Regulatory-Associated Protein of mTOR
"Regulatory-Associated Protein of mTOR" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An adaptor protein component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 that forms stoichiometric complexes with TOR KINASES, which it negatively regulates. It functions as a positive regulator of RIBOSOMAL PROTEIN S6 KINASES.
| Descriptor ID |
D000076223
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| MeSH Number(s) |
D05.500.337.500 D08.811.913.696.620.682.700.931.500.500 D12.644.360.024.324 D12.776.157.057.157 D12.776.476.024.419 D12.776.476.925.500.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Regulatory-Associated Protein of mTOR".
Below are MeSH descriptors whose meaning is more specific than "Regulatory-Associated Protein of mTOR".
This graph shows the total number of publications written about "Regulatory-Associated Protein of mTOR" by people in this website by year, and whether "Regulatory-Associated Protein of mTOR" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Regulatory-Associated Protein of mTOR" by people in Profiles.
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Loss of mTORC1 signalling impairs ß-cell homeostasis and insulin processing. Nat Commun. 2017 07 12; 8:16014.
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Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition. Oncogene. 2017 05 11; 36(19):2737-2749.
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Allele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations. PLoS Genet. 2010 Oct 28; 6(10):e1001178.
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Characterization of a novel splicing variant in the RAPTOR gene. Mutat Res. 2009 Mar 09; 662(1-2):88-92.
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mTOR phosphorylated at S2448 binds to raptor and rictor. Amino Acids. 2010 Jan; 38(1):223-8.
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Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1. J Biol Chem. 2006 Aug 25; 281(34):24293-303.