 Complementarity Determining Regions
"Complementarity Determining Regions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Three regions (CDR1; CDR2 and CDR3) of amino acid sequence in the IMMUNOGLOBULIN VARIABLE REGION that are highly divergent. Together the CDRs from the light and heavy immunoglobulin chains form a surface that is complementary to the antigen. These regions are also present in other members of the immunoglobulin superfamily, for example, T-cell receptors (RECEPTORS, ANTIGEN, T-CELL).
| Descriptor ID |
D022801
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| MeSH Number(s) |
D12.644.541.500.650.500.180 D12.776.124.486.485.680.650.500.180 D12.776.124.486.485.797.180 D12.776.124.790.651.680.650.500.180 D12.776.124.790.651.797.180 D12.776.377.715.548.680.650.500.180 D12.776.377.715.548.797.180 D12.776.543.750.705.816.824.300 G02.111.570.060.425.160
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| Concept/Terms |
Complementarity Determining Regions- Complementarity Determining Regions
- Region, Complementarity Determining
- Regions, Complementarity Determining
- Hypervariable Regions, Immunoglobulin
- Hypervariable Region, Immunoglobulin
- Immunoglobulin Hypervariable Region
- Immunoglobulin Hypervariable Regions
- Region, Immunoglobulin Hypervariable
- Regions, Immunoglobulin Hypervariable
- Complementarity Determining Region
- Complementarity-Determining Region
- Complementarity-Determining Regions
- Regions, Complementarity-Determining
Complementarity Determining Region 3- Complementarity Determining Region 3
- Complementarity-Determining Region 3
- Complementarity-Determining Region 3s
- Third Complementarity-Determining Region
- Complementarity-Determining Region, Third
- Complementarity-Determining Regions, Third
- Third Complementarity Determining Region
- Third Complementarity-Determining Regions
- Complementarity Determining Region III
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Below are MeSH descriptors whose meaning is more general than "Complementarity Determining Regions".
Below are MeSH descriptors whose meaning is more specific than "Complementarity Determining Regions".
This graph shows the total number of publications written about "Complementarity Determining Regions" by people in this website by year, and whether "Complementarity Determining Regions" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2007 | 0 | 1 | 1 | | 2008 | 2 | 1 | 3 | | 2009 | 1 | 0 | 1 | | 2011 | 2 | 0 | 2 | | 2012 | 0 | 1 | 1 | | 2014 | 0 | 2 | 2 | | 2015 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Complementarity Determining Regions" by people in Profiles.
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Boughter CT, Borowska MT, Guthmiller JJ, Bendelac A, Wilson PC, Roux B, Adams EJ. Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops. Elife. 2020 11 10; 9.
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Koirala D, Shelke SA, Dupont M, Ruiz S, DasGupta S, Bailey LJ, Benner SA, Piccirilli JA. Affinity maturation of a portable Fab-RNA module for chaperone-assisted RNA crystallography. Nucleic Acids Res. 2018 03 16; 46(5):2624-2635.
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Yew PY, Alachkar H, Yamaguchi R, Kiyotani K, Fang H, Yap KL, Liu HT, Wickrema A, Artz A, van Besien K, Imoto S, Miyano S, Bishop MR, Stock W, Nakamura Y. Quantitative characterization of T-cell repertoire in allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 2015 Sep; 50(9):1227-34.
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Robert L, Tsoi J, Wang X, Emerson R, Homet B, Chodon T, Mok S, Huang RR, Cochran AJ, Comin-Anduix B, Koya RC, Graeber TG, Robins H, Ribas A. CTLA4 blockade broadens the peripheral T-cell receptor repertoire. Clin Cancer Res. 2014 May 01; 20(9):2424-32.
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Kalinina O, Wang Y, Sia K, Radic M, Cazenave PA, Weigert M. Light chain editors of anti-DNA receptors in human B cells. J Exp Med. 2014 Feb 10; 211(2):357-64.
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Persson H, Ye W, Wernimont A, Adams JJ, Koide A, Koide S, Lam R, Sidhu SS. CDR-H3 diversity is not required for antigen recognition by synthetic antibodies. J Mol Biol. 2013 Feb 22; 425(4):803-11.
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Sandstrom A, Scharf L, McRae G, Hawk AJ, Meredith SC, Adams EJ. ?d T cell receptors recognize the non-classical major histocompatibility complex (MHC) molecule T22 via conserved anchor residues in a MHC peptide-like fashion. J Biol Chem. 2012 Feb 17; 287(8):6035-43.
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Koide S, Koide A, Lipovšek D. Target-binding proteins based on the 10th human fibronectin type III domain (¹°Fn3). Methods Enzymol. 2012; 503:135-56.
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Meng W, Yunk L, Wang LS, Maganty A, Xue E, Cohen PL, Eisenberg RA, Weigert MG, Mancini SJ, Prak ET. Selection of individual VH genes occurs at the pro-B to pre-B cell transition. J Immunol. 2011 Aug 15; 187(4):1835-44.
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Fanning SW, Horn JR. An anti-hapten camelid antibody reveals a cryptic binding site with significant energetic contributions from a nonhypervariable loop. Protein Sci. 2011 Jul; 20(7):1196-207.
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