 1990 | 2 | 0 | 2 | | 1991 | 2 | 0 | 2 | | 1992 | 1 | 0 | 1 | | 1993 | 2 | 0 | 2 | | 1995 | 3 | 0 | 3 | | 1996 | 1 | 1 | 2 | | 1998 | 2 | 0 | 2 | | 1999 | 1 | 1 | 2 | | 2001 | 3 | 0 | 3 | | 2002 | 0 | 1 | 1 | | 2003 | 1 | 1 | 2 | | 2004 | 0 | 2 | 2 | | 2005 | 1 | 1 | 2 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 1 | 2 | | 2008 | 2 | 1 | 3 | | 2009 | 3 | 1 | 4 | | 2010 | 6 | 1 | 7 | | 2011 | 5 | 3 | 8 | | 2012 | 8 | 3 | 11 | | 2013 | 7 | 2 | 9 | | 2014 | 0 | 4 | 4 | | 2015 | 7 | 3 | 10 | | 2016 | 4 | 2 | 6 | | 2017 | 2 | 1 | 3 | | 2018 | 4 | 1 | 5 | | 2019 | 4 | 1 | 5 | | 2020 | 2 | 3 | 5 | | 2021 | 2 | 3 | 5 |
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Below are the most recent publications written about "Tissue Plasminogen Activator" by people in Profiles.
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Maxwell AD, Haworth KJ, Holland CK, Hendley SA, Kreider W, Bader KB. Design and Characterization of an Ultrasound Transducer for Combined Histotripsy-Thrombolytic Therapy. IEEE Trans Ultrason Ferroelectr Freq Control. 2022 01; 69(1):156-165.
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Witsch J, Roh DJ, Avadhani R, Merkler AE, Kamel H, Awad I, Hanley DF, Ziai WC, Murthy SB. Association Between Intraventricular Alteplase Use and Parenchymal Hematoma Volume in Patients With Spontaneous Intracerebral Hemorrhage and Intraventricular Hemorrhage. JAMA Netw Open. 2021 12 01; 4(12):e2135773.
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Prabhakaran S, Khorzad R, Parnianpour Z, Romo E, Richards CT, Meurer WJ, Lee J, Mendelson SJ, Holl JL. Door-In-Door-Out Process Times at Primary Stroke Centers in Chicago. Ann Emerg Med. 2021 11; 78(5):674-681.
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Brinjikji W, Nogueira RG, Kvamme P, Layton KF, Delgado Almandoz JE, Hanel RA, Mendes Pereira V, Almekhlafi MA, Yoo AJ, Jahromi BS, Gounis MJ, Patel B, Abbasi M, Fitzgerald S, Mereuta OM, Dai D, Kadirvel R, Doyle K, Savastano L, Cloft HJ, Haussen DC, Al-Bayati AR, Mohammaden MH, Pisani L, Rodrigues GM, Thacker IC, Kayan Y, Copelan A, Aghaebrahim A, Sauvageau E, Demchuk AM, Bhuva P, Soomro J, Nazari P, Cantrell DR, Puri AS, Entwistle J, Polley EC, Kallmes DF. Association between clot composition and stroke origin in mechanical thrombectomy patients: analysis of the Stroke Thromboembolism Registry of Imaging and Pathology. J Neurointerv Surg. 2021 Jul; 13(7):594-598.
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Smith JR, Teven CM, Choudry U, Gottlieb LJ. Ultradelayed Arterial Thrombosis: Critical Flap Ischemia After Phalloplasty. Ann Plast Surg. 2021 02 01; 86(2):182-187.
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Polster SP, Carrión-Penagos J, Lyne SB, Goldenberg FD, Mansour A, Ziai W, Carlson AP, Camarata PJ, Caron JL, Harrigan MR, Gregson B, Mendelow AD, Zuccarello M, Hanley DF, Dodd R, Awad IA. Thrombolysis for Evacuation of Intracerebral and Intraventricular Hemorrhage: A Guide to Surgical Protocols With Practical Lessons Learned From the MISTIE and CLEAR Trials. Oper Neurosurg (Hagerstown). 2020 12 15; 20(1):98-108.
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Murthy SB, Cho SM, Gupta A, Shoamanesh A, Navi BB, Avadhani R, Gruber J, Li Y, Greige T, Lioutas VA, Norton C, Zhang C, Mandava P, Iadecola C, Falcone GJ, Sheth KN, Biffi A, Rosand J, Qureshi AI, Goldstein JN, Kidwell C, Awad I, Selim M, Hanley DF, Woo D, Kamel H, Ziai WC. A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage. JAMA Neurol. 2020 11 01; 77(11):1390-1397.
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Bulwa Z, Dresser LP, Clarke J, Mendelson S. Mystery Case: Clinical Reasoning: Recurrent cerebral ischemia during pregnancies. Neurology. 2020 10 27; 95(17):e2453-e2457.
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Polster SP, Awad IA. In Reply: Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure. Neurosurgery. 2020 04 01; 86(4):E411.
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Nelson SE, Mould WA, Gandhi D, Thompson RE, Salter S, Dlugash R, Awad IA, Hanley DF, Ziai W. Primary intraventricular hemorrhage outcomes in the CLEAR III trial. Int J Stroke. 2020 10; 15(8):872-880.
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