Kelch-Like ECH-Associated Protein 1
"Kelch-Like ECH-Associated Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS.
| Descriptor ID |
D000072019
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| MeSH Number(s) |
D12.644.360.024.306 D12.776.157.057.067 D12.776.476.024.387
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Kelch-Like ECH-Associated Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Kelch-Like ECH-Associated Protein 1".
This graph shows the total number of publications written about "Kelch-Like ECH-Associated Protein 1" by people in this website by year, and whether "Kelch-Like ECH-Associated Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
| 2019 | 0 | 2 | 2 |
| 2020 | 3 | 0 | 3 |
| 2023 | 0 | 3 | 3 |
| 2024 | 2 | 1 | 3 |
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Below are the most recent publications written about "Kelch-Like ECH-Associated Protein 1" by people in Profiles.
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CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors. Nature. 2024 Nov; 635(8038):462-471.
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Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer. Nat Metab. 2024 Jul; 6(7):1310-1328.
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Precision Immunotherapy for STK11/KEAP1-Mutant NSCLC. J Thorac Oncol. 2024 Jun; 19(6):877-882.
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Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC. Cancer Discov. 2023 07 07; 13(7):1556-1571.
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NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer. Cell Metab. 2023 03 07; 35(3):487-503.e7.
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A Multicenter Retrospective Chart Review of Clinical Outcomes Among Patients With KRAS G12C Mutant Non-Small Cell Lung Cancer. Clin Lung Cancer. 2023 05; 24(3):228-234.
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Mice Hypomorphic for Keap1, a Negative Regulator of the Nrf2 Antioxidant Response, Show Age-Dependent Diffuse Goiter with Elevated Thyrotropin Levels. Thyroid. 2021 01; 31(1):23-35.
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GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma. Sci Signal. 2020 08 18; 13(645).
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Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1. Nat Cancer. 2020 06; 1(6):589-602.
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Photoproximity Profiling of Protein-Protein Interactions in Cells. J Am Chem Soc. 2020 01 08; 142(1):146-153.