 Synapsins
"Synapsins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of synaptic vesicle-associated proteins involved in the short-term regulation of NEUROTRANSMITTER release. Synapsin I, the predominant member of this family, links SYNAPTIC VESICLES to ACTIN FILAMENTS in the presynaptic nerve terminal. These interactions are modulated by the reversible PHOSPHORYLATION of synapsin I through various signal transduction pathways. The protein is also a substrate for cAMP- and CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. It is believed that these functional properties are also shared by synapsin II.
| Descriptor ID |
D016704
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| MeSH Number(s) |
D12.776.641.750 D12.776.744.840
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Synapsins".
Below are MeSH descriptors whose meaning is more specific than "Synapsins".
This graph shows the total number of publications written about "Synapsins" by people in this website by year, and whether "Synapsins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Synapsins" by people in Profiles.
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Maiole F, Tedeschi G, Candiani S, Maragliano L, Benfenati F, Zullo L. Synapsins are expressed at neuronal and non-neuronal locations in Octopus vulgaris. Sci Rep. 2019 10 28; 9(1):15430.
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McMurray KM, Du X, Brownlee M, Palmer AA. Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice. Behav Brain Res. 2016 Mar 15; 301:119-23.
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Orlando M, Lignani G, Maragliano L, Fassio A, Onofri F, Baldelli P, Giovedà S, Benfenati F. Functional role of ATP binding to synapsin I in synaptic vesicle trafficking and release dynamics. J Neurosci. 2014 Oct 29; 34(44):14752-68.
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Diester I, Kaufman MT, Mogri M, Pashaie R, Goo W, Yizhar O, Ramakrishnan C, Deisseroth K, Shenoy KV. An optogenetic toolbox designed for primates. Nat Neurosci. 2011 Mar; 14(3):387-97.
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Cao D, Kevala K, Kim J, Moon HS, Jun SB, Lovinger D, Kim HY. Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J Neurochem. 2009 Oct; 111(2):510-21.
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Sheinin A, Talani G, Davis MI, Lovinger DM. Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region. J Neurophysiol. 2008 Aug; 100(2):1041-52.
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Kirchgessner CU, Trofatter JA, Mahtani MM, Willard HF, DeGennaro LJ. A highly polymorphic dinucleotide repeat on the proximal short arm of the human X chromosome: linkage mapping of the synapsin I/A-raf-1 genes. Am J Hum Genet. 1991 Jul; 49(1):184-91.
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