Ubiquitin-Protein Ligases
"Ubiquitin-Protein Ligases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.
| Descriptor ID |
D044767
|
| MeSH Number(s) |
D08.811.464.938.750
|
| Concept/Terms |
Ubiquitin-Protein Ligases- Ubiquitin-Protein Ligases
- Ligases, Ubiquitin-Protein
- Ubiquitin Protein Ligases
- E3 Ubiquitin Ligase
- Ligase, E3 Ubiquitin
- Ubiquitin Ligase, E3
- Ubiquitin-Protein Ligase E3
- Ligase E3, Ubiquitin-Protein
- Ubiquitin Protein Ligase E3
- Ubiquitin Ligase E3
- Ligase E3, Ubiquitin
- Ubiquitin-Protein Ligase
- Ligase, Ubiquitin-Protein
- Ubiquitin Protein Ligase
- E3 Ligase
- Ligase, E3
|
Below are MeSH descriptors whose meaning is more general than "Ubiquitin-Protein Ligases".
Below are MeSH descriptors whose meaning is more specific than "Ubiquitin-Protein Ligases".
This graph shows the total number of publications written about "Ubiquitin-Protein Ligases" by people in this website by year, and whether "Ubiquitin-Protein Ligases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 0 | 1 | 1 |
| 1996 | 2 | 2 | 4 |
| 1997 | 6 | 1 | 7 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 3 | 4 |
| 2001 | 0 | 7 | 7 |
| 2002 | 2 | 4 | 6 |
| 2003 | 4 | 3 | 7 |
| 2004 | 1 | 7 | 8 |
| 2005 | 4 | 4 | 8 |
| 2006 | 4 | 2 | 6 |
| 2007 | 3 | 2 | 5 |
| 2008 | 3 | 2 | 5 |
| 2009 | 5 | 5 | 10 |
| 2010 | 5 | 0 | 5 |
| 2011 | 5 | 4 | 9 |
| 2012 | 4 | 3 | 7 |
| 2013 | 3 | 2 | 5 |
| 2014 | 4 | 3 | 7 |
| 2015 | 0 | 2 | 2 |
| 2016 | 2 | 2 | 4 |
| 2017 | 2 | 1 | 3 |
| 2018 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 2 | 1 | 3 |
| 2021 | 3 | 1 | 4 |
| 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "Ubiquitin-Protein Ligases" by people in Profiles.
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LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2205629119.
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The E3 ligase TRIM1 ubiquitinates LRRK2 and controls its localization, degradation, and toxicity. J Cell Biol. 2022 04 04; 221(4).
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H5N1 infection impairs the alveolar epithelial barrier through intercellular junction proteins via Itch-mediated proteasomal degradation. Commun Biol. 2022 03 01; 5(1):186.
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Herpesvirus-mediated stabilization of ICP0 expression neutralizes restriction by TRIM23. Proc Natl Acad Sci U S A. 2021 12 21; 118(51).
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HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease. Mol Cell. 2021 12 16; 81(24):5052-5065.e6.
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Structural insights into Ubr1-mediated N-degron polyubiquitination. Nature. 2021 12; 600(7888):334-338.
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Autophagy-mitophagy induction attenuates cardiovascular inflammation in a murine model of Kawasaki disease vasculitis. JCI Insight. 2021 09 22; 6(18).
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K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle. Nat Chem Biol. 2021 08; 17(8):896-905.
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The Small t Antigen of JC Virus Antagonizes RIG-I-Mediated Innate Immunity by Inhibiting TRIM25's RNA Binding Ability. mBio. 2021 04 13; 12(2).
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p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability. Nat Commun. 2020 10 06; 11(1):5007.