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Nanduri R. Prabhakar

InstitutionUniversity of Chicago
DepartmentMedicine-Emergency Medicine
AddressChicago IL 60637
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    Nanduri R. Prabhakar, Ph.D., D.Sc.
    Harold Hines Jr. Professor of Medicine
    Director, Center for Systems Biology
    Director, Oxygen Sensing Department of Medicine

    The revolutionary advances in cell and molecular biology as well as in genetic engineering in the past half-a-century have provided spectacular insights into our understanding of structure and function of biological systems at the molecular, cellular and sub-cellular levels. Shifting the research emphasis from organ (or from the whole body levels) to cellular and molecular physiology has resulted in a rapid decline in research on physiology at the systems level. While the reductionist approaches are powerful, they have brought into focus a major gap that has developed between our understanding of the molecular/cellular alterations and their impact at the organ and/or whole animal level. Integrative physiology, on the other hand, embraces the concepts of cell/molecular physiology, biochemistry and applies these concepts and experimental approaches to understand the function at the level of whole animal or organ. Realizing its importance, the University of Chicago established the Institute for Integrative Physiology (IIP) at the Biological Sciences Division as of October 2010. The main missions of IIP are to provide intellectual home for faculty members interested in various areas of Physiology to foster interactive research programs and oversee physiology education to medical, graduate and undergraduate students. These missions are supported by exceptional faculty in the IIP. We believe that IIP reaches far beyond the BSD to enhance the national and international visibility of Physiological research at the University of Chicago and provide training to the next generation of leaders in Physiology.

    Collapse Biography 
    Collapse education and training
    M.S. University, Baroda, IndiaPh.D.05/1979Physiology
    Ruhr University, Bochum, Federal Republic of GermanyD.Sc.01/1982Biology
    Collapse awards and honors
    2017Elected Fellow of the American Physiological Society
    2017AAIMS Silver Jubilee Oration Award
    2016Michael de Burgh Daly Award, Physiological Society, U.K.
    2016Inaugural Lahiri-Cherniack Lecture, American Physiological Society
    2015Plenary Lecture, Oxford Meeting, Sydney, Australia
    2015Elected Foreign Member of National Academy of Sciences India
    2014Inaugural C. von Euler Lecture, Karolinska Nobel Institutet, Stockholm, Sweden
    2014Plenary Lecture, PanAm Physiological Congress, Brazil
    2014Prof. Mahabalinos Award, Physiological Society of India
    2013Mario Toppo Distinguished Scientist Award, ASIOA
    2012Julius H.Comroe Distinguished Lecture Award American Physiological Society
    2010Plenary Lecture. British Physiological Soc. Birmingham, U.K.
    2008Neil S. Cherniack Lecture, Case Western Reserve University, Cleveland
    2008A.S. Paintal Award, University of Delhi
    2007Dr. P.C.Roy Oration Award. Indian Physiological Society
    2005Plenary Lecture, Brazilian Physiological Society
    2005Plenary Lecture, O2 Homeostasis, University of Cardiff, U.K.
    2004Nobel Forum: Invited Speaker, Nobel Symposium on Oxygen Biology, Stockholm Sweden

    Collapse Research 
    Collapse research activities and funding
    1P01HL14445401     (Nanduri Prabhakar)Apr 15, 2019 - Mar 31, 2020
    Integrative Consequences of Intermittent Hypoxia
    Role: Principal Investigator

    5UH3HL123610     (Nanduri Prabhakar)
    Therapeutic Targeting of Carotid Body Chemoreflex for Sleep Disordered Breathing
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang N, Peng YJ, Kang W, Hildreth M, Prabhakar NR, Nanduri J. Transcriptomic Analysis of Postnatal Rat Carotid Body Development. Genes (Basel). 2024 Feb 27; 15(3). PMID: 38540361; PMCID: PMC10970570.
      Citations:    Fields:    Translation:AnimalsCells
    2. Wang N, Su X, Sams D, Prabhakar NR, Nanduri J. P300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia. Am J Respir Cell Mol Biol. 2024 Feb; 70(2):110-118. PMID: 37874694; PMCID: PMC10848695.
      Citations: 1     Fields:    Translation:Animals
    3. Vaddi DR, Piao L, Khan SA, Wang N, Prabhakar NR, Nanduri J. Correction: Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells. PLoS One. 2024; 19(1):e0297301. PMID: 38206933; PMCID: PMC10783753.
      Citations:    Fields:    
    4. Das KK, Majid DSA, Prabhakar NR. Editorial: Vascular pathophysiology in hypoxia. Front Physiol. 2023; 14:1235383. PMID: 37485063; PMCID: PMC10361607.
    5. Peng YJ, Nanduri J, Wang N, Kumar GK, Bindokas V, Paul BD, Chen X, Fox AP, Vignane T, Filipovic MR, Prabhakar NR. Hypoxia sensing requires H2S-dependent persulfidation of olfactory receptor 78. Sci Adv. 2023 07 07; 9(27):eadf3026. PMID: 37406126; PMCID: PMC10321732.
      Citations: 2     Fields:    Translation:HumansCells
    6. Prabhakar NR, Peng YJ, Nanduri J. Carotid body hypersensitivity in intermittent hypoxia and obtructive sleep apnoea. J Physiol. 2023 Dec; 601(24):5481-5494. PMID: 37029496.
      Citations: 3     Fields:    Translation:AnimalsCells
    7. Browe BM, Peng YJ, Nanduri J, Prabhakar NR, Garcia AJ. Gasotransmitter modulation of hypoglossal motoneuron activity. Elife. 2023 01 19; 12. PMID: 36656752; PMCID: PMC9977277.
      Citations: 2     Fields:    Translation:AnimalsCells
    8. Gray OA, Yoo J, Jousma J, Witonsky D, Sakabe NJ, Peng YJ, Prabhakar NR, Fang Y, Di Rienzo A, Sobreira DR, Nobréga MA. A pleiotropic hypoxia-sensitive EPAS1 enhancer is disrupted by adaptive alleles in Tibetans. Sci Adv. 2022 Nov 25; 8(47):eade1942. PMID: 36417539; PMCID: PMC9683707.
      Citations: 7     Fields:    
    9. Cetin-Atalay R, Meliton AY, Sun KA, Glass ME, Woods PS, Peng YJ, Fang Y, Hamanaka RB, Prabhakar NR, Mutlu GM. Intermittent hypoxia inhibits epinephrine-induced transcriptional changes in human aortic endothelial cells. Sci Rep. 2022 10 13; 12(1):17167. PMID: 36229484; PMCID: PMC9561121.
      Citations: 3     Fields:    Translation:HumansCells
    10. Peng YJ, Nanduri J, Wang N, Khan SA, Pamenter ME, Prabhakar NR. Carotid body responses to O2 and CO2 in hypoxia-tolerant naked mole rats. Acta Physiol (Oxf). 2022 10; 236(2):e13851. PMID: 35757963; PMCID: PMC9787741.
      Citations: 2     Fields:    Translation:AnimalsCells
    11. Wang N, Prabhakar NR, Nanduri J. Protein phosphatase 1 regulates reactive oxygen species-dependent degradation of histone deacetylase 5 by intermittent hypoxia. Am J Physiol Cell Physiol. 2022 08 01; 323(2):C423-C431. PMID: 35704695; PMCID: PMC9359641.
      Citations: 2     Fields:    Translation:Animals
    12. Prabhakar NR, Peng YJ, Nanduri J. Adaptive cardiorespiratory changes to chronic continuous and intermittent hypoxia. Handb Clin Neurol. 2022; 188:103-123. PMID: 35965023; PMCID: PMC9906984.
      Citations: 3     Fields:    Translation:Humans
    13. Nanduri J, Wang N, Wang BL, Prabhakar NR. Lysine demethylase KDM6B regulates HIF-1a-mediated systemic and cellular responses to intermittent hypoxia. Physiol Genomics. 2021 09 01; 53(9):385-394. PMID: 34297635; PMCID: PMC8887999.
      Citations: 9     Fields:    Translation:AnimalsCells
    14. Cetin-Atalay R, Meliton AY, Wu D, Woods PS, Sun KA, Peng YJ, Nanduri J, Su X, Fang Y, Hamanaka RB, Prabhakar N, Mutlu GM. Intermittent Hypoxia-Induced Activation of Endothelial Cells Is Mediated via Sympathetic Activation-Dependent Catecholamine Release. Front Physiol. 2021; 12:701995. PMID: 34322038; PMCID: PMC8311436.
      Citations: 3     
    15. Wang N, Peng YJ, Su X, Prabhakar NR, Nanduri J. Histone Deacetylase 5 Is an Early Epigenetic Regulator of Intermittent Hypoxia Induced Sympathetic Nerve Activation and Blood Pressure. Front Physiol. 2021; 12:688322. PMID: 34079475; PMCID: PMC8165245.
      Citations: 8     
    16. Peng YJ, Su X, Wang B, Matthews T, Nanduri J, Prabhakar NR. Role of olfactory receptor78 in carotid body-dependent sympathetic activation and hypertension in murine models of chronic intermittent hypoxia. J Neurophysiol. 2021 06 01; 125(6):2054-2067. PMID: 33909496; PMCID: PMC8424574.
      Citations: 10     Fields:    Translation:AnimalsCells
    17. Gridina A, Su X, Khan SA, Peng YJ, Wang B, Nanduri J, Fox AP, Prabhakar NR. Gaseous transmitter regulation of hypoxia-evoked catecholamine secretion from murine adrenal chromaffin cells. J Neurophysiol. 2021 05 01; 125(5):1533-1542. PMID: 33729866; PMCID: PMC8356764.
      Citations: 4     Fields:    Translation:AnimalsCells
    18. Wang B, Peng YJ, Su X, Zhang C, Nagati JS, Garcia JA, Prabhakar NR. Olfactory receptor 78 regulates erythropoietin and cardiorespiratory responses to hypobaric hypoxia. J Appl Physiol (1985). 2021 04 01; 130(4):1122-1132. PMID: 33539264; PMCID: PMC8262783.
      Citations: 4     Fields:    Translation:AnimalsCells
    19. Prabhakar NR, Peng YJ, Nanduri J. Hypoxia-inducible factors and obstructive sleep apnea. J Clin Invest. 2020 10 01; 130(10):5042-5051. PMID: 32730232; PMCID: PMC7524484.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    20. Wang N, Shi XF, Khan SA, Wang B, Semenza GL, Prabhakar NR, Nanduri J. Hypoxia-inducible factor-1 mediates pancreatic ß-cell dysfunction by intermittent hypoxia. Am J Physiol Cell Physiol. 2020 11 01; 319(5):C922-C932. PMID: 32936698; PMCID: PMC7789966.
      Citations: 12     Fields:    Translation:AnimalsCells
    21. Peng YJ, Gridina A, Wang B, Nanduri J, Fox AP, Prabhakar NR. Olfactory receptor 78 participates in carotid body response to a wide range of low O2 levels but not severe hypoxia. J Neurophysiol. 2020 05 01; 123(5):1886-1895. PMID: 32208891; PMCID: PMC7444916.
      Citations: 13     Fields:    Translation:AnimalsCells
    22. Prabhakar NR. 2019 Nobel Prize in Physiology or Medicine. Physiology (Bethesda). 2020 03 01; 35(2):81-83. PMID: 32024429.
      Citations: 4     Fields:    Translation:Humans
    23. Limberg JK, Johnson BD, Mozer MT, Holbein WW, Curry TB, Prabhakar NR, Joyner MJ. Role of the carotid chemoreceptors in insulin-mediated sympathoexcitation in humans. Am J Physiol Regul Integr Comp Physiol. 2020 01 01; 318(1):R173-R181. PMID: 31746629; PMCID: PMC6985802.
      Citations: 12     Fields:    Translation:HumansCells
    24. Makarenko VV, Peng YJ, Khan SA, Nanduri J, Fox AP, Prabhakar NR. Long-term facilitation of catecholamine secretion from adrenal chromaffin cells of neonatal rats by chronic intermittent hypoxia. J Neurophysiol. 2019 11 01; 122(5):1874-1883. PMID: 31483699; PMCID: PMC6879952.
      Citations: 3     Fields:    Translation:AnimalsCells
    25. Vaddi DR, Piao L, Khan SA, Wang N, Prabhakar NR, Nanduri J. Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells. PLoS One. 2019; 14(4):e0215905. PMID: 31017964; PMCID: PMC6481834.
      Citations: 3     Fields:    Translation:HumansCells
    26. Prabhakar NR, Peng YJ, Nanduri J. Recent advances in understanding the physiology of hypoxic sensing by the carotid body. F1000Res. 2018; 7. PMID: 30631432; PMCID: PMC6284772.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    27. Nanduri J, Peng YJ, Wang N, Prabhakar NR. Neural Activation of Molecular Circuitry in Intermittent Hypoxia. Curr Opin Physiol. 2019 Feb; 7:9-14. PMID: 31544168; PMCID: PMC6753940.
      Citations: 8     
    28. Peng YJ, Makarenko VV, Gridina A, Chupikova I, Zhang X, Kumar GK, Fox AP, Prabhakar NR. H2S mediates carotid body response to hypoxia but not anoxia. Respir Physiol Neurobiol. 2019 01; 259:75-85. PMID: 30086385; PMCID: PMC6252114.
      Citations: 8     Fields:    Translation:AnimalsCells
    29. Prabhakar NR, Peng YJ, Yuan G, Nanduri J. Reactive oxygen radicals and gaseous transmitters in carotid body activation by intermittent hypoxia. Cell Tissue Res. 2018 05; 372(2):427-431. PMID: 29470646; PMCID: PMC5918151.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    30. Semenza GL, Prabhakar NR. The role of hypoxia-inducible factors in carotid body (patho) physiology. J Physiol. 2018 08; 596(15):2977-2983. PMID: 29359806; PMCID: PMC6068252.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    31. Nanduri J, Peng YJ, Wang N, Khan SA, Semenza GL, Prabhakar NR. DNA methylation in the central and efferent limbs of the chemoreflex requires carotid body neural activity. J Physiol. 2018 08; 596(15):3087-3100. PMID: 29148180; PMCID: PMC6068255.
      Citations: 10     Fields:    Translation:AnimalsCells
    32. Peng YJ, Prabhakar NR. Measurement of Sensory Nerve Activity from the Carotid Body. Methods Mol Biol. 2018; 1742:115-124. PMID: 29330795.
      Citations: 1     Fields:    Translation:AnimalsCells
    33. Nanduri J, Prabhakar NR. Immunohistochemistry of the Carotid Body. Methods Mol Biol. 2018; 1742:155-166. PMID: 29330798.
      Citations: 1     Fields:    Translation:AnimalsCells
    34. Peng YJ, Zhang X, Nanduri J, Prabhakar NR. Therapeutic Targeting of the Carotid Body for Treating Sleep Apnea in a Pre-clinical Mouse Model. Adv Exp Med Biol. 2018; 1071:109-114. PMID: 30357741.
      Citations: 9     Fields:    Translation:AnimalsCells
    35. Nanduri J, Semenza GL, Prabhakar NR. Epigenetic changes by DNA methylation in chronic and intermittent hypoxia. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L1096-L1100. PMID: 28839104; PMCID: PMC5814703.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    36. Wu D, Huang RT, Hamanaka RB, Krause M, Oh MJ, Kuo CH, Nigdelioglu R, Meliton AY, Witt L, Dai G, Civelek M, Prabhakar NR, Fang Y, Mutlu GM. HIF-1a is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium. Elife. 2017 05 30; 6. PMID: 28556776; PMCID: PMC5495571.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    37. Samanta D, Prabhakar NR, Semenza GL. Systems biology of oxygen homeostasis. Wiley Interdiscip Rev Syst Biol Med. 2017 07; 9(4). PMID: 28221004; PMCID: PMC5606335.
      Citations: 27     Fields:    Translation:Humans
    38. Peng YJ, Zhang X, Gridina A, Chupikova I, McCormick DL, Thomas RJ, Scammell TE, Kim G, Vasavda C, Nanduri J, Kumar GK, Semenza GL, Snyder SH, Prabhakar NR. Complementary roles of gasotransmitters CO and H2S in sleep apnea. Proc Natl Acad Sci U S A. 2017 02 07; 114(6):1413-1418. PMID: 28115703; PMCID: PMC5307452.
      Citations: 37     Fields:    Translation:AnimalsCells
    39. Prabhakar NR, Peng YJ. Oxygen Sensing by the Carotid Body: Past and Present. Adv Exp Med Biol. 2017; 977:3-8. PMID: 28685420.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    40. Applebaum MA, Jha AR, Kao C, Hernandez KM, DeWane G, Salwen HR, Chlenski A, Dobratic M, Mariani CJ, Godley LA, Prabhakar N, White K, Stranger BE, Cohn SL. Integrative genomics reveals hypoxia inducible genes that are associated with a poor prognosis in neuroblastoma patients. Oncotarget. 2016 Nov 22; 7(47):76816-76826. PMID: 27765905; PMCID: PMC5340231.
      Citations: 22     Fields:    Translation:HumansCells
    41. Nanduri J, Peng YJ, Wang N, Khan SA, Semenza GL, Kumar GK, Prabhakar NR. Epigenetic regulation of redox state mediates persistent cardiorespiratory abnormalities after long-term intermittent hypoxia. J Physiol. 2017 01 01; 595(1):63-77. PMID: 27506145; PMCID: PMC5199741.
      Citations: 35     Fields:    Translation:AnimalsCells
    42. Yuan G, Peng YJ, Khan SA, Nanduri J, Singh A, Vasavda C, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR. H2S production by reactive oxygen species in the carotid body triggers hypertension in a rodent model of sleep apnea. Sci Signal. 2016 08 16; 9(441):ra80. PMID: 27531649; PMCID: PMC5505181.
      Citations: 26     Fields:    Translation:AnimalsCells
    43. Prabhakar NR. Carotid body chemoreflex: a driver of autonomic abnormalities in sleep apnoea. Exp Physiol. 2016 08 01; 101(8):975-85. PMID: 27474260; PMCID: PMC4968581.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    44. Garcia AJ, Zanella S, Dashevskiy T, Khan SA, Khuu MA, Prabhakar NR, Ramirez JM. Chronic Intermittent Hypoxia Alters Local Respiratory Circuit Function at the Level of the preBötzinger Complex. Front Neurosci. 2016; 10:4. PMID: 26869872; PMCID: PMC4740384.
      Citations: 32     
    45. Wang N, Kang HS, Ahmmed G, Khan SA, Makarenko VV, Prabhakar NR, Nanduri J. Calpain activation by ROS mediates human ether-a-go-go-related gene protein degradation by intermittent hypoxia. Am J Physiol Cell Physiol. 2016 Mar 01; 310(5):C329-36. PMID: 26659724; PMCID: PMC4865081.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    46. Makarenko VV, Ahmmed GU, Peng YJ, Khan SA, Nanduri J, Kumar GK, Fox AP, Prabhakar NR. CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia. J Neurophysiol. 2016 Jan 01; 115(1):345-54. PMID: 26561606; PMCID: PMC4760493.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    47. Prabhakar NR, Semenza GL. Oxygen Sensing and Homeostasis. Physiology (Bethesda). 2015 Sep; 30(5):340-8. PMID: 26328879; PMCID: PMC4556828.
      Citations: 108     Fields:    Translation:HumansAnimalsCells
    48. Prabhakar NR, Semenza GL. Regulation of carotid body oxygen sensing by hypoxia-inducible factors. Pflugers Arch. 2016 Jan; 468(1):71-75. PMID: 26265380; PMCID: PMC4548826.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    49. Semenza GL, Prabhakar NR. Neural regulation of hypoxia-inducible factors and redox state drives the pathogenesis of hypertension in a rodent model of sleep apnea. J Appl Physiol (1985). 2015 Nov 15; 119(10):1152-6. PMID: 25953833; PMCID: PMC4816415.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    50. Yuan G, Vasavda C, Peng YJ, Makarenko VV, Raghuraman G, Nanduri J, Gadalla MM, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR. Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal. 2015 Apr 21; 8(373):ra37. PMID: 25900831; PMCID: PMC4418480.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    51. Prabhakar NR, Peng YJ, Kumar GK, Nanduri J. Peripheral chemoreception and arterial pressure responses to intermittent hypoxia. Compr Physiol. 2015 Apr; 5(2):561-77. PMID: 25880505; PMCID: PMC4423746.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    52. Nanduri J, Peng YJ, Yuan G, Kumar GK, Prabhakar NR. Hypoxia-inducible factors and hypertension: lessons from sleep apnea syndrome. J Mol Med (Berl). 2015 May; 93(5):473-80. PMID: 25772710; PMCID: PMC4409567.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    53. Nanduri J, Vaddi DR, Khan SA, Wang N, Makarenko V, Semenza GL, Prabhakar NR. HIF-1a activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase. PLoS One. 2015; 10(3):e0119762. PMID: 25751622; PMCID: PMC4353619.
      Citations: 53     Fields:    Translation:AnimalsCells
    54. Kumar GK, Nanduri J, Peng YJ, Prabhakar NR. Neuromolecular mechanisms mediating the effects of chronic intermittent hypoxia on adrenal medulla. Respir Physiol Neurobiol. 2015 Apr; 209:115-9. PMID: 25583660; PMCID: PMC4373452.
      Citations: 4     Fields:    Translation:HumansAnimals
    55. Nanduri J, Prabhakar NR. Epigenetic Regulation of Carotid Body Oxygen Sensing: Clinical Implications. Adv Exp Med Biol. 2015; 860:1-8. PMID: 26303461; PMCID: PMC4870818.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    56. Kumar GK, Peng YJ, Nanduri J, Prabhakar NR. Carotid Body Chemoreflex Mediates Intermittent Hypoxia-Induced Oxidative Stress in the Adrenal Medulla. Adv Exp Med Biol. 2015; 860:195-9. PMID: 26303481; PMCID: PMC4872510.
      Citations: 9     Fields:    Translation:AnimalsCells
    57. Peers C, Kumar P, Wyatt C, Gauda E, Nurse C, Prabhakar N. This volume of Advances in Experimental Medicine and Biology holds the proceedings of the XVIIIth meeting. Introduction. Adv Exp Med Biol. 2015; 860:v-vi. PMID: 26605404.
      Citations:    Fields:    
    58. Makarenko VV, Peng YJ, Yuan G, Fox AP, Kumar GK, Nanduri J, Prabhakar NR. CaV3.2 T-type Ca²? channels in H2S-mediated hypoxic response of the carotid body. Am J Physiol Cell Physiol. 2015 Jan 15; 308(2):C146-54. PMID: 25377087; PMCID: PMC4297770.
      Citations: 12     Fields:    Translation:AnimalsCells
    59. Peng YJ, Yuan G, Khan S, Nanduri J, Makarenko VV, Reddy VD, Vasavda C, Kumar GK, Semenza GL, Prabhakar NR. Regulation of hypoxia-inducible factor-a isoforms and redox state by carotid body neural activity in rats. J Physiol. 2014 Sep 01; 592(17):3841-58. PMID: 24973414; PMCID: PMC4192707.
      Citations: 54     Fields:    Translation:AnimalsCells
    60. Mkrtchian S, Ebberyd A, Hammarstedt-Nordenvall L, Nordlander B, Yoshitake T, Kehr J, Prabhakar N, Poellinger L, Fagerlund MJ, Eriksson LI, Kåhlin J. The human carotid body releases acetylcholine, ATP and cytokines during hypoxia. Exp Physiol. 2014 Aug; 99(8):1089-98. PMID: 24887113.
      Citations: 23     Fields:    Translation:HumansCells
    61. Mariani CJ, Vasanthakumar A, Madzo J, Yesilkanal A, Bhagat T, Yu Y, Bhattacharyya S, Wenger RH, Cohn SL, Nanduri J, Verma A, Prabhakar NR, Godley LA. TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma. Cell Rep. 2014 Jun 12; 7(5):1343-1352. PMID: 24835990; PMCID: PMC4516227.
      Citations: 89     Fields:    Translation:HumansCells
    62. Limberg JK, Curry TB, Prabhakar NR, Joyner MJ. Is insulin the new intermittent hypoxia? Med Hypotheses. 2014 Jun; 82(6):730-5. PMID: 24690299; PMCID: PMC4023546.
      Citations: 15     Fields:    Translation:HumansCells
    63. Takano N, Luo W, Hu H, Shimoda LA, Semenza GL, Peng YJ, Kumar GK, Suematsu M, Prabhakar NR. Hypoxia-inducible factors regulate human and rat cystathionine ß-synthase gene expression. Biochem J. 2014 Mar 01; 458(2):203-11. PMID: 24328859; PMCID: PMC4374488.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    64. Makarenko VV, Usatyuk PV, Yuan G, Lee MM, Nanduri J, Natarajan V, Kumar GK, Prabhakar NR. Intermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation. Am J Physiol Cell Physiol. 2014 Apr 15; 306(8):C745-52. PMID: 24477234; PMCID: PMC3989715.
      Citations: 27     Fields:    Translation:HumansCells
    65. Peng YJ, Makarenko VV, Nanduri J, Vasavda C, Raghuraman G, Yuan G, Gadalla MM, Kumar GK, Snyder SH, Prabhakar NR. Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1174-9. PMID: 24395806; PMCID: PMC3903201.
      Citations: 44     Fields:    Translation:AnimalsCells
    66. Prabhakar NR, Peers C. Gasotransmitter regulation of ion channels: a key step in O2 sensing by the carotid body. Physiology (Bethesda). 2014 Jan; 29(1):49-57. PMID: 24382871; PMCID: PMC3929115.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    67. Nanduri J, Vaddi DR, Khan SA, Wang N, Makerenko V, Prabhakar NR. Xanthine oxidase mediates hypoxia-inducible factor-2a degradation by intermittent hypoxia. PLoS One. 2013; 8(10):e75838. PMID: 24124516; PMCID: PMC3790816.
      Citations: 44     Fields:    Translation:AnimalsCells
    68. Peng YJ, Nanduri J, Raghuraman G, Wang N, Kumar GK, Prabhakar NR. Role of oxidative stress-induced endothelin-converting enzyme activity in the alteration of carotid body function by chronic intermittent hypoxia. Exp Physiol. 2013 Nov; 98(11):1620-30. PMID: 23913764; PMCID: PMC3808500.
      Citations: 19     Fields:    Translation:AnimalsCells
    69. Ramirez JM, Garcia AJ, Anderson TM, Koschnitzky JE, Peng YJ, Kumar GK, Prabhakar NR. Central and peripheral factors contributing to obstructive sleep apneas. Respir Physiol Neurobiol. 2013 Nov 01; 189(2):344-53. PMID: 23770311; PMCID: PMC3901437.
      Citations: 51     Fields:    Translation:Humans
    70. Wang N, Khan SA, Prabhakar NR, Nanduri J. Impairment of pancreatic ß-cell function by chronic intermittent hypoxia. Exp Physiol. 2013 Sep; 98(9):1376-85. PMID: 23709585; PMCID: PMC3756548.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    71. Yuan G, Peng YJ, Reddy VD, Makarenko VV, Nanduri J, Khan SA, Garcia JA, Kumar GK, Semenza GL, Prabhakar NR. Mutual antagonism between hypoxia-inducible factors 1a and 2a regulates oxygen sensing and cardio-respiratory homeostasis. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):E1788-96. PMID: 23610397; PMCID: PMC3651442.
      Citations: 41     Fields:    Translation:AnimalsCells
    72. Prabhakar NR. Sensing hypoxia: physiology, genetics and epigenetics. J Physiol. 2013 May 01; 591(9):2245-57. PMID: 23459758; PMCID: PMC3650692.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    73. Nanduri J, Prabhakar NR. Developmental programming of O(2) sensing by neonatal intermittent hypoxia via epigenetic mechanisms. Respir Physiol Neurobiol. 2013 Jan 01; 185(1):105-9. PMID: 22846496; PMCID: PMC3893877.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    74. Prabhakar NR, Semenza GL. Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1 and 2. Physiol Rev. 2012 Jul; 92(3):967-1003. PMID: 22811423; PMCID: PMC3893888.
      Citations: 261     Fields:    Translation:HumansAnimalsCells
    75. Makarenko VV, Nanduri J, Raghuraman G, Fox AP, Gadalla MM, Kumar GK, Snyder SH, Prabhakar NR. Endogenous H2S is required for hypoxic sensing by carotid body glomus cells. Am J Physiol Cell Physiol. 2012 Nov 01; 303(9):C916-23. PMID: 22744006; PMCID: PMC3492824.
      Citations: 34     Fields:    Translation:AnimalsCells
    76. Prabhakar NR, Kumar GK, Peng YJ. Sympatho-adrenal activation by chronic intermittent hypoxia. J Appl Physiol (1985). 2012 Oct 15; 113(8):1304-10. PMID: 22723632; PMCID: PMC3472486.
      Citations: 54     Fields:    Translation:HumansAnimals
    77. Prabhakar NR. Carbon monoxide (CO) and hydrogen sulfide (H(2)S) in hypoxic sensing by the carotid body. Respir Physiol Neurobiol. 2012 Nov 15; 184(2):165-9. PMID: 22664830; PMCID: PMC3449038.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    78. Rajamohan SB, Raghuraman G, Prabhakar NR, Kumar GK. NADPH oxidase-derived H(2)O(2) contributes to angiotensin II-induced aldosterone synthesis in human and rat adrenal cortical cells. Antioxid Redox Signal. 2012 Aug 01; 17(3):445-59. PMID: 22214405; PMCID: PMC3365360.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    79. Semenza GL, Prabhakar NR. Gas biology: small molecular medicine. J Mol Med (Berl). 2012 Mar; 90(3):213-5. PMID: 22349395.
      Citations: 4     Fields:    Translation:HumansAnimals
    80. Prabhakar NR, Semenza GL. Gaseous messengers in oxygen sensing. J Mol Med (Berl). 2012 Mar; 90(3):265-72. PMID: 22349394.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    81. Nanduri J, Makarenko V, Reddy VD, Yuan G, Pawar A, Wang N, Khan SA, Zhang X, Kinsman B, Peng YJ, Kumar GK, Fox AP, Godley LA, Semenza GL, Prabhakar NR. Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2515-20. PMID: 22232674; PMCID: PMC3289330.
      Citations: 68     Fields:    Translation:AnimalsCells
    82. Kumar P, Prabhakar NR. Peripheral chemoreceptors: function and plasticity of the carotid body. Compr Physiol. 2012 Jan; 2(1):141-219. PMID: 23728973; PMCID: PMC3919066.
      Citations: 246     Fields:    Translation:HumansCells
    83. Semenza GL, Prabhakar NR. The role of hypoxia-inducible factors in oxygen sensing by the carotid body. Adv Exp Med Biol. 2012; 758:1-5. PMID: 23080136; PMCID: PMC3715076.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    84. Prabhakar NR. Hydrogen sulfide (H(2)S): a physiologic mediator of carotid body response to hypoxia. Adv Exp Med Biol. 2012; 758:109-13. PMID: 23080150.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    85. Raghuraman G, Prabhakar NR, Kumar GK. Differential regulation of tyrosine hydroxylase by continuous and intermittent hypoxia. Adv Exp Med Biol. 2012; 758:381-5. PMID: 23080186.
      Citations: 4     Fields:    Translation:HumansAnimals
    86. Prabhakar NR. Institute for integrative physiology: resurrection of physiology at the University of Chicago. Physiologist. 2011 Dec; 54(6):235-6. PMID: 22256730.
      Citations:    Fields:    Translation:Humans
    87. Wang T, Lang GD, Moreno-Vinasco L, Huang Y, Goonewardena SN, Peng YJ, Svensson EC, Natarajan V, Lang RM, Linares JD, Breysse PN, Geyh AS, Samet JM, Lussier YA, Dudley S, Prabhakar NR, Garcia JG. Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels. Am J Respir Cell Mol Biol. 2012 Apr; 46(4):524-31. PMID: 22108299; PMCID: PMC5460922.
      Citations: 26     Fields:    Translation:AnimalsCells
    88. Yuan G, Khan SA, Luo W, Nanduri J, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia. J Cell Physiol. 2011 Nov; 226(11):2925-33. PMID: 21302291; PMCID: PMC4695992.
      Citations: 119     Fields:    Translation:AnimalsCells
    89. Peng YJ, Nanduri J, Zhang X, Wang N, Raghuraman G, Seagard J, Kumar GK, Prabhakar NR. Endothelin-1 mediates attenuated carotid baroreceptor activity by intermittent hypoxia. J Appl Physiol (1985). 2012 Jan; 112(1):187-96. PMID: 22016368; PMCID: PMC3774513.
      Citations: 25     Fields:    Translation:AnimalsCells
    90. Garcia AJ, Khan SA, Kumar GK, Prabhakar NR, Ramirez JM. Hydrogen peroxide differentially affects activity in the pre-Bötzinger complex and hippocampus. J Neurophysiol. 2011 Dec; 106(6):3045-55. PMID: 21849609; PMCID: PMC3234088.
      Citations: 13     Fields:    Translation:AnimalsCells
    91. Peng YJ, Raghuraman G, Khan SA, Kumar GK, Prabhakar NR. Angiotensin II evokes sensory long-term facilitation of the carotid body via NADPH oxidase. J Appl Physiol (1985). 2011 Oct; 111(4):964-70. PMID: 21636565; PMCID: PMC3191792.
      Citations: 30     Fields:    Translation:AnimalsCells
    92. Prabhakar NR. Sensory plasticity of the carotid body: role of reactive oxygen species and physiological significance. Respir Physiol Neurobiol. 2011 Sep 30; 178(3):375-80. PMID: 21621009; PMCID: PMC3170509.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    93. Raghuraman G, Kalari A, Dhingra R, Prabhakar NR, Kumar GK. Enhanced neuropeptide Y synthesis during intermittent hypoxia in the rat adrenal medulla: role of reactive oxygen species-dependent alterations in precursor peptide processing. Antioxid Redox Signal. 2011 Apr 01; 14(7):1179-90. PMID: 20836657; PMCID: PMC3048839.
      Citations: 11     Fields:    Translation:AnimalsCells
    94. Peng YJ, Nanduri J, Khan SA, Yuan G, Wang N, Kinsman B, Vaddi DR, Kumar GK, Garcia JA, Semenza GL, Prabhakar NR. Hypoxia-inducible factor 2a (HIF-2a) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):3065-70. PMID: 21288809; PMCID: PMC3041114.
      Citations: 67     Fields:    Translation:AnimalsCells
    95. Raghuraman G, Prabhakar NR, Kumar GK. Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling. J Neurochem. 2010 Dec; 115(6):1568-78. PMID: 20969567; PMCID: PMC2997678.
      Citations: 7     Fields:    Translation:AnimalsCells
    96. Khan SA, Nanduri J, Yuan G, Kinsman B, Kumar GK, Joseph J, Kalyanaraman B, Prabhakar NR. NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: relevance to blood pressure changes in rats. Antioxid Redox Signal. 2011 Feb 15; 14(4):533-42. PMID: 20618070; PMCID: PMC3038125.
      Citations: 51     Fields:    Translation:AnimalsCells
    97. Prabhakar NR, Kumar GK, Nanduri J. Intermittent hypoxia augments acute hypoxic sensing via HIF-mediated ROS. Respir Physiol Neurobiol. 2010 Dec 31; 174(3):230-4. PMID: 20804864; PMCID: PMC3042769.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    98. Prabhakar NR, Kumar GK. Mechanisms of sympathetic activation and blood pressure elevation by intermittent hypoxia. Respir Physiol Neurobiol. 2010 Nov 30; 174(1-2):156-61. PMID: 20804865; PMCID: PMC3042768.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    99. Prabhakar NR. Redox Pioneer: Professor Gregg L. Semenza. Antioxid Redox Signal. 2010 Aug 15; 13(4):559-64. PMID: 20214500.
      Citations: 1     Fields:    Translation:Cells
    100. Souvannakitti D, Nanduri J, Yuan G, Kumar GK, Fox AP, Prabhakar NR. NADPH oxidase-dependent regulation of T-type Ca2+ channels and ryanodine receptors mediate the augmented exocytosis of catecholamines from intermittent hypoxia-treated neonatal rat chromaffin cells. J Neurosci. 2010 Aug 11; 30(32):10763-72. PMID: 20705601; PMCID: PMC6634712.
      Citations: 44     Fields:    Translation:AnimalsCells
    101. Souvannakitti D, Kuri B, Yuan G, Pawar A, Kumar GK, Smith C, Fox AP, Prabhakar NR. Neonatal intermittent hypoxia impairs neuronal nicotinic receptor expression and function in adrenal chromaffin cells. Am J Physiol Cell Physiol. 2010 Aug; 299(2):C381-8. PMID: 20664070; PMCID: PMC2928622.
      Citations: 9     Fields:    Translation:AnimalsCells
    102. Peng YJ, Nanduri J, Raghuraman G, Souvannakitti D, Gadalla MM, Kumar GK, Snyder SH, Prabhakar NR. H2S mediates O2 sensing in the carotid body. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10719-24. PMID: 20556885; PMCID: PMC2890835.
      Citations: 153     Fields:    Translation:AnimalsCells
    103. Prabhakar NR, Kumar GK, Nanduri J. Intermittent hypoxia-mediated plasticity of acute O2 sensing requires altered red-ox regulation by HIF-1 and HIF-2. Ann N Y Acad Sci. 2009 Oct; 1177:162-8. PMID: 19845618.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    104. Nanduri J, Bergson P, Wang N, Ficker E, Prabhakar NR. Hypoxia inhibits maturation and trafficking of hERG K(+) channel protein: Role of Hsp90 and ROS. Biochem Biophys Res Commun. 2009 Oct 16; 388(2):212-6. PMID: 19654002; PMCID: PMC2735591.
      Citations: 9     Fields:    Translation:HumansCells
    105. Raghuraman G, Rai V, Peng YJ, Prabhakar NR, Kumar GK. Pattern-specific sustained activation of tyrosine hydroxylase by intermittent hypoxia: role of reactive oxygen species-dependent downregulation of protein phosphatase 2A and upregulation of protein kinases. Antioxid Redox Signal. 2009 Aug; 11(8):1777-89. PMID: 19335094; PMCID: PMC2848511.
      Citations: 21     Fields:    Translation:AnimalsCells
    106. Braga VA, Prabhakar NR. Refinement of telemetry for measuring blood pressure in conscious rats. J Am Assoc Lab Anim Sci. 2009 May; 48(3):268-71. PMID: 19476715; PMCID: PMC2696829.
      Citations: 6     Fields:    Translation:Animals
    107. Peng YJ, Nanduri J, Yuan G, Wang N, Deneris E, Pendyala S, Natarajan V, Kumar GK, Prabhakar NR. NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia. J Neurosci. 2009 Apr 15; 29(15):4903-10. PMID: 19369559; PMCID: PMC2692682.
      Citations: 104     Fields:    Translation:AnimalsCells
    108. Souvannakitti D, Kumar GK, Fox A, Prabhakar NR. Neonatal intermittent hypoxia leads to long-lasting facilitation of acute hypoxia-evoked catecholamine secretion from rat chromaffin cells. J Neurophysiol. 2009 Jun; 101(6):2837-46. PMID: 19339466; PMCID: PMC2694101.
      Citations: 35     Fields:    Translation:AnimalsCells
    109. Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ. Strategic plan for pediatric respiratory diseases research: an NHLBI working group report. Proc Am Thorac Soc. 2009 Jan 15; 6(1):1-10. PMID: 19131525; PMCID: PMC5820807.
      Citations: 13     Fields:    Translation:Humans
    110. Nanduri J, Wang N, Yuan G, Khan SA, Souvannakitti D, Peng YJ, Kumar GK, Garcia JA, Prabhakar NR. Intermittent hypoxia degrades HIF-2alpha via calpains resulting in oxidative stress: implications for recurrent apnea-induced morbidities. Proc Natl Acad Sci U S A. 2009 Jan 27; 106(4):1199-204. PMID: 19147445; PMCID: PMC2626608.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
    111. Souvannakitti D, Kumar GK, Fox A, Prabhakar NR. Contrasting effects of intermittent and continuous hypoxia on low O(2) evoked catecholamine secretion from neonatal rat chromaffin cells. Adv Exp Med Biol. 2009; 648:345-9. PMID: 19536498.
      Citations: 7     Fields:    Translation:AnimalsCells
    112. Abman S, Jobe A, Chernick V, Blaisdell C, Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ, Gail D, Hamvas A, Kercsmar C, Kiley J, Weinmann G, NHLBI working group report. Strategic plan for pediatric respiratory diseases research: an NHLBI working group report. Pediatr Pulmonol. 2009 Jan; 44(1):2-13. PMID: 19086051; PMCID: PMC2778243.
      Citations: 3     Fields:    Translation:Humans
    113. Prabhakar NR, Peng YJ, Kumar GK, Nanduri J, Di Giulio C, Lahiri S. Long-term regulation of carotid body function: acclimatization and adaptation--invited article. Adv Exp Med Biol. 2009; 648:307-17. PMID: 19536494; PMCID: PMC3893881.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    114. Pawar A, Nanduri J, Yuan G, Khan SA, Wang N, Kumar GK, Prabhakar NR. Reactive oxygen species-dependent endothelin signaling is required for augmented hypoxic sensory response of the neonatal carotid body by intermittent hypoxia. Am J Physiol Regul Integr Comp Physiol. 2009 Mar; 296(3):R735-42. PMID: 19109370; PMCID: PMC2665844.
      Citations: 50     Fields:    Translation:AnimalsCells
    115. Kumar GK, Prabhakar NR. Post-translational modification of proteins during intermittent hypoxia. Respir Physiol Neurobiol. 2008 Dec 10; 164(1-2):272-6. PMID: 18602876; PMCID: PMC2642904.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    116. Nanduri J, Yuan G, Kumar GK, Semenza GL, Prabhakar NR. Transcriptional responses to intermittent hypoxia. Respir Physiol Neurobiol. 2008 Dec 10; 164(1-2):277-81. PMID: 18692603; PMCID: PMC3390913.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    117. Marek W, Muckenhoff K, Prabhakar NR. Significance of pulmonary vagal afferents for respiratory muscle activity in the cat. J Physiol Pharmacol. 2008 Dec; 59 Suppl 6:407-20. PMID: 19218665.
      Citations: 7     Fields:    Translation:AnimalsCells
    118. Yuan G, Nanduri J, Khan S, Semenza GL, Prabhakar NR. Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR. J Cell Physiol. 2008 Dec; 217(3):674-85. PMID: 18651560; PMCID: PMC2696817.
      Citations: 163     Fields:    Translation:AnimalsCells
    119. Sharma SD, Raghuraman G, Lee MS, Prabhakar NR, Kumar GK. Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing. J Appl Physiol (1985). 2009 Jan; 106(1):12-9. PMID: 18818385; PMCID: PMC2636940.
      Citations: 20     Fields:    Translation:AnimalsCells
    120. Nanduri J, Wang N, Bergson P, Yuan G, Ficker E, Prabhakar NR. Mitochondrial reactive oxygen species mediate hypoxic down-regulation of hERG channel protein. Biochem Biophys Res Commun. 2008 Aug 22; 373(2):309-14. PMID: 18570888.
      Citations: 9     Fields:    Translation:HumansCells
    121. Pawar A, Peng YJ, Jacono FJ, Prabhakar NR. Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia. J Appl Physiol (1985). 2008 May; 104(5):1287-94. PMID: 18187605; PMCID: PMC3893879.
      Citations: 61     Fields:    Translation:AnimalsCells
    122. Akada S, Fagerlund MJ, Lindahl SG, Sakamoto A, Prabhakar NR, Eriksson LI. Pronounced depression by propofol on carotid body response to CO2 and K+-induced carotid body activation. Respir Physiol Neurobiol. 2008 Feb 29; 160(3):284-8. PMID: 18054527.
      Citations: 3     Fields:    Translation:AnimalsCells
    123. Semenza GL, Prabhakar NR. HIF-1-dependent respiratory, cardiovascular, and redox responses to chronic intermittent hypoxia. Antioxid Redox Signal. 2007 Sep; 9(9):1391-6. PMID: 17627473.
      Citations: 52     Fields:    Translation:HumansCells
    124. Prabhakar NR, Kumar GK, Nanduri J, Semenza GL. ROS signaling in systemic and cellular responses to chronic intermittent hypoxia. Antioxid Redox Signal. 2007 Sep; 9(9):1397-403. PMID: 17627465.
      Citations: 67     Fields:    Translation:HumansCells
    125. Kuri BA, Khan SA, Chan SA, Prabhakar NR, Smith CB. Increased secretory capacity of mouse adrenal chromaffin cells by chronic intermittent hypoxia: involvement of protein kinase C. J Physiol. 2007 Oct 01; 584(Pt 1):313-9. PMID: 17702812; PMCID: PMC2277058.
      Citations: 22     Fields:    Translation:AnimalsCells
    126. Kumar P, Prabhakar N. Sensing hypoxia: carotid body mechanisms and reflexes in health and disease. Respir Physiol Neurobiol. 2007 Jul 01; 157(1):1-3. PMID: 17368118.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    127. Prabhakar NR, Peng YJ, Kumar GK, Pawar A. Altered carotid body function by intermittent hypoxia in neonates and adults: relevance to recurrent apneas. Respir Physiol Neurobiol. 2007 Jul 01; 157(1):148-53. PMID: 17317339.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    128. Prabhakar NR. Novel role for reactive oxygen species as amplifiers of intermittent hypoxia. Focus on "Reactive oxygen species mediate central cardiorespiratory network responses to acute intermittent hypoxia". J Neurophysiol. 2007 Mar; 97(3):1877. PMID: 17215495.
      Citations: 1     Fields:    Translation:Animals
    129. Nanduri J, Nanduri RP. Cellular mechanisms associated with intermittent hypoxia. Essays Biochem. 2007; 43:91-104. PMID: 17705795.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    130. Dick TE, Hsieh YH, Wang N, Prabhakar N. Acute intermittent hypoxia increases both phrenic and sympathetic nerve activities in the rat. Exp Physiol. 2007 Jan; 92(1):87-97. PMID: 17138622.
      Citations: 78     Fields:    Translation:Animals
    131. Prabhakar NR, Dick TE, Nanduri J, Kumar GK. Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia. Exp Physiol. 2007 Jan; 92(1):39-44. PMID: 17124274.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    132. Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL, Prabhakar NR. Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J Physiol. 2006 Dec 01; 577(Pt 2):705-16. PMID: 16973705; PMCID: PMC1890436.
      Citations: 196     Fields:    Translation:AnimalsCells
    133. Jacono FJ, Peng YJ, Nethery D, Faress JA, Lee Z, Kern JA, Prabhakar NR. Acute lung injury augments hypoxic ventilatory response in the absence of systemic hypoxemia. J Appl Physiol (1985). 2006 Dec; 101(6):1795-802. PMID: 16888052.
      Citations: 23     Fields:    Translation:AnimalsCells
    134. Peng YJ, Yuan G, Jacono FJ, Kumar GK, Prabhakar NR. 5-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase. J Physiol. 2006 Oct 01; 576(Pt 1):289-95. PMID: 16887872; PMCID: PMC1995625.
      Citations: 50     Fields:    Translation:AnimalsCells
    135. Kumar GK, Rai V, Sharma SD, Ramakrishnan DP, Peng YJ, Souvannakitti D, Prabhakar NR. Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress. J Physiol. 2006 Aug 15; 575(Pt 1):229-39. PMID: 16777938; PMCID: PMC1819426.
      Citations: 90     Fields:    Translation:Animals
    136. Prabhakar NR, Peng YJ, Yuan G, Kumar GK. Reactive oxygen species facilitate oxygen sensing. Novartis Found Symp. 2006; 272:95-9; discussion 100-5, 131-40. PMID: 16686431.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    137. Semenza GL, Shimoda LA, Prabhakar NR. Regulation of gene expression by HIF-1. Novartis Found Symp. 2006; 272:2-8; discussion 8-14, 33-6. PMID: 16686426.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    138. Wang H, Yuan G, Prabhakar NR, Boswell M, Katz DM. Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling. J Neurochem. 2006 Feb; 96(3):694-705. PMID: 16390493.
      Citations: 26     Fields:    Translation:AnimalsCells
    139. Prabhakar NR. O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters? Exp Physiol. 2006 Jan; 91(1):17-23. PMID: 16239252.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    140. Lahiri S, Roy A, Baby SM, Hoshi T, Semenza GL, Prabhakar NR. Oxygen sensing in the body. Prog Biophys Mol Biol. 2006 Jul; 91(3):249-86. PMID: 16137743.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    141. Prabhakar NR, Peng YJ, Jacono FJ, Kumar GK, Dick TE. Cardiovascular alterations by chronic intermittent hypoxia: importance of carotid body chemoreflexes. Clin Exp Pharmacol Physiol. 2005 May-Jun; 32(5-6):447-9. PMID: 15854156.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    142. Kline DD, Buniel MC, Glazebrook P, Peng YJ, Ramirez-Navarro A, Prabhakar NR, Kunze DL. Kv1.1 deletion augments the afferent hypoxic chemosensory pathway and respiration. J Neurosci. 2005 Mar 30; 25(13):3389-99. PMID: 15800194; PMCID: PMC6724910.
      Citations: 27     Fields:    Translation:AnimalsCells
    143. Jacono FJ, Peng YJ, Kumar GK, Prabhakar NR. Modulation of the hypoxic sensory response of the carotid body by 5-hydroxytryptamine: role of the 5-HT2 receptor. Respir Physiol Neurobiol. 2005 Feb 15; 145(2-3):135-42. PMID: 15705529.
      Citations: 23     Fields:    Translation:AnimalsCells
    144. Malik MT, Peng YJ, Kline DD, Adhikary G, Prabhakar NR. Impaired ventilatory acclimatization to hypoxia in mice lacking the immediate early gene fos B. Respir Physiol Neurobiol. 2005 Jan 15; 145(1):23-31. PMID: 15652785.
      Citations: 9     Fields:    Translation:Animals
    145. Prabhakar NR, Jacono FJ. Cellular and molecular mechanisms associated with carotid body adaptations to chronic hypoxia. High Alt Med Biol. 2005; 6(2):112-20. PMID: 16060846.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    146. Yuan G, Nanduri J, Bhasker CR, Semenza GL, Prabhakar NR. Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia. J Biol Chem. 2005 Feb 11; 280(6):4321-8. PMID: 15569687.
      Citations: 109     Fields:    Translation:AnimalsCells
    147. Peng YJ, Rennison J, Prabhakar NR. Intermittent hypoxia augments carotid body and ventilatory response to hypoxia in neonatal rat pups. J Appl Physiol (1985). 2004 Nov; 97(5):2020-5. PMID: 15258129.
      Citations: 54     Fields:    Translation:AnimalsCells
    148. Yuan G, Adhikary G, McCormick AA, Holcroft JJ, Kumar GK, Prabhakar NR. Role of oxidative stress in intermittent hypoxia-induced immediate early gene activation in rat PC12 cells. J Physiol. 2004 Jun 15; 557(Pt 3):773-83. PMID: 15107478; PMCID: PMC1665161.
      Citations: 63     Fields:    Translation:AnimalsCells
    149. Dick TE, Hsieh YH, Morrison S, Coles SK, Prabhakar N. Entrainment pattern between sympathetic and phrenic nerve activities in the Sprague-Dawley rat: hypoxia-evoked sympathetic activity during expiration. Am J Physiol Regul Integr Comp Physiol. 2004 Jun; 286(6):R1121-8. PMID: 15001434.
      Citations: 34     Fields:    Translation:AnimalsCells
    150. Prabhakar NR, Kumar GK. Oxidative stress in the systemic and cellular responses to intermittent hypoxia. Biol Chem. 2004 Mar-Apr; 385(3-4):217-21. PMID: 15134334.
      Citations: 43     Fields:    Translation:HumansAnimals
    151. Prabhakar NR, Peng YJ. Peripheral chemoreceptors in health and disease. J Appl Physiol (1985). 2004 Jan; 96(1):359-66. PMID: 14660497.
      Citations: 53     Fields:    Translation:HumansCells
    152. Prabhakar NR, Peng YJ, Overholt JL, Kumar GK. Detection of oxygen sensing during intermittent hypoxia. Methods Enzymol. 2004; 381:107-20. PMID: 15063668.
      Citations: 1     Fields:    Translation:AnimalsCells
    153. Li YL, Sun SY, Overholt JL, Prabhakar NR, Rozanski GJ, Zucker IH, Schultz HD. Attenuated outward potassium currents in carotid body glomus cells of heart failure rabbit: involvement of nitric oxide. J Physiol. 2004 Feb 15; 555(Pt 1):219-29. PMID: 14673183; PMCID: PMC1664828.
      Citations: 20     Fields:    Translation:AnimalsCells
    154. Peng YJ, Prabhakar NR. Effect of two paradigms of chronic intermittent hypoxia on carotid body sensory activity. J Appl Physiol (1985). 2004 Mar; 96(3):1236-42; discussion 1196. PMID: 14660510.
      Citations: 110     Fields:    Translation:AnimalsCells
    155. Kim DK, Natarajan N, Prabhakar NR, Kumar GK. Facilitation of dopamine and acetylcholine release by intermittent hypoxia in PC12 cells: involvement of calcium and reactive oxygen species. J Appl Physiol (1985). 2004 Mar; 96(3):1206-15; discussion 1196. PMID: 14657041.
      Citations: 14     Fields:    Translation:AnimalsCells
    156. Prabhakar NR. Regulation of breathing by tissue oxygen: evidence from mutant mice with Presbyterian hemoglobinopathy. Am J Physiol Regul Integr Comp Physiol. 2003 Oct; 285(4):R724. PMID: 12959918.
      Citations:    Fields:    Translation:Animals
    157. Kim DK, Prabhakar NR, Kumar GK. Acetylcholine release from the carotid body by hypoxia: evidence for the involvement of autoinhibitory receptors. J Appl Physiol (1985). 2004 Jan; 96(1):376-83. PMID: 12923121.
      Citations: 8     Fields:    Translation:AnimalsCells
    158. Peng YJ, Overholt JL, Kline D, Kumar GK, Prabhakar NR. Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):10073-8. PMID: 12907705; PMCID: PMC187770.
      Citations: 212     Fields:    Translation:HumansAnimalsCells
    159. Kumar GK, Prabhakar NR. Tachykinins in the control of breathing by hypoxia: pre- and post-genomic era. Respir Physiol Neurobiol. 2003 May 30; 135(2-3):145-54. PMID: 12809615.
      Citations: 3     Fields:    Translation:HumansAnimals
    160. Kumar GK, Kim DK, Lee MS, Ramachandran R, Prabhakar NR. Activation of tyrosine hydroxylase by intermittent hypoxia: involvement of serine phosphorylation. J Appl Physiol (1985). 2003 Aug; 95(2):536-44. PMID: 12692140.
      Citations: 16     Fields:    Translation:AnimalsCells
    161. Peng YJ, Prabhakar NR. Reactive oxygen species in the plasticity of respiratory behavior elicited by chronic intermittent hypoxia. J Appl Physiol (1985). 2003 Jun; 94(6):2342-9. PMID: 12533494.
      Citations: 71     Fields:    Translation:Animals
    162. Kim DK, Summers BA, Prabhakar NR, Kumar GK. Hypoxia does not uniformly facilitate the release of multiple transmitters from the carotid body. Adv Exp Med Biol. 2003; 536:291-6. PMID: 14635680.
      Citations: 1     Fields:    Translation:AnimalsCells
    163. Peng Y, Yuan G, Overholt JL, Kumar GK, Prabhakar NR. Systemic and cellular responses to intermittent hypoxia: evidence for oxidative stress and mitochondrial dysfunction. Adv Exp Med Biol. 2003; 536:559-64. PMID: 14635713.
      Citations: 13     Fields:    Translation:AnimalsCells
    164. Summers BA, Overholt JL, Prabhakar NR. CO(2) and pH independently modulate L-type Ca(2+) current in rabbit carotid body glomus cells. J Neurophysiol. 2002 Aug; 88(2):604-12. PMID: 12163513.
      Citations: 32     Fields:    Translation:AnimalsCells
    165. Yin Z, Haynie J, Yang X, Han B, Kiatchoosakun S, Restivo J, Yuan S, Prabhakar NR, Herrup K, Conlon RA, Hoit BD, Watanabe M, Yang YC. The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10488-93. PMID: 12149478; PMCID: PMC124951.
      Citations: 88     Fields:    Translation:AnimalsCells
    166. Prabhakar NR. Sleep apneas: an oxidative stress? Am J Respir Crit Care Med. 2002 Apr 01; 165(7):859-60. PMID: 11934709.
      Citations: 26     Fields:    Translation:HumansAnimals
    167. Kline DD, Overholt JL, Prabhakar NR, Kline DD, Overholt JL, Prabhakar NR. Mutant mice deficient in NOS-1 exhibit attenuated long-term facilitation and short-term potentiation in breathing. J Physiol. 2002 Feb 15; 539(Pt 1):309-15. PMID: 11850522; PMCID: PMC2290125.
      Citations: 24     Fields:    Translation:Animals
    168. Kline DD, Peng YJ, Manalo DJ, Semenza GL, Prabhakar NR. Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):821-6. PMID: 11792862; PMCID: PMC117389.
      Citations: 110     Fields:    Translation:AnimalsCells
    169. Prabhakar NR, Kline DD. Ventilatory changes during intermittent hypoxia: importance of pattern and duration. High Alt Med Biol. 2002; 3(2):195-204. PMID: 12162863.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    170. Prabhakar NR, Fields RD, Baker T, Fletcher EC, Prabhakar NR, Fields RD, Baker T, Fletcher EC. Intermittent hypoxia: cell to system. Am J Physiol Lung Cell Mol Physiol. 2001 Sep; 281(3):L524-8. PMID: 11504675.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    171. Clanton TL, Wright VP, Reiser PJ, Klawitter PF, Prabhakar NR. Selected Contribution: Improved anoxic tolerance in rat diaphragm following intermittent hypoxia. J Appl Physiol (1985). 2001 Jun; 90(6):2508-13. PMID: 11356820.
      Citations: 5     Fields:    Translation:Animals
    172. Prabhakar NR. Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms. J Appl Physiol (1985). 2001 May; 90(5):1986-94. PMID: 11299293.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    173. Kim DK, Oh EK, Summers BA, Prabhakar NR, Kumar GK. Release of substance P by low oxygen in the rabbit carotid body: evidence for the involvement of calcium channels. Brain Res. 2001 Feb 23; 892(2):359-69. PMID: 11172784.
      Citations: 9     Fields:    Translation:AnimalsCells
    174. Peng Y, Kline DD, Dick TE, Prabhakar NR. Chronic intermittent hypoxia enhances carotid body chemoreceptor response to low oxygen. Adv Exp Med Biol. 2001; 499:33-8. PMID: 11729902.
      Citations: 29     Fields:    Translation:AnimalsCells
    175. Nattie EE, Prabhakar NR. Peripheral and central chemosensitivity: multiple mechanisms, multiple sites? A workshop summary. Adv Exp Med Biol. 2001; 499:73-80. PMID: 11729937.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    176. Kline DD, Prabhakar NR. Role of nitric oxide in short-term potentiation and long-term facilitation: involvement of NO in breathing stability. Adv Exp Med Biol. 2001; 499:215-9. PMID: 11729880.
      Citations: 6     Fields:    Translation:Animals
    177. Kim DK, Summers BA, Prabhakar NR, Kumar GK. Neurotransmitter release from the rabbit carotid body: differential effects of hypoxia on substance P and acetylcholine release. Adv Exp Med Biol. 2001; 499:39-43. PMID: 11729913.
      Citations: 1     Fields:    Translation:AnimalsCells
    178. Longobardo G, Evangelisti C, Prabhakar N, Cherniack NS. Neural drives and breathing stability. Adv Exp Med Biol. 2001; 499:453-8. PMID: 11729925.
      Citations:    Fields:    Translation:HumansCells
    179. Overholt JL, Summers BA, Ficker E, Prabhakar NR. CO2/HCO3- modulates K+ and Ca2+ currents in glomus cells of the carotid body. Adv Exp Med Biol. 2001; 499:61-6. PMID: 11729935.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    180. Adhikary G, Kline D, Yuan G, Kumar GK, Simonson MS, Cherniack NS, Prabhakar NR. Gene regulation during intermittent hypoxia: evidence for the involvement of reactive oxygen species. Adv Exp Med Biol. 2001; 499:297-302. PMID: 11729895.
      Citations: 3     Fields:    Translation:AnimalsCells
    181. Summers BA, Overholt JL, Prabhakar NR. Augmentation of L-type calcium current by hypoxia in rabbit carotid body glomus cells: evidence for a PKC-sensitive pathway. J Neurophysiol. 2000 Sep; 84(3):1636-44. PMID: 10980033.
      Citations: 15     Fields:    Translation:AnimalsCells
    182. Prabhakar NR, Overholt JL. Cellular mechanisms of oxygen sensing at the carotid body: heme proteins and ion channels. Respir Physiol. 2000 Sep; 122(2-3):209-21. PMID: 10967345.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    183. Prabhakar NR. Oxygen sensing by the carotid body chemoreceptors. J Appl Physiol (1985). 2000 Jun; 88(6):2287-95. PMID: 10846047.
      Citations: 74     Fields:    Translation:AnimalsCells
    184. Premkumar DR, Mishra RR, Overholt JL, Simonson MS, Cherniack NS, Prabhakar NR. L-type Ca(2+) channel activation regulates induction of c-fos transcription by hypoxia. J Appl Physiol (1985). 2000 May; 88(5):1898-906. PMID: 10797155.
      Citations: 15     Fields:    Translation:AnimalsCells
    185. Kline DD, Yang T, Premkumar DR, Thomas AJ, Prabhakar NR. Blunted respiratory responses to hypoxia in mutant mice deficient in nitric oxide synthase-3. J Appl Physiol (1985). 2000 Apr; 88(4):1496-508. PMID: 10749847.
      Citations: 15     Fields:    Translation:AnimalsCells
    186. Overholt JL, Ficker E, Yang T, Shams H, Bright GR, Prabhakar NR. HERG-Like potassium current regulates the resting membrane potential in glomus cells of the rabbit carotid body. J Neurophysiol. 2000 Mar; 83(3):1150-7. PMID: 10712445.
      Citations: 26     Fields:    Translation:AnimalsCells
    187. Overholt JL, Ficker E, Yang T, Shams H, Bright GR, Prabhakar NR. Chemosensing at the carotid body. Involvement of a HERG-like potassium current in glomus cells. Adv Exp Med Biol. 2000; 475:241-8. PMID: 10849664.
      Citations: 3     Fields:    Translation:AnimalsCells
    188. Adhikary G, Premkumar DR, Prabhakar NR. Dual influence of nitric oxide on gene regulation during hypoxia. Adv Exp Med Biol. 2000; 475:285-92. PMID: 10849669.
      Citations: 1     Fields:    Translation:AnimalsCells
    189. Kline DD, Prabhakar NR. Peripheral chemosensitivity in mutant mice deficient in nitric oxide synthase. Adv Exp Med Biol. 2000; 475:571-9. PMID: 10849697.
      Citations: 9     Fields:    Translation:AnimalsCells
    190. Summers BA, Overholt JL, Prabhakar NR. Augmentation of calcium current by hypoxia in carotid body glomus cells. Adv Exp Med Biol. 2000; 475:589-99. PMID: 10849699.
      Citations: 2     Fields:    Translation:AnimalsCells
    191. Premkumar DR, Adhikary G, Overholt JL, Simonson MS, Cherniack NS, Prabhakar NR. Intracellular pathways linking hypoxia to activation of c-fos and AP-1. Adv Exp Med Biol. 2000; 475:101-9. PMID: 10849652.
      Citations: 21     Fields:    Translation:AnimalsCells
    192. Kumar GK, Kou YR, Overholt JL, Prabhakar NR. Involvement of substance P in neutral endopeptidase modulation of carotid body sensory responses to hypoxia. J Appl Physiol (1985). 2000 Jan; 88(1):195-202. PMID: 10642381.
      Citations: 3     Fields:    Translation:AnimalsCells
    193. Kumar GK, Yu RK, Overholt JL, Prabhakar NR. Role of substance P in neutral endopeptidase modulation of hypoxic response of the carotid body. Adv Exp Med Biol. 2000; 475:705-13. PMID: 10849712.
      Citations: 4     Fields:    Translation:AnimalsCells
    194. Summers BA, Overholt JL, Prabhakar NR. Nitric oxide inhibits L-type Ca2+ current in glomus cells of the rabbit carotid body via a cGMP-independent mechanism. J Neurophysiol. 1999 Apr; 81(4):1449-57. PMID: 10200181.
      Citations: 26     Fields:    Translation:AnimalsCells
    195. Prabhakar NR. NO and CO as second messengers in oxygen sensing in the carotid body. Respir Physiol. 1999 Apr 01; 115(2):161-8. PMID: 10385030.
      Citations: 43     Fields:    Translation:AnimalsCells
    196. Overholt JL, Prabhakar NR. Norepinephrine inhibits a toxin resistant Ca2+ current in carotid body glomus cells: evidence for a direct G protein mechanism. J Neurophysiol. 1999 Jan; 81(1):225-33. PMID: 9914283.
      Citations: 9     Fields:    Translation:AnimalsCells
    197. Prabhakar NR. Endogenous carbon monoxide in control of respiration. Respir Physiol. 1998 Oct; 114(1):57-64. PMID: 9858051.
      Citations: 13     Fields:    Translation:Cells
    198. Kline DD, Yang T, Huang PL, Prabhakar NR. Altered respiratory responses to hypoxia in mutant mice deficient in neuronal nitric oxide synthase. J Physiol. 1998 Aug 15; 511 ( Pt 1):273-87. PMID: 9679181; PMCID: PMC2231102.
      Citations: 36     Fields:    Translation:AnimalsCells
    199. Mishra RR, Adhikary G, Simonson MS, Cherniack NS, Prabhakar NR. Role of c-fos in hypoxia-induced AP-1 cis-element activity and tyrosine hydroxylase gene expression. Brain Res Mol Brain Res. 1998 Aug 15; 59(1):74-83. PMID: 9729288.
      Citations: 10     Fields:    Translation:AnimalsCells
    200. Kumar GK, Overholt JL, Bright GR, Hui KY, Lu H, Gratzl M, Prabhakar NR. Release of dopamine and norepinephrine by hypoxia from PC-12 cells. Am J Physiol. 1998 06; 274(6):C1592-600. PMID: 9611124.
      Citations: 18     Fields:    Translation:AnimalsCells
    201. Ernsberger P, Kou YR, Prabhakar NR. Carotid body I1-imidazoline receptors: binding, visualization and modulatory function. Respir Physiol. 1998 Jun; 112(3):239-51. PMID: 9749948.
      Citations:    Fields:    Translation:AnimalsCells
    202. Overholt JL, Prabhakar NR. Ca2+ current in rabbit carotid body glomus cells is conducted by multiple types of high-voltage-activated Ca2+ channels. J Neurophysiol. 1997 Nov; 78(5):2467-74. PMID: 9356397.
      Citations: 19     Fields:    Translation:AnimalsCells
    203. Prabhakar NR, Pieramici SF, Premkumar DR, Kumar GK, Kalaria RN. Activation of nitric oxide synthase gene expression by hypoxia in central and peripheral neurons. Brain Res Mol Brain Res. 1996 Dec 31; 43(1-2):341-6. PMID: 9037552.
      Citations: 16     Fields:    Translation:AnimalsCells
    204. Zakharov SI, Pieramici S, Kumar GK, Prabhakar NR, Harvey RD. Nitric oxide synthase activity in guinea pig ventricular myocytes is not involved in muscarinic inhibition of cAMP-regulated ion channels. Circ Res. 1996 May; 78(5):925-35. PMID: 8620613.
      Citations: 10     Fields:    Translation:Animals
    205. Bright GR, Agani FH, Haque U, Overholt JL, Prabhakar NR. Heterogeneity in cytosolic calcium responses to hypoxia in carotid body cells. Brain Res. 1996 Jan 15; 706(2):297-302. PMID: 8822371.
      Citations: 7     Fields:    Translation:AnimalsCells
    206. Overholt JL, Bright GR, Prabhakar NR. Carbon monoxide and carotid body chemoreception. Adv Exp Med Biol. 1996; 410:341-4. PMID: 9030322.
      Citations: 2     Fields:    Translation:AnimalsCells
    207. Cherniack NS, Shenoy PC, Mishra R, Simonson M, Prabhakar NR. Induction of immediate early response genes by hypoxia. Possible molecular bases for systems adaptation to low pO2. Adv Exp Med Biol. 1996; 410:127-34. PMID: 9030289.
      Citations: 2     Fields:    Translation:AnimalsCells
    208. Prabhakar NR, Rao S, Premkumar D, Pieramici SF, Kumar GK, Kalaria RK. Regulation of neuronal nitric oxide synthase gene expression by hypoxia. Role of nitric oxide in respiratory adaptation to low pO2. Adv Exp Med Biol. 1996; 410:345-8. PMID: 9030323.
      Citations: 6     Fields:    Translation:Animals
    209. Prabhakar NR, Shenoy BC, Simonson MS, Cherniack NS. Cell selective induction and transcriptional activation of immediate early genes by hypoxia. Brain Res. 1995 Oct 30; 697(1-2):266-70. PMID: 8593588.
      Citations: 7     Fields:    Translation:AnimalsCells
    210. Haxhiu MA, Chang CH, Dreshaj IA, Erokwu B, Prabhakar NR, Cherniack NS. Nitric oxide and ventilatory response to hypoxia. Respir Physiol. 1995 Sep; 101(3):257-66. PMID: 8606998.
      Citations: 14     Fields:    Translation:AnimalsCells
    211. Prabhakar NR, Kou YR, Kumar GK. G proteins in carotid body chemoreception. Biol Signals. 1995 Sep-Oct; 4(5):271-6. PMID: 8704827.
      Citations: 1     Fields:    Translation:AnimalsCells
    212. Prabhakar NR, Gouda E, Kumar GK, Kou YR. Analysis of carotid chemoreceptor responses to substance P analogue in anaesthetized cats. J Auton Nerv Syst. 1995 Mar 18; 52(1):43-50. PMID: 7540190.
      Citations:    Fields:    Translation:AnimalsCells
    213. Prabhakar NR, Dinerman JL, Agani FH, Snyder SH. Carbon monoxide: a role in carotid body chemoreception. Proc Natl Acad Sci U S A. 1995 Mar 14; 92(6):1994-7. PMID: 7892214; PMCID: PMC42409.
      Citations: 56     Fields:    Translation:AnimalsCells
    214. Cherniack NS, Prabhakar N, Haxhiu M. Possible genomic mechanism involved in control systems responses to hypoxia. Adv Exp Med Biol. 1995; 393:89-94. PMID: 8629528.
      Citations:    Fields:    Translation:HumansAnimalsCells
    215. Prabhakar NR. Gases as chemical messengers in the carotid body. Role of nitric oxide and carbon monoxide in chemoreception. Adv Exp Med Biol. 1995; 393:309-12. PMID: 8629504.
      Citations: 2     Fields:    Translation:AnimalsCells
    216. Cragg PA, Runold M, Kou YR, Prabhakar NR. Tachykinin antagonists in carotid body responses to hypoxia and substance P in the rat. Respir Physiol. 1994 Mar; 95(3):295-310. PMID: 7520191.
      Citations: 5     Fields:    Translation:AnimalsCells
    217. Kumar GK, Prabhakar NR, Strohl KP, Thomas A, Cragg PA. Low PO2 dependency of neutral endopeptidase and acetylcholinesterase activities of the rat carotid body. Adv Exp Med Biol. 1994; 360:217-20. PMID: 7872091.
      Citations:    Fields:    Translation:AnimalsCells
    218. Prabhakar NR. Neurotransmitters in the carotid body. Adv Exp Med Biol. 1994; 360:57-69. PMID: 7872130.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    219. Prabhakar NR, Kou YR. Inhibitory sympathetic action on the carotid body responses to sustained hypoxia. Respir Physiol. 1994 Jan; 95(1):67-79. PMID: 7908747.
      Citations: 4     Fields:    Translation:AnimalsCells
    220. Prabhakar NR, Cao H, Lowe JA, Snider RM. Selective inhibition of the carotid body sensory response to hypoxia by the substance P receptor antagonist CP-96,345. Proc Natl Acad Sci U S A. 1993 Nov 01; 90(21):10041-5. PMID: 8234254; PMCID: PMC47709.
      Citations: 4     Fields:    Translation:AnimalsCells
    221. Prabhakar NR, Kumar GK, Chang CH, Agani FH, Haxhiu MA. Nitric oxide in the sensory function of the carotid body. Brain Res. 1993 Oct 15; 625(1):16-22. PMID: 7694772.
      Citations: 34     Fields:    Translation:AnimalsCells
    222. Prabhakar NR, Snider RM, Lowe JA, Cao H. Selective blockade of sensory response of the carotid body to hypoxia by NK-1 receptor antagonist CP-96,345. Regul Pept. 1993 Jul 02; 46(1-2):266-8. PMID: 7692512.
      Citations:    Fields:    Translation:AnimalsCells
    223. Cragg PA, Kou YR, Prabhakar NR. Role of substance P in rat carotid body responses to hypoxia and capsaicin. Adv Exp Med Biol. 1993; 337:265-70. PMID: 7509112.
      Citations:    Fields:    Translation:AnimalsCells
    224. Prabhakar NR, Kou YR, Cragg PA, Cherniack NS. Effect of arterial chemoreceptor stimulation: role of norepinephrine in hypoxic chemotransmission. Adv Exp Med Biol. 1993; 337:301-6. PMID: 7906485.
      Citations: 3     Fields:    Translation:AnimalsCells
    225. Mitra J, Dev NB, Romaniuk JR, Trivedi R, Prabhakar NR, Cherniack NS. Cardiorespiratory changes induced by vertebral artery injection of sodium cyanide in cats. Respir Physiol. 1992 Jan; 87(1):49-61. PMID: 1553449.
      Citations: 1     Fields:    Translation:Animals
    226. Kou YR, Ernsberger P, Cragg PA, Cherniack NS, Prabhakar NR. Role of alpha 2-adrenergic receptors in the carotid body response to isocapnic hypoxia. Respir Physiol. 1991 Mar; 83(3):353-64. PMID: 1647054.
      Citations: 16     Fields:    Translation:AnimalsCells
    227. Lagercrantz H, Srinivasan M, Yamamoto Y, Prabhakar N. Functional role of substance P for respiratory control during development. Ann N Y Acad Sci. 1991; 632:48-52. PMID: 1719909.
      Citations: 1     Fields:    Translation:HumansAnimals
    228. Prabhakar NR, Runold M. Chemoreceptor responses to substance P, physalaemin and eledoisin: evidence for neurokinin-1 receptors in the cat carotid body. Neurosci Lett. 1990 Dec 11; 120(2):183-6. PMID: 1705679.
      Citations: 1     Fields:    Translation:AnimalsCells
    229. Kumar GK, Runold M, Ghai RD, Cherniack NS, Prabhakar NR. Occurrence of neutral endopeptidase activity in the cat carotid body and its significance in chemoreception. Brain Res. 1990 May 28; 517(1-2):341-3. PMID: 2376002.
      Citations: 4     Fields:    Translation:AnimalsCells
    230. Runold M, Cherniack NS, Prabhakar NR. Effect of adenosine on isolated and superfused cat carotid body activity. Neurosci Lett. 1990 May 18; 113(1):111-4. PMID: 2366949.
      Citations: 14     Fields:    Translation:AnimalsCells
    231. Runold M, Cherniack NS, Prabhakar NR. Effect of adenosine on chemosensory activity of the cat aortic body. Respir Physiol. 1990 May-Jun; 80(2-3):299-306. PMID: 2218102.
      Citations: 6     Fields:    Translation:AnimalsCells
    232. Mitra J, Prabhakar NR, Overholt JL, Cherniack NS. Respiratory effects of N-methyl-D-aspartate on the ventrolateral medullary surface. J Appl Physiol (1985). 1989 Nov; 67(5):1814-9. PMID: 2574718.
      Citations: 1     Fields:    Translation:Animals
    233. Prabhakar NR, Runold M, Kumar GK, Cherniack NS, Scarpa A. Substance P and mitochondrial oxygen consumption: evidence for a direct intracellular role for the peptide. Peptides. 1989 Sep-Oct; 10(5):1003-6. PMID: 2481845.
      Citations: 3     Fields:    Translation:AnimalsCells
    234. Runold M, Lagercrantz H, Prabhakar NR, Fredholm BB. Role of adenosine in hypoxic ventilatory depression. J Appl Physiol (1985). 1989 Aug; 67(2):541-6. PMID: 2793655.
      Citations: 13     Fields:    Translation:Animals
    235. Prabhakar NR, Landis SC, Kumar GK, Mullikin-Kilpatrick D, Cherniack NS, Leeman S. Substance P and neurokinin A in the cat carotid body: localization, exogenous effects and changes in content in response to arterial pO2. Brain Res. 1989 Mar 06; 481(2):205-14. PMID: 2470465.
      Citations: 6     Fields:    Translation:AnimalsCells
    236. Prabhakar NR, Mitra J, Adams EM, Cherniack NS. Involvement of ventral medullary surface in respiratory responses induced by 2,4-dinitrophenol. J Appl Physiol (1985). 1989 Feb; 66(2):598-605. PMID: 2708191.
      Citations:    Fields:    Translation:AnimalsCells
    237. Cherniack NS, Adams EM, Prabhakar NR, Haxhiu M, Mitra J. Integration of cardiorespiratory responses in the ventrolateral medulla. Prog Brain Res. 1989; 81:215-20. PMID: 2616783.
      Citations:    Fields:    Translation:Animals
    238. Yamamoto Y, Runold M, Prabhakar N, Pantaleo T, Lagercrantz H. Somatostatin in the control of respiration. Acta Physiol Scand. 1988 Dec; 134(4):529-33. PMID: 2907961.
      Citations: 3     Fields:    Translation:Animals
    239. Overholt JL, Mitra J, van Lunteren E, Prabhakar NR, Cherniack NS. Naloxone enhances the response to hypercapnia of spinal and cranial respiratory nerves. Respir Physiol. 1988 Dec; 74(3):299-309. PMID: 3222562.
      Citations:    Fields:    Translation:Animals
    240. Mitra J, Prabhakar NR, Overholt JL, Cherniack NS. Respiratory and vasomotor responses to focal cooling of the ventral medullary surface (VMS) of the rat. Respir Physiol. 1988 Oct; 74(1):35-47. PMID: 3187204.
      Citations:    Fields:    Translation:Animals
    241. van Lunteren E, Prabhakar NR, Cherniack NS, Haxhiu MA, Dick TE. Inhibition of expiratory muscle EMG and motor unit activity during augmented breaths in cats. Respir Physiol. 1988 Jun; 72(3):303-14. PMID: 3406552.
      Citations: 4     Fields:    Translation:Animals
    242. Kieschke J, Mense S, Prabhakar NR. Influence of adrenaline and hypoxia on rat muscle receptors in vitro. Prog Brain Res. 1988; 74:91-7. PMID: 2973083.
      Citations: 2     Fields:    Translation:AnimalsCells
    243. Cherniack NS, Mitra J, Prabhakar NR, Adams EM. Respiratory and vasomotor influences of the ventrolateral medulla. Clin Exp Hypertens A. 1988; 10 Suppl 1:1-9. PMID: 3072119.
      Citations:    Fields:    Translation:HumansAnimals
    244. Prabhakar NR, Mitra J, Cherniack NS. Role of substance P in hypercapnic excitation of carotid chemoreceptors. J Appl Physiol (1985). 1987 Dec; 63(6):2418-25. PMID: 2449416.
      Citations: 3     Fields:    Translation:AnimalsCells
    245. Prabhakar NR, Runold M, Yamamoto Y, Lagercrantz H, Cherniack NS, von Euler C. Role of the vagal afferents in substance P-induced respiratory responses in anaesthetized rabbits. Acta Physiol Scand. 1987 Sep; 131(1):63-71. PMID: 2445172.
      Citations: 1     Fields:    Translation:Animals
    246. Van Lunteren E, Mitra J, Prabhakar NR, Haxhiu MA, Cherniack NS. Ventral medullary surface inputs to cervical sympathetic respiratory oscillations. Am J Physiol. 1987 Jun; 252(6 Pt 2):R1032-8. PMID: 3109263.
      Citations:    Fields:    Translation:Animals
    247. Mitra J, Prabhakar NR, Overholt JL, Cherniack NS. Respiratory and vasomotor effects of excitatory amino acid on ventral medullary surface. Brain Res Bull. 1987 May; 18(5):681-4. PMID: 2886198.
      Citations: 1     Fields:    Translation:Animals
    248. Prabhakar NR, Mitra J, Overholt JL, Cherniack NS. Analysis of postinspiratory activity of phrenic motoneurons with chemical and vagal reflexes. J Appl Physiol (1985). 1986 Oct; 61(4):1499-509. PMID: 3096939.
      Citations: 6     Fields:    Translation:AnimalsCells
    249. Prabhakar NR, Mitra J, Van de Graaff W, Haxhiu MA, Cherniack NS. Effect of focal cooling of central chemosensitive areas on cerebral ischemic response. Am J Physiol. 1986 Aug; 251(2 Pt 2):R295-302. PMID: 2874745.
      Citations: 1     Fields:    Translation:AnimalsCells
    250. Mitra J, Prabhakar NR, Haxhiu M, Cherniack NS. Comparison of the effects of hypercapnia on phrenic and hypoglossal activity in anesthetized decerebrate and decorticate animals. Brain Res Bull. 1986 Aug; 17(2):181-7. PMID: 3768733.
      Citations: 5     Fields:    Translation:Animals
    251. Mense S, Prabhakar NR. Spinal termination of nociceptive afferent fibres from deep tissues in the cat. Neurosci Lett. 1986 May 15; 66(2):169-74. PMID: 3725183.
      Citations: 7     Fields:    Translation:AnimalsCells
    252. Haxhiu MA, Mitra J, van Lunteren E, Prabhakar N, Bruce EN, Cherniack NS. Responses of hypoglossal and phrenic nerves to decreased respiratory drive in cats. Respiration. 1986; 50(2):130-8. PMID: 3749614.
      Citations: 5     Fields:    Translation:AnimalsCells
    253. Haxhiu MA, Mitra J, van Lunteren E, Prabhakar NR, Cherniack NS. Influence of central chemoreceptor afferent inputs on respiratory muscle activity. Am J Physiol. 1985 Aug; 249(2 Pt 2):R266-73. PMID: 4025583.
      Citations: 2     Fields:    Translation:AnimalsCells
    254. Mitra J, Prabhakar NR, Haxhiu MA, Cherniack NS. The effects of hypercapnia and cooling the ventral medullary surface on capsaicin induced respiratory reflexes. Respir Physiol. 1985 Jun; 60(3):377-85. PMID: 3929349.
      Citations: 1     Fields:    Translation:AnimalsCells
    255. Prabhakar NR, Marek W, Loeschcke HH. Altered breathing pattern elicited by stimulation of abdominal visceral afferents. J Appl Physiol (1985). 1985 Jun; 58(6):1755-60. PMID: 4008397.
      Citations: 9     Fields:    Translation:AnimalsCells
    256. Marek W, Prabhakar NR, Loeschcke HH. Electrical stimulation of arterial and central chemosensory afferents at different times in the respiratory cycle of the cat: I. Ventilatory responses. Pflugers Arch. 1985 Apr; 403(4):415-21. PMID: 4011393.
      Citations: 3     Fields:    Translation:AnimalsCells
    257. Marek W, Prabhakar NR. Electrical stimulation of arterial and central chemosensory afferents at different times in the respiratory cycle of the cat: II. Responses of respiratory muscles and their motor nerves. Pflugers Arch. 1985 Apr; 403(4):422-8. PMID: 3160005.
      Citations: 2     Fields:    Translation:AnimalsCells
    258. Prabhakar NR, Runold M, Yamamoto Y, Lagercrantz H, von Euler C. Effect of substance P antagonist on the hypoxia-induced carotid chemoreceptor activity. Acta Physiol Scand. 1984 Jul; 121(3):301-3. PMID: 6206685.
      Citations: 5     Fields:    Translation:AnimalsCells
    259. Funke PJ, Prabhakar NR, Hertle L, Runkel N, Dahlheim H. Plasma renin activity and cardiovascular changes in patients with chronic bladder distension. Urol Int. 1982; 37(5):363-8. PMID: 6760517.
      Citations: 2     Fields:    Translation:Humans
    260. Prabhakar NR, Nishith SD, Saxena JP. Effect of distension of urinary bladder on blood pressure and respiration. Indian J Physiol Pharmacol. 1973 Oct-Dec; 17(4):370-5. PMID: 4802452.
      Citations: 1     Fields:    Translation:AnimalsCells
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