"Complement Factor B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A glycine-rich, heat-labile serum glycoprotein that contains a component of the C3 CONVERTASE ALTERNATE PATHWAY (C3bBb). Bb, a serine protease, is generated when factor B is cleaved by COMPLEMENT FACTOR D into Ba and Bb.
| Descriptor ID |
D011415
|
| MeSH Number(s) |
D08.622.200 D08.811.277.656.300.760.198 D08.811.277.656.959.350.198 D12.776.124.486.274.900
|
| Concept/Terms |
Complement Factor B- Complement Factor B
- Factor B, Complement
- C3 Proactivator
- Proactivator, C3
- C3PA
- Complement 3 Proactivator
- Proactivator, Complement 3
- Factor B
- Complement Protein B
- Protein B, Complement
- Complement Protein Factor B
- Properdin Factor B
- Factor B, Properdin
- Complement Factor B, Alternative Pathway
Complement Factor Bb- Complement Factor Bb
- Bb, Complement Factor
- Factor Bb, Complement
- Properdin Factor Bb
- Factor Bb, Properdin
- Complement Factor B-Derived Fragment Bb
- Complement Factor B Derived Fragment Bb
- Bb Fragment of Factor B
- Complement Factor B Fragment, Bb
Complement Factor Ba- Complement Factor Ba
- Factor Ba, Complement
- Properdin Factor Ba
- Factor Ba, Properdin
|
Below are MeSH descriptors whose meaning is more general than "Complement Factor B".
Below are MeSH descriptors whose meaning is more specific than "Complement Factor B".
This graph shows the total number of publications written about "Complement Factor B" by people in this website by year, and whether "Complement Factor B" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1999 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2020 | 0 | 2 | 2 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Complement Factor B" by people in Profiles.
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Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis. Gut. 2023 11; 72(11):2068-2080.
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Mutation of complement factor B causing massive fluid-phase dysregulation of the alternative complement pathway can result in atypical hemolytic uremic syndrome. Kidney Int. 2020 11; 98(5):1265-1274.
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Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension. Am J Respir Crit Care Med. 2020 01 15; 201(2):224-239.
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Complement alternative pathway activation in the autologous phase of nephrotoxic serum nephritis. Am J Physiol Renal Physiol. 2012 Jun 15; 302(12):F1529-36.
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Absence of functional alternative complement pathway alleviates lupus cerebritis. Eur J Immunol. 2007 Jun; 37(6):1691-701.
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Complement processing and immunoglobulin binding to Neisseria gonorrhoeae determined in vitro simulates in vivo effects. J Infect Dis. 1999 Jan; 179(1):124-35.
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Complement activation by whole endotoxin is blocked by a monoclonal antibody to factor B. Infect Immun. 1994 Oct; 62(10):4549-55.
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Autoantibody to complement neoantigens in membranoproliferative glomerulonephritis. J Pediatr. 1990 May; 116(5):S98-102.