 Granzymes
"Granzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells.
| Descriptor ID |
D053804
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| MeSH Number(s) |
D08.811.277.656.300.760.397 D08.811.277.656.959.350.397
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| Concept/Terms |
Granzyme K- Granzyme K
- Natural Killer Cell Granule Tryptase-2
- Natural Killer Cell Granule Tryptase 2
- NK-Tryptase-2
- NK Tryptase 2
- Granzyme-3
- Granzyme 3
Granzyme A- Granzyme A
- Cytotoxic T-Lymphocyte Proteinase 1
- Cytotoxic T Lymphocyte Proteinase 1
- Hanukah Factor
Granzyme B- Granzyme B
- Fragmentin 2
- Cytotoxic T-Lymphocyte Associated 1 Protein
- Cytotoxic T Lymphocyte Associated 1 Protein
- Granzyme-Like Protein III
- Granzyme Like Protein III
- Cytotoxic Serine Protease B
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Below are MeSH descriptors whose meaning is more general than "Granzymes".
Below are MeSH descriptors whose meaning is more specific than "Granzymes".
This graph shows the total number of publications written about "Granzymes" by people in this website by year, and whether "Granzymes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1989 | 0 | 1 | 1 | | 1991 | 0 | 1 | 1 | | 1993 | 0 | 2 | 2 | | 1994 | 0 | 2 | 2 | | 1995 | 0 | 1 | 1 | | 1996 | 0 | 6 | 6 | | 1997 | 0 | 2 | 2 | | 1998 | 0 | 10 | 10 | | 1999 | 0 | 4 | 4 | | 2000 | 0 | 3 | 3 | | 2001 | 0 | 4 | 4 | | 2002 | 0 | 3 | 3 | | 2003 | 0 | 5 | 5 | | 2004 | 0 | 6 | 6 | | 2005 | 0 | 4 | 4 | | 2006 | 1 | 1 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 4 | 2 | 6 | | 2009 | 3 | 0 | 3 | | 2010 | 2 | 0 | 2 | | 2011 | 2 | 1 | 3 | | 2013 | 1 | 1 | 2 | | 2014 | 2 | 1 | 3 | | 2015 | 2 | 0 | 2 | | 2016 | 0 | 2 | 2 | | 2017 | 2 | 2 | 4 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Granzymes" by people in Profiles.
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Chong AS. Urinary nanosensors of early transplant rejection. Nat Biomed Eng. 2019 04; 3(4):251-252.
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Wu J, Zhang H, Shi X, Xiao X, Fan Y, Minze LJ, Wang J, Ghobrial RM, Xia J, Sciammas R, Li XC, Chen W. Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction. Immunity. 2017 12 19; 47(6):1114-1128.e6.
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Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Grunwell JR, Lindsell CJ. Improved Risk Stratification in Pediatric Septic Shock Using Both Protein and mRNA Biomarkers. PERSEVERE-XP. Am J Respir Crit Care Med. 2017 08 15; 196(4):494-501.
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Ikeda Y, Kiyotani K, Yew PY, Sato S, Imai Y, Yamaguchi R, Miyano S, Fujiwara K, Hasegawa K, Nakamura Y. Clinical significance of T cell clonality and expression levels of immune-related genes in endometrial cancer. Oncol Rep. 2017 May; 37(5):2603-2610.
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Santiago L, Menaa C, Arias M, Martin P, Jaime-Sánchez P, Metkar S, Comas L, Erill N, Gonzalez-Rumayor V, Esser E, Galvez EM, Raja S, Simon MM, Sprague SM, Gabay C, Martinez-Lostao L, Pardo J, Froelich CJ. Granzyme A Contributes to Inflammatory Arthritis in Mice Through Stimulation of Osteoclastogenesis. Arthritis Rheumatol. 2017 Feb; 69(2):320-334.
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Akbarpour M, Khalyfa A, Qiao Z, Gileles-Hillel A, Almendros I, Farré R, Gozal D. Altered CD8+ T-Cell Lymphocyte Function and TC1 Cell Stemness Contribute to Enhanced Malignant Tumor Properties in Murine Models of Sleep Apnea. Sleep. 2017 Feb 01; 40(2).
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Alachkar H, Mutonga M, Kato T, Kalluri S, Kakuta Y, Uemura M, Imamura R, Nonomura N, Vujjini V, Alasfar S, Rabb H, Nakamura Y, Alachkar N. Quantitative characterization of T-cell repertoire and biomarkers in kidney transplant rejection. BMC Nephrol. 2016 11 21; 17(1):181.
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Wong HR, Atkinson SJ, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Lindsell CJ. Combining Prognostic and Predictive Enrichment Strategies to Identify Children With Septic Shock Responsive to Corticosteroids. Crit Care Med. 2016 10; 44(10):e1000-3.
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Xu Y, Evaristo C, Alegre ML, Gurbuxani S, Kee BL. Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage. PLoS One. 2015; 10(4):e0125211.
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Catalán E, Jaime-Sánchez P, Aguiló N, Simon MM, Froelich CJ, Pardo J. Mouse cytotoxic T cell-derived granzyme B activates the mitochondrial cell death pathway in a Bim-dependent fashion. J Biol Chem. 2015 Mar 13; 290(11):6868-77.
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