High-Temperature Requirement A Serine Peptidase 2
"High-Temperature Requirement A Serine Peptidase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.
| Descriptor ID |
D000074923
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| MeSH Number(s) |
D08.811.277.656.300.760.431 D08.811.277.656.959.350.431 D12.644.360.075.429 D12.776.476.075.429 D12.776.575.656 D12.776.637.625
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| Concept/Terms |
High-Temperature Requirement A Serine Peptidase 2- High-Temperature Requirement A Serine Peptidase 2
- High Temperature Requirement A Serine Peptidase 2
- Serine Protease HTRA2
- HTRA2, Serine Protease
- Protease HTRA2, Serine
- Serine Protease Omi
- Omi, Serine Protease
- Protease Omi, Serine
- HtrA2 Protease
- Protease, HtrA2
- HtrA Serine Peptidase 2
- Omi Serine Protease
- Protease, Omi Serine
- Serine Protease, Omi
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Below are MeSH descriptors whose meaning is more general than "High-Temperature Requirement A Serine Peptidase 2".
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Below are the most recent publications written about "High-Temperature Requirement A Serine Peptidase 2" by people in Profiles.
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A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease. Neurobiol Aging. 2011 Mar; 32(3):548.e9-18.