"Ataxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of predominantly nuclear proteins that regulate gene transcription and protein degradation. The expansion of CAG trinucleotide repeats in genes that encode Ataxins is associated with SPINOCEREBELLAR ATAXIAS (SCA). In SCA patients, the number of CAG repeats correlates with the severity of disease and inversely correlates with the age of disease onset.
- Spinocerebellar Ataxia Proteins
- Ataxia Proteins, Spinocerebellar
- Proteins, Spinocerebellar Ataxia
- Ataxin Proteins
- Proteins, Ataxin
Below are MeSH descriptors whose meaning is more general than "Ataxins".
Below are MeSH descriptors whose meaning is more specific than "Ataxins".
This graph shows the total number of publications written about "Ataxins" by people in this website by year, and whether "Ataxins" was a major or minor topic of these publications.
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Below are the most recent publications written about "Ataxins" by people in Profiles.
Neurochemical abnormalities in premanifest and early spinocerebellar ataxias. Ann Neurol. 2018 04; 83(4):816-829.
The Initial Symptom and Motor Progression in Spinocerebellar Ataxias. Cerebellum. 2017 06; 16(3):615-622.
Large-scale assessment of polyglutamine repeat expansions in Parkinson disease. Neurology. 2015 Oct 13; 85(15):1283-92.
Massive expansion of SCA2 with autonomic dysfunction, retinitis pigmentosa, and infantile spasms. Neurology. 2011 Sep 13; 77(11):1055-60.
Childhood-onset ataxia: testing for large CAG-repeats in SCA2 and SCA7. Am J Med Genet. 2002 Jul 15; 110(4):338-45.
Inherited neurodegenerative diseases and transgenic models. Brain Pathol. 1996 Oct; 6(4):467-80.
Evidence of linkage disequilibrium between schizophrenia and the SCa1 CAG repeat on chromosome 6p23. Am J Hum Genet. 1996 Sep; 59(3):731-6.