"Furin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.
| Descriptor ID |
D045683
|
| MeSH Number(s) |
D08.811.277.656.300.760.353 D08.811.277.656.837.249 D08.811.277.656.959.350.353
|
| Concept/Terms |
Furin- Furin
- Dibasic Processing Enzyme
- Processing Enzyme, Dibasic
- Furin Protein
- SPC1 Proteinase
- Paired Basic Amino Acid Cleaving Enzyme
|
Below are MeSH descriptors whose meaning is more general than "Furin".
Below are MeSH descriptors whose meaning is more specific than "Furin".
This graph shows the total number of publications written about "Furin" by people in this website by year, and whether "Furin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Furin" by people in Profiles.
-
Engineering protein processing of the mammary gland to produce abundant hemophilia B therapy in milk. Sci Rep. 2015 Sep 21; 5:14176.
-
Recombinant antibody mediated delivery of organelle-specific DNA pH sensors along endocytic pathways. Nanoscale. 2014 Jan 21; 6(2):1144-52.
-
Human monoclonal antibodies generated following vaccination with AVA provide neutralization by blocking furin cleavage but not by preventing oligomerization. Vaccine. 2012 Jun 13; 30(28):4276-83.
-
Role of PCSK5 expression in mouse ovarian follicle development: identification of the inhibin a- and ß-subunits as candidate substrates. PLoS One. 2011 Mar 08; 6(3):e17348.
-
Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine. J Biol Chem. 2004 Aug 27; 279(35):36788-94.
-
Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone. Endocrinology. 2004 Apr; 145(4):1961-71.
-
Familial British dementia: expression and metabolism of BRI. Ann N Y Acad Sci. 2000; 920:93-9.
-
Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia. Nat Neurosci. 1999 Nov; 2(11):984-8.
-
Predicted structural alterations in proinsulin during its interactions with prohormone convertases. Biochemistry. 1999 Jan 19; 38(3):890-6.
-
PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE. Biochemistry. 1993 Nov 02; 32(43):11586-90.