"Granzymes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of serine endopeptidases found in the SECRETORY GRANULES of LEUKOCYTES such as CYTOTOXIC T-LYMPHOCYTES and NATURAL KILLER CELLS. When secreted into the intercellular space granzymes act to eliminate transformed and virus-infected host cells.
| Descriptor ID |
D053804
|
| MeSH Number(s) |
D08.811.277.656.300.760.397 D08.811.277.656.959.350.397
|
| Concept/Terms |
Granzyme K- Granzyme K
- Natural Killer Cell Granule Tryptase-2
- Natural Killer Cell Granule Tryptase 2
- NK-Tryptase-2
- NK Tryptase 2
- Granzyme-3
- Granzyme 3
Granzyme A- Granzyme A
- Cytotoxic T-Lymphocyte Proteinase 1
- Cytotoxic T Lymphocyte Proteinase 1
- Hanukah Factor
Granzyme B- Granzyme B
- Fragmentin 2
- Cytotoxic T-Lymphocyte Associated 1 Protein
- Cytotoxic T Lymphocyte Associated 1 Protein
- Granzyme-Like Protein III
- Granzyme Like Protein III
- Cytotoxic Serine Protease B
|
Below are MeSH descriptors whose meaning is more general than "Granzymes".
Below are MeSH descriptors whose meaning is more specific than "Granzymes".
This graph shows the total number of publications written about "Granzymes" by people in this website by year, and whether "Granzymes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 2 | 2 |
| 1994 | 0 | 1 | 1 |
| 1995 | 0 | 1 | 1 |
| 1996 | 0 | 6 | 6 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 10 | 10 |
| 1999 | 0 | 4 | 4 |
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 4 | 4 |
| 2002 | 0 | 3 | 3 |
| 2003 | 0 | 5 | 5 |
| 2004 | 0 | 6 | 6 |
| 2005 | 0 | 4 | 4 |
| 2006 | 1 | 1 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 4 | 2 | 6 |
| 2009 | 3 | 0 | 3 |
| 2010 | 2 | 0 | 2 |
| 2011 | 2 | 1 | 3 |
| 2013 | 1 | 2 | 3 |
| 2014 | 2 | 1 | 3 |
| 2015 | 2 | 0 | 2 |
| 2016 | 0 | 3 | 3 |
| 2017 | 2 | 2 | 4 |
| 2019 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Granzymes" by people in Profiles.
-
Tcf-1 protects anti-tumor TCR-engineered CD8+ T-cells from GzmB mediated self-destruction. Cancer Immunol Immunother. 2022 Dec; 71(12):2881-2898.
-
Urinary nanosensors of early transplant rejection. Nat Biomed Eng. 2019 04; 3(4):251-252.
-
Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction. Immunity. 2017 12 19; 47(6):1114-1128.e6.
-
Improved Risk Stratification in Pediatric Septic Shock Using Both Protein and mRNA Biomarkers. PERSEVERE-XP. Am J Respir Crit Care Med. 2017 08 15; 196(4):494-501.
-
Clinical significance of T cell clonality and expression levels of immune-related genes in endometrial cancer. Oncol Rep. 2017 May; 37(5):2603-2610.
-
Granzyme A Contributes to Inflammatory Arthritis in Mice Through Stimulation of Osteoclastogenesis. Arthritis Rheumatol. 2017 Feb; 69(2):320-334.
-
Altered CD8+ T-Cell Lymphocyte Function and TC1 Cell Stemness Contribute to Enhanced Malignant Tumor Properties in Murine Models of Sleep Apnea. Sleep. 2017 Feb 01; 40(2).
-
Quantitative characterization of T-cell repertoire and biomarkers in kidney transplant rejection. BMC Nephrol. 2016 11 21; 17(1):181.
-
Pediatric Sepsis Biomarker Risk Model-II: Redefining the Pediatric Sepsis Biomarker Risk Model With Septic Shock Phenotype. Crit Care Med. 2016 Nov; 44(11):2010-2017.
-
Combining Prognostic and Predictive Enrichment Strategies to Identify Children With Septic Shock Responsive to Corticosteroids. Crit Care Med. 2016 10; 44(10):e1000-3.