"Fibrillins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of extracellular matrix glycoproteins that is structurally similar to LATENT TGF-BETA BINDING PROTEINS, but contain additional TGF-beta binding domains, in addition to unique domains at their N and C-terminals. Fibrillins assemble into 10-12 nm MICROFIBRILS that function in a variety of cell interactions with the EXTRACELLULAR MATRIX and developmental processes such as ELASTIC TISSUE maintenance and assembly, and the targeting of growth factors to the extracellular matrix.
| Descriptor ID |
D000071837
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| MeSH Number(s) |
D09.400.430.875 D12.776.395.341 D12.776.860.300.400
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Fibrillins".
Below are MeSH descriptors whose meaning is more specific than "Fibrillins".
This graph shows the total number of publications written about "Fibrillins" by people in this website by year, and whether "Fibrillins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Fibrillins" by people in Profiles.
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Association of fibrillin-3 and transcription factor-7-like 2 gene variants with metabolic phenotypes in PCOS. Obesity (Silver Spring). 2012 Jun; 20(6):1273-8.
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Characterization of large genomic deletions in the FBN1 gene using multiplex ligation-dependent probe amplification. BMC Med Genet. 2011 Sep 21; 12:119.
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Identification of a polycystic ovary syndrome susceptibility variant in fibrillin-3 and association with a metabolic phenotype. J Clin Endocrinol Metab. 2007 Nov; 92(11):4191-8.